Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Nature Cell Biology

Volumn 19, Issue 9, 2017, Pages 1061-1070

  Glück, Selene ^a   Guey, Baptiste ^a   Gulen, Muhammet Fatih ^a   Wolter, Katharina ^b,c   Kang, Tae Won ^b,c,d   Schmacke, Niklas Arndt ^a   Bridgeman, Anne ^e   Rehwinkel, Jan ^e   Zender, Lars ^b,c,d   Ablasser, Andrea ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP AMP SYNTHASE; MEMBRANE PROTEIN; STIMULATOR OF INTERFERON GENES; SYNTHETASE; UNCLASSIFIED DRUG; CHROMATIN; MB21D1 PROTEIN, MOUSE; MPYS PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CGAS-STING PATHWAY; CHROMATIN; CONTROLLED STUDY; CYTOSOLIC CHROMATIN FRAGMENT; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE DNA SENSING; IRRADIATION; MALE; MOUSE; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PARACRINE SENESCENCE; PRIORITY JOURNAL; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL AGING; CELL CULTURE; CELL PROLIFERATION; CYTOSOL; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; GENOTYPE; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; PARACRINE SIGNALING; PHENOTYPE; RADIATION RESPONSE; RNA INTERFERENCE; TIME FACTOR;

ANIMALS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; CYTOSOL; ENZYME ACTIVATION; FEMALE; GENOTYPE; IMMUNITY, INNATE; MALE; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEOTIDYLTRANSFERASES; OXIDATIVE STRESS; PARACRINE COMMUNICATION; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 85028633520     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3586     Document Type: Article

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