Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Nature Communications

Volumn 7, Issue , 2016, Pages

  Pattaro, Cristian ^a   Teumer, Alexander ^b   Gorski, Mathias ^c,d   Chu, Audrey Y ^e   Li, Man ^f   Mijatovic, Vladan ^g   Garnaas, Maija ^e   Tin, Adrienne ^f   Sorice, Rossella ^h   Li, Yong ⁱ   Taliun, Daniel ^a   Olden, Matthias ^c,d   Foster, Meredith ^j   Yang, Qiong ^k   Chen, Ming Huei ^k,l   Pers, Tune H ^m,n   Johnson, Andrew D ^o   Ko, Yi An ^p   Fuchsberger, Christian ^a   Tayo, Bamidele ^q   Nalls, Michael ^r   Feitosa, Mary F ^s   Isaacs, Aaron ^t,u   Dehghan, Abbas ^t   D'Adamo, Pio ^v   Adeyemo, Adebowale ^w   Dieffenbach, Aida Karina ^x   Zonderman, Alan B ^r   Nolte, Ilja M ^y   Van Der Most, Peter J ^y   Wright, Alan F ^z   Shuldiner, Alan R ^aa,ab   Morrison, Alanna C ^ac   Hofman, Albert ^t   Smith, Albert V ^ad,ae   Dreisbach, Albert W ^af   Franke, Andre ^ag   Uitterlinden, Andre G ^t   Metspalu, Andres ^ah,ai   Tonjes, Anke ^aj   Lupo, Antonio ^ak   Robino, Antonietta ^v   Johansson, Åsa ^al   Demirkan, Ayse ^t   Kollerits, Barbara ^am   Freedman, Barry I ^an   Ponte, Belen ^ao   Oostra, Ben A ^t   Paulweber, Bernhard ^ap   Krämer, Bernhard K ^aq   Mitchell, Braxton D ^aa,ab   Buckley, Brendan M ^ar   Peralta, Carmen A ^as   Hayward, Caroline ^z   Helmer, Catherine ^at,au   Rotimi, Charles N ^w   Shaffer, Christian M ^av   Müller, Christian ^aw,ax   Sala, Cinzia ^ay   Van Duijn, Cornelia M ^t   Saint Pierre, Aude ^a,az   Ackermann, Daniel ^ao   Shriner, Daniel ^w   Ruggiero, Daniela ^h   Toniolo, Daniela ^ay,ba   Lu, Yingchang ^bb   Cusi, Daniele ^bc   Czamara, Darina ^bd   Ellinghaus, David ^ag   Siscovick, David S ^be   Ruderfer, Douglas ^bb   Gieger, Christian ^bf   Grallert, Harald ^bf,bg   Rochtchina, Elena ^bh   Atkinson, Elizabeth J ^bi   Holliday, Elizabeth G ^bj,bk   Boerwinkle, Eric ^ac   Salvi, Erika ^bc   Bottinger, Erwin P ^bb   Murgia, Federico ^ba   Rivadeneira, Fernando ^t   Ernst, Florian ^b   Kronenberg, Florian ^am   Hu, Frank B ^bl   Navis, Gerjan J ^y   Curhan, Gary C ^e   Ehret, George B ^ao   Homuth, Georg ^b   Coassin, Stefan ^am   Thun, Gian Andri ^bm,bn   Pistis, Giorgio ^ay   Gambaro, Giovanni ^bo   Malerba, Giovanni ^g   Montgomery, Grant W ^bp   Eiriksdottir, Gudny ^ad   Jacobs, Gunnar ^ag   Li, Guo ^be   Wichmann, H Erich ^bf,bq,br   Campbell, Harry ^bs   Schmidt, Helena ^bt   Wallaschofski, Henri ^ax,bu   Völzke, Henry ^b,ax   Brenner, Hermann ^x   Kroemer, Heyo K ^b   Kramer, Holly ^q   Lin, Honghuang ^l   Leach, I Mateo ^y   Ford, Ian ^bv   Guessous, Idris ^ao,bw,bx   Rudan, Igor ^bs   Prokopenko, Inga ^by   Borecki, Ingrid ^s   Heid, Iris M ^c,bf   Kolcic, Ivana ^bz   Persico, Ivana ^ba   Jukema, J Wouter ^ca,cb,cc,cd   Wilson, James F ^bs   Felix, Janine F ^t   Divers, Jasmin ^ce   Lambert, Jean Charles ^cf   Stafford, Jeanette M ^ce   Gaspoz, Jean Michel ^ao   Smith, Jennifer A ^cg   Faul, Jessica D ^cg   Wang, Jie Jin ^bh   Ding, Jingzhong ^an   Hirschhorn, Joel N ^m,n,ch   Attia, John ^bi,bj   Whitfield, John B ^bp   Chalmers, John ^bh   Viikari, Jorma ^ci   Coresh, Josef ^f,cj   Denny, Joshua C ^av   Karjalainen, Juha ^y   Fernandes, Jyotika K ^ck   Endlich, Karlhans ^b   Butterbach, Katja ^x   Keene, Keith L ^cl   Lohman, Kurt ^an   Portas, Laura ^ba   Launer, Lenore J ^r   Lyytikäinen, Leo Pekka ^cm   Yengo, Loic ^cf,cn,co   Franke, Lude ^y   Ferrucci, Luigi ^r   Rose, Lynda M ^e   Kedenko, Lyudmyla ^ap   Rao, Madhumathi ^j   Struchalin, Maksim ^t   Kleber, Marcus E ^cp   Cavalieri, Margherita ^bt   Haun, Margot ^am   Cornelis, Marilyn C ^bl   Ciullo, Marina ^h   Pirastu, Mario ^ba   De Andrade, Mariza ^bi   McEvoy, Mark A ^cq   Woodward, Mark ^f,bh,ci,cr   Adam, Martin ^bm,bn   Cocca, Massimiliano ^ay   Nauck, Matthias ^ax,bu   Imboden, Medea ^bm,bn   Waldenberger, Melanie ^bf   Pruijm, Menno ^cs   Metzger, Marie ^ct   Stumvoll, Michael ^aj   Evans, Michele K ^r   Sale, Michele M ^cu   Kähönen, Mika ^cv   Boban, Mladen ^bz   Bochud, Murielle ^cs   Rheinberger, Myriam ^d   Verweij, Niek ^y   Bouatia Naji, Nabila ^cw,cx   Martin, Nicholas G ^e,bp   Hastie, Nick ^z   Probst Hensch, Nicole ^bm,bn   Soranzo, Nicole ^cy   Devuyst, Olivier ^cz   Raitakari, Olli ^da   Gottesman, Omri ^bb   Franco, Oscar H ^t   Polasek, Ozren ^bz   Gasparini, Paolo ^v   Munroe, Patricia B ^db,dc   Ridker, Paul M ^ch   Mitchell, Paul ^bh   Muntner, Paul ^dd,de   Meisinger, Christa ^bf   Smit, Johannes H ^df   Abecasis, Goncalo R ^cg   Adair, Linda S ^do   Alexander, Myriam ^dp   Altshuler, David ^ch   Amin, Najaf ^t   Arking, Dan E ^dq   Arora, Pankaj ^dr   Aulchenko, Yurii ^t   Bakker, Stephan J L ^y   Bandinelli, Stefania ^ds   Barroso, Ines ^cy   Beckmann, Jacques S ^dt   Beilby, John P ^du   Bergman, Richard N ^dv   Bergmann, Sven ^dt   Bis, Joshua C ^be   Boehnke, Michael ^cg   Bonnycastle, Lori L ^w   Bornstein, Stefan R ^dw   Bots, Michiel L ^dx   Bragg Gresham, Jennifer L ^cg   Brand, Stefan Martin ^dy   Brand, Eva ^dz   Braund, Peter S ^ea   Brown, Morris J ^dp   Burton, Paul R ^eb   Casas, Juan P ^ec   Caulfield, Mark J ^db   Chakravarti, Aravinda ^dq   Chambers, John C ^by   Chandak, Giriraj R ^ed   Chang, Yen Pei C ^aa   Charchar, Fadi J ^ee   Chaturvedi, Nish ^ef   Cho, Yoon Shin ^eg   Clarke, Robert ^eh   Collins, Francis S ^w   Collins, Rory ^eh   Connell, John M ^ei   Cooper, Jackie A ^ej   Cooper, Matthew N ^du   Cooper, Richard S ^ek   Corsi, Anna Maria ^el   Dörr, Marcus ^b   Dahgam, Santosh ^em   Danesh, John ^dp   Smith, George Davey ^en   Day, Ian N M ^en   Deloukas, Panos ^cy   Denniff, Matthew ^ea   Dominiczak, Anna F ^eo   Dong, Yanbin ^ep   Doumatey, Ayo ^w   Elliott, Paul ^by   Elosua, Roberto ^eq   Erdmann, Jeanette ^dm   Eyheramendy, Susana ^er   Farrall, Martin ^es   Fava, Cristiano ^et   Forrester, Terrence ^eu   Fowkes, F Gerald R ^bs   Fox, Ervin R ^af   Frayling, Timothy M ^ev   Galan, Pilar ^ew   Ganesh, Santhi K ^ex   Garcia, Melissa ^r   Gaunt, Tom R ^en   Glazer, Nicole L ^be   Go, Min Jin ^eg   Goel, Anuj ^es   Grässler, Jürgen ^dw   Grobbee, Diederick E ^dx   Groop, Leif ^ey   Guarrera, Simonetta ^ez   Guo, Xiuqing ^fa   Hadley, David ^fb   Hamsten, Anders ^fc   Han, Bok Ghee ^eg   Hardy, Rebecca ^fd   Hartikainen, Anna Liisa ^fe   Heath, Simon ^ff   Heckbert, Susan R ^dh   Hedblad, Bo ^et   Hercberg, Serge ^ew   Hernandez, Dena ^r   Hicks, Andrew A ^a   Hilton, Gina ^dq   