Antimetastatic therapies of the polysulfide diallyl trisulfide against triple-negative breast cancer (TNBC) via suppressing MMP2/9 by blocking NF-κB and ERK/MAPK signaling pathways

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Liu, Yuping ^a   Zhu, Pingting ^a,b   Wang, Yingyu ^a   Wei, Zhonghong ^a   Tao, Li ^a   Zhu, Zhijie ^a   Sheng, Xiaobo ^a   Wang, Siliang ^a   Ruan, Junshan ^a   Liu, Zhaoguo ^a   Cao, Yuzhu ^a   Shan, Yunlong ^a   Sun, Lihua ^a   Wang, Aiyun ^a   Chen, Wenxing ^a   Lu, Yin ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b YANGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIALLYL TRISULFIDE; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; ALLYL COMPOUND; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; SULFIDE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST METASTASIS; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; EMBRYO; ENZYME ACTIVITY; IMMUNOFLUORESCENCE; MOLECULAR DYNAMICS; MORPHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRIPLE NEGATIVE BREAST CANCER; WOUND HEALING; ZEBRA FISH; ANIMAL; BIOSYNTHESIS; BREAST NEOPLASMS; CELL MOTION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; FEMALE; HUMAN; METABOLISM; METASTASIS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ALLYL COMPOUNDS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NF-KAPPA B; SULFIDES; ZEBRAFISH;

EID: 84957798102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123781     Document Type: Article

References (38)

