-
1
-
-
0027418622
-
Transport of lactate and other monocarboxylates across mammalian plasma membranes
-
Poole RC, Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 1993; 264: C761-82.
-
(1993)
Am J Physiol
, vol.264
-
-
Poole, R.C.1
Halestrap, A.P.2
-
2
-
-
0030933001
-
Lactate-proton cotransport in skeletal muscle
-
Juel C. Lactate-proton cotransport in skeletal muscle. Physiol Rev 1997; 77: 321-58.
-
(1997)
Physiol Rev
, vol.77
, pp. 321-358
-
-
Juel, C.1
-
3
-
-
0033569442
-
The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
-
Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999; 343 Pt 2: 281-99.
-
(1999)
Biochem J
, vol.343
, Issue.PART 2
, pp. 281-299
-
-
Halestrap, A.P.1
Price, N.T.2
-
4
-
-
0030044996
-
The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2', 7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
-
Jackson VN, Halestrap AP. The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2', 7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. J Biol Chem 1996; 271: 861-8.
-
(1996)
J Biol Chem
, vol.271
, pp. 861-868
-
-
Jackson, V.N.1
Halestrap, A.P.2
-
5
-
-
3242679774
-
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter
-
Coady MJ, Chang MH, Charron FM, et al. The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol 2004; 557: 719-31.
-
(2004)
J Physiol
, vol.557
, pp. 719-731
-
-
Coady, M.J.1
Chang, M.H.2
Charron, F.M.3
-
6
-
-
7244236578
-
Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate
-
Gopal E, Fei YJ, Sugawara M, et al. Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate. J Biol Chem 2004; 279: 44522-32.
-
(2004)
J Biol Chem
, vol.279
, pp. 44522-44532
-
-
Gopal, E.1
Fei, Y.J.2
Sugawara, M.3
-
7
-
-
29644435407
-
Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)
-
Srinivas SR, Gopal E, Zhuang L, et al. Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). Biochem J 2005; 392: 655-64.
-
(2005)
Biochem J
, vol.392
, pp. 655-664
-
-
Srinivas, S.R.1
Gopal, E.2
Zhuang, L.3
-
8
-
-
1242340302
-
The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
-
Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004; 447: 619-28.
-
(2004)
Pflugers Arch
, vol.447
, pp. 619-628
-
-
Halestrap, A.P.1
Meredith, D.2
-
9
-
-
21344444566
-
Monocarboxylate transporters in the central nervous system: Distribution, regulation and function
-
Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 2005; 94: 1-14.
-
(2005)
J Neurochem
, vol.94
, pp. 1-14
-
-
Pierre, K.1
Pellerin, L.2
-
10
-
-
33745955759
-
Transport of gammahydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters
-
Wang Q, Darling IM, Morris ME. Transport of gammahydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters. J Pharmacol Exp Ther 2006; 318: 751-61.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 751-761
-
-
Wang, Q.1
Darling, I.M.2
Morris, M.E.3
-
11
-
-
34249106145
-
Monocarboxylate transporter (MCT) mediates the transport of gamma-hydroxybutyrate in human kidney HK-2 cells
-
Wang Q, Lu Y, Morris ME. Monocarboxylate transporter (MCT) mediates the transport of gamma-hydroxybutyrate in human kidney HK-2 cells. Pharm Res 2007; 24: 1067-78.
-
(2007)
Pharm Res
, vol.24
, pp. 1067-1078
-
-
Wang, Q.1
Lu, Y.2
Morris, M.E.3
-
12
-
-
34547218143
-
The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells
-
Wang Q, Morris ME. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos 2007; 35: 1393-9.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1393-1399
-
-
Wang, Q.1
Morris, M.E.2
-
13
-
-
67649397435
-
The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-mediated uptake and inhibition
-
Cui D, Morris ME. The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. Drug Metab Dispos 2009; 37: 1404-10.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1404-1410
-
-
Cui, D.1
Morris, M.E.2
-
14
-
-
0020468306
-
Monocarboxylate transport in erythrocytes
-
Deuticke B. Monocarboxylate transport in erythrocytes. J Membr Biol 1982; 70: 89-103.
-
(1982)
J Membr Biol
, vol.70
, pp. 89-103
-
-
Deuticke, B.1
-
15
-
-
0017099416
-
Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier
-
Halestrap AP. Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier. Biochem J 1976; 156: 193-207.
-
(1976)
Biochem J
, vol.156
, pp. 193-207
-
-
Halestrap, A.P.1
-
16
-
-
0020956323
-
Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylatespecific carrier system
-
De Bruijne AW, Vreeburg H, Van Steveninck J. Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylatespecific carrier system. Biochim Biophys Acta 1983; 732: 562-8.
-
(1983)
Biochim Biophys Acta
, vol.732
, pp. 562-568
-
-
De Bruijne, A.W.1
Vreeburg, H.2
Van Steveninck, J.3
-
17
-
-
0030473710
-
Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1)
-
Poole RC, Sansom CE, Halestrap AP. Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1). Biochem J 1996; 320 (Pt 3): 817-24.
-
(1996)
Biochem J
, vol.320
, Issue.PART 3
, pp. 817-824
-
-
Poole, R.C.1
Sansom, C.E.2
Halestrap, A.P.3
-
18
-
-
0344086180
-
Lactate transport in skeletal muscle-role and regulation of the monocarboxylate transporter
-
Juel C, Halestrap AP. Lactate transport in skeletal muscle-role and regulation of the monocarboxylate transporter. J Physiol 1999; 517 (Pt 3): 633-42.
-
(1999)
J Physiol
, vol.517
, Issue.PART 3
, pp. 633-642
-
-
Juel, C.1
Halestrap, A.P.2
-
19
-
-
33750723755
-
Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle
-
Enoki T, Yoshida Y, Lally J, Hatta H, Bonen A. Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle. J Physiol 2006; 577: 433-43.