Hingorani, Aroon D ^ej   Hoffman Bolton, Judith A ^f   Hopewell, Jemma C ^eh   Howard, Philip ^db   Humphries, Steve E ^ej   Hunt, Steven C ^fg   Hveem, Kristian ^fh   Ikram, M Arfan ^t   Islam, Muhammad ^fi,fj   Iwai, Naoharu ^fk   Jarvelin, Marjo Riitta ^by   Jackson, Anne U ^cg   Jafar, Tazeen H ^fi,fj   Janipalli, Charles S ^ed   Johnson, Toby ^db   Kathiresan, Sekar ⁿ   Khaw, Kay Tee ^dp   Kim, Hyung Lae ^eg   Kinra, Sanjay ^ec   Kita, Yoshikuni ^fl   Kivimaki, Mika ^ej   Kooner, Jaspal S ^ef   Kumar, M J Kranthi ^ed   Kuh, Diana ^fd   Kulkarni, Smita R ^fm   Kumari, Meena ^ej   Kuusisto, Johanna ^fn   Kuznetsova, Tatiana ^fo   Laakso, Markku ^fn   Laan, Maris ^ai   Laitinen, Jaana ^fp   Lakatta, Edward G ^fq   Langefeld, Carl D ^ce   Larson, Martin G ^o   Lathrop, Mark ^ff   Lawlor, Debbie A ^en   Lawrence, Robert W ^du   Lee, Jong Young ^eg   Lee, Nanette R ^fr   Levy, Daniel ^o   Li, Yali ^fs   Longstreth, Will T ^dh   Luan, Jian'an ^ft   Lucas, Gavin ^eq   Ludwig, Barbara ^dw   Mangino, Massimo ^fu   Mani, K Radha ^ed   Marmot, Michael G ^ej   Mattace Raso, Francesco U S ^t   Matullo, Giuseppe ^fv   McArdle, Wendy L ^en   McKenzie, Colin A ^eu   Meitinger, Thomas ^bf   Melander, Olle ^et   Meneton, Pierre ^at   Meschia, James F ^fw   Miki, Tetsuro ^fx   Milaneschi, Yuri ^r   Mohlke, Karen L ^fy   Mooser, Vincent ^fz   Morken, Mario A ^w   Morris, Richard W ^ej   Mosley, Thomas H ^af   Najjar, Samer ^r   Narisu, Narisu ^w   Newton Cheh, Christopher ^dr   Nguyen, Khanh Dung Hoang ^dq   Nilsson, Peter ^et   Nyberg, Fredrik ^em   O'Donnell, Christopher J ^o   Ogihara, Toshio ^ga   Ohkubo, Takayoshi ^gb   Okamura, Tomonori ^fk   Ong, Rick Twee Hee ^gc   Ongen, Halit ^es   Onland Moret, N Charlotte ^dx   O'Reilly, Paul F ^by   Org, Elin ^ai   Orru, Marco ^ba   Palmas, Walter ^gd   Palmen, Jutta ^ej   Palmer, Lyle J ^du   Palmer, Nicholette D ^ce   Parker, Alex N ^ge   Peden, John F ^es   Peltonen, Leena ^cy   Perola, Markus ^gf   Pihur, Vasyl ^dq   Platou, Carl G P ^fh   Plump, Andrew ^gg   Prabhakaran, Dorairajan ^gh   Psaty, Bruce M ^be   Raffel, Leslie J ^fa   Rao, Dabeeru C ^s   Rasheed, Asif ^gi   Ricceri, Fulvio ^fv   Rice, Kenneth M ^dh   Rosengren, Annika ^em   Rotter, Jerome I ^fa   Rudock, Megan E ^an   Sõber, Siim ^ai   Salako, Tunde ^gj   Saleheen, Danish ^gi   Salomaa, Veikko ^gf   Samani, Nilesh J ^ea   Schwartz, Steven M ^dh   Schwarz, Peter E H ^dw   Scott, Laura J ^cg   Scott, James ^ef   Scuteri, Angelo ^fq   Sehmi, Joban S ^ef   Seielstad, Mark ^as   Seshadri, Sudha ^l   Sharma, Pankaj ^by   Shaw Hawkins, Sue ^db   Shi, Gang ^s   Shrine, Nick R G ^eb   Sijbrands, Eric J G ^t   Sim, Xueling ^gk   Singleton, Andrew ^r   Sjögren, Marketa ^et   Smith, Nicholas L ^dh   Artigas, Maria Soler ^eb   Spector, Tim D ^fu   Staessen, Jan A ^fp   Stancakova, Alena ^fn   Steinle, Nanette I ^aa   Strachan, David P ^fb   Stringham, Heather M ^cg   Sun, Yan V ^cg   Swift, Amy J ^w   Tabara, Yasuharu ^fx   Tai, E Shyong ^gl   Talmud, Philippa J ^ej   Taylor, Andrew ^ej   Terzic, Janos ^bz   Thelle, Dag S ^gm   Tobin, Martin D ^db   Tomaszewski, Maciej ^ea   Tripathy, Vikal ^gh   Tuomilehto, Jaakko ^gf   Tzoulaki, Ioanna ^by   