Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

Nature Genetics

Volumn 49, Issue 2, 2017, Pages 262-268

  Lee, James C ^a   Biasci, Daniele ^a   Roberts, Rebecca ^b   Gearry, Richard B ^b   Mansfield, John C ^c   Ahmad, Tariq ^d   Prescott, Natalie J ^e   Satsangi, Jack ^f   Wilson, David C ^g   Jostins, Luke ^h   Anderson, Carl A ⁱ   Traherne, James A ^j   Lyons, Paul A ^a   Parkes, Miles ^a   Smith, Kenneth G C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA B ANTIGEN; HLA DQA1 ANTIGEN; HLA DRB1 ANTIGEN; HLA DRB3 ANTIGEN; PROTEIN; PROTEIN IGFBP1; PROTEIN XACT; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ARTICLE; CROHN DISEASE; DISEASE PREDISPOSITION; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME; GENOTYPE; MALE; PROCEDURES;

CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS;

EID: 85008689993     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3755     Document Type: Article

References (106)

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56. Weinshenker, B.G., et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 112, 133-146 (1989).
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64. Jung, C., et al. Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphisms. PLoS One 7, e52223 (2012).
65. Jensen, C.J., et al. Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PLoS One 5, e10003 (2010).
66. Scott, I.C., et al. Do genetic susceptibility variants associate with disease severity in early active rheumatoid arthritis? J. Rheumatol. 42, 1131-1140 (2015).
67. Plomin, R., Haworth, C.M., Davis, O.S. Common disorders are quantitative traits. Nat. Rev. Genet. 10, 872-878 (2009).
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69. Cleynen, I., et al. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet 387, 156-167 (2016).
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104. Kundu, S., Aulchenko, Y.S., van Duijn, C.M., Janssens, A.C. PredictABEL: an R package for the assessment of risk prediction models. Eur. J. Epidemiol. 26, 261-264 (2011).
105. Bulik-Sullivan, B., et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
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