Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema

Journal of Clinical Investigation

Volumn 124, Issue 3, 2014, Pages 1371-1381

  Shan, Ming ^a   You, Ran ^a   Yuan, Xiaoyi ^a   Frazier, Michael V ^a   Porter, Paul ^a   Seryshev, Alexander ^a   Hong, Jeong Soo ^a   Song, Li Zhen ^a   Zhang, Yiqun ^a   Hilsenbeck, Susan ^a   Whitehead, Lawrence ^b   Zarinkamar, Nazanin ^c   Perusich, Sarah ^a,c   Corry, David B ^a,c   Kheradmand, Farrah ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Michael E DeBakey VA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GLYCOPROTEIN P 15095; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIGARETTE SMOKE-INDUCED EMPHYSEMA; CONTROLLED STUDY; GENE EXPRESSION; HEREDITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOKING;

ANIMALS; CASE-CONTROL STUDIES; CELLS, CULTURED; COCULTURE TECHNIQUES; DENDRITIC CELLS; DRUG EVALUATION, PRECLINICAL; EMPHYSEMA; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOPONTIN; PNEUMOCYTES; PPAR GAMMA; SMOKING; THIAZOLIDINEDIONES; TRANSCRIPTOME;

EID: 84896783702     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70587     Document Type: Article

References (58)