Uda, Manuela ^ba   Ueshima, Hirotsugu ^fl   Uiterwaal, Cuno S P M ^dz   Umemura, Satoshi ^gn   Van Der Harst, Pim ^y   Van Der Schouw, Yvonne T ^dx   Van Gilst, Wiek H ^y   Vartiainen, Erkki ^gf   Vasan, Ramachandran S ^o   Veldre, Gudrun ^ai   Verwoert, Germaine C ^t   Viigimaa, Margus ^go   Vinay, D G ^ed   Vineis, Paolo ^by   Voight, Benjamin F ⁿ   Vollenweider, Peter ^cs   Wagenknecht, Lynne E ^ce   Wain, Louise V ^eb   Wang, Xiaoling ^ep   Wang, Thomas J ^o   Wareham, Nicholas J ^ft   Watkins, Hugh ^es   Weder, Alan B ^ex   Whincup, Peter H ^fb   Wiggins, Kerri L ^be   Witteman, Jacqueline C M ^t   Wong, Andrew ^fd   Wu, Ying ^fx   Yajnik, Chittaranjan S ^fm   Yao, Jie ^fa   Young, J H ^dq   Zelenika, Diana ^ff   Zhai, Guangju ^fu   Zhang, Weihua ^by   Zhang, Feng ^fu   Zhao, Jing Hua ^ft   Zhu, Haidong ^ep   Zhu, Xiaofeng ^fs   Zitting, Paavo ^gp   Zukowska Szczechowska, Ewa ^gq   Okada, Yukinori ^gr,gs   Wu, Jer Yuarn ^gt,gu   Gu, Dongfeng ^gv   Takeuchi, Fumihiko ^gw   Takahashi, Atsushi ^gr   Maeda, Shiro ^gr   Tsunoda, Tatsuhiko ^gr   Chen, Peng ^gx   Lim, Su Chi ^gk,gy   Wong, Tien Yin ^gk,gz,ha   Liu, Jianjun ^gc   Young, Terri L ^hb   Aung, Tin ^gk,gz   Teo, Yik Ying ^gc,gk,gx   Kim, Young Jin ^eg   Kang, Daehee ^hc   Chen, Chien Hsiun ^gt,gu   Tsai, Fuu Jen ^gu   Chang, Li Ching ^gt   Fann, S J Cathy ^gt   Mei, Hao ^hd   Hixson, James E ^ac   Chen, Shufeng ^gv   Katsuya, Tomohiro ^ga   Isono, Masato ^gw   Albrecht, Eva ^bf   Yamamoto, Kazuhiko ^he   Kubo, Michiaki ^gr   Nakamura, Yusuke ^hf   Kamatani, Naoyuki ^gr   Kato, Norihiro ^gw   He, Jiang ^hd   Chen, Yuan Tsong ^gt   Tanaka, Toshihiro ^gr,gs   Reilly, Muredach P ^hg   Schunkert, Heribert ^ax,dm,hh   Assimes, Themistocles L ^hi   Hall, Alistair ^hj   Hengstenberg, Christian ^d   König, Inke R ^dm   Laaksonen, Reijo ^cv   McPherson, Ruth ^hk   Thompson, John R ^eb   Thorsteinsdottir, Unnur ^ae,hl   Ziegler, Andreas ^dm   Absher, Devin ^hm   Chen, Li ^hk   Cupples, L Adrienne ^k,o   Halperin, Eran ^hn,ho   Li, Mingyao ^hg   Musunuru, Kiran ^cy,dr   Preuss, Michael ^dm   Schillert, Arne ^dm   Thorleifsson, Gudmar ^hl   Wells, George A ^hk   Holm, Hilma ^hl   Roberts, Robert ^hk   Stewart, Alexandre F R ^hk   Fortmann, Stephen ^hi   Go, Alan ^hp   Hlatky, Mark ^hi   Iribarren, Carlos ^hp   Knowles, Joshua ^hi   Myers, Richard ^hm   Quertermous, Thomas ^hi   Sidney, Steven ^hp   Risch, Neil ^hq   Tang, Hua ^hr   Blankenberg, Stefan ^hs   Schnabel, Renate ^hs   Sinning, Christoph ^hs   Lackner, Karl J ^hs   Tiret, Laurence ^at   Nicaud, Viviane ^at   Cambien, Francois ^at   Bickel, Christoph ^hs   Rupprecht, Hans J ^hs   Perret, Claire ^at   Proust, Carole ^at   Münzel, Thomas F ^hs   Barbalic, Maja ^ac   Chen, Ida Yii Der ^fa   Demissie Banjaw, Serkalem ^ce,ht   Folsom, Aaron ^hu   Lumley, Thomas ^gi   Marciante, Kristin ^dh   Taylor, Kent D ^fa   Volcik, Kelly ^hv   Gretarsdottir, Solveig ^hl   Gulcher, Jeffrey R ^hl   Kong, Augustine ^hl   Stefansson, Kari ^ae,hl   Thorgeirsson, Gudmundur ^ae,hw   Andersen, Karl ^ae,hw   Fischer, Marcus ^d   Grosshennig, Anika ^dm   Linsel Nitschke, Patrick ^dm   Stark, Klaus ^d   Schreiber, Stefan ^ag   Aherrahrou, Zouhair ^ax,dm   