메뉴 건너뛰기




Volumn 28, Issue 3, 2017, Pages 227-236

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

Author keywords

inflammation; ketone body; lactate; lipolysis; therapy of diseases

Indexed keywords

CARBOXYLIC ACID; HYDROXY CARBOXYLIC ACID RECEPTOR; HYDROXYACID; UNCLASSIFIED DRUG; 3 HYDROXYBUTYRIC ACID; G PROTEIN COUPLED RECEPTOR; KETONE; LACTIC ACID;

EID: 85009193567     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.11.007     Document Type: Review
Times cited : (126)

References (99)
  • 1
    • 56249140398 scopus 로고    scopus 로고
    • Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors
    • 1 Hong, C., Tontonoz, P., Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Curr. Opin. Genet. Dev. 18 (2008), 461–467.
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 461-467
    • Hong, C.1    Tontonoz, P.2
  • 2
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: the yin and yang of cholesterol and fat metabolism
    • 2 Kalaany, N.Y., Mangelsdorf, D.J., LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68 (2006), 159–191.
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 3
    • 84864541097 scopus 로고    scopus 로고
    • G protein-coupled receptors for energy metabolites as new therapeutic targets
    • 3 Blad, C.C., et al. G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 11 (2012), 603–619.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 603-619
    • Blad, C.C.1
  • 4
    • 79955769365 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B)
    • 4 Offermanns, S., et al. International Union of Basic and Clinical Pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). Pharmacol. Rev. 63 (2011), 269–290.
    • (2011) Pharmacol. Rev. , vol.63 , pp. 269-290
    • Offermanns, S.1
  • 5
    • 51649111846 scopus 로고    scopus 로고
    • The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist
    • 5 Tang, H., et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem. Biophys. Res. Commun. 375 (2008), 562–565.
    • (2008) Biochem. Biophys. Res. Commun. , vol.375 , pp. 562-565
    • Tang, H.1
  • 6
    • 77955300428 scopus 로고    scopus 로고
    • Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
    • 6 Hanson, J., et al. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J. Clin. Invest. 120 (2010), 2910–2919.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2910-2919
    • Hanson, J.1
  • 7
    • 67650410238 scopus 로고    scopus 로고
    • Novel patent publications on high-affinity nicotinic acid receptor agonists
    • 7 Shen, H.C., Colletti, S.L., Novel patent publications on high-affinity nicotinic acid receptor agonists. Expert Opin. Ther. Pat. 19 (2009), 957–967.
    • (2009) Expert Opin. Ther. Pat. , vol.19 , pp. 957-967
    • Shen, H.C.1    Colletti, S.L.2
  • 8
    • 80054782749 scopus 로고    scopus 로고
    • Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions
    • 8 Kuei, C., et al. Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions. Mol. Pharmacol. 80 (2011), 848–858.
    • (2011) Mol. Pharmacol. , vol.80 , pp. 848-858
    • Kuei, C.1
  • 9
    • 11344288910 scopus 로고    scopus 로고
    • Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors
    • 9 Zellner, C., et al. Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors. Hum. Mutat. 25 (2005), 18–21.
    • (2005) Hum. Mutat. , vol.25 , pp. 18-21
    • Zellner, C.1
  • 10
    • 56249083891 scopus 로고    scopus 로고
    • Role of GPR81 in lactate-mediated reduction of adipose lipolysis
    • 10 Cai, T.Q., et al. Role of GPR81 in lactate-mediated reduction of adipose lipolysis. Biochem. Biophys. Res. Commun. 377 (2008), 987–991.
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 987-991
    • Cai, T.Q.1
  • 11
    • 59149094602 scopus 로고    scopus 로고
    • Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
    • 11 Liu, C., et al. Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. J. Biol. Chem. 284 (2009), 2811–2822.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2811-2822
    • Liu, C.1
  • 12
    • 69249083201 scopus 로고    scopus 로고
    • Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
    • 12 Ahmed, K., et al. Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J. Biol. Chem. 284 (2009), 21928–21933.
    • (2009) J. Biol. Chem. , vol.284 , pp. 21928-21933
    • Ahmed, K.1
  • 13
    • 77950261397 scopus 로고    scopus 로고
    • An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81
    • 13 Ahmed, K., et al. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. 11 (2010), 311–319.
