-
2
-
-
70350734315
-
Erythropoiesis: Model systems, molecular regulators, and developmental programs
-
Tsiftsoglou, A. S., Vizirianakis, I. S. & Strouboulis, J. Erythropoiesis: model systems, molecular regulators, and developmental programs. IUBMB Life 61, 800-830 (2009).
-
(2009)
IUBMB Life
, vol.61
, pp. 800-830
-
-
Tsiftsoglou, A.S.1
Vizirianakis, I.S.2
Strouboulis, J.3
-
3
-
-
50949089311
-
Erythroblastic islands: Niches for erythropoiesis
-
Chasis, J. A. & Mohandas, N. Erythroblastic islands: niches for erythropoiesis. Blood 112, 470-478 (2008).
-
(2008)
Blood
, vol.112
, pp. 470-478
-
-
Chasis, J.A.1
Mohandas, N.2
-
4
-
-
84868632060
-
A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
-
Ito, K. et al. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat. Med. 18, 1350-1358 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 1350-1358
-
-
Ito, K.1
-
5
-
-
84867075651
-
Fate through fat: Lipid metabolism determines stem cell division outcome
-
Yusuf, R. Z. & Scadden, D. T. Fate through fat: lipid metabolism determines stem cell division outcome. Cell Metab. 16, 411-413 (2012).
-
(2012)
Cell Metab
, vol.16
, pp. 411-413
-
-
Yusuf, R.Z.1
Scadden, D.T.2
-
6
-
-
67650572994
-
Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells
-
Bhatia, H. et al. Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood 113, 6440-6448 (2009).
-
(2009)
Blood
, vol.113
, pp. 6440-6448
-
-
Bhatia, H.1
-
7
-
-
84925503908
-
Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells
-
Carey, B. W., Finley, L. W., Cross, J. R., Allis, C. D. & Thompson, C. B. Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518, 413-416 (2015).
-
(2015)
Nature
, vol.518
, pp. 413-416
-
-
Carey, B.W.1
Finley, L.W.2
Cross, J.R.3
Allis, C.D.4
Thompson, C.B.5
-
8
-
-
84924369505
-
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells
-
Moussaieff, A. et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab. 21, 392-402 (2015).
-
(2015)
Cell Metab
, vol.21
, pp. 392-402
-
-
Moussaieff, A.1
-
9
-
-
84905921360
-
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
-
Oburoglu, L. et al. Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell 15, 169-184 (2014).
-
(2014)
Cell Stem Cell
, vol.15
, pp. 169-184
-
-
Oburoglu, L.1
-
10
-
-
84928225287
-
The mtorc1/4e-bp pathway coordinates hemoglobin production with l-leucine availability
-
Chung, J. et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal 8, ra34 (2015).
-
(2015)
Sci Signal
, vol.8
, pp. ra34
-
-
Chung, J.1
-
11
-
-
80053916176
-
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
-
Suda, T., Takubo, K. & Semenza, G. L. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9, 298-310 (2011).
-
(2011)
Cell Stem Cell
, vol.9
, pp. 298-310
-
-
Suda, T.1
Takubo, K.2
Semenza, G.L.3
-
12
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
Simsek, T. et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7, 380-390 (2010).
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
-
13
-
-
84877575509
-
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
-
Nombela-Arrieta, C. et al. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat. Cell Biol. 15, 533-543 (2013).
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 533-543
-
-
Nombela-Arrieta, C.1
-
14
-
-
0026770646
-
Lactate production in adipose tissue: A regulated function with extra-Adipose implications
-
DiGirolamo, M., Newby, F. D. & Lovejoy, J. Lactate production in adipose tissue: A regulated function with extra-Adipose implications. FASEB J. 6, 2405-2412 (1992).
-
(1992)
FASEB J
, vol.6
, pp. 2405-2412
-
-
DiGirolamo, M.1
Newby, F.D.2
Lovejoy, J.3
-
15
-
-
61449221901
-
Lactate boosts tlr4 signaling and nf-kappab pathway-mediated gene transcription in macrophages via monocarboxylate transporters and md-2 up-regulation
-
Samuvel, D. J., Sundararaj, K. P., Nareika, A., Lopes-Virella, M. F. & Huang, Y. Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation. J. Immunol. 182, 2476-2484 (2009).