-
(2006)
J Physiol
, vol.577
, pp. 433-443
-
-
Enoki, T.1
Yoshida, Y.2
Lally, J.3
Hatta, H.4
Bonen, A.5
-
20
-
-
34347242128
-
Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
-
Chenal J, Pellerin L. Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. J Neurochem 2007; 102: 389-97.
-
(2007)
J Neurochem
, vol.102
, pp. 389-397
-
-
Chenal, J.1
Pellerin, L.2
-
21
-
-
22844442936
-
Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: The ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)
-
Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 2005; 280: 27213-21.
-
(2005)
J Biol Chem
, vol.280
, pp. 27213-27221
-
-
Wilson, M.C.1
Meredith, D.2
Fox, J.E.3
Manoharan, C.4
Davies, A.J.5
Halestrap, A.P.6
-
22
-
-
0026463075
-
cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function
-
Kim CM, Goldstein JL, Brown MS. cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function. J Biol Chem 1992; 267: 23113-21.
-
(1992)
J Biol Chem
, vol.267
, pp. 23113-23121
-
-
Kim, C.M.1
Goldstein, J.L.2
Brown, M.S.3
-
23
-
-
0029115356
-
cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle
-
Jackson VN, Price NT, Halestrap AP. cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle. Biochim Biophys Acta 1995; 1238: 193-6.
-
(1995)
Biochim Biophys Acta
, vol.1238
, pp. 193-196
-
-
Jackson, V.N.1
Price, N.T.2
Halestrap, A.P.3
-
24
-
-
0029881113
-
Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function
-
Carpenter L, Poole RC, Halestrap AP. Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim Biophys Acta 1996; 1279: 157-63.
-
(1996)
Biochim Biophys Acta
, vol.1279
, pp. 157-163
-
-
Carpenter, L.1
Poole, R.C.2
Halestrap, A.P.3
-
25
-
-
0029616310
-
cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter
-
Takanaga H, Tamai I, Inaba S, et al. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem Biophys Res Commun 1995; 217: 370-7.
-
(1995)
Biochem Biophys Res Commun
, vol.217
, pp. 370-377
-
-
Takanaga, H.1
Tamai, I.2
Inaba, S.3
-
26
-
-
0028294023
-
Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle
-
Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 1994; 76: 865-73.
-
(1994)
Cell
, vol.76
, pp. 865-873
-
-
Garcia, C.K.1
Goldstein, J.L.2
Pathak, R.K.3
Anderson, R.G.4
Brown, M.S.5
-
27
-
-
0032127127
-
Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH
-
Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW. Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J 1998; 333 (Pt 1): 167-74.
-
(1998)
Biochem J
, vol.333
, Issue.PART 1
, pp. 167-174
-
-
Broer, S.1
Schneider, H.P.2
Broer, A.3
Rahman, B.4
Hamprecht, B.5
Deitmer, J.W.6
-
28
-
-
0021921626
-
Alternativesubstrate inhibition of L-lactate transport via the monocarboxylatespecific carrier system in human erythrocytes
-
de Bruijne AW, Vreeburg H, van Steveninck J. Alternativesubstrate inhibition of L-lactate transport via the monocarboxylatespecific carrier system in human erythrocytes. Biochim Biophys Acta 1985; 812: 841-4.
-
(1985)
Biochim Biophys Acta
, vol.812
, pp. 841-844
-
-
de Bruijne, A.W.1
Vreeburg, H.2
van Steveninck, J.3
-
29
-
-
53749107434
-
Overview of the proton-coupled MCT (SLC16A) family of transporters: Characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid
-
Morris ME, Felmlee MA. Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J 2008; 10: 311-21.
-
(2008)
AAPS J
, vol.10
, pp. 311-321
-
-
Morris, M.E.1
Felmlee, M.A.2
-
30
-
-
0015973650
-
Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate
-
Halestrap AP, Denton RM. Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate. Biochem J 1974; 138: 313-6.
-
(1974)
Biochem J
, vol.138
, pp. 313-316
-
-
Halestrap, A.P.1
Denton, R.M.2
-
31
-
-
0016259467
-
Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alpha-ketoisocaproate
-
Halestrap AP, Brand MD, Denton RM. Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alpha-ketoisocaproate. Biochim Biophys Acta 1974; 367: 102-8.
-
(1974)
Biochim Biophys Acta
, vol.367
, pp. 102-108
-
-
Halestrap, A.P.1
Brand, M.D.2
Denton, R.M.3
-
32
-
-
0016756374
-
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors
-
Halestrap AP. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J 1975; 148: 85-96.
-
(1975)
Biochem J
, vol.148
, pp. 85-96
-
-
Halestrap, A.P.1
-
33
-
-
0016814829
-
The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compounds
-
Halestrap AP, Denton RM. The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compounds. Biochem J 1975; 148: 97-106.
-
(1975)
Biochem J
, vol.148
, pp. 97-106
-
-
Halestrap, A.P.1
Denton, R.M.2
-
34
-
-
0028909335
-
cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
-
Garcia CK, Brown MS, Pathak RK, Goldstein JL. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 1995; 270: 1843-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 1843-1849
-
-
Garcia, C.K.1
Brown, M.S.2
Pathak, R.K.3
Goldstein, J.L.4
-
35
-
-
0030909127
-
Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation
-
Jackson VN, Price NT, Carpenter L, Halestrap AP. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Biochem J 1997; 324 (Pt 2): 447-53.
-
(1997)
Biochem J
, vol.324
, Issue.PART 2
, pp. 447-453
-
-
Jackson, V.N.1
Price, N.T.2
Carpenter, L.3
Halestrap, A.P.4
-
36
-
-
0032582702
-
Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter
-
Lin RY, Vera JC, Chaganti RS, Golde DW. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem 1998; 273: 28959-65.