    • (2010) Cell Metab. , vol.11 , pp. 311-319
    • Ahmed, K.1
  • 14
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • 14 Tunaru, S., et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9 (2003), 352–355.
    • (2003) Nat. Med. , vol.9 , pp. 352-355
    • Tunaru, S.1
  • 15
    • 0037470749 scopus 로고    scopus 로고
    • Molecular identification of nicotinic acid receptor
    • 15 Soga, T., et al. Molecular identification of nicotinic acid receptor. Biochem. Biophys. Res. Commun. 303 (2003), 364–369.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 364-369
    • Soga, T.1
  • 16
    • 0003293442 scopus 로고    scopus 로고
    • Molecular identification of high and low affinity receptors for nicotinic acid
    • 16 Wise, A., et al. Molecular identification of high and low affinity receptors for nicotinic acid. J. Biol. Chem. 278 (2003), 9869–9874.
    • (2003) J. Biol. Chem. , vol.278 , pp. 9869-9874
    • Wise, A.1
  • 17
    • 44949159107 scopus 로고    scopus 로고
    • Elucidation of signaling and functional activities of an orphan GPCR, GPR81
    • 17 Ge, H., et al. Elucidation of signaling and functional activities of an orphan GPCR, GPR81. J. Lipid Res. 49 (2008), 797–803.
    • (2008) J. Lipid Res. , vol.49 , pp. 797-803
    • Ge, H.1
  • 18
    • 70350400862 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81)
    • 18 Jeninga, E.H., et al. Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). J. Biol. Chem. 284 (2009), 26385–26393.
    • (2009) J. Biol. Chem. , vol.284 , pp. 26385-26393
    • Jeninga, E.H.1
  • 19
    • 54549087794 scopus 로고    scopus 로고
    • Anatomical profiling of G protein-coupled receptor expression
    • 19 Regard, J.B., et al. Anatomical profiling of G protein-coupled receptor expression. Cell 135 (2008), 561–571.
    • (2008) Cell , vol.135 , pp. 561-571
    • Regard, J.B.1
  • 20
    • 0035666867 scopus 로고    scopus 로고
    • PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily
    • 20 Schaub, A., et al. PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur. J. Immunol. 31 (2001), 3714–3725.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3714-3725
    • Schaub, A.1
  • 21
    • 31044448925 scopus 로고    scopus 로고
    • GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
    • 21 Benyo, Z., et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J. Clin. Invest. 115 (2005), 3634–3640.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3634-3640
    • Benyo, Z.1
  • 22
    • 37348999056 scopus 로고    scopus 로고
    • Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)
    • 22 Kostylina, G., et al. Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A). Cell Death Differ. 15 (2008), 134–142.
    • (2008) Cell Death Differ. , vol.15 , pp. 134-142
    • Kostylina, G.1
  • 24
    • 66149084058 scopus 로고    scopus 로고
    • GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
    • 24 Thangaraju, M., et al. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res. 69 (2009), 2826–2832.
    • (2009) Cancer Res. , vol.69 , pp. 2826-2832
    • Thangaraju, M.1
  • 25
    • 61849183060 scopus 로고    scopus 로고
    • Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium
    • 25 Martin, P.M., et al. Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium. Mol. Vis. 15 (2009), 362–372.
    • (2009) Mol. Vis. , vol.15 , pp. 362-372
    • Martin, P.M.1
  • 26
    • 77950516928 scopus 로고    scopus 로고
    • Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8
    • 26 Cresci, G.A., et al. Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8. J. Gastrointest. Surg. 14 (2010), 449–461.
    • (2010) J. Gastrointest. Surg. , vol.14 , pp. 449-461
    • Cresci, G.A.1
  • 27
    • 0037069743 scopus 로고    scopus 로고
    • Molecular cloning and characterization of prokineticin receptors
    • 27 Soga, T., et al. Molecular cloning and characterization of prokineticin receptors. Biochim. Biophys. Acta 1579 (2002), 173–179.
    • (2002) Biochim. Biophys. Acta , vol.1579 , pp. 173-179
    • Soga, T.1
  • 28
    • 62649093908 scopus 로고    scopus 로고
    • Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B
    • 28 Irukayama-Tomobe, Y., et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 3930–3934.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 3930-3934
    • Irukayama-Tomobe, Y.1
  • 29
    • 0027370159 scopus 로고
    • Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors
    • 29 Nomura, H., et al. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. 5 (1993), 1239–1249.
