The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells

Molecular Carcinogenesis

Volumn 55, Issue 8, 2016, Pages 1213-1228

  Kaschula, Catherine H ^a   Hunter, Roger ^a   Cotton, Jonathan ^a   Tuveri, Rossana ^b   Ngarande, Ellen ^c   Dzobo, Kevin ^a   Schäfer, Georgia ^a   Siyo, Vuyolwethu ^a   Lang, Dirk ^a   Kusza, Daniel A ^a   Davies, Bronwen ^a   Katz, Arieh A ^a   Parker, M Iqbal ^a,c  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

ajoene; cancer prevention; endoplasmic reticulum; garlic; protein folding

Indexed keywords

AJOENE; COLLAGEN TYPE 1; DANSYLAJOENE; FLUORESCEIN AJOENE; GLUCOSE REGULATED PROTEIN 78; PROTEASOME; PROTEIN AGGREGATE; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL; CELL VIABILITY; COMPETITIVE BINDING ASSAY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENDOPLASMIC RETICULUM; ESOPHAGEAL CANCER CELL LINE; GARLIC; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN FOLDING; TRANSMISSION ELECTRON MICROSCOPY; UNFOLDED PROTEIN RESPONSE;

EID: 84977496298     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22364     Document Type: Article

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