Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

Cell

Volumn 176, Issue 6, 2019, Pages 1432-1446.e11

  Barnett, Katherine C ^a   Coronas Serna, Julia M ^a,b   Zhou, Wen ^c,d   Ernandes, Michael J ^a   Cao, Anh ^a   Kranzusch, Philip J ^c,d   Kagan, Jonathan C ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

cGAS; innate immunity; interferon; localization; macrophages; phosphoinositides; STING

Indexed keywords

BETA1 INTERFERON; CASPASE 3; CYCLIC GMP; CYCLIC GMP AMP SYNTHASE; DOXORUBICIN; FAT DROPLET; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; STAT1 PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA; CGAS PROTEIN, MOUSE; INTERFERON; MEMBRANE PROTEIN; NUCLEOTIDYLTRANSFERASE; PHOSPHATIDYLINOSITOL; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL NUCLEUS; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DNA BINDING; DNA DAMAGE; DNA VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; LIPID BILAYER; MACROPHAGE; MONOCYTE; NONHUMAN; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; VIRUS INFECTION; ANIMAL; C57BL MOUSE; CELL LINE; FEMALE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL MEMBRANE; CYTOSOL; DNA, VIRAL; FEMALE; HEK293 CELLS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERONS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NUCLEOTIDYLTRANSFERASES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 85062423136     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2019.01.049     Document Type: Article

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