-
(1998)
J Biol Chem
, vol.273
, pp. 28959-28965
-
-
Lin, R.Y.1
Vera, J.C.2
Chaganti, R.S.3
Golde, D.W.4
-
37
-
-
0039351371
-
Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes
-
Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J 1999; 341 (Pt 3): 529-35.
-
(1999)
Biochem J
, vol.341
, Issue.PART 3
, pp. 529-535
-
-
Broer, S.1
Broer, A.2
Schneider, H.P.3
Stegen, C.4
Halestrap, A.P.5
Deitmer, J.W.6
-
38
-
-
84855444042
-
The monocarboxylate transporter family--Structure and functional characterization
-
Halestrap AP. The monocarboxylate transporter family--Structure and functional characterization. IUBMB Life 2012; 64: 1-9.
-
(2012)
IUBMB Life
, vol.64
, pp. 1-9
-
-
Halestrap, A.P.1
-
39
-
-
0030982108
-
Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium
-
Yoon H, Fanelli A, Grollman EF, Philp NJ. Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium. Biochem Biophys Res Commun 1997; 234: 90-4.
-
(1997)
Biochem Biophys Res Commun
, vol.234
, pp. 90-94
-
-
Yoon, H.1
Fanelli, A.2
Grollman, E.F.3
Philp, N.J.4
-
40
-
-
0034622518
-
Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast
-
Grollman EF, Philp NJ, McPhie P, Ward RD, Sauer B. Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast. Biochemistry 2000; 39: 9351-7.
-
(2000)
Biochemistry
, vol.39
, pp. 9351-9357
-
-
Grollman, E.F.1
Philp, N.J.2
McPhie, P.3
Ward, R.D.4
Sauer, B.5
-
41
-
-
0031775697
-
Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE
-
Philp NJ, Yoon H, Grollman EF. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Am J Physiol 1998; 274: R1824-8.
-
(1998)
Am J Physiol
, vol.274
-
-
Philp, N.J.1
Yoon, H.2
Grollman, E.F.3
-
42
-
-
0344527986
-
Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat
-
Bergersen L, Johannsson E, Veruki ML, et al. Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat. Neuroscience 1999; 90: 319-31.
-
(1999)
Neuroscience
, vol.90
, pp. 319-331
-
-
Bergersen, L.1
Johannsson, E.2
Veruki, M.L.3
-
43
-
-
0032518981
-
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
-
Price NT, Jackson VN, Halestrap AP. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 1998; 329 (Pt 2): 321-8.
-
(1998)
Biochem J
, vol.329
, Issue.PART 2
, pp. 321-328
-
-
Price, N.T.1
Jackson, V.N.2
Halestrap, A.P.3
-
44
-
-
0034663601
-
The lowaffinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
-
Dimmer KS, Friedrich B, Lang F, Deitmer JW, Broer S. The lowaffinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 2000; 350 Pt 1: 219-27.
-
(2000)
Biochem J
, vol.350
, Issue.PART 1
, pp. 219-227
-
-
Dimmer, K.S.1
Friedrich, B.2
Lang, F.3
Deitmer, J.W.4
Broer, S.5
-
45
-
-
0034525940
-
Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle
-
Manning Fox JE, Meredith D, Halestrap AP. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 2000; 529 Pt 2: 285-93.
-
(2000)
J Physiol
, vol.529
, Issue.PART 2
, pp. 285-293
-
-
Manning Fox, J.E.1
Meredith, D.2
Halestrap, A.P.3
-
46
-
-
28144438907
-
Functional characterization of human monocarboxylate transporter 6 (SLC16A5)
-
Murakami Y, Kohyama N, Kobayashi Y, et al. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). Drug Metab Dispos 2005; 33: 1845-51.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1845-1851
-
-
Murakami, Y.1
Kohyama, N.2
Kobayashi, Y.3
-
47
-
-
0028332347
-
A novel transmembrane transporter encoded by the XPCT gene in Xq13. 2
-
Lafreniere RG, Carrel L, Willard HF. A novel transmembrane transporter encoded by the XPCT gene in Xq13. 2. Hum Mol Genet 1994; 3: 1133-9.
-
(1994)
Hum Mol Genet
, vol.3
, pp. 1133-1139
-
-
Lafreniere, R.G.1
Carrel, L.2
Willard, H.F.3
-
48
-
-
0141891099
-
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
-
Friesema EC, Ganguly S, Abdalla A, et al. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 2003; 278: 40128-35.
-
(2003)
J Biol Chem
, vol.278
, pp. 40128-40135
-
-
Friesema, E.C.1
Ganguly, S.2
Abdalla, A.3
-
49
-
-
78650916392
-
Minireview: Thyroid hormone transporters: The knowns and the unknowns
-
Visser WE, Friesema EC, Visser TJ. Minireview: thyroid hormone transporters: the knowns and the unknowns. Mol Endocrinol 2011; 25: 1-14.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1-14
-
-
Visser, W.E.1
Friesema, E.C.2
Visser, T.J.3
-
50
-
-
0035907362
-
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters
-
Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 2001; 276: 17221-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 17221-17228
-
-
Kim, D.K.1
Kanai, Y.2
Chairoungdua, A.3
Matsuo, H.4
Cha, S.H.5
Endou, H.6
-
51
-
-
48749086146
-
The SLC16 monocaboxylate transporter family
-
Meredith D, Christian HC. The SLC16 monocaboxylate transporter family. Xenobiotica 2008; 38: 1072-106.
