Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins

Journal of Biological Chemistry

Volumn 291, Issue 20, 2016, Pages 10659-10676

  Smagris, Eriks ^a   Gilyard, Shenise ^a   BasuRay, Soumik ^a   Cohen, Jonathan C ^a   Hobbs, Helen H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DROPS; GENES; LIPIDS; LIPOPROTEINS; MAMMALS; PARTICLE SIZE; PHYSIOLOGY; PROTEINS;

CELL FRACTIONATION; ENDOPLASMIC RETICULUM; FATTY LIVER DISEASE; HEPATIC STEATOSIS; PLASMA CHOLESTEROL; POLYTOPIC PROTEINS; SMALL INTESTINE; VERY LOW DENSITY LIPOPROTEINS;

DISEASES;

APOLIPOPROTEIN B; CHOLESTEROL; FAT DROPLET; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; FAT INTAKE; FATTY LIVER; FEMALE; GENE; GENE INACTIVATION; GOLGI COMPLEX; HYPERTRANSAMINASEMIA; HYPOCHOLESTEROLEMIA; LIPID ABSORPTION; LIPID METABOLISM; LIVER; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; SMALL INTESTINE; TM6SF2 GENE; ANIMAL; GENETICS; KNOCKOUT MOUSE; LIPOYLATION; METABOLISM; MISSENSE MUTATION; PATHOLOGY; SECRETION (PROCESS);

ANIMALS; ENDOPLASMIC RETICULUM; FATTY LIVER; GOLGI APPARATUS; LIPID DROPLETS; LIPOPROTEINS, VLDL; LIPOYLATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; TRIGLYCERIDES;

EID: 84969277864     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.719955     Document Type: Article

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