Bruse, Petra ^ax,dm   Doering, Angela ^bf   Klopp, Norman ^bf   Diemert, Patrick ^dm   Loley, Christina ^dm   Medack, Anja ^ax,dm   Nahrstedt, Janja ^dm   Peters, Annette ^bf   Wagner, Arnika K ^dm   Willenborg, Christina ^ax,dm   Böhm, Bernhard O ^hx   Dobnig, Harald ^bt   Grammer, Tanja B ^dj   Hoffmann, Michael M ^hy   Meinitzer, Andreas ^bt   Winkelmann, Bernhard R ^hz   Pilz, Stefan ^bt   Renner, Wilfried ^bt   Scharnagl, Hubert ^bt   Stojakovic, Tatjana ^bt   Tomaschitz, Andreas ^bt   Winkler, Karl ^hy   Guiducci, Candace ⁿ   Burtt, Noel ⁿ   Gabriel, Stacey B ⁿ   Dandona, Sonny ^hk   Jarinova, Olga ^hk   Qu, Liming ^hg   Wilensky, Robert ^hg   Matthai, William ^hg   Hakonarson, Hakon H ^ia   Devaney, Joe ^ib   Burnett, Mary Susan ^ib   Pichard, Augusto D ^ib   Kent, Kenneth M ^ib   Satler, Lowell ^ib   Lindsay, Joseph M ^ib   Waksman, Ron ^ib   Knouff, Christopher W ^fz   Waterworth, Dawn M ^fz   Walker, Max C ^fz   Epstein, Stephen E ^ib   Rader, Daniel J ^p,hg   Nelson, Christopher P ^ea   Wright, Benjamin J ^eb   Balmforth, Anthony J ^hj   Ball, Stephen G ^ic   Loehr, Laura R ^do,fy,id   Rosamond, Wayne D ^do   Benjamin, Emelia ^o   Haritunians, Talin ^fa   Couper, David ^do   Murabito, Joanne ^o   Wang, Ying A ^k   Stricker, Bruno H ^t   Chang, Patricia P ^fy   Willerson, James T ^ac,ie   Felix, Stephan B ^b   Watzinger, Norbert ^bt   Aragam, Jayashri ^o   Zweiker, Robert ^bt   Lind, Lars ^if   Rodeheffer, Richard J ^bi   Greiser, Karin Halina ^ig   Deckers, Jaap W ^t   Stritzke, Jan ^dm   Ingelsson, Erik ^fc   Kullo, Iftikhar ^bi   Haerting, Johannes ^ig   Reffelmann, Thorsten ^b   Redfield, Margaret M ^bi   Werdan, Karl ^ig   Mitchell, Gary F ^o   Arnett, Donna K ^de   Gottdiener, John S ^ih   Blettner, Maria ^hs   Friedrich, Nele ^b   Kovacs, Peter ^aj   Wild, Philipp S ^dg   Froguel, Philippe ^cf,cn,co   Rettig, Rainer ^b   Mägi, Reedik ^ah   Biffar, Reiner ^b   Schmidt, Reinhold ^bt   Middelberg, Rita P S ^bp   Carroll, Robert J ^av   Penninx, Brenda W ^df   Scott, Rodney J ^cq   Katz, Ronit ^dh   Sedaghat, Sanaz ^t   Wild, Sarah H ^bs   Kardia, Sharon L R ^cg   Ulivi, Sheila ^di   Hwang, Shih Jen ^o   Enroth, Stefan ^al   Kloiber, Stefan ^bd   Trompet, Stella ^ca   Stengel, Benedicte ^ct   Hancock, Stephen J ^bj,bk   Turner, Stephen T ^bi   Rosas, Sylvia E ^p   Stracke, Sylvia ^b,cf   Harris, Tamara B ^r   Zeller, Tanja ^aw,ax   Zemunik, Tatijana ^bz   Lehtimäki, Terho ^cm   Illig, Thomas ^bf   Aspelund, Thor ^ad,ae   Nikopensius, Tiit ^ah,ai   Esko, Tonu ^m,ah,ai   Tanaka, Toshiko ^r   Gyllensten, Ulf ^al   Völker, Uwe ^b,ax   Emilsson, Valur ^ad,ae   Vitart, Veronique ^z   Aalto, Ville ^ci   Gudnason, Vilmundur ^ad,ae   Chouraki, Vincent ^cf   Chen, Wei Min ^cu   Igl, Wilmar ^al   März, Winfried ^dj   Koenig, Wolfgang ^dk   Lieb, Wolfgang ^ag   Loos, Ruth J F ^bb   Liu, Yongmei ^an   Snieder, Harold ^y   Pramstaller, Peter P ^a,dl,dm   Parsa, Afshin ^aa   O'Connell, Jeffrey R ^aa   Susztak, Katalin ^p   Hamet, Pavel ^dn   Tremblay, Johanne ^dn   De Boer, Ian H ^dh   Böger, Carsten A ^d   Goessling, Wolfram ^e   Chasman, Daniel I ^e,ch   Köttgen, Anna ^f,i   Kao, W H Linda ^f,cj   Fox, Caroline S ^e,o   more..

