The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

BMC Cancer

Volumn 19, Issue 1, 2019, Pages

  Kaschula, Catherine H ^a   Tuveri, Rosanna ^b   Ngarande, Ellen ^c   Dzobo, Kevin ^c,d   Barnett, Christopher ^e   Kusza, Daniel A ^e   Graham, Lisa M ^c   Katz, Arieh A ^c   Rafudeen, Mohamed Suhail ^e   Parker, M Iqbal ^c   Hunter, Roger ^e   Schäfer, Georgia ^c  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Ajoene; Antimetastatic; Cancer; EMT; Garlic; Natural product; Vimentin

Indexed keywords

AJOENE; CYSTEINE; TETRAMER; VIMENTIN; DISULFIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; VIM PROTEIN, HUMAN;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; COVALENT BOND; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; GARLIC; MDA-MB-231 CELL LINE; METASTASIS INHIBITION; PROTEIN EXPRESSION; CELL MOTION; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR MODEL; NEOPLASM; PATHOLOGY; PREVENTION AND CONTROL; TUMOR CELL LINE; TUMOR INVASION;

CELL LINE, TUMOR; CELL MOVEMENT; COMPUTER SIMULATION; DISULFIDES; DRUG SCREENING ASSAYS, ANTITUMOR; GARLIC; HUMANS; MODELS, MOLECULAR; NEOPLASM INVASIVENESS; NEOPLASMS; PROTEIN BINDING; RECOMBINANT PROTEINS; VIMENTIN;

EID: 85063284935     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-019-5388-8     Document Type: Article

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