Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Science Translational Medicine

Volumn 8, Issue 326, 2016, Pages

  Luke, Thomas ^a   Wu, Hua ^b   Zhao, Jincun ^c,d   Channappanavar, Rudragouda ^c   Coleman, Christopher M ^e   Jiao, Jin An ^b   Matsushita, Hiroaki ^b   Liu, Ye ^f   Postnikova, Elena N ^g   Ork, Britini L ^g   Glenn, Gregory ^f   Flyer, David ^f   Defang, Gabriel ^h   Raviprakash, Kanakatte ^a   Kochel, Tadeusz ^a,j   Wang, Jonathan ⁱ   Nie, Wensheng ⁱ   Smith, Gale ^f   Hensley, Lisa E ^g   Olinger, Gene G ^g   Kuhn, Jens H ^g   Holbrook, Michael R ^g   Johnson, Reed F ^g   Perlman, Stanley ^c   Sullivan, Eddie ^b   Frieman, Matthew B ^e   more..

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b SAB Biotherapeutics   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f NOVAVAX INC   (United States)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^h US Naval Medical Research Unit No 3 Egypt   (Egypt)

ⁱ Thermo Fisher Scientific   (United States)

^j National Biodefense Analysis and Countermeasures Center   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DNA; IMMUNOGLOBULIN G; NANOPARTICLE; NEUTRALIZING ANTIBODY; SAB 301; UNCLASSIFIED DRUG; VIRUS VACCINE; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANTIBODY DEPENDENT ENHANCEMENT; ANTIBODY TITER; ARTICLE; BOVINE; CLADISTICS; CONTROLLED STUDY; DNA MODIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME; VACCINATION; VIRUS INFECTION; VIRUS STRAIN; ANIMAL; BAGG ALBINO MOUSE; CHROMOSOME; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SERODIAGNOSIS; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY-DEPENDENT ENHANCEMENT; CATTLE; CHROMOSOMES, MAMMALIAN; DIPEPTIDYL PEPTIDASE 4; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN G; MICE, INBRED BALB C; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NEUTRALIZATION TESTS; RNA, MESSENGER; TRANSDUCTION, GENETIC; VACCINATION; VIRUS REPLICATION;

EID: 84973153410     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaf1061     Document Type: Article

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