Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease

Journal of Clinical Investigation

Volumn 128, Issue 11, 2018, Pages 5110-5122

  Liu, Ta Chiang ^a   Kern, Justin T ^a   VanDussen, Kelli L ^a   Xiong, Shanshan ^a   Kaiko, Gerard E ^a   Wilen, Craig B ^a   Rajala, Michael W ^b   Caruso, Roberta ^b   Holtzman, Michael J ^a   Gao, Feng ^a   McGovern, Dermot P B ^c   Nunez, Gabriel ^b   Head, Richard D ^a   Stappenbeck, Thaddeus S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; ATG16L1 PROTEIN; AUTOPHAGY RELATED PROTEIN; CARBOBENZOXY VALYL ALANYL ASPARTYL [O METHYL] FLUOROMETHYLKETONE; CASPASE INHIBITOR; NICOTINE; RNA 16S; ROSIGLITAZONE; TOBACCO SMOKE; UNCLASSIFIED DRUG; Z VAD FMK; ATG16L1 PROTEIN, HUMAN; ATG16L1 PROTEIN, MOUSE; CARRIER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPARG PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CIGARETTE SMOKING; CLINICAL OUTCOME; CONTROLLED STUDY; CROHN DISEASE; CRYPT CELL; ENVIRONMENTAL EXPOSURE; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; ILEUM; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; ANIMAL; DRUG EFFECT; FEMALE; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MISSENSE MUTATION; PATHOLOGY; SMOKING;

ANIMALS; APOPTOSIS; AUTOPHAGY-RELATED PROTEINS; CARRIER PROTEINS; CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; PANETH CELLS; PPAR GAMMA; ROSIGLITAZONE; SMOKING;

EID: 85055182725     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI120453     Document Type: Article

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