-
(2009)
J. Immunol
, vol.182
, pp. 2476-2484
-
-
Samuvel, D.J.1
Sundararaj, K.P.2
Nareika, A.3
Lopes-Virella, M.F.4
Huang, Y.5
-
16
-
-
81155126061
-
Lactate: A metabolic key player in cancer
-
Hirschhaeuser, F., Sattler, U. G. & Mueller-Klieser, W. Lactate: A metabolic key player in cancer. Cancer Res. 71, 6921-6925 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 6921-6925
-
-
Hirschhaeuser, F.1
Sattler, U.G.2
Mueller-Klieser, W.3
-
17
-
-
84872134149
-
Regulation of erythropoiesis by hypoxia-inducible factors
-
Haase, V. H. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 27, 41-53 (2013).
-
(2013)
Blood Rev
, vol.27
, pp. 41-53
-
-
Haase, V.H.1
-
18
-
-
0014433979
-
The erythropoiesis-stimulating factors produced by tumors
-
Waldmann, T. A., Rosse, W. F. & Swarm, R. L. The erythropoiesis-stimulating factors produced by tumors. Ann. N. Y. Acad. Sci. 149, 509-515 (1968).
-
(1968)
Ann. N. Y. Acad. Sci
, vol.149
, pp. 509-515
-
-
Waldmann, T.A.1
Rosse, W.F.2
Swarm, R.L.3
-
19
-
-
84892142012
-
A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism
-
Kozan, P., Chalasani, S., Handelsman, D. J., Pike, A. H. & Crawford, B. A. A Leydig cell tumor of the ovary resulting in extreme hyperandrogenism, erythrocytosis, and recurrent pulmonary embolism. J. Clin. Endocrinol. Metab. 99, 12-17 (2014).
-
(2014)
J. Clin. Endocrinol. Metab
, vol.99
, pp. 12-17
-
-
Kozan, P.1
Chalasani, S.2
Handelsman, D.J.3
Pike, A.H.4
Crawford, B.A.5
-
20
-
-
0016110253
-
Lactate stimulation of renal cortical adenylate cyclase: A mechanism for erythropoietin production following cobalt treatment or hypoxia
-
Rodgers, G. M., Fisher, J. W. & George, W. J. Lactate stimulation of renal cortical adenylate cyclase: A mechanism for erythropoietin production following cobalt treatment or hypoxia. J. Pharmacol. Exp. Ther. 190, 542-550 (1974).
-
(1974)
J. Pharmacol. Exp. Ther
, vol.190
, pp. 542-550
-
-
Rodgers, G.M.1
Fisher, J.W.2
George, W.J.3
-
21
-
-
0031472234
-
Fog, a multitype zinc finger protein, acts as a cofactor for transcription factor gata-1 in erythroid and megakaryocytic differentiation
-
Tsang, A. P. et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 90, 109-119 (1997).
-
(1997)
Cell
, vol.90
, pp. 109-119
-
-
Tsang, A.P.1
-
22
-
-
84878752653
-
Alpha-1, 6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells
-
Sasaki, H. et al. alpha-1, 6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells. J. Biol. Chem. 288, 16839-16847 (2013).
-
(2013)
J. Biol. Chem
, vol.288
, pp. 16839-16847
-
-
Sasaki, H.1
-
23
-
-
84897019445
-
Pml4 facilitates erythroid differentiation by enhancing the transcriptional activity of gata-1
-
Wu, J. et al. PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Blood 123, 261-270 (2014).
-
(2014)
Blood
, vol.123
, pp. 261-270
-
-
Wu, J.1
-
24
-
-
33745634866
-
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo
-
Liu, Y. et al. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 108, 123-133 (2006).
-
(2006)
Blood
, vol.108
, pp. 123-133
-
-
Liu, Y.1
-
25
-
-
84863809186
-
Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via tgf-beta in the brain
-
Yamada, H. et al. Blood lactate functions as a signal for enhancing fatty acid metabolism during exercise via TGF-beta in the brain. J. Nutr. Sci. Vitaminol. 58, 88-95 (2012).
-
(2012)
J. Nutr. Sci. Vitaminol
, vol.58
, pp. 88-95
-
-
Yamada, H.1
-
26
-
-
69549096366
-
Endurance capacity of mice selectively bred for high voluntary wheel running
-
Meek, T. H., Lonquich, B. P., Hannon, R. M. & Garland, T. Jr. Endurance capacity of mice selectively bred for high voluntary wheel running. J. Exp. Biol. 212, 2908-2917 (2009).
-
(2009)
J. Exp. Biol
, vol.212
, pp. 2908-2917
-
-
Meek, T.H.1
Lonquich, B.P.2
Hannon, R.M.3
Garland, T.4
-
27
-
-
78149461195
-
Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse
-
Flynn, J. M., Meadows, E., Fiorotto, M. & Klein, W. H. Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. PLoS One 5, e13535 (2010).