-
(2008)
Xenobiotica
, vol.38
, pp. 1072-1106
-
-
Meredith, D.1
Christian, H.C.2
-
52
-
-
84872072151
-
MCT8 Deficiency: Extrapyramidal Symptoms and Delayed Myelination as Prominent Features
-
Tonduti D, Vanderver A, Berardinelli A, et al. MCT8 Deficiency: Extrapyramidal Symptoms and Delayed Myelination as Prominent Features. J Child Neurol 2012.
-
(2012)
J Child Neurol
-
-
Tonduti, D.1
Vanderver, A.2
Berardinelli, A.3
-
53
-
-
84862956363
-
Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport
-
Braun D, Kim TD, le Coutre P, Kohrle J, Hershman JM, Schweizer U. Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport. J Clin Endocrinol Metab 2012; 97: E100-5.
-
(2012)
J Clin Endocrinol Metab
, vol.97
-
-
Braun, D.1
Kim, T.D.2
le Coutre, P.3
Kohrle, J.4
Hershman, J.M.5
Schweizer, U.6
-
54
-
-
51249118120
-
Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
-
Ganapathy V, Thangaraju M, Gopal E, et al. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J 2008; 10: 193-9.
-
(2008)
AAPS J
, vol.10
, pp. 193-199
-
-
Ganapathy, V.1
Thangaraju, M.2
Gopal, E.3
-
55
-
-
0038153876
-
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
-
Li H, Myeroff L, Smiraglia D, et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A 2003; 100: 8412-7.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8412-8417
-
-
Li, H.1
Myeroff, L.2
Smiraglia, D.3
-
56
-
-
0019082780
-
Lactate-sodium cotransport in rat renal brush border membranes
-
Barac-Nieto M, Murer H, Kinne R. Lactate-sodium cotransport in rat renal brush border membranes. Am J Physiol 1980; 239: F496-506.
-
(1980)
Am J Physiol
, vol.239
-
-
Barac-Nieto, M.1
Murer, H.2
Kinne, R.3
-
57
-
-
35848971238
-
Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney
-
Gopal E, Umapathy NS, Martin PM, et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochim Biophys Acta 2007; 1768: 2690-7.
-
(2007)
Biochim Biophys Acta
, vol.1768
, pp. 2690-2697
-
-
Gopal, E.1
Umapathy, N.S.2
Martin, P.M.3
-
58
-
-
4143051638
-
Energy metabolism in mammalian brain during development
-
Erecinska M, Cherian S, Silver IA. Energy metabolism in mammalian brain during development. Prog Neurobiol 2004; 73: 397-445.
-
(2004)
Prog Neurobiol
, vol.73
, pp. 397-445
-
-
Erecinska, M.1
Cherian, S.2
Silver, I.A.3
-
59
-
-
0032584084
-
Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain
-
Pellerin L, Pellegri G, Martin JL, Magistretti PJ. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci U S A 1998; 95: 3990-5.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 3990-3995
-
-
Pellerin, L.1
Pellegri, G.2
Martin, J.L.3
Magistretti, P.J.4
-
60
-
-
0018876377
-
Physiological roles of ketone bodies as substrates and signals in mammalian tissues
-
Robinson AM, Williamson DH. Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 1980; 60: 143-87.
-
(1980)
Physiol Rev
, vol.60
, pp. 143-187
-
-
Robinson, A.M.1
Williamson, D.H.2
-
61
-
-
0022442548
-
Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate
-
Fernandez E, Medina JM. Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate. Biochem J 1986; 234: 489-92.
-
(1986)
Biochem J
, vol.234
, pp. 489-492
-
-
Fernandez, E.1
Medina, J.M.2
-
62
-
-
0022552442
-
Regional ketone body utilization by rat brain in starvation and diabetes
-
Hawkins RA, Mans AM, Davis DW. Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol 1986; 250: E169-78.
-
(1986)
Am J Physiol
, vol.250
-
-
Hawkins, R.A.1
Mans, A.M.2
Davis, D.W.3
-
63
-
-
0036130456
-
Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system
-
Bergersen L, Rafiki A, Ottersen OP. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Neurochem Res 2002; 27: 89-96.
-
(2002)
Neurochem Res
, vol.27
, pp. 89-96
-
-
Bergersen, L.1
Rafiki, A.2
Ottersen, O.P.3
-
64
-
-
0034721575
-
Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
-
Pierre K, Pellerin L, Debernardi R, Riederer BM, Magistretti PJ. Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy. Neuroscience 2000; 100: 617-27.
-
(2000)
Neuroscience
, vol.100
, pp. 617-627
-
-
Pierre, K.1
Pellerin, L.2
Debernardi, R.3
Riederer, B.M.4
Magistretti, P.J.5
-
65
-
-
0030774069
-
Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons
-
Broer S, Rahman B, Pellegri G, et al. Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem 1997; 272: 30096-102.
-
(1997)
J Biol Chem
, vol.272
, pp. 30096-30102
-
-
Broer, S.1
Rahman, B.2
Pellegri, G.3
-
66
-
-
0242406757
-
Lactate is a preferential oxidative energy substrate over glucose for neurons in culture
-
Bouzier-Sore AK, Voisin P, Canioni P, Magistretti PJ, Pellerin L. Lactate is a preferential oxidative energy substrate over glucose for neurons in culture. J Cereb Blood Flow Metab 2003; 23: 1298-306.
-
(2003)
J Cereb Blood Flow Metab
, vol.23
, pp. 1298-1306
-
-
Bouzier-Sore, A.K.1
Voisin, P.2
Canioni, P.3
Magistretti, P.J.4
Pellerin, L.5
-
67
-
-
0037446874
-
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
-
Itoh Y, Esaki T, Shimoji K, et al. Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo. Proc Natl Acad Sci U S A 2003; 100: 4879-84.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 4879-4884
-
-
Itoh, Y.1
Esaki, T.2
Shimoji, K.3
-
68
-
-
79952305803
-
Astrocyte-neuron lactate transport is required for long-term memory formation
-
Suzuki A, Stern SA, Bozdagi O, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 2011; 144: 810-23.
