Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway

PLoS Pathogens

Volumn 4, Issue 8, 2008, Pages

  Aggarwal, Kamna ^a   Rus, Florentina ^a   Vriesema Magnuson, Christie ^a   Ertürk Hasdemir, Deniz ^a   Paquette, Nicholas ^a   Silverman, Neal ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSECT PROTEIN; PEPTIDOGLYCAN RECOGNITION PROTEIN; RUDRA PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; PEPTIDOGLYCAN RECEPTOR; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; FLY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INFECTION RESISTANCE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTANT; NEGATIVE FEEDBACK; NONHUMAN; PECTOBACTERIUM CAROTOVORUM; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DROSOPHILA MELANOGASTER; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); HEXAPODA; PECTOBACTERIUM CAROTOVORUM SUBSP. CAROTOVORUM; RUDRA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; IMMUNITY, NATURAL; PECTOBACTERIUM CAROTOVORUM; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 50849094860     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000120     Document Type: Article

References (48)

1. Brennan CA, Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-483.
2. Cherry S, Silverman N (2006) Host-pathogen interactions in drosophila: new tricks from an old friend. Nat Immunol 7: 911-917.
3. Hultmark D (2003) Drosophila immunity: paths and patterns. Curr Opin Immunol 15: 12-19.
4. Lemaitre B, Hoffmann J (2007) The Host Defense of Drosophila melanogaster. Annu Rev Immunol 25: 697-743.
5. Lemaitre B, Reichhart JM, Hoffmann JA (1997) Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 94: 14614-14619.
6. Meister M, Lemaitre B, Hoffmann JA (1997) Antimicrobial peptide defense in Drosophila. Bioessays 19: 1019-1026.
7. Aggrawal K, Silverman N (2007) Peptidoglycan recognition in Drosophila. Biochem Soc Trans 35: 1496-1500.
8. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-983.
9. Kaneko T, Goldman WE, Mellroth P, Steiner H, Fukase K, et al. (2004) Monomeric and Polymeric Gram-Negative Peptidoglycan but Not Purified LPS Stimulate the Drosophila IMD Pathway. Immunity 20: 637-649.
10. Leulier F, Parquet C, Pili-Floury S, Ryu JH, Caroff M, et al. (2003) The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol 4: 478-484.
11. Choe KM, Werner T, Stöven S, Hultmark D, Anderson KV (2002) Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296: 359-362.
12. Gottar M, Gobert V, Michel T, Belvin M, Duyk G, et al. (2002) The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416: 640-644.
13. Ramet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA (2002) Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416: 644-648.
14. Werner T, Liu G, Kang D, Ekengren S, Steiner H, et al. (2000) A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A 97: 13772-13777.
15. Kaneko T, Yano T, Aggarwal K, Lim JH, Ueda K, et al. (2006) PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol 7: 715-723.
16. Takehana A, Katsuyama T, Yano T, Oshima Y, Takada H, et al. (2002) Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A 99: 13705-13710.
17. Choe KM, Lee H, Anderson KV (2005) Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. Proc Natl Acad Sci U S A 102: 1122-1126.
18. Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, et al. (2006) Structural Basis for Preferential Recognition of Diaminopimelic Acid-type Peptidoglycan by a Subset of Peptidoglycan Recognition Proteins. J Biol Chem 281: 8286-8295.
19. Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, et al. (2001) Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell 1: 503-514.
20. Flatt T, Tu MP, Tatar M (2005) Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays 27: 999-1010.
21. Lang T, Mansell A (2007) The negative regulation of Toll-like receptor and associated pathways. Immunol Cell Biol 85: 425-434.
22. Zerofsky M, Harel E, Silverman N, Tatar M (2005) Aging of the innate immune response in Drosophila melanogaster. Aging Cell 4: 103-108.
