Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 116, Issue 6, 2019, Pages 2200-2209

  Wang, Andrew ^a   Pope, Scott D ^a   Weinstein, Jason S ^a   Yu, Shuang ^a   Zhang, Cuiling ^a   Booth, Carmen J ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hemophagocytic lymphohistiocytosis; Inflammation; Sepsis

Indexed keywords

DEOXYGLUCOSE; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; CYTOKINE; TOLL LIKE RECEPTOR;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC TRANSCRIPTION; HEMOPHAGOCYTIC SYNDROME; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA SEQUENCE; SEQUENCE ANALYSIS; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD CELL COUNT; CELL LINE; COMMUNICABLE DISEASE; COMPLICATION; DISEASE MODEL; GENE EXPRESSION PROFILING; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; METABOLOMICS; MICROBIOLOGY; PROCEDURES; VIROLOGY;

ANIMALS; BIOMARKERS; BLOOD CELL COUNT; CELL LINE; COMMUNICABLE DISEASES; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; LIPOPOLYSACCHARIDES; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MACROPHAGES; MALE; METABOLOMICS; MICE; MICE, KNOCKOUT; TOLL-LIKE RECEPTORS;

EID: 85061160093     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1820704116     Document Type: Article

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