^a University of Lubeck   (Italy)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g UNIVERSITY OF VERONA   (Italy)

^h INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

ⁱ UNIVERSITY OF FREIBURG   (Germany)

^j TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^l BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m BOSTON CHILDREN S HOSPITAL   (United States)

ⁿ BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^o FRAMINGHAM HEART STUDY   (United States)

^p UNIVERSITY OF PENNSYLVANIA   (United States)

^q LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^r NATIONAL INSTITUTE ON AGING   (United States)

^s WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^t ERASMUS MEDICAL CENTER   (Netherlands)

^u Center for Medical System Biology   (Netherlands)

^v UNIVERSITY OF TRIESTE   (Italy)

^w NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^x GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^y UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^z UNIVERSITY OF EDINBURGH   (United Kingdom)

^aa UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^ab BALTIMORE VA MEDICAL CENTER   (United States)

^ac UNIVERSITY OF TEXAS   (United States)

^ad ICELANDIC HEART ASSOCIATION   (Iceland)

^ae UNIVERSITY OF ICELAND   (Iceland)

^af UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^ag UNIVERSITY OF KIEL   (Germany)

^ah UNIVERSITY OF TARTU   (Estonia)

^ai UNIVERSITY OF TARTU   (Estonia)

^aj UNIVERSITY OF LEIPZIG   (Germany)

^ak UNIVERSITY OF VERONA   (Italy)

^al UPPSALA UNIVERSITY   (Sweden)

^am INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^an WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ao GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^ap PARACELSUS MEDICAL UNIVERSITY   (Austria)

^aq UNIVERSITY OF HEIDELBERG   (Germany)

^ar UNIVERSITY COLLEGE CORK   (Ireland)

^as UNIVERSITY OF CALIFORNIA   (United States)

^at INSERM   (France)

^au UNIVERSITÉ DE BORDEAUX   (France)

^av VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aw UNIVERSITY HEART CENTER HAMBURG   (Germany)

^ax DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^ay SAN RAFFAELE HOSPITAL   (Italy)

^az ETABLISSEMENT FRANÇAIS DU SANG   (France)

^ba CNR   (Italy)

^bb MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^bc UNIVERSITY OF MILAN   (Italy)

^bd MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^be UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^bf INSTITUTE OF EPIDEMIOLOGY   (Germany)

^bg GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^bh UNIVERSITY OF SYDNEY   (Australia)

^bi MAYO CLINIC   (United States)

^bj UNIVERSITY OF NEWCASTLE   (Australia)

^bk HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^bl HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^bm SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^bn UNIVERSITY OF BASEL   (Switzerland)

^bo FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^bp ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^bq UNIVERSITY OF MUNICH   (Germany)

^br LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^bs UNIVERSITY OF EDINBURGH   (United Kingdom)

^bt MEDICAL UNIVERSITY OF GRAZ   (Austria)

^bu UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^bv UNIVERSITY OF GLASGOW   (United Kingdom)

^bw UNIVERSITY OF LAUSANNE   (Switzerland)

^bx EMORY UNIVERSITY   (United States)

^by IMPERIAL COLLEGE LONDON   (United Kingdom)

^bz UNIVERSITY OF SPLIT   (Croatia)

^ca LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^cb INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^cc Einthoven Laboratory of Experimental Vascular Medicine   (Netherlands)

^cd Durrer Center for Cardiogenetic Research   (Netherlands)

^ce WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^cf INSTITUT PASTEUR DE LILLE   (France)

^cg UNIVERSITY OF MICHIGAN   (United States)

^ch HARVARD MEDICAL SCHOOL   (United States)

^ci TURKU UNIVERSITY HOSPITAL   (Finland)

^cj JOHNS HOPKINS UNIVERSITY   (United States)

^ck MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^cl EAST CAROLINA UNIVERSITY   (United States)

^cm TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^cn Institut Pasteur de Lille   (France)

^co UNIV LILLE   (France)

^cp UNIVERSITY OF HEIDELBERG   (Germany)

^cq UNIVERSITY OF NEWCASTLE   (Australia)

^cr UNIVERSITY OF OXFORD   (United Kingdom)

^cs LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ct CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^cu UNIVERSITY OF VIRGINIA   (United States)

^cv TAMPERE UNIVERSITY HOSPITAL   (Finland)

^cw PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^cx UNIVERSITÉ PARIS DESCARTES   (France)

^cy WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^cz UNIVERSITY OF ZURICH   (Switzerland)

^da UNIVERSITY OF TURKU   (Finland)

^db QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^dc QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^dd University of Alabama at Birmingham   (United States)

^de UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^df VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^dg UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^dh UNIVERSITY OF WASHINGTON   (United States)

^di INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^dj SYNLAB ACADEMY   (Germany)

^dk UNIVERSITY HOSPITAL ULM   (Germany)

^dl General Central Hospital   (Italy)

^dm UNIVERSITY OF LÜBECK   (Germany)

^dn CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^do IL   (United States)

^dp UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^dq JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dr MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ds SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^dt UNIVERSITY OF LAUSANNE   (Switzerland)

^du UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^dv UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^dw DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^dx UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^dy UNIVERSITY OF MÜNSTER   (Germany)

^dz UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^ea UNIVERSITY OF LEICESTER   (United Kingdom)

^eb UNIVERSITY OF LEICESTER   (United Kingdom)

^ec LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^ed CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^ee UNIVERSITY OF BALLARAT   (Australia)

^ef NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^eg Korea National Institute of Health   (South Korea)

^eh UNIVERSITY OF OXFORD   (United Kingdom)

^ei UNIVERSITY OF DUNDEE   (United Kingdom)

^ej UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ek LOYOLA UNIVERSITY CHICAGO   (United States)

^el Tuscany Regional Health Agency   (Italy)

^em UNIVERSITY OF GOTHENBURG   (Sweden)

^en UNIVERSITY OF BRISTOL   (United Kingdom)