-
(2011)
Cell
, vol.144
, pp. 810-823
-
-
Suzuki, A.1
Stern, S.A.2
Bozdagi, O.3
-
69
-
-
0028080101
-
Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
-
Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A 1994; 91: 10625-9.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 10625-10629
-
-
Pellerin, L.1
Magistretti, P.J.2
-
70
-
-
0027763898
-
Neurotransmitters regulate energy metabolism in astrocytes: Implications for the metabolic trafficking between neural cells
-
Magistretti PJ, Sorg O, Yu N, Martin JL, Pellerin L. Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells. Dev Neurosci 1993; 15: 306-12.
-
(1993)
Dev Neurosci
, vol.15
, pp. 306-312
-
-
Magistretti, P.J.1
Sorg, O.2
Yu, N.3
Martin, J.L.4
Pellerin, L.5
-
71
-
-
0031788835
-
Lactate transport by cortical synaptosomes from adult rat brain: Characterization of kinetics and inhibitor specificity
-
McKenna MC, Tildon JT, Stevenson JH, Hopkins IB, Huang X, Couto R. Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificity. Dev Neurosci 1998; 20: 300-9.
-
(1998)
Dev Neurosci
, vol.20
, pp. 300-309
-
-
McKenna, M.C.1
Tildon, J.T.2
Stevenson, J.H.3
Hopkins, I.B.4
Huang, X.5
Couto, R.6
-
72
-
-
0029990892
-
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
-
Bittar PG, Charnay Y, Pellerin L, Bouras C, Magistretti PJ. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 1996; 16: 1079-89.
-
(1996)
J Cereb Blood Flow Metab
, vol.16
, pp. 1079-1089
-
-
Bittar, P.G.1
Charnay, Y.2
Pellerin, L.3
Bouras, C.4
Magistretti, P.J.5
-
73
-
-
0030837750
-
Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats
-
Gerhart DZ, Enerson BE, Zhdankina OY, Leino RL, Drewes LR. Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am J Physiol 1997; 273: E207-13.
-
(1997)
Am J Physiol
, vol.273
-
-
Gerhart, D.Z.1
Enerson, B.E.2
Zhdankina, O.Y.3
Leino, R.L.4
Drewes, L.R.5
-
74
-
-
0018287463
-
Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats
-
Cremer JE, Cunningham VJ, Pardridge WM, Braun LD, Oldendorf WH. Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats. J Neurochem 1979; 33: 439-45.
-
(1979)
J Neurochem
, vol.33
, pp. 439-445
-
-
Cremer, J.E.1
Cunningham, V.J.2
Pardridge, W.M.3
Braun, L.D.4
Oldendorf, W.H.5
-
75
-
-
0033548527
-
Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: A quantitative electron microscopic immunogold study
-
Leino RL, Gerhart DZ, Drewes LR. Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. Brain Res Dev Brain Res 1999; 113: 47-54.
-
(1999)
Brain Res Dev Brain Res
, vol.113
, pp. 47-54
-
-
Leino, R.L.1
Gerhart, D.Z.2
Drewes, L.R.3
-
76
-
-
0142084655
-
Developmental switch in brain nutrient transporter expression in the rat
-
Vannucci SJ, Simpson IA. Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 2003; 285: E1127-34.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Vannucci, S.J.1
Simpson, I.A.2
-
77
-
-
79960407068
-
Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea
-
Wang Y, Guo SZ, Bonen A, et al. Monocarboxylate transporter 2 and stroke severity in a rodent model of sleep apnea. J Neurosci 2011; 31: 10241-8.
-
(2011)
J Neurosci
, vol.31
, pp. 10241-10248
-
-
Wang, Y.1
Guo, S.Z.2
Bonen, A.3
-
78
-
-
84871451510
-
Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)
-
Moschen I, Broer A, Galic S, Lang F, Broer S. Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT). Neurochem Res 2012.
-
(2012)
Neurochem Res
-
-
Moschen, I.1
Broer, A.2
Galic, S.3
Lang, F.4
Broer, S.5
-
79
-
-
0034041755
-
Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo
-
Hanu R, McKenna M, O'Neill A, Resneck WG, Bloch RJ. Monocarboxylic acid transporters, MCT1 and MCT2, in cortical astrocytes in vitro and in vivo. Am J Physiol Cell Physiol 2000; 278: C921-30.
-
(2000)
Am J Physiol Cell Physiol
, vol.278
-
-
Hanu, R.1
McKenna, M.2
O'Neill, A.3
Resneck, W.G.4
Bloch, R.J.5
-
80
-
-
0037963512
-
Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
-
Debernardi R, Pierre K, Lengacher S, Magistretti PJ, Pellerin L. Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures. J Neurosci Res 2003; 73: 141-55.
-
(2003)
J Neurosci Res
, vol.73
, pp. 141-155
-
-
Debernardi, R.1
Pierre, K.2
Lengacher, S.3
Magistretti, P.J.4
Pellerin, L.5
-
81
-
-
79961096875
-
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
-
Shawahna R, Uchida Y, Decleves X, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm 2011; 8: 1332-41.
-
(2011)
Mol Pharm
, vol.8
, pp. 1332-1341
-
-
Shawahna, R.1
Uchida, Y.2
Decleves, X.3
-
82
-
-
0031719871
-
Monocarboxylate transporter expression in mouse brain
-
Koehler-Stec EM, Simpson IA, Vannucci SJ, Landschulz KT, Landschulz WH. Monocarboxylate transporter expression in mouse brain. Am J Physiol 1998; 275: E516-24.
