New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Nature Communications

Volumn 7, Issue , 2016, Pages

  Lu, Yingchang ^a   Day, Felix R ^b   Gustafsson, Stefan ^c   Buchkovich, Martin L ^d   Na, Jianbo ^a   Bataille, Veronique ^e,f   Cousminer, Diana L ^g   Dastani, Zari ^h   Drong, Alexander W ⁱ   Esko, Toñu ^j,k,l,m   Evans, David M ^n,o   Falchi, Mario ^f,p   Feitosa, Mary F ^q   Ferreira, Teresa ⁱ   Hedman, Åsa K ^c,i   Haring, Robin ^r,s   Hysi, Pirro G ^f   Iles, Mark M ^t   Justice, Anne E ^u   Kanoni, Stavroula ^v,w   Lagou, Vasiliki ^i,x   Li, Rui ^h   Li, Xin ^y   Locke, Adam ^z   Lu, Chen ^aa   Mägi, Reedik ^i,j   Perry, John R B ^b   Pers, Tune H ^i,k,m,ab,ac   Qi, Qibin ^ad   Sanna, Marianna ^f,p   Schmidt, Ellen M ^ae   Scott, William R ^p,af   Shungin, Dmitry ^ag,ah,ai   Teumer, Alexander ^i,r   Vinkhuyzen, Anna A E ⁿ   Walker, Ryan W ^a   Westra, Harm Jan ^aj,ak,al   Zhang, Mingfeng ^ak   Zhang, Weihua ^p,af   Zhao, Jing Hua ^b   Zhu, Zhihong ⁿ   Afzal, Uzma ^p,af   Ahluwalia, Tarunveer Singh ^ab,am,an,ao   Bakker, Stephan J L ^ap   Bellis, Claire ^aq   Bonnefond, Amélie ^ar,as,at   Borodulin, Katja ^au   Buchman, Aron S ^av   Cederholm, Tommy ^c   Choh, Audrey C ^aw   Choi, Hyung Jin ^ax   Curran, Joanne E ^ay   De Groot, Lisette C P G M ^az   De Jager, Philip L ^m,aj,ba   Dhonukshe Rutten, Rosalie A M ^az   Enneman, Anke W ^bb   Eury, Elodie ^ar,as,at   Evans, Daniel S ^bc   Forsen, Tom ^g   Friedrich, Nele ^r   Fumeron, Frédéric ^bd,be,bf   Garcia, Melissa E ^bg   Gärtner, Simone ^r   Han, Bok Ghee ^ba   Havulinna, Aki S ^au   Hayward, Caroline ^bi   Hernandez, Dena ^bg   Hillege, Hans ^ap   Ittermann, Till ^r   Kent, Jack W ^aq   Kolcic, Ivana ^bj   Laatikainen, Tiina ^au,bk,bl   Lahti, Jari ^g,bm   Leach, Irene Mateo ^ap   Lee, Christine G ^bn,bo   Lee, Jong Young ^bh   Liu, Tian ^bp,bq   Liu, Youfang ^d   Lobbens, Stéphane ^ar,as,at   Loh, Marie ^p,br   Lyytikaïnen, Leo Pekka ^bs   Medina Gomez, Carolina ^bb,bt   Michaëlsson, Karl ^c   Nalls, Mike A ^bg   Nielson, Carrie M ^bu   Oozageer, Laticia ^af   Pascoe, Laura ^bv   Paternoster, Lavinia ^o   Polašek, Ozren ^bj,bw   Ripatti, Samuli ^g,w   Sarzynski, Mark A ^bx   Shin, Chan Soo ^ax   Naranäiä, Nina Smolej ^by   Spira, Dominik ^bz   Srikanth, Priya ^bu   Steinhagen Thiessen, Elisabeth ^bz   Sung, Yun Ju ^q   Swart, Karin M A ^ca   Taittonen, Leena ^cb,cc   Tanaka, Toshiko ^bg   Tikkanen, Emmi ^g   Van Der Velde, Nathalie ^bb   Van Schoor, Natasja M ^ca   Verweij, Niek ^ap   Wright, Alan F ^bi   Yu, Lei ^av   Zmuda, Joseph M ^cd   Eklund, Niina ^au   Forrester, Terrence ^ce   Grarup, Niels ^ab   Jackson, Anne U ^z   Kristiansson, Kati ^g,au   Kuulasmaa, Teemu ^bl   Kuusisto, Johanna ^bl,cf   Lichtner, Peter ^cg   Luan, Jian'an ^b   Mahajan, Anubha ⁱ   Männistö, Satu ^au   Palmer, Cameron D ^k,l   Ried, Janina S ^cg   Scott, Robert A ^b   Stancáková, Alena ^cf   Wagner, Peter J ^g,au   Demirkan, Ayse ^bb   Döring, Angela ^cg   Gudnason, Vilmundur ^ch,ci   Kiel, Douglas P ^m,cj   Kühnel, Brigitte ^cg   Mangino, Massimo ^f   McKnight, Barbara ^ck,cl,cm   Menni, Cristina ^f   O'Connell, Jeffrey R ^cn   Oostra, Ben A ^bb   Shuldiner, Alan R ^cn,co   Song, Kijoung ^cp   Vandenput, Liesbeth ^cq   Van Duijn, Cornelia M ^bb,bt,cr   Vollenweider, Peter ^cs   White, Charles C ^aa   Boehnke, Michael ^z   Boettcher, Yvonne ^ct   Cooper, Richard S ^cu   Forouhi, Nita G ^b   Gieger, Christian ^cg   Grallert, Harald ^cg,cv   Hingorani, Aroon ^cw   Jørgensen, Torben ^cx,cy,cz   Jousilahti, Pekka ^au   Kivimaki, Mika ^cw   Kumari, Meena ^cw   Laakso, Markku ^bl,cf   Langenberg, Claudia ^b,cw   Linneberg, Allan ^da   Luke, Amy ^cu   McKenzie, Colin A ^ce   Palotie, Aarno ^g,w,ba   Pedersen, Oluf ^ab   Peters, Annette ^cg   Strauch, Konstantin ^cg,db   Tayo, Bamidele O ^cu   Wareham, Nicholas J ^b   Bennett, David A ^av   Bertram, Lars ^p,dc   Blangero, John ^ay   Blüher, Matthias ^ct   Bouchard, Claude ^bx   Campbell, Harry ^bw   Cho, Nam H ^dd   Cummings, Steven R ^bc   Czerwinski, Stefan A ^aw   Demuth, Ilja ^bz   Eckardt, Rahel ^bz   Eriksson, Johan G ^g,au,bm   Ferrucci, Luigi ^bg   Franco, Oscar H ^bb,bt   Froguel, Philippe ^ar,as,at   Gansevoort, Ron T ^ap   Hansen, Torben ^ab,de   Harris, Tamara B ^bg   Hastie, Nicholas ^bi   Heliövaara, Markku ^au   Hofman, Albert ^bb,bt   Jordan, Joanne M ^d   Jula, Antti ^au   Kähönen, Mika ^bs,df   Kajantie, Eero ^au,cb,dg   Knekt, Paul B ^au   Koskinen, Seppo ^au   Kovacs, Peter ^ct   Lehtimäki, Terho ^bs   Lind, Lars ^c   Liu, Yongmei ^dh   Orwoll, Eric S ^bu   Osmond, Clive ^di   Perola, Markus ^g,j,au   Pérusse, Louis ^dj   Raitakari, Olli T ^dk,dl   Rankinen, Tuomo ^bx   Rao, D C ^q   Rice, Treva K ^q   Rivadeneira, Fernando ^bb,bt   Rudan, Igor ^bw   Salomaa, Veikko ^au   Sørensen, Thorkild I A ^o,ab,dm   Stumvoll, Michael ^ct   Tönjes, Anke ^ct   Towne, Bradford ^aw   Tranah, Gregory J ^bc   Tremblay, Angelo ^dj   Uitterlinden, André G ^bb,bt   Van Der Harst, Pim ^ap,dn   Vartiainen, Erkki ^au   Viikari, Jorma S ^do   Vitart, Veronique ^bi   Vohl, Marie Claude ^dj   Völzke, Henry ^r,dp   Walker, Mark ^aj,bv   Wallaschofski, Henri ^r,dp   Wild, Sarah ^bw   Wilson, James F ^bi,bw   Yengo, Loïc ^ar,as,at   Bishop, D Timothy ^t   Borecki, Ingrid B ^q,dq   Chambers, John C ^w,x,dr   Cupples, L Adrienne ^aa,ds   Dehghan, Abbas ^bb   Deloukas, Panos ^v,w,dt   Fatemifar, Ghazaleh ^o   Fox, Caroline ^m,ds   Furey, Terrence S ^d,du   Franke, Lude ^ap   Han, Jiali ^dv   Hunter, David J ^k,y,ak   Karjalainen, Juha ^ap   Karpe, Fredrik ^x,dw   Kaplan, Robert C ^ad   Kooner, Jaspal S ^af,dr,dx   McCarthy, Mark I ^i,x,dw   Murabito, Joanne M ^ds,dy   Morris, Andrew P ^i,dz   Bishop, Julia A N ^t   North, Kari E ^u   Ohlsson, Claes ^cq   Ong, Ken K ^b,cw,ea   Prokopenko, Inga ^i,p,x   Richards, J Brent ^h,eb   Schadt, Eric E ^h,ec   Spector, Tim D ^f   Widén, Elisabeth ^g   Willer, Cristen J ^ae   Yang, Jian ⁿ   Ingelsson, Erik ^c   Mohlke, Karen L ^d   Hirschhorn, Joel N ^k,l,m   Pospisilik, John Andrew ^ec   Zillikens, M Carola ^bb,bt   Lindgren, Cecilia ^i,k   Kilpelaïnen, Tuomas Oskari ^b,ab   Loos, Ruth J F ^a,b   more..