    • (1993) Int. Immunol. , vol.5 , pp. 1239-1249
    • Nomura, H.1
  • 30
    • 0034703615 scopus 로고    scopus 로고
    • cDNA representational difference analysis of human neutrophils stimulated by GM-CSF
    • 30 Yousefi, S., et al. cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. Biochem. Biophys. Res. Commun. 277 (2000), 401–409.
    • (2000) Biochem. Biophys. Res. Commun. , vol.277 , pp. 401-409
    • Yousefi, S.1
  • 31
    • 84865359455 scopus 로고    scopus 로고
    • Effects of high fat diet on GPR109A and GPR81 gene expression
    • 31 Wanders, D., et al. Effects of high fat diet on GPR109A and GPR81 gene expression. Biochem. Biophys. Res. Commun. 425 (2012), 278–283.
    • (2012) Biochem. Biophys. Res. Commun. , vol.425 , pp. 278-283
    • Wanders, D.1
  • 32
    • 80955135092 scopus 로고    scopus 로고
    • Inflammation inhibits GPR81 expression in adipose tissue
    • 32 Feingold, K.R., et al. Inflammation inhibits GPR81 expression in adipose tissue. Inflamm. Res. 60 (2011), 991–995.
    • (2011) Inflamm. Res. , vol.60 , pp. 991-995
    • Feingold, K.R.1
  • 33
    • 0015262566 scopus 로고
    • Acid-base balance after maximal exercise of short duration
    • 33 Osnes, J.B., Hermansen, L., Acid-base balance after maximal exercise of short duration. J. Appl. Physiol. 32 (1972), 59–63.
    • (1972) J. Appl. Physiol. , vol.32 , pp. 59-63
    • Osnes, J.B.1    Hermansen, L.2
  • 34
    • 0026770646 scopus 로고
    • Lactate production in adipose tissue: a regulated function with extra-adipose implications
    • 34 DiGirolamo, M., et al. Lactate production in adipose tissue: a regulated function with extra-adipose implications. FASEB J. 6 (1992), 2405–2412.
    • (1992) FASEB J. , vol.6 , pp. 2405-2412
    • DiGirolamo, M.1
  • 35
    • 33947172448 scopus 로고    scopus 로고
    • Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women
    • 35 Qvisth, V., et al. Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women. Am. J. Physiol. Endocrinol. Metab. 292 (2007), E709–E714.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292 , pp. E709-E714
    • Qvisth, V.1
  • 36
    • 0027954996 scopus 로고
    • Lactate release from the subcutaneous tissue in lean and obese men
    • 36 Jansson, P.A., et al. Lactate release from the subcutaneous tissue in lean and obese men. J. Clin. Invest. 93 (1994), 240–246.
    • (1994) J. Clin. Invest. , vol.93 , pp. 240-246
    • Jansson, P.A.1
  • 37
    • 29244465509 scopus 로고    scopus 로고
    • Human fat cell lipolysis: biochemistry, regulation and clinical role
    • 37 Arner, P., Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract. Res. Clin. Endocrinol. Metab. 19 (2005), 471–482.
    • (2005) Best Pract. Res. Clin. Endocrinol. Metab. , vol.19 , pp. 471-482
    • Arner, P.1
  • 38
    • 84899489259 scopus 로고    scopus 로고
    • Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance
    • 38 Arner, P., Langin, D., Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol. Metab. 25 (2014), 255–262.
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 255-262
    • Arner, P.1    Langin, D.2
  • 39
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • 39 Harms, M., Seale, P., Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19 (2013), 1252–1263.
    • (2013) Nat. Med. , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 40
    • 0014481080 scopus 로고
    • Liver and kidney metabolism during prolonged starvation
    • 40 Owen, O.E., et al. Liver and kidney metabolism during prolonged starvation. J. Clin. Invest. 48 (1969), 574–583.
    • (1969) J. Clin. Invest. , vol.48 , pp. 574-583
    • Owen, O.E.1
  • 41
    • 0014404928 scopus 로고
    • Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man
    • 41 Senior, B., Loridan, L., Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man. Nature 219 (1968), 83–84.