1. Han MK, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med. 2010;182(5):598-604.
2. Rennard SI, Vestbo J. COPD: the dangerous underestimate of 15%. Lancet. 2006;367(9518):1216-1219.
3. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science. 1997;277(5334):2002-2004.
4. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol. 2003;163(6):2329-2335.
5. Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of Lung Health Study participants after 11 years. Am J Respir Crit Care Med. 2002;166(5):675-679.
6. Nishimura M, et al. Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2012;185(1):44-52.
7. Thun MJ, et al. 50-year trends in smoking-related mortality in the United States. N Engl J Med. 2013;368(4):351-364.
8. Vestbo J, et al. Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med. 2011;365(13):1184-1192.
9. Hurst JR, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128-1138.
10. Kheradmand F, Shan M, Xu C, Corry DB. Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence. Expert Rev Clin Immunol. 2012;8(3):285-292.
11. Shan M, et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med. 2009;1(4):4ra10.
12. Chen K, et al. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011;6(5):e20333.
13. Cosio MG, Guerassimov A. Chronic obstructive pulmonary disease. Inflammation of small airways and lung parenchyma. Am J Respir Crit Care Med. 1999;160(5 pt 2):S21-S25.
14. Saetta M, et al. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(2):711-717.
15. Lee S-H, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med. 2007;13(5):567-569.
16. Feghali-Bostwick CA, et al. Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177(2):156-163.
17. Xu C, et al. AutoreactiveT cells in human smokers is predictive of clinical outcome. Front Immunol. 2012;3:267.
18. Shan M, et al. Cigarette smoke induction of osteopontin (SPP1) mediates Th17 inflammation in human and experimental emphysema. Sci Transl Med. 2012;4(117):117ra9.
19. Gregersen PK, Olsson LM. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol. 2009;27:363-391.
20. Nunez B, et al. Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011; 183(8):1025-1031.
21. Reddy RC. Immunomodulatory role of PPAR-γ in alveolar macrophages. J Investig Med. 2008;56(2):522-527.
22. Nencioni A, Grunebach F, Zobywlaski A, Denzlinger C, Brugger W, Brossart P. Dendritic cell immunogenicity is regulated by peroxisome proliferator- activated receptor gamma. J Immunol. 2002;169(3):1228-1235.
23. Szatmari I, et al. PPARγ regulates the function of human dendritic cells primarily by altering lipid metabolism. Blood. 2007;110(9):3271-3280.
24. Klotz L, et al. Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J Immunol. 2007;178(4):2122-2131.
25. Housley WJ, et al. PPARgamma regulates retinoic acid-mediated DC induction of Tregs. J Leukoc Biol. 2009;86(2):293-301.
26. Malur A, et al. Deletion of PPAR γ in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J Immunol. 2009;182(9):5816-5822.
27. Churg A, et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release. Am J Respir Crit Care Med. 2003;167(8):1083-1089.
28. Leslie DS, et al. Serum lipids regulate dendritic cell CD1 expression and function. Immunology. 2008;125(3):289-301.
29. Hesselbacher S, et al. Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers. Int J Environ Research Public Health. 2011;8(5):1324-1340.
30. Grumelli S, et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004;1(1):e8.
31. Kheradmand F, Shan M, Corry DB. Smoking gun: mature dendritic cells in human lung provide clues to chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;180(12):1166-1167.
32. Seimetz M, et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell. 2011;147(2):293-305.
33. Churg A, et al. Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(1):34-43.
34. Simon DM, Mariani TJ. Role of PPARs and retinoid X receptors in the regulation of lung maturation and development. PPAR Res. 2007;2007:91240.
35. Simon DM, et al. Epithelial cell PPARγ contributes to normal lung maturation. FASEB J. 2006;20(9):1507-1509.
36. Kajstura J, et al. Evidence for human lung stem cells. N Engl J Med. 2011;364(19):1795-1806.
37. Klotz L, et al. Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1. J Immunol. 2009;183(1):129-136.
38. Derosa G. Pioglitazone is a valid alternative to rosiglitazone. Am J Cardiovasc Drugs. 2011; 11(6):357-362.
39. Rizos CV, Elisaf MS, Mikhailidis DP, Liberopoulos EN. How safe is the use of thiazolidinediones in clinical practice? Expert Opin Drug Saf. 2009;8(1):15-32.
40. Park SJ, et al. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. J Immunol. 2009;183(5):3259-3267.
41. Lian X, Yan C, Qin Y, Knox L, Li T, Du H. Neutral lipids and peroxisome proliferator-activated receptor-γ control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice. Am J Pathol. 2005;167(3):813-821.
42. Egesten A, et al. Increased prevalence of multiple sclerosis among COPD patients and their first-degree relatives: a population-based study. Lung. 2008;186(3):173-178.
43. Domagala-Kulawik J. Effects of cigarette smoke on the lung and systemic immunity. J Physiol Pharmacol. 2008;59(suppl 6):19-34.
44. Dreiher J, Weitzman D, Shapiro J, Davidovici B, Cohen AD. Psoriasis and chronic obstructive pulmonary disease: a case-control study. Br J Dermatol. 2008;159(4):956-960.
45. Al-Shali KZ, et al. Genetic variation in PPARG encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis. Stroke. 2004;35(9):2036-2040.
46. Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A. Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPARγ. Circ Res. 2010;107(8):953-958.
47. Wang N, Yin R, Liu Y, Mao G, Xi F. Role of peroxisome proliferator-activated receptor-γ in atherosclerosis: an update. Circ J. 2011;75(3):528-535.
48. Penyige A, et al. Analyses of association between PPAR γ and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study. BMC Med Genet. 2010;11:152.
49. Klotz L, et al. The nuclear receptor PPAR γ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med. 2009;206(10):2079-2089.
50. Bright JJ, Kanakasabai S, Chearwae W, Chakraborty S. PPAR regulation of inflammatory signaling in CNS diseases. PPAR Res. 2008;2008:658520.
51. Hamminga EA, van der Lely AJ, Neumann HA, Thio HB. Chronic inflammation in psoriasis and obesity: implications for therapy. Med Hypotheses. 2006;67(4):768-773.
52. Szeles L, Torocsik D, Nagy L. PPARγ in immunity and inflammation: cell types and diseases. Biochim Biophys Acta. 2007;1771(8):1014-1030.
53. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-246.
54. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of COPD. GOLD Web site. http://www.goldcopd.org/guidelinesglobal-strategy-for-diagnosis-management.html. Accessed January 10, 2014.
55. Coxson HO, Rogers RM. Quantitative computed tomography of chronic obstructive pulmonary disease. Acad Radiol. 2005;12(11):1457-1463.
56. Froese AR, et al. Three-dimensional computed tomography imaging in an animal model of emphysema. Eur Respir J. 2007;30(6):1082-1089.
57. Lucey EC, Keane J, Kuang PP, Snider GL, Goldstein RH. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest. 2002;82(1):79-85.
58. Goswami S, et al. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol. 2009;10(5):496-503.