-
(2010)
PLoS One
, vol.5
, pp. e13535
-
-
Flynn, J.M.1
Meadows, E.2
Fiorotto, M.3
Klein, W.H.4
-
28
-
-
70349446465
-
Reactive oxygen species prime drosophila haematopoietic progenitors for differentiation
-
Owusu-Ansah, E. & Banerjee, U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461, 537-541 (2009).
-
(2009)
Nature
, vol.461
, pp. 537-541
-
-
Owusu-Ansah, E.1
Banerjee, U.2
-
29
-
-
34547790342
-
Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis
-
Hashimoto, T., Hussien, R., Oommen, S., Gohil, K. & Brooks, G. A. Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis. FASEB J. 21, 2602-2612 (2007).
-
(2007)
FASEB J
, vol.21
, pp. 2602-2612
-
-
Hashimoto, T.1
Hussien, R.2
Oommen, S.3
Gohil, K.4
Brooks, G.A.5
-
30
-
-
84857222449
-
Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors
-
Boidot, R. et al. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Cancer Res. 72, 939-948 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 939-948
-
-
Boidot, R.1
-
31
-
-
0016165532
-
Paraneoplastic erythrocytosis and ectopic erythropoietins
-
Hammond, D. & Winnick, S. Paraneoplastic erythrocytosis and ectopic erythropoietins. Ann. N. Y. Acad. Sci. 230, 219-227 (1974).
-
(1974)
Ann. N. Y. Acad. Sci
, vol.230
, pp. 219-227
-
-
Hammond, D.1
Winnick, S.2
-
32
-
-
84864381949
-
Hypoxia-inducible factor 1-mediated human gata1 induction promotes erythroid differentiation under hypoxic conditions
-
Zhang, F. L. et al. Hypoxia-inducible factor 1-mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions. J. Cell. Mol. Med. 16, 1889-1899 (2012).
-
(2012)
J. Cell. Mol. Med
, vol.16
, pp. 1889-1899
-
-
Zhang, F.L.1
-
33
-
-
37249085190
-
Hypoxia alters progression of the erythroid program
-
Rogers, H. M. et al. Hypoxia alters progression of the erythroid program. Exp. Hematol. 36, 17-27 (2008).
-
(2008)
Exp. Hematol
, vol.36
, pp. 17-27
-
-
Rogers, H.M.1
-
34
-
-
84874171223
-
Enhanced erythropoiesis in mice exposed to low environmental temperature
-
Maekawa, S., Iemura, H. & Kato, T. Enhanced erythropoiesis in mice exposed to low environmental temperature. J. Exp. Biol. 216, 901-908 (2013).
-
(2013)
J. Exp. Biol
, vol.216
, pp. 901-908
-
-
Maekawa, S.1
Iemura, H.2
Kato, T.3
-
35
-
-
0036842334
-
Pancytopenia induced by hypothermia
-
Lo, L., Singer, S. T. & Vichinsky, E. Pancytopenia induced by hypothermia. J. Pediatr. Hematol. Oncol. 24, 681-684 (2002).
-
(2002)
J. Pediatr. Hematol. Oncol
, vol.24
, pp. 681-684
-
-
Lo, L.1
Singer, S.T.2
Vichinsky, E.3
-
36
-
-
84908575778
-
Lactate regulates myogenesis in C2C12 myoblasts in vitro
-
Willkomm, L. et al. Lactate regulates myogenesis in C2C12 myoblasts in vitro. Stem Cell Res 12, 742-753 (2014).
-
(2014)
Stem Cell Res
, vol.12
, pp. 742-753
-
-
Willkomm, L.1
-
37
-
-
84900436669
-
Lactate regulates rat male germ cell function through reactive oxygen species
-
Galardo, M. N. et al. Lactate regulates rat male germ cell function through reactive oxygen species. PLoS One 9, e88024 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e88024
-
-
Galardo, M.N.1
-
38
-
-
77950490138
-
In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species
-
Badham, H. J. & Winn, L. M. In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species. Toxicol. Appl. Pharmacol. 244, 273-279 (2010).
-
(2010)
Toxicol. Appl. Pharmacol
, vol.244
, pp. 273-279
-
-
Badham, H.J.1
Winn, L.M.2
-
39
-
-
84899429716
-
The role of ros in hydroquinone-induced inhibition of k562 cell erythroid differentiation
-
Yu, C. H. et al. The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation. Biomed. Environ. Sci. 27, 212-214 (2014).
-
(2014)
Biomed. Environ. Sci
, vol.27
, pp. 212-214
-
-
Yu, C.H.1
-
40
-
-
84903594375
-
Targeted shrna screening identified critical roles of pleckstrin-2 in erythropoiesis
-
Zhao, B. et al. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Haematologica 99, 1157-1167 (2014).