    • (1968) Nature , vol.219 , pp. 83-84
    • Senior, B.1    Loridan, L.2
  • 42
    • 22844439234 scopus 로고    scopus 로고
    • (D)-β-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
    • 42 Taggart, A.K., et al. (D)-β-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J. Biol. Chem. 280 (2005), 26649–26652.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26649-26652
    • Taggart, A.K.1
  • 43
    • 0031914110 scopus 로고    scopus 로고
    • Simultaneous analysis of plasma free fatty acids and their 3-hydroxy analogs in fatty acid beta-oxidation disorders
    • 43 Costa, C.G., et al. Simultaneous analysis of plasma free fatty acids and their 3-hydroxy analogs in fatty acid beta-oxidation disorders. Clin. Chem. 44 (1998), 463–471.
    • (1998) Clin. Chem. , vol.44 , pp. 463-471
    • Costa, C.G.1
  • 44
    • 22644437126 scopus 로고    scopus 로고
    • Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review
    • 44 Carlson, L.A., Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J. Intern. Med. 258 (2005), 94–114.
    • (2005) J. Intern. Med. , vol.258 , pp. 94-114
    • Carlson, L.A.1
  • 45
    • 33847772179 scopus 로고    scopus 로고
    • Critical role of cholesterol ester transfer protein in nicotinic acid-mediated HDL elevation in mice
    • 45 Hernandez, M., et al. Critical role of cholesterol ester transfer protein in nicotinic acid-mediated HDL elevation in mice. Biochem. Biophys. Res. Commun. 355 (2007), 1075–1080.
    • (2007) Biochem. Biophys. Res. Commun. , vol.355 , pp. 1075-1080
    • Hernandez, M.1
  • 46
    • 55449114841 scopus 로고    scopus 로고
    • Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
    • 46 van der Hoorn, J.W., et al. Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice. Arterioscler. Thromb. Vasc. Biol. 28 (2008), 2016–2022.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 2016-2022
    • van der Hoorn, J.W.1
  • 47
    • 84865330824 scopus 로고    scopus 로고
    • Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression
    • 47 Lauring, B., et al. Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci. Transl. Med., 4, 2012, 148ra115.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 148ra115
    • Lauring, B.1
  • 48
    • 84901924957 scopus 로고    scopus 로고
    • HDL-targeted therapies: progress, failures and future
    • 48 Kingwell, B.A., et al. HDL-targeted therapies: progress, failures and future. Nat. Rev. Drug Discov. 13 (2014), 445–464.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 445-464
    • Kingwell, B.A.1
  • 49
    • 84968853461 scopus 로고    scopus 로고
    • Adipocyte lipolysis and insulin resistance
    • 49 Morigny, P., et al. Adipocyte lipolysis and insulin resistance. Biochimie 125 (2016), 259–266.
    • (2016) Biochimie , vol.125 , pp. 259-266
    • Morigny, P.1
  • 50
    • 84874692963 scopus 로고    scopus 로고
    • Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
    • 50 Girousse, A., et al. Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol., 11, 2013, e1001485.
    • (2013) PLoS Biol. , vol.11 , pp. e1001485
    • Girousse, A.1
  • 51
    • 84925448638 scopus 로고    scopus 로고
    • GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial
    • 51 Dobbins, R., et al. GSK256073 acutely regulates NEFA levels via HCA2 agonism but does not achieve durable glycaemic control in type 2 diabetes. A randomised trial. Eur. J. Pharmacol. 755 (2015), 95–101.
    • (2015) Eur. J. Pharmacol. , vol.755 , pp. 95-101
    • Dobbins, R.1
  • 52
    • 84922250464 scopus 로고    scopus 로고
    • Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets
    • 52 Chen, L., et al. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Mol. Cell. Endocrinol. 404 (2015), 56–66.
    • (2015) Mol. Cell. Endocrinol. , vol.404 , pp. 56-66
    • Chen, L.1
  • 53
    • 84984808071 scopus 로고    scopus 로고
    • Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells
    • 53 Wang, N., et al. Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells. Gen. Comp. Endocrinol. 237 (2016), 98–108.
    • (2016) Gen. Comp. Endocrinol. , vol.237 , pp. 98-108
    • Wang, N.1
  • 54
    • 79952240405 scopus 로고    scopus 로고
    • Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • 54 Lukasova, M., et al. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J. Clin. Invest. 121 (2011), 1163–1173.
