Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

Nature Communications

Volumn 6, Issue , 2015, Pages

  Kasar, S ^a   Kim, J ^b   Improgo, R ^a   Tiao, G ^b   Polak, P ^b   Haradhvala, N ^b   Lawrence, M S ^b   Kiezun, A ^b   Fernandes, S M ^a   Bahl, S ^b   Sougnez, C ^b   Gabriel, S ^b   Lander, E S ^b   Kim, H T ^c   Getz, G ^b,d,e   Brown, J R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE;

BLOOD; CANCER; CHROMOSOME; COHORT ANALYSIS; CYTOGENETICS; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; MUTATION; PROTEIN; TUMOR;

AGING; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC HYPERMUTATION; SOMATIC MUTATION; TRANSCRIPTION INITIATION SITE; COHORT ANALYSIS; ENZYMOLOGY; EVOLUTION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN GENOME; METABOLISM;

AGING; BIOLOGICAL EVOLUTION; COHORT STUDIES; CYTIDINE DEAMINASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MUTATION;

EID: 84949518098     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9866     Document Type: Article

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