메뉴 건너뛰기




Volumn 8, Issue JAN, 2017, Pages

Metabolism supports macrophage activation

Author keywords

AKT; Electron transport chain; Immunometabolism; Macrophage; Macrophage activation; Macrophage metabolism; Mitochondria; MTOR

Indexed keywords

ACETYL COENZYME A; GLUCOSE TRANSPORTER 1; GLUTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 4; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B;

EID: 85012110611     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00061     Document Type: Short Survey
Times cited : (135)

References (40)
  • 1
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 11:723-37. doi: 10.1038/nri3073
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 3
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: nomenclature and experimental guidelines
    • Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity (2014) 41:14-20. doi:10.1016/j.immuni.2014.06.008
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1    Allen, J.E.2    Biswas, S.K.3    Fisher, E.A.4    Gilroy, D.W.5    Goerdt, S.6
  • 5
    • 84994797642 scopus 로고    scopus 로고
    • Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation
    • Huang SC-C, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, et al. Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity (2016) 45:817-30. doi:10.1016/j.immuni.2016.09.016
    • (2016) Immunity , vol.45 , pp. 817-830
    • Huang, S.C.-C.1    Smith, A.M.2    Everts, B.3    Colonna, M.4    Pearce, E.L.5    Schilling, J.D.6
  • 6
    • 84951906010 scopus 로고    scopus 로고
    • Control of macrophage metabolism and activation by mTOR and Akt signaling
    • Covarrubias AJ, Aksoylar HI, Horng T. Control of macrophage metabolism and activation by mTOR and Akt signaling. Semin Immunol (2015) 27:286-96. doi:10.1016/j.smim.2015.08.001
    • (2015) Semin Immunol , vol.27 , pp. 286-296
    • Covarrubias, A.J.1    Aksoylar, H.I.2    Horng, T.3
  • 7
    • 84896654124 scopus 로고    scopus 로고
    • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKe supports the anabolic demands of dendritic cell activation
    • Everts B, Amiel E, Huang SC-C, Smith AM, Chang C-H, Lam WY, et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKe supports the anabolic demands of dendritic cell activation. Nat Immunol (2014) 15:323-32. doi:10.1038/ni.2833
    • (2014) Nat Immunol , vol.15 , pp. 323-332
    • Everts, B.1    Amiel, E.2    Huang, S.C.-C.3    Smith, A.M.4    Chang, C.-H.5    Lam, W.Y.6
  • 8
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D, Carling D, Stout RD, Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol (2008) 181:8633-41. doi:10.4049/jimmunol.181.12.8633
    • (2008) J Immunol , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 9
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 115:4742-9. doi:10.1182/blood-2009-10-249540
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1    Holowka, T.2    Sun, J.3    Blagih, J.4    Amiel, E.5    DeBerardinis, R.J.6
  • 10
    • 84961281785 scopus 로고    scopus 로고
    • Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
    • Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife (2016) 5:e11612. doi:10.7554/eLife.11612.001
    • (2016) Elife , vol.5
    • Covarrubias, A.J.1    Aksoylar, H.I.2    Yu, J.3    Snyder, N.W.4    Worth, A.J.5    Iyer, S.S.6
  • 11
    • 84907069550 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function
    • Amiel E, Everts B, Fritz D, Beauchamp S, Ge B, Pearce EL, et al. Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function. J Immunol (2014) 193:2821-30. doi:10.4049/jimmunol.1302498
    • (2014) J Immunol , vol.193 , pp. 2821-2830
    • Amiel, E.1    Everts, B.2    Fritz, D.3    Beauchamp, S.4    Ge, B.5    Pearce, E.L.6
  • 12
    • 84991447931 scopus 로고    scopus 로고
    • Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
    • Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun (2016) 7:1-15. doi:10.1038/ncomms13130
    • (2016) Nat Commun , vol.7 , pp. 1-15
    • Kimura, T.1    Nada, S.2    Takegahara, N.3    Okuno, T.4    Nojima, S.5    Kang, S.6
  • 13
    • 84960399221 scopus 로고    scopus 로고
    • Immunometabolism governs dendritic cell and macrophage function
    • O'Neill LAJ, Pearce EJ. Immunometabolism governs dendritic cell and macrophage function. J Exp Med (2016) 213:15-23. doi:10.1084/jem.20151570
    • (2016) J Exp Med , vol.213 , pp. 15-23
    • O'Neill, L.A.J.1    Pearce, E.J.2
  • 14
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
    • Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, et al. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab (2006) 4:13-24. doi:10.1016/j.cmet.2006.05.011