    • (2011) J. Clin. Invest. , vol.121 , pp. 1163-1173
    • Lukasova, M.1
  • 55
    • 77951483195 scopus 로고    scopus 로고
    • Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids
    • 55 Wu, B.J., et al. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arterioscler. Thromb. Vasc. Biol. 30 (2010), 968–975.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 968-975
    • Wu, B.J.1
  • 56
    • 84887098198 scopus 로고    scopus 로고
    • The role of HCA2 (GPR109A) in regulating macrophage function
    • 56 Zandi-Nejad, K., et al. The role of HCA2 (GPR109A) in regulating macrophage function. FASEB J. 27 (2013), 4366–4374.
    • (2013) FASEB J. , vol.27 , pp. 4366-4374
    • Zandi-Nejad, K.1
  • 57
    • 64749109569 scopus 로고    scopus 로고
    • Niacin stimulates adiponectin secretion through the GPR109A receptor
    • 57 Plaisance, E.P., et al. Niacin stimulates adiponectin secretion through the GPR109A receptor. Am. J. Physiol. Endocrinol. Metab. 296 (2009), E549–E558.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E549-E558
    • Plaisance, E.P.1
  • 58
    • 84959518014 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2
    • 58 Graff, E.C., et al. Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2. Metabolism 65 (2016), 102–113.
    • (2016) Metabolism , vol.65 , pp. 102-113
    • Graff, E.C.1
  • 59
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • 59 Boden, W.E., et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N. Engl. J. Med. 365 (2011), 2255–2267.
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2255-2267
    • Boden, W.E.1
  • 60
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • 60 Hps2 Thrive Collaborative Group, HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur. Heart J. 34 (2013), 1279–1291.
    • (2013) Eur. Heart J. , vol.34 , pp. 1279-1291
    • Hps2 Thrive Collaborative Group1
  • 61
    • 84958252911 scopus 로고    scopus 로고
    • Niacin alternatives for dyslipidemia: fool's gold or gold mine? Part I: alternative niacin regimens
    • 61 Dunbar, R.L., Goel, H., Niacin alternatives for dyslipidemia: fool's gold or gold mine? Part I: alternative niacin regimens. Curr. Atheroscler. Rep., 18, 2016, 11.
    • (2016) Curr. Atheroscler. Rep. , vol.18 , pp. 11
    • Dunbar, R.L.1    Goel, H.2
  • 62
    • 85026933236 scopus 로고    scopus 로고
    • Niacin alternatives for dyslipidemia: fool's gold or gold mine? Part II: novel niacin mimetics
    • 62 Goel, H., Dunbar, R.L., Niacin alternatives for dyslipidemia: fool's gold or gold mine? Part II: novel niacin mimetics. Curr. Atheroscler. Rep., 18, 2016, 17.
    • (2016) Curr. Atheroscler. Rep. , vol.18 , pp. 17
    • Goel, H.1    Dunbar, R.L.2
  • 64
    • 54149116366 scopus 로고    scopus 로고
    • Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • 64 Kappos, L., et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 372 (2008), 1463–1472.
    • (2008) Lancet , vol.372 , pp. 1463-1472
    • Kappos, L.1
  • 65
    • 84899722143 scopus 로고    scopus 로고
    • Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE
    • 65 Chen, H., et al. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J. Clin. Invest. 124 (2014), 2188–2192.
    • (2014) J. Clin. Invest. , vol.124 , pp. 2188-2192
    • Chen, H.1
  • 66
    • 84937816017 scopus 로고    scopus 로고
    • Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS
    • 66 Parodi, B., et al. Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS. Acta Neuropathol. 130 (2015), 279–295.
    • (2015) Acta Neuropathol. , vol.130 , pp. 279-295
    • Parodi, B.1
  • 67
    • 84901325457 scopus 로고    scopus 로고
    • The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
    • 67 Rahman, M., et al. The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat. Commun., 5, 2014, 3944.
    • (2014) Nat. Commun. , vol.5 , pp. 3944
    • Rahman, M.1
  • 68
    • 84991228245 scopus 로고    scopus 로고
    • Oral fumaric acid esters for psoriasis
    • 68 Atwan, A., et al. Oral fumaric acid esters for psoriasis. Cochrane Database Syst. Rev., 2015, CD010497.
    • (2015) Cochrane Database Syst. Rev. , pp. CD010497
    • Atwan, A.1
  • 69
    • 11844304978 scopus 로고    scopus 로고
    • Dimethylfumarate for psoriasis: more than a dietary curiosity
    • 69 Mrowietz, U., Asadullah, K., Dimethylfumarate for psoriasis: more than a dietary curiosity. Trends Mol. Med. 11 (2005), 43–48.
