Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation

Scientific Reports

Volumn 4, Issue , 2015, Pages

  Yoo, Chae Hwa ^a   Yeom, Ji Hyun ^a   Heo, Jin Ju ^a   Song, Eun Kyung ^a   Lee, Sang Il ^b   Han, Myung Kwan ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BETA INTERFERON; CYTOKINE; JANUS KINASE; LIPOPOLYSACCHARIDE; SIRTUIN 1; STAT PROTEIN;

ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM; MORTALITY; MOUSE; PATHOLOGY; SEPTIC SHOCK; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; INTERFERON-BETA; JANUS KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SIRTUIN 1; STAT TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84905741001     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04220     Document Type: Article

References (34)

1. Bochud, P. Y. & Calandra, T. Pathogenesis of sepsis: new concepts and implications for future treatment. BMJ 326, 262-266 (2003).
2. Yethon, J. A. & Whitfield, C. Lipopolysaccharide as a target for the development of novel therapeutics in gram-negative bacteria. Curr. Drug Targets Infect. Disord. 1, 91-106 (2001).
3. Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A., Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997).
4. Akira, S. Toll-like receptor signaling. J. Biol. Chem. 278, 38105-38108 (2003).
5. Zhang, F. X. et al. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274, 7611-7614 (1999).
6. Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat.Immunol. 2, 835-841 (2001).
7. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
8. Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat.Immunol. 2, 675-680 (2001).
9. Lu, Y. C., Yeh, W. C. & Ohashi, P. S. LPS/TLR4 signal transduction pathway. Cytokine 42, 145-151 (2008).
10. Prinz, M. et al. Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Rep. 4, 195-199 (2003).
11. Chi, H. et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc. Nat'l Acad. Sci. U. S. A. 103, 2274-2279 (2006).
12. Luo, J. et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (2001).
13. Rogina, B. & Helfand, S. L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Nat'l Acad. Sci. U. S. A. 101, 15998-16003 (2004).
14. Han, M. K. et al. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2, 241-251 (2008).
15. Yeung, F. et al.Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23, 2369-2380 (2004).
16. Vaziri, H. et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001).
17. Rodgers, J. T. et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118 (2005).
18. Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).
19. Yang, S. R. et al. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L567-576 (2007).
20. Yoshizaki, T. et al. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 298, E419-428 (2010).
21. Yoshizaki, T. et al. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol. Cell Biol. 29, 1363-1374 (2009).
22. Toshchakov, V. et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1α/β-dependent gene expression in macrophages. Nat. Immunol. 3, 392-398 (2002).
23. Karaghiosoff, M. et al. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat.Immunol. 4, 471-477 (2003).
24. Mahieu, T. et al. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc. Nat'l Acad. Sci. U. S. A. 103, 2292-2297 (2006).
25. Maeda, Y., Musoh, K., Shichijo, M., Tanaka, H. & Nagai, H. Interferon-β prevents antigen-induced bronchial inflammation and airway hyperreactivity in mice. Pharmacology 55, 32-43 (1997).
26. Jungo, F., Dayer, J. M., Modoux, C., Hyka, N. & Burger, D. IFN-β inhibits the ability of T lymphocytes to induce TNF-α and IL-1β production in monocytes upon direct cell-cell contact. Cytokine 14, 272-282 (2001).
27. Danis, V. A., Kulesz, A. J., Nelson, D. S. & Brooks, P. M. Cytokine regulation of human monocyte interleukin-1 (IL-1) production in vitro. Enhancement of IL-1 production by interferon (IFN)γ, tumour necrosis factor-α, IL-2 and IL-1, and inhibition by IFN-α. Clin.Exp.Immunol. 80, 435-443 (1990).
28. Tzung, S. P., Mahl, T. C., Lance, P., Andersen, V. & Cohen, S. A. Interferon-alpha prevents endotoxin-induced mortality in mice. Eur. J. Immunol. 22, 3097-3101 (1992).
29. Shin, H. J. et al. Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins. Mol. Cells 24, 119-124 (2007).
30. Jiang, W., Bell, C. W. & Pisetsky, D. S. The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. J. Immunol. 178, 6495-6503 (2007).
31. Manna, S. K. & Aggarwal, B. B. Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-κB activation and reactive oxygen intermediates. J. Immunol. 162, 1510-1518 (1999).
32. Kim, J. H. et al. Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-β signaling pathway. J. Immunol. 182, 2458-2466 (2009).
33. Lee, J. H. et al. Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway. Diabetes 58, 344-351 (2009).
34. Rittirsch, D., Huber-Lang, M. S., Flierl, M. A. & Ward, P. A. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4, 31-36 (2009).