-
(1998)
Am J Physiol
, vol.275
-
-
Koehler-Stec, E.M.1
Simpson, I.A.2
Vannucci, S.J.3
Landschulz, K.T.4
Landschulz, W.H.5
-
83
-
-
0036254152
-
MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain
-
Pierre K, Magistretti PJ, Pellerin L. MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J Cereb Blood Flow Metab 2002; 22: 586-95.
-
(2002)
J Cereb Blood Flow Metab
, vol.22
, pp. 586-595
-
-
Pierre, K.1
Magistretti, P.J.2
Pellerin, L.3
-
84
-
-
0035114149
-
A novel postsynaptic density protein: The monocarboxylate transporter MCT2 is colocalized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses
-
Bergersen L, Waerhaug O, Helm J, et al. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is colocalized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp Brain Res 2001; 136: 523-34.
-
(2001)
Exp Brain Res
, vol.136
, pp. 523-534
-
-
Bergersen, L.1
Waerhaug, O.2
Helm, J.3
-
85
-
-
0032031107
-
Expression of the monocarboxylate transporter MCT2 by rat brain glia
-
Gerhart DZ, Enerson BE, Zhdankina OY, Leino RL, Drewes LR. Expression of the monocarboxylate transporter MCT2 by rat brain glia. Glia 1998; 22: 272-81.
-
(1998)
Glia
, vol.22
, pp. 272-281
-
-
Gerhart, D.Z.1
Enerson, B.E.2
Zhdankina, O.Y.3
Leino, R.L.4
Drewes, L.R.5
-
86
-
-
0038742068
-
Expression of monocarboxylic acid transporters (MCT) in brain cells. Implication for branched chain alpha-ketoacids transport in neurons
-
Mac M, Nalecz KA. Expression of monocarboxylic acid transporters (MCT) in brain cells. Implication for branched chain alpha-ketoacids transport in neurons. Neurochem Int 2003; 43: 305-9.
-
(2003)
Neurochem Int
, vol.43
, pp. 305-309
-
-
Mac, M.1
Nalecz, K.A.2
-
87
-
-
12244262261
-
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
-
Pellerin L, Bergersen LH, Halestrap AP, Pierre K. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res 2005; 79: 55-64.
-
(2005)
J Neurosci Res
, vol.79
, pp. 55-64
-
-
Pellerin, L.1
Bergersen, L.H.2
Halestrap, A.P.3
Pierre, K.4
-
88
-
-
33745081830
-
Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain
-
Martin PM, Gopal E, Ananth S, et al. Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. J Neurochem 2006; 98: 279-88.
-
(2006)
J Neurochem
, vol.98
, pp. 279-288
-
-
Martin, P.M.1
Gopal, E.2
Ananth, S.3
-
89
-
-
0025322779
-
Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids
-
Kang YS, Terasaki T, Tsuji A. Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids. J Pharmacobiodyn 1990; 13: 158-63.
-
(1990)
J Pharmacobiodyn
, vol.13
, pp. 158-163
-
-
Kang, Y.S.1
Terasaki, T.2
Tsuji, A.3
-
90
-
-
0025989302
-
Transport of monocarboxylic acids at the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells
-
Terasaki T, Takakuwa S, Moritani S, Tsuji A. Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. J Pharmacol Exp Ther 1991; 258: 932-7.
-
(1991)
J Pharmacol Exp Ther
, vol.258
, pp. 932-937
-
-
Terasaki, T.1
Takakuwa, S.2
Moritani, S.3
Tsuji, A.4
-
91
-
-
28444498930
-
Functional characteristics of H+-dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex
-
Shimada A, Nakagawa Y, Morishige H, Yamamoto A, Fujita T. Functional characteristics of H+-dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. Neurosci Lett 2006; 392: 207-12.
-
(2006)
Neurosci Lett
, vol.392
, pp. 207-212
-
-
Shimada, A.1
Nakagawa, Y.2
Morishige, H.3
Yamamoto, A.4
Fujita, T.5
-
92
-
-
19544379492
-
Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family
-
Gopal E, Fei YJ, Miyauchi S, Zhuang L, Prasad PD, Ganapathy V. Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. Biochem J 2005; 388: 309-16.
-
(2005)
Biochem J
, vol.388
, pp. 309-316
-
-
Gopal, E.1
Fei, Y.J.2
Miyauchi, S.3
Zhuang, L.4
Prasad, P.D.5
Ganapathy, V.6
-
93
-
-
3442875363
-
Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline
-
Morris MC, Evans DA, Bienias JL, et al. Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline. J Neurol Neurosurg Psychiatry 2004; 75: 1093-9.
-
(2004)
J Neurol Neurosurg Psychiatry
, vol.75
, pp. 1093-1099
-
-
Morris, M.C.1
Evans, D.A.2
Bienias, J.L.3
-
94
-
-
0028281788
-
In vivo and in vitro bloodbrain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
-
Saheki A, Terasaki T, Tamai I, Tsuji A. In vivo and in vitro bloodbrain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm Res 1994; 11: 305-11.
-
(1994)
Pharm Res
, vol.11
, pp. 305-311
-
-
Saheki, A.1
Terasaki, T.2
Tamai, I.3
Tsuji, A.4
-
95
-
-
0027723663
-
Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier
-
Tsuji A, Saheki A, Tamai I, Terasaki T. Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier. J Pharmacol Exp Ther 1993; 267: 1085-90.
-
(1993)
J Pharmacol Exp Ther
, vol.267
, pp. 1085-1090
-
-
Tsuji, A.1
Saheki, A.2
Tamai, I.3
Terasaki, T.4
-
96
-
-
33745000275
-
Inhibitory effects of statins on human monocarboxylate transporter 4
-
Kobayashi M, Otsuka Y, Itagaki S, Hirano T, Iseki K. Inhibitory effects of statins on human monocarboxylate transporter 4. Int J Pharm 2006; 317: 19-25.
