The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 7, 2016, Pages 1439-1449

  Smith, Muneerah ^a   Hunter, Roger ^a   Stellenboom, Nashia ^a   Kusza, Daniel A ^a   Parker, M Iqbal ^a,b   Hammouda, Ahmed N H ^a   Jackson, Graham ^a   Kaschula, Catherine H ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; ASCORBIC ACID; DISULFIDE; REACTIVE OXYGEN METABOLITE; THIOSULFONATE; TROLOX C; UNCLASSIFIED DRUG; ANTIOXIDANT; SULFONIC ACID DERIVATIVE; THIOL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESOPHAGEAL CANCER CELL LINE; G2 PHASE CELL CYCLE CHECKPOINT; GARLIC; IC50; LYSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN THIOLATION; THERMODYNAMICS; THIOLYSIS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME FACTOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGEAL NEOPLASMS; G2 PHASE CELL CYCLE CHECKPOINTS; GARLIC; HUMANS; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; THIOSULFONIC ACIDS; TIME FACTORS;

EID: 84964670264     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.03.032     Document Type: Article

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