A whole-genome RNA interference screen reveals a role for Spry2 in insulin transcription and the unfolded protein response

Diabetes

Volumn 66, Issue 6, 2017, Pages 1703-1712

  Pappalardo, Zachary ^a   Chopra, Deeksha Gambhir ^a   Hennings, Thomas G ^a   Richards, Hunter ^a   Choe, Justin ^a   Yang, Katherine ^a   Baeyens, Luc ^a   Ang, Kenny ^a   Chen, Steven ^a   Arkin, Michelle ^a   German, Michael S ^a,b   McManus, Michael T ^a,b   Ku, Gregory M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 75; GENOMIC RNA; GLUCOSE; INITIATION FACTOR 2ALPHA; INSULIN; MESSENGER RNA; MITOCHONDRIAL DNA; NEUROGENIC DIFFERENTIATION FACTOR; REGULATOR PROTEIN; SERCA2 PROTEIN; SMALL INTERFERING RNA; SPROUTY 2 PROTEIN; SPROUTY PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLIS3; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; LIPOCORTIN 5; MEMBRANE PROTEIN; PERK KINASE; PROTEIN KINASE R; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SIGNAL PEPTIDE; SPRY2 PROTEIN, HUMAN; SPRY2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; HYPOINSULINEMIA; IN VITRO STUDY; INSULIN RELEASE; MIN6 CELL LINE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA INTERFERENCE; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WHOLE GENOME SEQUENCING; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANNEXIN A5; BLOTTING, WESTERN; CALCIUM; CELL LINE; DIABETES MELLITUS, TYPE 2; EIF-2 KINASE; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; UNFOLDED PROTEIN RESPONSE;

EID: 85019627373     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0962     Document Type: Conference Paper

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