    • (2005) Trends Mol. Med. , vol.11 , pp. 43-48
    • Mrowietz, U.1    Asadullah, K.2
  • 70
    • 84971519476 scopus 로고    scopus 로고
    • From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites
    • 70 Koh, A., et al. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165 (2016), 1332–1345.
    • (2016) Cell , vol.165 , pp. 1332-1345
    • Koh, A.1
  • 72
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • 72 Singh, N., et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 40 (2014), 128–139.
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1
  • 73
    • 84926367699 scopus 로고    scopus 로고
    • Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
    • 73 Macia, L., et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun., 6, 2015, 6734.
    • (2015) Nat. Commun. , vol.6 , pp. 6734
    • Macia, L.1
  • 74
    • 84975168249 scopus 로고    scopus 로고
    • Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways
    • 74 Tan, J., et al. Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep. 15 (2016), 2809–2824.
    • (2016) Cell Rep. , vol.15 , pp. 2809-2824
    • Tan, J.1
  • 75
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • 75 Chang, P.V., et al. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 2247–2252.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 2247-2252
    • Chang, P.V.1
  • 76
    • 84984633287 scopus 로고    scopus 로고
    • The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC
    • 76 Schilderink, R., et al. The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC. Am. J. Physiol. Gastrointest. Liver Physiol. 310 (2016), G1138–G1146.
    • (2016) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.310 , pp. G1138-G1146
    • Schilderink, R.1
  • 77
    • 84937801681 scopus 로고    scopus 로고
    • Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
    • 77 Staubert, C., et al. Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism. Oncotarget 6 (2015), 19706–19720.
    • (2015) Oncotarget , vol.6 , pp. 19706-19720
    • Staubert, C.1
  • 78
    • 84937798733 scopus 로고    scopus 로고
    • L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation
    • 78 Wagner, W., et al. L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation. Cell Commun. Signal., 13, 2015, 36.
    • (2015) Cell Commun. Signal. , vol.13 , pp. 36
    • Wagner, W.1
  • 79
    • 84907486950 scopus 로고    scopus 로고
    • Cell surface lactate receptor GPR81 is crucial for cancer cell survival
    • 79 Roland, C.L., et al. Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Res. 74 (2014), 5301–5310.
    • (2014) Cancer Res. , vol.74 , pp. 5301-5310
    • Roland, C.L.1
  • 80
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • 80 Walenta, S., et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 60 (2000), 916–921.
    • (2000) Cancer Res. , vol.60 , pp. 916-921
    • Walenta, S.1
  • 81
    • 76049105429 scopus 로고    scopus 로고
    • Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives
    • 81 Menendez, J.A., Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives. Biochim. Biophys. Acta 1801 (2010), 381–391.
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 381-391
    • Menendez, J.A.1
  • 82
    • 84994291790 scopus 로고    scopus 로고
    • G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion
    • Published online September 27, 2016
    • 82 Lee, Y.J., et al. G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. Oncotarget., 2016 Published online September 27, 2016 http://dx.doi.org/10.18632/oncotarget.12286.
    • (2016) Oncotarget.
    • Lee, Y.J.1
  • 83
    • 84894261181 scopus 로고    scopus 로고
    • The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival
    • 83 Elangovan, S., et al. The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. Cancer Res. 74 (2014), 1166–1178.
    • (2014) Cancer Res. , vol.74 , pp. 1166-1178
    • Elangovan, S.1
  • 84
    • 84869176200 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype
    • 84 Singh, V., et al. Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype. Cell Host Microbe 12 (2012), 669–681.
    • (2012) Cell Host Microbe , vol.12 , pp. 669-681
    • Singh, V.1
  • 85
    • 77649112187 scopus 로고    scopus 로고
    • Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis
    • 85 Kumar, D., et al. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140 (2010), 731–743.
    • (2010) Cell , vol.140 , pp. 731-743
    • Kumar, D.1
  • 86
    • 84938897054 scopus 로고    scopus 로고
    • M. tuberculosis secretory protein ESAT-6 induces metabolic flux perturbations to drive foamy macrophage differentiation
    • 86 Singh, V., et al. M. tuberculosis secretory protein ESAT-6 induces metabolic flux perturbations to drive foamy macrophage differentiation. Sci. Rep., 5, 2015, 12906.