23. Bischoff V, Vignal C, Duvic B, Boneca IG, Hoffmann JA, et al. (2006) Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog 2: e14. doi:10.1371/journal.ppat.0020014.
24. Zaidman-Remy A, Herve M, Poidevin M, Pili-Floury S, Kim MS, et al. (2006) The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity 24: 463-473.
25. Foley E, O'Farrell PH (2004) Functional dissection of an innate immune response by a genome-wide RNAi screen. PLoS Biol 2: e203. doi:10.1371/journal. pbio.0020203.
26. Khush RS, Cornwell WD, Uram JN, Lemaitre B (2002) A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Curr Biol 12: 1728-1737.
27. Kim M, Lee JH, Lee SY, Kim E, Chung J (2006) Caspar, a suppressor of antibacterial immunity in Drosophila. Proc Natl Acad Sci U S A 103: 16358-16363.
28. Tsuda M, Seong KH, Aigaki T (2006) POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. FEBS Lett 580: 3296-3300.
29. Park JM, Brady H, Ruocco MG, Sun H, Williams D, et al. (2004) Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev 18: 584-594.
30. Kim LK, Choi UY, Cho HS, Lee JS, Lee WB, et al. (2007) Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol 5: e238. doi:10.1371/journal.pbio.0050238.
31. Kim T, Yoon J, Cho H, Lee WB, Kim J, et al. (2005) Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. Nat Immunol 6: 211-218.
32. James P, Halladay J, Craig EA (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
33. Silverman N, Zhou R, Stöven S, Pandey N, Hultmark D, et al. (2000) A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev 14: 2461-2471.
34. Boutros M, Agaisse H, Perrimon N (2002) Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila. Dev Cell 3: 711-722.
35. De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B (2002) The Toll and Imd pathways are the major regulators of the immune response in Drosophila. Embo J 21: 2568-2579.
36. Kleino A, Myllymaki H, Kallio J, Vanha-Aho LM, Oksanen K, et al. (2008) Pirk is a negative regulator of the Drosophila imd pathway. J Immunol 180: 5413-5422.
37. Spradling AC, Stern D, Beaton A, Rhem EJ, Laverty T, et al. (1999) The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153: 135-177.
38. Spradling AC, Stern DM, Kiss I, Roote J, Laverty T, et al. (1995) Gene disruptions using P transposable elements: an integral component of the Drosophila genome project. Proc Natl Acad Sci U S A 92: 10824-10830.
39. Bellen HJ, Levis RW, Liao G, He Y, Carlson JW, et al. (2004) The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167: 761-781.
40. Basset A, Khush RS, Braun A, Gardan L, Boccard F, et al. (2000) The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci U S A 97: 3376-3381.
41. Stöven S, Ando I, Kadalayil L, Engström Y, Hultmark D (2000) Activation of the Drosophila NF-kB factor Relish by rapid endoproteolytic cleavage. EMBO Rep 1: 347-352.
42. Stöven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, et al. (2003) Caspase-mediated processing of the Drosophila NF-{kappa}B factor Relish. Proc Natl Acad Sci U S A.
43. Gordon MD, Dionne MS, Schneider DS, Nusse R (2005) WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature 437: 746-749.
44. Ryu JH, Kim SH, Lee HY, Bai JY, Nam YD, et al. (2008) Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science 319: 777-782.
45. Takehana A, Yano T, Mita S, Kotani A, Oshima Y, et al. (2004) Peptidoglycan Recognition Protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity. Embo J 23: 4690-4700.
46. Di Nocera PP, Dawid IB (1983) Transient expression of genes introduced into cultured cells of Drosophila. Proc Natl Acad Sci U S A 80: 7095-7098.
47. Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, et al. (2002) Heterochromatic sequences in a Drosophila whole-genome shotgun assembly. Genome Biol 3: RESEARCH0085.
48. Thummel CS, Boulet AM, Lipshitz HD (1988) Vectors for Drosophila Pelement-mediated transformation and tissue culture transfection. Gene 74: 445-456.