Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function

Cell Host and Microbe

Volumn 22, Issue 6, 2017, Pages 757-765.e3

  Yang, Jason H ^a,b   Bhargava, Prerna ^a,b   McCloskey, Douglas ^c,d   Mao, Ning ^a,e,f   Palsson, Bernhard O ^c,d   Collins, James J ^a,b,f  

^a Massachusetts Institute of Technology   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Chalmers University of Technology   (Denmark)

^e Boston University   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

antibiotic; germ free; immunomodulation; LC MS MS; metabolic environment; metabolomics; phagocytosis; respiration; systems biology

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; DRINKING WATER; ANTIINFECTIVE AGENT; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; CELL RESPIRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; HOST CELL; IMMUNE SYSTEM; IMMUNOMODULATION; IN VIVO STUDY; INTESTINE FLORA; MALE; METABOLISM; METABOLITE; METABOLOMICS; MICROBIAL METABOLISM; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MULTIVARIATE ANALYSIS; NONHUMAN; PERITONEUM; PHAGOCYTOSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ANIMAL; C57BL MOUSE; DISEASE MODEL; METABOLOME; MICROBIAL VIABILITY; MICROBIOLOGY; MITOCHONDRION; PERITONITIS;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI INFECTIONS; IMMUNOLOGIC FACTORS; METABOLOME; METABOLOMICS; MICE, INBRED C57BL; MICROBIAL VIABILITY; MITOCHONDRIA; PERITONITIS; PHAGOCYTOSIS;

EID: 85035791870     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.10.020     Document Type: Article

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