Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 236-254

  Kaschula, Catherine H ^a,b   Hunter, Roger ^a   Stellenboom, Nashia ^a   Caira, Mino R ^a   Winks, Susan ^a   Ogunleye, Thozama ^a   Richards, Philip ^a   Cotton, Jonathan ^a   Zilbeyaz, Kani ^a,c   Wang, Yabing ^a,b   Siyo, Vuyolwethu ^a,b   Ngarande, Ellen ^a,b   Parker, M Iqbal ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c AGRI IBRAHIM CECEN UNIVERSITY   (Turkey)

Author keywords

Ajoene; Anti cancer; End substituted ajoene derivatives; Garlic; Structure activity; Vinyl disulfide; WHCO1 oesophageal cancer cell line

Indexed keywords

1 METHOXY 4 [(2 PROPYN 1 YLTHIO)METHYL] BENZENE; 10 (PARA METHOXYPHENYL) 4,5,9 TRITHIADECA 1,6 DIENE; 10 PHENYL 4,5,9 TRITHIADECA 1,6 DIENE; 10,10 DIMETHYL 4,5,9 TRITHIAUNDECA 1,6 DIENE; 12 (PARA METHOXYBENZYLOXY) 4,5,9 TRITHIADODECA 1,6 DIENE; 12 (T BUTYLDIMETHYLSILYLOXY) 4,5,9 TRITHIADODECA 1, 6 DIENE; 12 PHTHALIMIDO 4,5,9 TRITHIADODECA 1,6 DIENE; 3 ((3' PARA METHOXYBENZYLOXY)PROP 1 YLTHIO) 1 PROPYNE; 3 (3' PHTHALIMIDOPROP 1 YLTHIO) 1 PROPYNE; 3 (PROPYLTHIO) 1 PROPYNE; 3 [(10,10 DIMETHYLETHYL)THIO] 1 PROPYNE; 3 [30 ((TERT BUTYL)DIMETHYLSILYLOXY) PROP 1 YLTHIO] 1 PROPYNE; 3 BENZYLTHIO 1 PROPYNE; 4,5,9 TRITHIADODECA 1,6 DIENE; 4,5,9 TRITHIADODECA 6 ENE; [3 ((1,1 DIMETHYLETHYL)THIO)PROPEN 1 YL] ETHANETHIOATE; [3 (3 N PHTHALIMIDOPROP 1 YLTHIO]PROPEN 1 YL] ETHANETHIOATE; [3 (3 PARA METHOXYBENZYL PROP 1 YLTHIO) PROPEN 1 YL] ETHANETHIOATE; [3 (3 TERT BUTYLDIMETHYLSILYLOXY PROP 1 YLTHIO) PROPEN 1 YL] ETHANETHIOATE; [3 (BENZYLTHIO)PROPEN 1 YL] ETHANETHIOATE; [3 (PARA METHOXYBENZYLTHIO)PROPEN 1 YL] ETHANETHIOATE; [3 (PROP 1 YLTHIO)PROPEN 1 YL] ETHANETHIOAT; AJOENE; CASPASE 3; CISPLATIN; CYSTEINE; FLUOROURACIL; N (3 BROMOPROPYL) PHTHALIMIDE; SULFOXIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL ADHESION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL PROLIFERATION; CHEMICAL BOND; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; OXIDATION; PHARMACOPHORE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DISULFIDES; ESOPHAGEAL NEOPLASMS; FLOW CYTOMETRY; GARLIC; GROWTH INHIBITORS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84862830339     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.058     Document Type: Article

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