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e WEST HERTFORDSHIRE HOSPITALS NHS TRUST   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF HELSINKI   (Finland)

^h MCGILL UNIVERSITY   (Canada)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j UNIVERSITY OF TARTU   (Estonia)

^k BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^l BOSTON CHILDREN S HOSPITAL   (United States)

^m HARVARD MEDICAL SCHOOL   (United States)

ⁿ UNIVERSITY OF QUEENSLAND   (Australia)

^o UNIVERSITY OF BRISTOL   (United Kingdom)

^p IMPERIAL COLLEGE LONDON   (United Kingdom)

^q WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^s European University of Applied Sciences   (Germany)

^t UNIVERSITY OF LEEDS   (United Kingdom)

^u IL   (United States)

^v QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^w WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^x UNIVERSITY OF OXFORD   (United Kingdom)

^y HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^z UNIVERSITY OF MICHIGAN   (United States)

^aa BOSTON UNIVERSITY   (United States)

^ab Capital Region   (Denmark)

^ac STATENS SERUM INSTITUT   (Denmark)

^ad ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^ae UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^af EALING HOSPITAL NHS TRUST   (United Kingdom)

^ag LUND UNIVERSITY HOSPITAL   (Sweden)

^ah UMEÅ UNIVERSITY   (Sweden)

^ai UMEÅ UNIVERSITY   (Sweden)

^aj MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^ak BRIGHAM AND WOMEN S HOSPITAL   (United States)

^al LABORATORY FOR MOLECULAR MEDICINE   (United States)

^am UNIVERSITY OF COPENHAGEN   (Denmark)

^an GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^ao STENO DIABETES CENTER   (Denmark)

^ap UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^aq SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^ar CNRS   (France)

^as France   (France)

^at UNIV LILLE   (France)

^au NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^av RUSH UNIVERSITY MEDICAL CENTER   (United States)

^aw WRIGHT STATE UNIVERSITY   (United States)

^ax Seoul National University   (South Korea)

^ay University of Texas Rio Grande Valley School of Medicine   (United States)

^az WAGENINGEN UNIVERSITY   (Netherlands)

^ba MASSACHUSETTS GENERAL HOSPITAL   (United States)

^bb ERASMUS MEDICAL CENTER   (Netherlands)

^bc CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^bd CENTRE DE RECHERCHE DES CORDELIERS   (France)

^be SORBONNE UNIVERSITÉ   (France)

^bf UNIVERSITÉ PARIS DESCARTES   (France)

^bg NATIONAL INSTITUTE ON AGING   (United States)

^bh Korea National Institute of Health   (South Korea)

^bi UNIVERSITY OF EDINBURGH   (United Kingdom)

^bj UNIVERSITY OF SPLIT   (Croatia)

^bk Hospital District of North Karelia   (Finland)

^bl UNIVERSITY OF EASTERN FINLAND   (Finland)

^bm FOLKHÄLSAN RESEARCH CENTER   (Finland)

^bn OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^bo PORTLAND VA MEDICAL CENTER   (United States)

^bp MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^bq MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^br AGENCY FOR SCIENCE   (Singapore)

^bs TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^bt Netherlands Genomics Initiative   (Netherlands)