1. Galeone C, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, et al. (2009) Allium vegetables intake and endometrial cancer risk. Public Health Nutr. 12:1576-1579. doi: 10.1017/S1368980008003820 PMID: 18986589
2. Levi F, Pasche C, La Vecchia C, Lucchini F, Franceschi S (1999) Food groups and colorectal cancer risk. Br. J. Cancer 79:1283-1287. PMID: 10098773
3. Calvo-Góme O, Morales-López J, López MG (2004) Solid-phase microextraction-gas chromatographicmass spectrometric analysis of garlic oil obtained by hydrodistillation. J. Chromatogr. A 1036:91-93. PMID: 15139418
4. Lai KC, Hsu SC, Kuo CL, Yang JS, Ma CY, Lu HF, et al. (2013) Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions. Environ Toxicol. J 28:479-488 doi: 10.1002/tox. 20737 PMID: 21695758
5. Xin-JW, Ying H, Evelyn L, Volker MS (2009) Apoptosis Induction in Human Lung AdenocarcinomaCells by Oil-Soluble Allyl Sulfides: Triggers, Pathways, and Modulators. J. 50:266-275
6. Chandra-Kuntal K, Lee J, Singh SV (2013) Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic. Breast Cancer Res. Treat. 138:69-79. doi: 10.1007/s10549-013-2440-2 PMID: 23412769
7. Malki A, El-Saadani M, Sultan AS (2009) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells. Cancer Biol. Ther. 8:2175-2185. PMID: 19823037
8. Nkrumah-Elie YM, Reuben JS, Hudson A, Taka E, Badisa R, Ardley T, et al. (2012) Diallyl trisulfide as an inhibitor of benzo (a) pyrene-induced precancerous carcinogenesis in MCF-10A cells. Food Chem. Toxicol. 50:2524-2530. doi: 10.1016/j.fct.2012.04.010 PMID: 22525868
9. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, et al. (2012) Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11, Available from: http://globocan. iarc.fr. Accessed: December 20, 2013.
10. Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple-negative breast cancer. N. Engl. J. Med. 363:1938-1948. doi: 10.1056/NEJMra1001389 PMID: 21067385
11. Elias AD (2010) Triple-negative breast cancer: a short review. Am. J. Clin. Oncol 33:637-645. doi: 10. 1097/COC.0b013e3181b8afcf PMID: 20023571
12. Hong BH, Wu CH, Yeh CT, Yen GC (2013) Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion. Mol Nutr Food Res 57:886-895. doi: 10.1002/mnfr.201200715 PMID: 23417847
13. Overall CM, Kleifeld O (2006) Tumour microenvironment-opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat. Rev. Cancer 6:227-239. PMID: 16498445
14. Mehner C, Hockla A, Miller E, Ran S, Radisky DC, Radisky ES (2014) Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget 5:2736-2749. PMID: 24811362
15. Garg P, Sarma D, Jeppsson S, Patel NR, Gewirtz AT, Merlin D, et al. (2010) Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res 70:792-801. doi: 10.1158/0008-5472. CAN-09-3166 PMID: 20068187
16. Reddy KB, Krueger JS, Kondapaka SB, Diglio CA (1999) Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells. Int. J. Cancer 82:268-273. PMID: 10389762
17. Shin DY, Kim GY, Hwang HJ, Kim WJ, Choi YH (2014) Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. Environ. Toxicol. Pharmacol 37:74-83. doi: 10.1016/j.etap. 2013.11.002 PMID: 24309133
18. Hosono T, Fukao T, Ogihara J, Ito Y (2005) Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. J. Biol. Chem 280:41487-41493. PMID: 16219763
19. Yi L, Su Q (2013) Molecular mechanisms for the anti-cancer effects of diallyl disulfide. Food Chem. Toxicol 57:362-370. doi: 10.1016/j.fct.2013.04.001 PMID: 23583486
20. Li W, Tian H, Li L, Li S, Yue WM, Chen ZT, et al. (2012) Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo. Acta Biochim. Biophys. Sin. (Shanghai) 44:577-583. doi: 10.1093/abbs/gms033 PMID: 22595511
21. Jakubíková J, Sedlák J (2006) Garlic-derived organosulfides induce cytotoxicity, apoptosis, cell cycle arrest and oxidative stress in human colon carcinoma cell lines. Neoplasma 53:191-199. PMID: 16652187
22. Luo Y, Liang F, Zhang ZY (2009) PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry 48:1838-1846. doi: 10.1021/bi8020789 PMID: 19199380
23. Hadler-Olsen E, Winberg JO, Uhlin-Hansen L (2013) Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumour Biol 34:2041-2051. doi: 10. 1007/s13277-013-0842-8 PMID: 23681802
24. Irvin WJ Jr, Carey LA (2008) What is triple-negative breast cancer? Eur. J. Cancer 18:2799-2805. doi: 10.1016/j.ejca.2008.09.034 PMID: 19008097
25. Arslan C, Dizdar O, Altundag K (2009) Pharmacotherapy of triple-negative breast cancer. Expert Opin. Pharmacother 13:2081-2093. doi: 10.1517/14656560903117309 PMID: 19640211
26. Tan AR, Swain SM (2008) Therapeutic strategies for triple-negative breast cancer. Cancer J 6:343-351. doi: 10.1097/PPO.0b013e31818d839b PMID: 19060597
27. Wu XJ, Hu Y, Lamy E, Mersch-Sundermann V (2009) Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators. Environ. Mol. Mutagen 50:266-275. doi: 10.1002/em.20467 PMID: 19197990
28. Chandra-Kuntal K, Singh SV (2010) Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo. Cancer Prev. Res. (Phila) 3:1473-1483. doi: 10.1158/1940-6207. CAPR-10-0123 PMID: 20959517
29. Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K (2011) Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anticancer Agents Med. Chem 11:249-253. PMID: 21269259
30. Antosiewicz J, Herman-Antosiewicz A, Marynowski SW, Singh SV (2006) c-Jun. NH (2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells. Cancer Res, 66:5379-86. PMID: 16707465
31. Eckhardt BL, Francis PA, Parker BS, Anderson RL (2012) Strategies for the discovery and development of therapies for metastatic breast cancer. Nat. Rev. Drug Discov 11:479-497. doi: 10.1038/nrd2372 PMID: 22653217
32. Gong Y, Chippada-Venkata UD, Oh WK (2014) Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression. Cancers (Basel) 6:1298-1327. doi: 10.3390/cancers6031298 PMID: 24978435
33. Gilkes DM, Semenza GL, Wirtz D (2014) Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat. Rev. Cancer 14:430-439. doi: 10.1038/nrc3726 PMID: 24827502
34. Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67. doi: 10.1016/j.cell.2010.03.015 PMID: 20371345
35. Gershtein ES, Scherbakov AM, Platova AM, Tchemeris GY, Letyagin VP, Kushlinskii NE (2010) The expression and DNA-binding activity of NF-κB nuclear transcription factor in the tumors of patients with breast cancer. Bull. Exp. Biol. Med 150:71-74. PMID: 21161056
36. Hayden MS, Ghosh S (2014) Regulation of NF-κB by TNF family cytokines. Semin. Immunol 26:253-266. doi: 10.1016/j.smim.2014.05.004 PMID: 24958609
37. Berra E, Díaz-Meco MT, Lozano J, Frutos S, Municio MM, Sanchez P, et al. (1995) Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J 14:6157-6163. PMID: 8557035
38. Uekita T, Fujii S, Miyazawa Y, Iwakawa R, Narisawa-Saito M, Nakashima K, et al. (2014) Oncogenic Ras/ERK signaling activates CDCP1 to promote tumor invasion and metastasis. Mol. Cancer Res, in press.