^eo UNIVERSITY OF GLASGOW   (United Kingdom)

^ep MEDICAL COLLEGE OF GEORGIA   (United States)

^eq Barcelona Biomedical Research Park   (Spain)

^er PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^es UNIVERSITY OF OXFORD   (United Kingdom)

^et LUND UNIVERSITY   (Sweden)

^eu UNIVERSITY OF THE WEST INDIES   (Jamaica)

^ev UNIVERSITY OF EXETER   (United Kingdom)

^ew University of Ballarat ^*  (France)

^ex UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^ey LUND UNIVERSITY HOSPITAL   (Sweden)

^ez Human Genetics Foundation (HuGeF)   (Italy)

^fa CEDARS SINAI MEDICAL CENTER   (United States)

^fb ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^fc KAROLINSKA INSTITUTE   (Sweden)

^fd MEDICAL RESEARCH COUNCIL   (United Kingdom)

^fe UNIVERSITY OF OULU   (Finland)

^ff CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^fg UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^fh NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^fi AGA KHAN UNIVERSITY   (Pakistan)

^fj AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^fk NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^fl SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^fm KEM HOSPITAL   (India)

^fn KUOPIO UNIVERSITY HOSPITAL   (Finland)

^fo UNIVERSITY OF LEUVEN   (Belgium)

^fp FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^fq NATIONAL INSTITUTE ON AGING   (United States)

^fr UNIVERSITY OF SAN CARLOS   (Philippines)

^fs CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ft INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^fu KING'S COLLEGE LONDON   (United Kingdom)

^fv UNIVERSITY OF TURIN   (Italy)

^fw MAYO CLINIC   (United States)

^fx EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^fy UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^fz GLAXOSMITHKLINE   (United States)

^ga OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^gb TOHOKU UNIVERSITY   (Japan)

^gc GENOME INSTITUTE OF SINGAPORE   (Singapore)

^gd Och Spine at New York Presbyterian Hospitals   (United States)

^ge AMGEN INC   (United States)

^gf NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^gg MERCK RESEARCH LABORATORIES   (United States)

^gh PUBLIC HEALTH FOUNDATION OF INDIA   (India)

^gi Center for Non Communicable Diseases   (Pakistan)

^gj UNIVERSITY OF IBADAN   (Nigeria)

^gk NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^gl Dept Medicine Endocrinol Diabet   (Singapore)

^gm UNIVERSITY OF OSLO   (Norway)

^gn YOKOHAMA CITY UNIVERSITY   (Japan)

^go TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

^gp LAPLAND CENTRAL HOSPITAL   (Finland)

^gq MEDICAL UNIVERSITY OF SILESIA   (Poland)

^gr RIKEN Center for Integrative Medical Sciences   (Japan)

^gs TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^gt INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^gu CHINA MEDICAL UNIVERSITY   (Taiwan)

^gv FUWAI HOSPITAL   (China)

^gw NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^gx NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^gy KHOO TECK PUAT HOSPITAL   (Singapore)

^gz SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^ha UNIVERSITY OF MELBOURNE   (Australia)

^hb DUKE UNIVERSITY MEDICAL CENTER   (United States)

^hc Seoul National University College of Medicine   (South Korea)

^hd TULANE UNIVERSITY   (United States)

^he UNIVERSITY OF TOKYO   (Japan)

^hf UNIVERSITY OF TOKYO   (Japan)

^hg UNIVERSITY OF PENNSYLVANIA   (United States)

^hh TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^hi STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^hj UNIVERSITY OF LEEDS   (United Kingdom)

^hk UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^hl DECODE GENETICS   (Iceland)

^hm HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^hn TEL AVIV UNIVERSITY   (Israel)

^ho INTERNATIONAL COMPUTER SCIENCE INSTITUTE   (United States)

^hp DIVISION OF RESEARCH   (United States)

^hq UNIVERSITY OF CALIFORNIA   (United States)

^hr LERNER RESEARCH INSTITUTE   (United States)

^hs JOHANNES GUTENBERG UNIVERSITY   (Germany)

^ht BOSTON UNIVERSITY   (United States)

^hu UNIVERSITY OF MINNESOTA   (United States)

^hv UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^hw LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^hx UNIVERSITY OF ULM   (Germany)

^hy UNIVERSITY OF FREIBURG   (Germany)

^hz Cardiology Group Frankfurt Sachsenhausen   (Germany)

^ia CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^ib WASHINGTON HOSPITAL CENTER   (United States)

^ic UNIVERSITY OF LEEDS   (United Kingdom)

^id NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^ie TEXAS HEART INSTITUTE   (United States)

^if UPPSALA UNIVERSITY   (Sweden)

^ig MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^ih UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CREATININE; CYSTATIN C; DEOXYRIBONUCLEASE I; MORPHOLINO OLIGONUCLEOTIDE;

CARDIOVASCULAR DISEASE; CELLS AND CELL COMPONENTS; DIABETES; ENZYME ACTIVITY; GENETIC ANALYSIS; GLUCOSE; META-ANALYSIS; METABOLISM; PHYSIOLOGICAL RESPONSE;

