A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF

Gastroenterology

Volumn 151, Issue 4, 2016, Pages 710-723.e2

  Chuang, Ling Shiang ^a   Villaverde, Nicole ^a   Hui, Ken Y ^b,c   Mortha, Arthur ^a   Rahman, Adeeb ^a   Levine, Adam P ^d   Haritunians, Talin ^c   Evelyn Ng, Sok Meng ^c   Zhang, Wei ^c   Hsu, Nai Yun ^a   Facey, Jody Ann ^a   Luong, Tramy ^a   Fernandez Hernandez, Heriberto ^a   Li, Dalin ^e   Rivas, Manuel ^f,g,h   Schiff, Elena R ^d   Gusev, Alexander ⁱ   Schumm, L Phillip ^j   Bowen, Beatrice M ^c   Sharma, Yashoda ^a,c   Ning, Kaida ^c,k   Remark, Romain ^a   Gnjatic, Sacha ^a   Legnani, Peter ^a   George, James ^a   Sands, Bruce E ^a   Stempak, Joanne M ^l,m   Datta, Lisa W ^o,p   Lipka, Seth ^q   Katz, Seymour ^r   Cheifetz, Adam S ^s   Barzilai, Nir ^t   Pontikos, Nikolas ^d   Abraham, Clara ^c   Dubinsky, Marla J ^a   Targan, Stephan ^e   Taylor, Kent ^u   Rotter, Jerome I ^u   Scherl, Ellen J ^v   Desnick, Robert J ^a   Abreu, Maria T ^w   Zhao, Hongyu ^b   Atzmon, Gil ^t   Pe'er, Itsik ^x   Kugathasan, Subra ^y   Hakonarson, Hakon ^z,aa   McCauley, Jacob L ^w   Lencz, Todd ^ab   Darvasi, Ariel ^ac   Plagnol, Vincent ^d   Silverberg, Mark S ^l,m   Muise, Aleixo M ^n,ad   Brant, Steven R ^o,p   Daly, Mark J ^f,g,ae   Segal, Anthony W ^d   Duerr, Richard H ^af   Merad, Miriam ^a   McGovern, Dermot P B ^e   Peter, Inga ^a   Cho, Judy H ^a   more..

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e CEDARS SINAI MEDICAL CENTER   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ HARVARD UNIVERSITY   (United States)

^j UNIVERSITY OF CHICAGO   (United States)

^k UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^l MOUNT SINAI HOSPITAL   (Canada)

^m UNIVERSITY OF TORONTO   (Canada)

ⁿ UNIVERSITY OF TORONTO   (Canada)

^o JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^q UNIVERSITY OF SOUTH FLORIDA   (United States)

^r NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^t ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^u HARBOR UCLA MEDICAL CENTER   (United States)

^v Department of Molecular Biology and Genetics   (United States)

^w UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^x Fu Foundation School of Engineering and Applied Science   (United States)

^y EMORY UNIVERSITY   (United States)

^z CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^aa UNIVERSITY OF PENNSYLVANIA   (United States)

^ab FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^ac HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^ad HOSPITAL FOR SICK CHILDREN   (Canada)

^ae HARVARD MEDICAL SCHOOL   (United States)

^af UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Ethnic Variation; IBD; Inflammatory Bowel Disease; Risk Factor

Indexed keywords

ALDEHYDE DEHYDROGENASE; APC PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; COLONY STIMULATING FACTOR 2 RECEPTOR BETA COMMON SUBUNIT; COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOL DEHYDROGENASE; STAT5 PROTEIN; UNCLASSIFIED DRUG; CD131 ANTIGEN; CSF2RB PROTEIN, HUMAN;

ARTICLE; ASHKENAZI JEW; BLOOD SAMPLING; CASE CONTROL STUDY; CELL DIFFERENTIATION; CELL MEMBRANE; COHORT ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; CRYSTAL STRUCTURE; DENDRITIC CELL; ENZYME ACTIVITY; EXOME; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC TRANSFECTION; GENOTYPE; HEK293 CELL LINE; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; INTESTINAL TISSUE; LAMINA PROPRIA; LEUKOCYTE; MACROPHAGE; MAJOR CLINICAL STUDY; MONOCYTE; MONONUCLEAR PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; CYTOLOGY; ETHNOLOGY; FEMALE; GENETICS; INTESTINE; JEW; MALE; METABOLISM; PATHOLOGY; RISK FACTOR;

CASE-CONTROL STUDIES; CROHN DISEASE; CYTOKINE RECEPTOR COMMON BETA SUBUNIT; FEMALE; FRAMESHIFT MUTATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTESTINES; JEWS; MALE; MONOCYTES; RISK FACTORS; SIGNAL TRANSDUCTION;

EID: 84989868666     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.06.045     Document Type: Article

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