Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells

Science Translational Medicine

Volumn 5, Issue 192, 2013, Pages

  Kalghatgi, Sameer ^a   Spina, Catherine S ^a,b,c   Costello, James C ^a   Liesa, Marc ^c   Morones Ramirez, J Ruben ^a   Slomovic, Shimyn ^a   Molina, Anthony ^c,d   Shirihai, Orian S ^c   Collins, James J ^a,b,c  

^a Boston University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CARBONYL DERIVATIVE; CIPROFLOXACIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; DNA; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; HISTONE H2AX; HYDROGEN PEROXIDE; KANAMYCIN; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MEMBRANE LIPID; MEMBRANE PROTEIN; OXYGEN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; TETRACYCLINE; TRANSCRIPTION FACTOR FKHRL1; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CELL CULTURE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG SAFETY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MALE; MAMMAL CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CARBONYLATION; UPREGULATION; URINARY TRACT INFECTION;

ADENOSINE TRIPHOSPHATE; AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CELL LINE; CELLS, CULTURED; FEMALE; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATIVE STRESS; QUINOLONES; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 84880543846     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006055     Document Type: Article

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