ADRENAL CORTEX; ADRENAL GLAND; ADULT; ARTICLE; BIOINFORMATICS; CHROMATIN; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; EMBRYO; EMBRYONIC STEM CELL; ETHNIC GROUP; ETHNICITY; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY CELL; KIDNEY DEVELOPMENT; KIDNEY EPITHELIUM; KIDNEY FUNCTION; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY STRUCTURE; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; CHRONIC KIDNEY FAILURE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; META ANALYSIS;

GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84957605211     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10023     Document Type: Article

References (48)

1. Eckardt, K. U. et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 382, 158-169 (2013).
2. El Nahas, M. The global challenge of chronic kidney disease. Kidney Int. 68, 2918-2929 (2005).
3. Baumeister, S. E. et al. Effect of chronic kidney disease and comorbid conditions on health care costs: A 10-year observational study in a general population. Am. J. Nephrol. 31, 222-229 (2010).
4. Fox, C. S. et al. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta- analysis. Lancet 380, 1662-1673 (2012).
5. Mahmoodi, B. K. et al. Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis. Lancet 380, 1649-1661 (2012).
6. Himmelfarb, J. & Tuttle, K. R. New therapies for diabetic kidney disease. N. Engl. J. Med. 369, 2549-2550 (2013).
7. Pattaro, C. et al. Genome-wide association and functional follow- up reveals new loci for kidney function. PLoS Genet. 8, e1002584 (2012).
8. Kottgen, A. et al. New loci associated with kidney function and chronic kidney disease. Nat. Genet. 42, 376-384 (2010).
9. Kottgen, A. et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat. Genet. 41, 712-717 (2009).
10. Chambers, J. C. et al. Genetic loci influencing kidney function and chronic kidney disease. Nat. Genet. 42, 373-375 (2010).
11. Okada, Y. et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nat. Genet. 44, 904-909 (2012).
12. Liu, C. T. et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 7, e1002264 (2011).
13. Boger, C. A. et al. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. PLoS Genet. 7, e1002292 (2011).
14. Chasman, D. I. et al. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum. Mol. Genet. 21, 5329-5343 (2012).
15. Pattaro, C. et al. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. BMC Med. Genet. 11, 41 (2010).
16. Trudu, M. et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat. Med. 19, 1655-1660 (2013).
17. International Consortium for Blood Pressure Genome-Wide Association Studies et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103-109 (2011).
18. Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338 (2011).
19. Vasan, R. S. et al. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA 302, 168-178 (2009).
20. Smith, N. L. et al. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Circ. Cardiovasc. Genet. 3, 256-266 (2010).
21. Dupuis, J. et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42, 105-116 (2010).
22. Morris, A. P. Transethnic meta-analysis of genomewide association studies. Genet. Epidemiol. 35, 809-822 (2011).
23. Pers, T. H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
24. Trynka, G. et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 45, 124-130 (2013).
25. Raychaudhuri, S. et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 5, e1000534 (2009).
26. Panagiotou, O. A., Willer, C. J., Hirschhorn, J. N. & Ioannidis, J. P. The power of meta-analysis in genome-wide association studies. Annu. Rev. Genomics Hum. Genet. 14, 441-465 (2013).
27. Barker, D. J. The fetal and infant origins of adult disease. BMJ 301, 1111 (1990).
28. Boubred, F. et al. Developmental origins of chronic renal disease: an integrative hypothesis. Int. J. Nephrol. 2013, 346067 (2013).
29. Fox, C. S. et al. Predictors of new-onset kidney disease in a community-based population. JAMA 291, 844-850 (2004).
30. Coresh, J. et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am. J. Kidney Dis. 39, 920-929 (2002).
31. Stevens, L. A. et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am. J. Kidney Dis. 51, 395-406 (2008).
32. Fuchsberger, C., Taliun, D., Pramstaller, P. P. & Pattaro, C. CKDGen consortium. GWAtoolbox: an R package for fast quality control and handling of GWAS meta-analysis data. Bioinformatics 28, 444-445 (2012).
33. Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190- 2191 (2010).
34. Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
35. Skol, A. D., Scott, L. J., Abecasis, G. R. & Boehnke, M. Joint analysis is more efficient than replication-based analysis for two-stage genome- wide association studies. Nat. Genet. 38, 209-213 (2006).
36. Storey, J. D. A direct approach to false discovery rates. J. R. Stat. Soc. B 64, 479-498 (2002).
37. Storey, J. D., Taylor, J. E. & Siegmund, D. Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: a unified approach. J. R. Stat. Soc. B 66, 187-205 (2004).
38. Gauderman, W. J. Sample size requirements for matched case-control studies of gene-environment interaction. Stat. Med. 21, 35-50 (2002).
39. Rosner, B. in Fundamentals of Biostatistics (Thomson-Brooks/Cole, Duxbury, 2006).
40. Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42, D1001-D1006 (2014).
41. Wang, X. et al. Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. Hum. Mol. Genet. 22, 2303-2311 (2013).
42. Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
43. International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
44. Maurano, M. T. et al. Systematic localization of common disease- associated variation in regulatory DNA. Science 337, 1190-1195 (2012).
45. ENCODE Project Consortium et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
46. Ko, Y. A. et al. Cytosine methylation changes in enhancer regions of core profibrotic genes characterize kidney fibrosis development. Genome Biol. 14, R108 (2013).
47. Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
48. Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504 (2003).