-
(2006)
Int J Pharm
, vol.317
, pp. 19-25
-
-
Kobayashi, M.1
Otsuka, Y.2
Itagaki, S.3
Hirano, T.4
Iseki, K.5
-
97
-
-
77649180644
-
In vitro antioxidant activity of pravastatin provides vascular protection
-
Kassan M, Montero MJ, Sevilla MA. In vitro antioxidant activity of pravastatin provides vascular protection. Eur J Pharmacol 2010; 630: 107-11.
-
(2010)
Eur J Pharmacol
, vol.630
, pp. 107-111
-
-
Kassan, M.1
Montero, M.J.2
Sevilla, M.A.3
-
98
-
-
79751532850
-
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action
-
Barone E, Cenini G, Di Domenico F, et al. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res 2011; 63: 172-80.
-
(2011)
Pharmacol Res
, vol.63
, pp. 172-180
-
-
Barone, E.1
Cenini, G.2
Di Domenico, F.3
-
99
-
-
0030942484
-
Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: Possible involvement of the monocarboxylic acid transport system
-
Deguchi Y, Nozawa K, Yamada S, Yokoyama Y, Kimura R. Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system. J Pharmacol Exp Ther 1997; 280: 551-60.
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 551-560
-
-
Deguchi, Y.1
Nozawa, K.2
Yamada, S.3
Yokoyama, Y.4
Kimura, R.5
-
100
-
-
0034614361
-
Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier
-
Deguchi Y, Yokoyama Y, Sakamoto T, et al. Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier. Life Sci 2000; 66: 649-62.
-
(2000)
Life Sci
, vol.66
, pp. 649-662
-
-
Deguchi, Y.1
Yokoyama, Y.2
Sakamoto, T.3
-
101
-
-
4644328982
-
XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters
-
Cundy KC, Branch R, Chernov-Rogan T, et al. XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters. J Pharmacol Exp Ther 2004; 311: 315-23.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 315-323
-
-
Cundy, K.C.1
Branch, R.2
Chernov-Rogan, T.3
-
102
-
-
4644251930
-
XP13512 [(+/-)-1-([(alphaisobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys
-
Cundy KC, Annamalai T, Bu L, et al. XP13512 [(+/-)-1-([(alphaisobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther 2004; 311: 324-33.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 324-333
-
-
Cundy, K.C.1
Annamalai, T.2
Bu, L.3
-
103
-
-
57449097189
-
Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin
-
Cundy KC, Sastry S, Luo W, Zou J, Moors TL, Canafax DM. Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin. J Clin Pharmacol 2008; 48: 1378-88.
-
(2008)
J Clin Pharmacol
, vol.48
, pp. 1378-1388
-
-
Cundy, K.C.1
Sastry, S.2
Luo, W.3
Zou, J.4
Moors, T.L.5
Canafax, D.M.6
-
104
-
-
0030895783
-
The gamma-hydroxybutyrate signalling system in brain: Organization and functional implications
-
Maitre M. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 1997; 51: 337-61.
-
(1997)
Prog Neurobiol
, vol.51
, pp. 337-361
-
-
Maitre, M.1
-
105
-
-
0022842842
-
Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings
-
Mamelak M, Scharf MB, Woods M. Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings. Sleep 1986; 9: 285-9.
-
(1986)
Sleep
, vol.9
, pp. 285-289
-
-
Mamelak, M.1
Scharf, M.B.2
Woods, M.3
-
107
-
-
0018372970
-
Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat
-
Lettieri JT, Fung HL. Dose-dependent pharmacokinetics and hypnotic effects of sodium gamma-hydroxybutyrate in the rat. J Pharmacol Exp Ther 1979; 208: 7-11.
-
(1979)
J Pharmacol Exp Ther
, vol.208
, pp. 7-11
-
-
Lettieri, J.T.1
Fung, H.L.2
-
108
-
-
0027364308
-
Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers
-
Palatini P, Tedeschi L, Frison G, et al. Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers. Eur J Clin Pharmacol 1993; 45: 353-6.
-
(1993)
Eur J Clin Pharmacol
, vol.45
, pp. 353-356
-
-
Palatini, P.1
Tedeschi, L.2
Frison, G.3
-
109
-
-
0026794477
-
Pharmacokinetics of gammahydroxybutyric acid in alcohol dependent patients after single and repeated oral doses
-
Ferrara SD, Zotti S, Tedeschi L, et al. Pharmacokinetics of gammahydroxybutyric acid in alcohol dependent patients after single and repeated oral doses. Br J Clin Pharmacol 1992; 34: 231-5.
-
(1992)
Br J Clin Pharmacol
, vol.34
, pp. 231-235
-
-
Ferrara, S.D.1
Zotti, S.2
Tedeschi, L.3
-
110
-
-
0018176540
-
Improved pharmacological activity via prodrug modification: Comparative pharmacokinetics of sodium gamma-hydroxybutyrate and gamma-butyrolactone
-
Lettieri J, Fung HL. Improved pharmacological activity via prodrug modification: comparative pharmacokinetics of sodium gamma-hydroxybutyrate and gamma-butyrolactone. Res Commun Chem Pathol Pharmacol 1978; 22: 107-18.
-
(1978)
Res Commun Chem Pathol Pharmacol
, vol.22
, pp. 107-118
-
-
Lettieri, J.1
Fung, H.L.2
-
111
-
-
0018894476
-
Absorption of sodium gamma-hydroxybutyrate and its prodrug gamma-butyrolactone: Relationship between in vitro transport and in vivo absorption
-
Arena C, Fung HL. Absorption of sodium gamma-hydroxybutyrate and its prodrug gamma-butyrolactone: relationship between in vitro transport and in vivo absorption. J Pharm Sci 1980; 69: 356-8.