    • (2006) Cell Metab , vol.4 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3    Zhang, L.4    Smith, K.L.5    Morel, C.R.6
  • 15
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARd regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, et al. Adipocyte-derived Th2 cytokines and myeloid PPARd regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 7:485-95. doi:10.1016/j.cmet.2008.04.002
    • (2008) Cell Metab , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6
  • 17
    • 84990845578 scopus 로고    scopus 로고
    • Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
    • Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell (2016) 167:457-61. doi:10.1016/j.cell.2016.08.064
    • (2016) Cell , vol.167 , pp. 457-461
    • Mills, E.L.1    Kelly, B.2    Logan, A.3    Costa, A.S.H.4    Varma, M.5    Bryant, C.E.6
  • 18
    • 84920591180 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates Hif-1a; activity and IL-1β; induction and is a critical determinant of the Warburg effect in LPS-activated macrophages
    • Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MAR, Sheedy FJ, Gleeson LE, et al. Pyruvate kinase M2 regulates Hif-1a; activity and IL-1β; induction and is a critical determinant of the Warburg effect in LPS-activated macrophages. Cell Metab (2015) 21:65-80. doi:10.1016/j.cmet.2014.12.005
    • (2015) Cell Metab , vol.21 , pp. 65-80
    • Palsson-McDermott, E.M.1    Curtis, A.M.2    Goel, G.3    Lauterbach, M.A.R.4    Sheedy, F.J.5    Gleeson, L.E.6
  • 19
    • 0030048720 scopus 로고    scopus 로고
    • Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    • Fukuzumi M, Shinomiya H, Shimizu Y, Ohishi K, Utsumi S. Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1. Infect Immun (1996) 64:108-12.
    • (1996) Infect Immun , vol.64 , pp. 108-112
    • Fukuzumi, M.1    Shinomiya, H.2    Shimizu, Y.3    Ohishi, K.4    Utsumi, S.5
  • 20
    • 84924935721 scopus 로고    scopus 로고
    • Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
    • Jha AK, Huang SC-C, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity (2015) 42:419-30. doi:10.1016/j.immuni.2015.02.005
    • (2015) Immunity , vol.42 , pp. 419-430
    • Jha, A.K.1    Huang, S.C.-C.2    Sergushichev, A.3    Lampropoulou, V.4    Ivanova, Y.5    Loginicheva, E.6
  • 22
    • 84957800096 scopus 로고    scopus 로고
    • Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1 α-dependent
    • Liu L, Lu Y, Martinez J, Bi Y, Lian G, Wang T, et al. Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1 α-dependent. Proc Natl Acad Sci U S A (2016) 113:1564-9. doi:10.1073/pnas.1518000113
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. 1564-1569
    • Liu, L.1    Lu, Y.2    Martinez, J.3    Bi, Y.4    Lian, G.5    Wang, T.6
  • 23
    • 77956213727 scopus 로고    scopus 로고
    • Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation
    • Rodriguez-Prados JC, Traves PG, Cuenca J, Rico D, Aragones J, Martin-Sanz P, et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. The J Immunol (2010) 185:605-14. doi:10.4049/jimmunol.0901698
    • (2010) The J Immunol , vol.185 , pp. 605-614
    • Rodriguez-Prados, J.C.1    Traves, P.G.2    Cuenca, J.3    Rico, D.4    Aragones, J.5    Martin-Sanz, P.6
  • 24
    • 84976478216 scopus 로고    scopus 로고
    • Mitochondrial dynamics controls T cell fate through metabolic programming
    • Buck MD, O'Sullivan D, Geltink RIK, Curtis JD, Chang C-H, Sanin DE, et al. Mitochondrial dynamics controls T cell fate through metabolic programming. Cell (2016) 166:63-76. doi:10.1016/j.cell.2016.05.035
    • (2016) Cell , vol.166 , pp. 63-76
    • Buck, M.D.1    O'Sullivan, D.2    Geltink, R.I.K.3    Curtis, J.D.4    Chang, C.-H.5    Sanin, D.E.6
  • 25
    • 84877343356 scopus 로고    scopus 로고
    • Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
    • Michelucci A, Cordes T, Ghelfi J, Pailot A, Hiller K. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A (2013) 110:7820-5. doi:10.1073/pnas.1218599110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7820-7825
    • Michelucci, A.1    Cordes, T.2    Ghelfi, J.3    Pailot, A.4    Hiller, K.5
  • 26
    • 84976869322 scopus 로고    scopus 로고
    • Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels
    • Cordes T, Wallace M, Michelucci A, Divakaruni AS, Sapcariu SC, Sousa C, et al. Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels. J Biol Chem (2016) 291:14274-84. doi:10.1074/jbc.M115.685792
    • (2016) J Biol Chem , vol.291 , pp. 14274-14284
    • Cordes, T.1    Wallace, M.2    Michelucci, A.3    Divakaruni, A.S.4    Sapcariu, S.C.5    Sousa, C.6
  • 28
    • 84866434542 scopus 로고    scopus 로고
    • Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1
    • Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, et al. Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell Host and Microbe (2012) 12:313-23. doi:10.1016/j.chom.2012.07.012
    • (2012) Cell Host and Microbe , vol.12 , pp. 313-323
    • Qualls, J.E.1    Subramanian, C.2    Rafi, W.3    Smith, A.M.4    Balouzian, L.5    DeFreitas, A.A.6
  • 29
    • 84955126560 scopus 로고    scopus 로고
    • Amino acid auxotrophy as a system of immunological control nodes
    • Murray PJ. Amino acid auxotrophy as a system of immunological control nodes. Nat Immunol (2016) 17:132-9. doi:10.1038/ni.3323
    • (2016) Nat Immunol , vol.17 , pp. 132-139
    • Murray, P.J.1
  • 30
    • 84862016400 scopus 로고    scopus 로고
    • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
    • Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab (2012) 15:813-26. doi:10.1016/j.cmet.2012.04.023
    • (2012) Cell Metab , vol.15 , pp. 813-826
    • Haschemi, A.1    Kosma, P.2    Gille, L.3    Evans, C.R.4    Burant, C.F.5    Starkl, P.6
  • 32
    • 84906319549 scopus 로고    scopus 로고
    • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
    • Huang SC-C, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol (2014) 15:846-55. doi:10.1038/ni.2956
    • (2014) Nat Immunol , vol.15 , pp. 846-855
    • Huang, S.C.-C.1    Everts, B.2    Ivanova, Y.3    O'Sullivan, D.4    Nascimento, M.5    Smith, A.M.6
  • 33
    • 84950247027 scopus 로고    scopus 로고
    • Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling
    • York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, et al. Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling. Cell (2015) 163:1716-29. doi:10.1016/j.cell.2015.11.045
    • (2015) Cell , vol.163 , pp. 1716-1729
    • York, A.G.1    Williams, K.J.2    Argus, J.P.3    Zhou, Q.D.4    Brar, G.5    Vergnes, L.6
  • 34
    • 84865197492 scopus 로고    scopus 로고
    • Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
    • Everts B, Amiel E, van der Windt GJW, Freitas TC, Chott R, Yarasheski KE, et al. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood (2012) 120:1422-31. doi:10.1182/blood-2012-03-419747
    • (2012) Blood , vol.120 , pp. 1422-1431
    • Everts, B.1    Amiel, E.2    van der Windt, G.J.W.3    Freitas, T.C.4    Chott, R.5    Yarasheski, K.E.6
  • 35
    • 0023940538 scopus 로고
    • Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in l-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells
    • Drapier JC, Hibbs JB. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in l-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J Immunol (1988) 140:2829-38.
    • (1988) J Immunol , vol.140 , pp. 2829-2838
    • Drapier, J.C.1    Hibbs, J.B.2
  • 36
    • 79955532516 scopus 로고    scopus 로고
    • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    • West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 472:476-80. doi:10.1038/nature09973
    • (2011) Nature , vol.472 , pp. 476-480
    • West, A.P.1    Brodsky, I.E.2    Rahner, C.3    Woo, D.K.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 37
    • 84978468846 scopus 로고    scopus 로고
    • Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
    • Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metab (2016) 24:158-66. doi:10.1016/j.cmet.2016.06.004
    • (2016) Cell Metab , vol.24 , pp. 158-166
    • Lampropoulou, V.1    Sergushichev, A.2    Bambouskova, M.3    Nair, S.4    Vincent, E.E.5    Loginicheva, E.6
  • 38
    • 84976321970 scopus 로고    scopus 로고
    • Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense
    • Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, et al. Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat Immunol (2016) 17(9):1037-45. doi:10.1038/ni.3509
    • (2016) Nat Immunol , vol.17 , Issue.9 , pp. 1037-1045
    • Garaude, J.1    Acín-Pérez, R.2    Martínez-Cano, S.3    Enamorado, M.4    Ugolini, M.5    Nistal-Villán, E.6
  • 39
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 during hypoxia
    • Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1 during hypoxia. J Biol Chem (2000) 275:25130-8. doi:10.1074/jbc.M001914200
    • (2000) J Biol Chem , vol.275 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5    Rodriguez, A.M.6
  • 40
    • 84907543940 scopus 로고    scopus 로고
    • mTOR-and HIF-1-mediated aerobic glycolysis as metabolic basis for trained immunity
    • Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, et al. mTOR-and HIF-1-mediated aerobic glycolysis as metabolic basis for trained immunity. Science (2014) 345:1250684. doi:10.1126/science.1250684
    • (2014) Science , vol.345
    • Cheng, S.C.1    Quintin, J.2    Cramer, R.A.3    Shepardson, K.M.4    Saeed, S.5    Kumar, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.