Histone deacetylase 1 (HDAC1) negatively regulates thermogenic program in brown adipocytes via coordinated regulation of histone H3 lysine 27 (H3K27) deacetylation and methylation

Journal of Biological Chemistry

Volumn 291, Issue 9, 2016, Pages 4523-4536

  Li, Fenfen ^a   Wu, Rui ^a   Cui, Xin ^a   Zha, Lin ^a   Yu, Liqing ^b   Shi, Hang ^a   Xue, Bingzhong ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; ALKYLATION; AMINO ACIDS; CHEMICAL ACTIVATION; CYTOLOGY; DISSOCIATION; GENES; MAMMALS; METHYLATION; MOLECULAR WEIGHT; PROTEINS;

ADIPOCYTE DIFFERENTIATION; CO-ORDINATED CONTROL; HISTONE DEACETYLASES; NEGATIVE REGULATORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; TETRATRICOPEPTIDE REPEATS; TRANSCRIPTIONAL REPRESSION; UNCOUPLING PROTEIN-1;

GENE EXPRESSION;

BETA 3 ADRENERGIC RECEPTOR; BMI1 PROTEIN; ENTINOSTAT; HISTONE DEACETYLASE 1; HISTONE H3; HISTONE H3 LYSINE 27; ISOPRENALINE; METHYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLASMID DNA; RING FINGER PROTEIN; RING FINGER PROTEIN 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; EZH2 PROTEIN, MOUSE; HDAC1 PROTEIN, MOUSE; HISTONE; ION CHANNEL; LYSINE; MITOCHONDRIAL PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; PPARGC1A PROTEIN, MOUSE; RECOMBINANT PROTEIN; RNF2 PROTEIN, MOUSE; SUZ12 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; UCP1 PROTEIN, HUMAN; UCP1 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAT GENE; BAT1 GENE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; C57BL 6 MOUSE; CELL DIFFERENTIATION; COLD EXPOSURE; CONTROLLED STUDY; DEACETYLATION; DISSOCIATION; DRUG PROTEIN BINDING; ENERGY EXPENDITURE; EPIGENETICS; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSFECTION; HISTONE ACETYLATION; HISTONE METHYLATION; MOLECULAR PROBE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PGC1 GENE; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SUZ12 GENE; SYMPATHETIC NERVE; THERMOGENESIS; WHITE ADIPOSE TISSUE; ACETYLATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; INBRED MOUSE STRAIN; METABOLISM; METHYLATION; PROMOTER REGION; PROTEIN PROCESSING; RNA INTERFERENCE; TRANSFORMED CELL LINE;

ACETYLATION; ADIPOCYTES, BROWN; ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; CELL LINE, TRANSFORMED; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE 1; HISTONES; HUMANS; ION CHANNELS; LYSINE; METHYLATION; MICE, INBRED STRAINS; MITOCHONDRIAL PROTEINS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB REPRESSIVE COMPLEX 2; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; RNA INTERFERENCE; THERMOGENESIS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UNCOUPLING PROTEIN 1;

EID: 84964668099     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.677930     Document Type: Article

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