    • (2015) Sci. Rep. , vol.5 , pp. 12906
    • Singh, V.1
  • 87
    • 84981273184 scopus 로고    scopus 로고
    • Dissecting host factors that regulate the early stages of tuberculosis infection
    • 87 Agrawal, N., et al. Dissecting host factors that regulate the early stages of tuberculosis infection. Tuberculosis (Edinb) 100 (2016), 102–113.
    • (2016) Tuberculosis (Edinb) , vol.100 , pp. 102-113
    • Agrawal, N.1
  • 89
    • 33646258753 scopus 로고    scopus 로고
    • 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    • 2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 6682–6687.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 6682-6687
    • Cheng, K.1
  • 90
    • 84861372936 scopus 로고    scopus 로고
    • Extended-release niacin with laropiprant: a review on efficacy, clinical effectiveness and safety
    • 90 Yadav, R., et al. Extended-release niacin with laropiprant: a review on efficacy, clinical effectiveness and safety. Expert Opin. Pharmacother. 13 (2012), 1345–1362.
    • (2012) Expert Opin. Pharmacother. , vol.13 , pp. 1345-1362
    • Yadav, R.1
  • 91
    • 66449111715 scopus 로고    scopus 로고
    • beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice
    • 91 Walters, R.W., et al. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J. Clin. Invest. 119 (2009), 1312–1321.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1312-1321
    • Walters, R.W.1
  • 92
    • 84861559049 scopus 로고    scopus 로고
    • 3,5-Dihydroxybenzoic acid, a specific agonist for HCA1, inhibits lipolysis in adipocytes
    • 92 Liu, C., et al. 3,5-Dihydroxybenzoic acid, a specific agonist for HCA1, inhibits lipolysis in adipocytes. J. Pharmacol. Exp. Ther. 341 (2012), 794–801.
    • (2012) J. Pharmacol. Exp. Ther. , vol.341 , pp. 794-801
    • Liu, C.1
  • 93
    • 84889093491 scopus 로고    scopus 로고
    • Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
    • 93 Engelstoft, M.S., et al. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol. Metab. 2 (2013), 376–392.
    • (2013) Mol. Metab. , vol.2 , pp. 376-392
    • Engelstoft, M.S.1
  • 94
    • 84862969757 scopus 로고    scopus 로고
    • Discovery of SCH 900271, a potent nicotinic acid receptor agonist for the treatment of dyslipidemia
    • 94 Palani, A., et al. Discovery of SCH 900271, a potent nicotinic acid receptor agonist for the treatment of dyslipidemia. ACS Med. Chem. Lett. 3 (2012), 63–68.
    • (2012) ACS Med. Chem. Lett. , vol.3 , pp. 63-68
    • Palani, A.1
  • 95
    • 84860273364 scopus 로고    scopus 로고
    • (1aR,5aR)1a, 3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans
    • 95 Boatman, P.D., et al. (1aR,5aR)1a, 3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J. Med. Chem. 55 (2012), 3644–3666.
    • (2012) J. Med. Chem. , vol.55 , pp. 3644-3666
    • Boatman, P.D.1
  • 96
    • 77949868548 scopus 로고    scopus 로고
    • Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate
    • 96 Shen, H.C., et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J. Med. Chem. 53 (2010), 2666–2670.
    • (2010) J. Med. Chem. , vol.53 , pp. 2666-2670
    • Shen, H.C.1
  • 97
    • 84925442107 scopus 로고    scopus 로고
    • Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist
    • 97 Sprecher, D., et al. Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist. Eur. J. Pharmacol. 756 (2015), 1–7.
    • (2015) Eur. J. Pharmacol. , vol.756 , pp. 1-7
    • Sprecher, D.1
  • 98
    • 33144455148 scopus 로고    scopus 로고
    • 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
    • 98 Semple, G., et al. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J. Med. Chem. 49 (2006), 1227–1230.
    • (2006) J. Med. Chem. , vol.49 , pp. 1227-1230
    • Semple, G.1
  • 99
    • 67649984195 scopus 로고    scopus 로고
    • 5-N,N-disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b
    • 99 Skinner, P.J., et al. 5-N,N-disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg. Med. Chem. Lett. 19 (2009), 4207–4209.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4207-4209
    • Skinner, P.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.