Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

PLoS Medicine

Volumn 15, Issue 9, 2018, Pages

  Udler, Miriam S ^a,b,c   Kim, Jaegil ^b   von Grotthuss, Marcin ^b   Bonàs Guarch, Sílvia ^d   Cole, Joanne B ^a,b   Chiou, Joshua ^e   Boehnke, Michael ^f   Laakso, Markku ^g   Atzmon, Gil ^h,i   Glaser, Benjamin ^j   Mercader, Josep M ^a,b,d   Gaulton, Kyle ^e   Flannick, Jason ^b,k   Getz, Gad ^b   Florez, Jose C ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

^g UNIVERSITY OF EASTERN FINLAND   (Finland)

^h UNIVERSITY OF HAIFA   (Israel)

ⁱ ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^j HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^k BOSTON CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ALGORITHM; BAYES THEOREM; CLASSIFICATION; CLUSTER ANALYSIS; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DEFICIENCY; FEMALE; FOUNDER EFFECT; GENE LOCUS; GENETIC DATABASE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; INSULIN RESISTANCE; MALE; MULTIGENE FAMILY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PROSPECTIVE STUDY; RISK FACTOR;

ALGORITHMS; BAYES THEOREM; CLUSTER ANALYSIS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DATABASES, GENETIC; DIABETES MELLITUS, TYPE 2; FEMALE; FOUNDER EFFECT; GENETIC LOCI; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MULTIGENE FAMILY; PHENOTYPE; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 85054638667     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002654     Document Type: Article

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