Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling

Immunity

Volumn 47, Issue 4, 2017, Pages 635-647.e6

  Kleino, Anni ^a   Ramia, Nancy F ^a   Bozkurt, Gunes ^b   Shen, Yanfang ^c   Nailwal, Himani ^a   Huang, Jing ^c   Napetschnig, Johanna ^d   Gangloff, Monique ^e   Chan, Francis Ka Ming ^a   Wu, Hao ^b,d   Li, Jixi ^c   Silverman, Neal ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c FUDAN UNIVERSITY   (China)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

functional amyloid; Imd; innate immunity; NF B signaling; PGRP LC; PGRP LE; RHIM

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN IMD; AMYLOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEPTIDOGLYCAN; PIRK PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; IMMUNE DEFICIENCY PROTEIN, DROSOPHILA; PEPTIDOGLYCAN RECEPTOR; PEPTIDOGLYCAN RECOGNITION PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; GENETIC VARIABILITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL LINE; CONFOCAL MICROSCOPY; CYTOLOGY; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION; MALE; MICROSCOPY, CONFOCAL; MODELS, IMMUNOLOGICAL; MUTATION; NF-KAPPA B; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 85032818088     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.09.011     Document Type: Article

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