-
(1980)
J Pharm Sci
, vol.69
, pp. 356-358
-
-
Arena, C.1
Fung, H.L.2
-
112
-
-
19444362090
-
Renal clearance of gammahydroxybutyric acid in rats: Increasing renal elimination as a detoxification strategy
-
Morris ME, Hu K, Wang Q. Renal clearance of gammahydroxybutyric acid in rats: increasing renal elimination as a detoxification strategy. J Pharmacol Exp Ther 2005; 313: 1194-202.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 1194-1202
-
-
Morris, M.E.1
Hu, K.2
Wang, Q.3
-
113
-
-
76749149579
-
Monocarboxylate transportermediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells
-
Lam WK, Felmlee MA, Morris ME. Monocarboxylate transportermediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells. Drug Metab Dispos 2010; 38: 441-7.
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 441-447
-
-
Lam, W.K.1
Felmlee, M.A.2
Morris, M.E.3
-
114
-
-
4644337779
-
GHB (gamma-hydroxybutyrate) carriermediated transport across the blood-brain barrier
-
Bhattacharya I, Boje KM. GHB (gamma-hydroxybutyrate) carriermediated transport across the blood-brain barrier. J Pharmacol Exp Ther 2004; 311: 92-8.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 92-98
-
-
Bhattacharya, I.1
Boje, K.M.2
-
115
-
-
33748668794
-
Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: A pharmacokinetic simulation-based evaluation
-
Bhattacharya I, Boje KM. Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation. J Pharmacokinet Pharmacodyn 2006; 33: 657-81.
-
(2006)
J Pharmacokinet Pharmacodyn
, vol.33
, pp. 657-681
-
-
Bhattacharya, I.1
Boje, K.M.2
-
116
-
-
84455174556
-
Brain uptake of the drug of abuse gamma-hydroxybutyric acid in rats
-
Roiko SA, Felmlee MA, Morris ME. Brain uptake of the drug of abuse gamma-hydroxybutyric acid in rats. Drug Metab Dispos 2012; 40: 212-8.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 212-218
-
-
Roiko, S.A.1
Felmlee, M.A.2
Morris, M.E.3
-
117
-
-
84455171517
-
gamma-Hydroxybutyrate blood/plasma partitioning: Effect of physiologic pH on transport by monocarboxylate transporters
-
Morse BL, Felmlee MA, Morris ME. gamma-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters. Drug Metab Dispos 2012; 40: 64-9.
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 64-69
-
-
Morse, B.L.1
Felmlee, M.A.2
Morris, M.E.3
-
118
-
-
84858705550
-
Role of monocarboxylate transporters in human cancers: State of the art
-
Pinheiro C, Longatto-Filho A, Azevedo-Silva J, Casal M, Schmitt FC, Baltazar F. Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr 2012; 44: 127-39.
-
(2012)
J Bioenerg Biomembr
, vol.44
, pp. 127-139
-
-
Pinheiro, C.1
Longatto-Filho, A.2
Azevedo-Silva, J.3
Casal, M.4
Schmitt, F.C.5
Baltazar, F.6
-
119
-
-
10044278250
-
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: An in vitro study
-
discussion 1419
-
Mathupala SP, Parajuli P, Sloan AE. Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery 2004; 55: 1410-9; discussion 1419.
-
(2004)
Neurosurgery
, vol.55
, pp. 1410-1419
-
-
Mathupala, S.P.1
Parajuli, P.2
Sloan, A.E.3
-
120
-
-
79960039507
-
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: An in vivo study
-
Colen CB, Shen Y, Ghoddoussi F, et al. Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study. Neoplasia 2011; 13: 620-32.
-
(2011)
Neoplasia
, vol.13
, pp. 620-632
-
-
Colen, C.B.1
Shen, Y.2
Ghoddoussi, F.3
-
121
-
-
84870048116
-
Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
-
Cheng C, Edin NF, Lauritzen KH, et al. Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cell Oncol (Dordr) 2012; 35: 217-27.
-
(2012)
Cell Oncol (Dordr)
, vol.35
, pp. 217-227
-
-
Cheng, C.1
Edin, N.F.2
Lauritzen, K.H.3
-
122
-
-
84878218093
-
Expression of monocarboxylate transporter 8 mRNA in the brain tissue of rats with cerebral ischemia
-
Cui D, Guan Y, Jang H, Wang J, Xi L, Wang Q. Expression of monocarboxylate transporter 8 mRNA in the brain tissue of rats with cerebral ischemia. J Southern Med Univ 2012; 32: 913-5.
-
(2012)
J Southern Med Univ
, vol.32
, pp. 913-915
-
-
Cui, D.1
Guan, Y.2
Jang, H.3
Wang, J.4
Xi, L.5
Wang, Q.6
-
123
-
-
33644790739
-
Monocarboxylate transporter MCT1 is a target for immunosuppression
-
Murray CM, Hutchinson R, Bantick JR, et al. Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol 2005; 1: 371-6.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 371-376
-
-
Murray, C.M.1
Hutchinson, R.2
Bantick, J.R.3
-
124
-
-
74349094033
-
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
-
Ovens MJ, Davies AJ, Wilson MC, Murray CM, Halestrap AP. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J 2010; 425: 523-30.
-
(2010)
Biochem J
, vol.425
, pp. 523-530
-
-
Ovens, M.J.1
Davies, A.J.2
Wilson, M.C.3
Murray, C.M.4
Halestrap, A.P.5
-
125
-
-
34547624611
-
Supply and demand in cerebral energy metabolism: The role of nutrient transporters
-
Simpson IA, Carruthers A, Vannucci SJ. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab 2007; 27: 1766-91.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 1766-1791
-
-
Simpson, I.A.1
Carruthers, A.2
Vannucci, S.J.3
|