-
(2014)
Haematologica
, vol.99
, pp. 1157-1167
-
-
Zhao, B.1
-
41
-
-
84864800622
-
Enhanced th17 differentiation and aggravated arthritis in iex-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
-
Zhi, L., Ustyugova, I. V., Chen, X., Zhang, Q. & Wu, M. X. Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J. Immunol. 189, 1639-1647 (2012).
-
(2012)
J. Immunol
, vol.189
, pp. 1639-1647
-
-
Zhi, L.1
Ustyugova, I.V.2
Chen, X.3
Zhang, Q.4
Wu, M.X.5
-
42
-
-
79953329777
-
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis
-
Vegran, F., Boidot, R., Michiels, C., Sonveaux, P. & Feron, O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 71, 2550-2560 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 2550-2560
-
-
Vegran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
43
-
-
33344467760
-
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
-
Gottfried, E. et al. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107, 2013-2021 (2006).
-
(2006)
Blood
, vol.107
, pp. 2013-2021
-
-
Gottfried, E.1
-
44
-
-
34247352844
-
Inhibitory effect of tumor cell-derived lactic acid on human T cells
-
Fischer, K. et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819 (2007).
-
(2007)
Blood
, vol.109
, pp. 3812-3819
-
-
Fischer, K.1
-
45
-
-
18244432009
-
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
-
Neubauer, H. et al. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93, 397-409 (1998).
-
(1998)
Cell
, vol.93
, pp. 397-409
-
-
Neubauer, H.1
-
46
-
-
14744299761
-
Turning cells red: Signal transduction mediated by erythropoietin
-
Richmond, T. D., Chohan, M. & Barber, D. L. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol. 15, 146-155 (2005).
-
(2005)
Trends Cell Biol
, vol.15
, pp. 146-155
-
-
Richmond, T.D.1
Chohan, M.2
Barber, D.L.3
-
47
-
-
0027327484
-
Jak2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
-
Witthuhn, B. A. et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 74, 227-236 (1993).
-
(1993)
Cell
, vol.74
, pp. 227-236
-
-
Witthuhn, B.A.1
-
48
-
-
0030953469
-
Activation of jak2 catalytic activity requires phosphorylation of y1007 in the kinase activation loop
-
Feng, J. et al. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17, 2497-2501 (1997).
-
(1997)
Mol. Cell. Biol
, vol.17
, pp. 2497-2501
-
-
Feng, J.1
-
49
-
-
0035760889
-
Ineffective erythropoiesis in stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
-
Socolovsky, M. et al. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 98, 3261-3273 (2001).
-
(2001)
Blood
, vol.98
, pp. 3261-3273
-
-
Socolovsky, M.1
-
50
-
-
13444270650
-
Gata1 function, a paradigm for transcription factors in hematopoiesis
-
Ferreira, R., Ohneda, K., Yamamoto, M. & Philipsen, S. GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol. Cell. Biol. 25, 1215-1227 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 1215-1227
-
-
Ferreira, R.1
Ohneda, K.2
Yamamoto, M.3
Philipsen, S.4
-
51
-
-
34848883146
-
Reciprocal activation of gata-1 and pu.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
-
Arinobu, Y. et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 1, 416-427 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 416-427
-
-
Arinobu, Y.1
-
52
-
-
8644228649
-
Global regulation of erythroid gene expression by transcription factor gata-1
-
Welch, J. J. et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104, 3136-3147 (2004).
-
(2004)
Blood
, vol.104
, pp. 3136-3147
-
-
Welch, J.J.1
-
53
-
-
13244272059
-
Proximity among distant regulatory elements at the beta-globin locus requires gata-1 and fog-1
-
Vakoc, C. R. et al. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol. Cell 17, 453-462 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 453-462
-
-
Vakoc, C.R.1
-
54
-
-
79960884149
-
Eos negatively regulates human gamma-globin gene transcription during erythroid differentiation
-
Yu, H. C., Zhao, H. L., Wu, Z. K. & Zhang, J. W. Eos negatively regulates human gamma-globin gene transcription during erythroid differentiation. PLoS One 6, e22907 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e22907
-
-
Yu, H.C.1
Zhao, H.L.2
Wu, Z.K.3
Zhang, J.W.4
-
55
-
-
84988709200
-
Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
-
Wert, K. J. et al. Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy. Signal Transduct Target Ther 1, 16005 (2016).
-
(2016)
Signal Transduct Target Ther
, vol.1
, pp. 16005
-
-
Wert, K.J.1
|