^bu OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^bv NEWCASTLE UNIVERSITY   (United Kingdom)

^bw UNIVERSITY OF EDINBURGH   (United Kingdom)

^bx PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^by INSTITUTE FOR ANTHROPOLOGICAL RESEARCH   (Croatia)

^bz CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^ca VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^cb UNIVERSITY OF OULU   (Finland)

^cc VAASA CENTRAL HOSPITAL   (Finland)

^cd UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^ce UNIVERSITY OF THE WEST INDIES   (Jamaica)

^cf KUOPIO UNIVERSITY HOSPITAL   (Finland)

^cg INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ch ICELANDIC HEART ASSOCIATION   (Iceland)

^ci UNIVERSITY OF ICELAND   (Iceland)

^cj Hebrew SeniorLife Institute for Aging Research   (United States)

^ck UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^cl Fred Hutchinson Cancer Research Center   (United States)

^cm UNIVERSITY OF WASHINGTON   (United States)

^cn UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^co Oncology   (United States)

^cp GLAXOSMITHKLINE   (United States)

^cq UNIVERSITY OF GOTHENBURG   (Sweden)

^cr Center of Medical Systems Biology   (Netherlands)

^cs LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ct UNIVERSITY OF LEIPZIG   (Germany)

^cu LOYOLA UNIVERSITY CHICAGO   (United States)

^cv GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^cw UNIVERSITY COLLEGE LONDON   (United Kingdom)

^cx UNIVERSITY OF COPENHAGEN   (Denmark)

^cy AALBORG UNIVERSITY   (Denmark)

^cz Research Centre for Prevention and Health   (Denmark)

^da GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^db UNIVERSITY OF MUNICH   (Germany)

^dc UNIVERSITY OF LÜBECK   (Germany)

^dd Ajou University School of Medicine   (South Korea)

^de UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^df TAMPERE UNIVERSITY HOSPITAL   (Finland)

^dg UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^dh WAKE FOREST SCHOOL OF MEDICINE   (United States)

^di UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^dj UNIVERSITÉ LAVAL   (Canada)

^dk TURKU UNIVERSITY HOSPITAL   (Finland)

^dl UNIVERSITY OF TURKU   (Finland)

^dm The Capital Region   (Denmark)

^dn INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^do UNIVERSITY OF TURKU   (Finland)

^dp DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^dq AB)   (United States)

^dr IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ds FRAMINGHAM HEART STUDY   (United States)

^dt KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^du UNIVERSITY OF NORTH CAROLINA   (United States)

^dv INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dw NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^dx NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^dy BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dz UNIVERSITY OF LIVERPOOL   (United Kingdom)

^ea UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^eb STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ec MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CRTC1 PROTEIN; GLUCOSE; GRB14 PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IGF2BP1 PROTEIN; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLA2G6 PROTEIN; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; FATTY ACID; GENETIC ANALYSIS; GENOME; HEALTH RISK; META-ANALYSIS; METABOLISM;

ADIPOCYTE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH WEIGHT; BODY FAT; BODY FAT DISTRIBUTION; BODY MASS; CARDIOMETABOLIC RISK; CHOLESTEROL BLOOD LEVEL; COMORBIDITY; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPID STORAGE; MALE; META ANALYSIS (TOPIC); NONHUMAN; OBESITY; PHENOTYPE; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT; TRANSGENIC DROSOPHILA; ANIMAL; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HEART DISEASE; META ANALYSIS; METABOLISM; PHYSIOLOGY;

ADIPOSITY; ANIMALS; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HEART DISEASES; HUMANS; QUANTITATIVE TRAIT LOCI;

EID: 84965156172     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10495     Document Type: Article

References (70)

1. Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007).
2. Scuteri, A. et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3, e115 (2007).
3. Loos, R. J. et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768-775 (2008).
4. Chambers, J. C. et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716-718 (2008).
5. Willer, C. J. et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34 (2009).
6. Thorleifsson, G. et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18-24 (2009).
7. Meyre, D. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159 (2009).
8. Lindgren, C. M. et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 5, e1000508 (2009).
9. Heard-Costa, N. L. et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 5, e1000539 (2009).
10. Speliotes, E. K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010).
11. Heid, I. M. et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 42, 949-960 (2010).
12. Scherag, A. et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet. 6, e1000916 (2010).
13. Kilpelainen, T. O. et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat. Genet. 43, 753-760 (2011).
14. Wen, W. et al. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat. Genet. 44, 307-311 (2012).
15. Okada, Y. et al. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat. Genet. 44, 302-306 (2012).
16. Bradfield, J. P. et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat. Genet. 44, 526-531 (2012).
17. Monda, K. L. et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat. Genet. 45, 690-696 (2013).
18. Falchi, M. et al. Low copy number of the salivary amylase gene predisposes to obesity. Nat. Genet. 46, 492-497 (2014).
19. Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206 (2015).
20. Shungin, D. et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 518, 187-196 (2015).
21. Heo, M., Faith, M. S., Pietrobelli, A., Heymsfield, S. B. Percentage of body fat cutoffs by sex, age, and race-ethnicity in the US adult population from NHANES 1999-2004. Am. J. Clin. Nutr. 95, 594-602 (2012).
22. Despres, J. P., Lemieux, I., Prud'homme, D. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ 322, 716-720 (2001).
23. Urs, S. et al. Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J. 24, 3264-3273 (2010).
24. Perry, J. R. et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514, 92-97 (2014).
25. Guo, Y. et al. Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Hum. Mol. Genet. 22, 184-201 (2013).
26. Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet. 46, 1173-1186 (2014).
27. Fox, C. S. et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 8, e1002695 (2012).
28. Willer, C. J. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274-1283 (2013).
29. Scott, R. A. et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat. Genet. 44, 991-1005 (2012).
30. Morris, A. P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981-990 (2012).
31. Nikpay et al. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121-1130 (2015).
32. Horikoshi, M. et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat. Genet. 45, 76-82 (2013).
33. Cousminer, D. L. et al. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum. Mol. Genet. 22, 2735-2747 (2013).
34. Berryman, D. E., Glad, C. A., List, E. O., Johannsson, G. The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations. Nat. Rev. Endocrinol. 9, 346-356 (2013).
35. Pillas, D. et al. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet. 6, e1000856 (2010).
36. Hansen, T. V. et al. Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol. Cell. Biol. 24, 4448-4464 (2004).
37. Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
38. Dehghan, A. et al. Meta-analysis of genome-wide association studies in 480 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123, 731-738 (2011).
39. Jun, G. et al. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch. Neurol. 69, 1270-1279 (2012).
40. Davies, G. et al. A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Mol. Psychiatry 19, 76-87 (2014).
41. Deelen, J. et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10, 686-698 (2011).
42. Falchi, M. et al. Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi. Nat. Genet. 41, 915-919 (2009).
43. Nan, H. et al. Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. Hum. Mol. Genet. 20, 2673-2679 (2011).
44. Barrett, J. H. et al. Genome-wide association study identifies three new melanoma susceptibility loci. Nat. Genet. 43, 1108-1113 (2011).
45. Rung, J. et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat. Genet. 41, 1110-1115 (2009).
46. Sheffield, N. C. et al. Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res. 23, 777-788 (2013).
47. Garel, S., Yun, K., Grosschedl, R., Rubenstein, J. L. The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development 129, 5621-5634 (2002).
48. Ren, D., Li, M., Duan, C., Rui, L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. 2, 95-104 (2005).
49. Brown, L., Baer, R. HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer. Mol. Cell. Biol. 14, 1245-1255 (1994).
50. Pers, T. H. et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat. Commun. 6, 5890 (2015).
51. Rosen, E. D., Spiegelman, B. M. What we talk about when we talk about fat. Cell 156, 20-44 (2014).
52. Pospisilik, J. A. et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140, 148-160 (2010).
53. Musselman, L. P. et al. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis. Model. Mech. 4, 842-849 (2011).
54. Wheeler, E. et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat. Genet. 45, 513-517 (2013).
55. Berndt, S. I. et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat. Genet. 45, 501-512 (2013).
56. Cariou, B. et al. Increased adipose tissue expression of Grb14 in several models of insulin resistance. FASEB J. 18, 965-967 (2004).
57. Cooney, G. J. et al. Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice. EMBO J. 23, 582-593 (2004).
58. Holst, B. et al. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol. 11, e1001542 (2013).
59. Bondurand, N. et al. Deletions at the SOX10 gene locus cause Waardenburg syndrome types 2 and 4. Am. J. Hum. Genet. 81, 1169-1185 (2007).
60. Pingault, V. et al. Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness. Am. J. Hum. Genet. 92, 707-724 (2013).
61. Altarejos, J. Y. et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat. Med. 14, 1112-1117 (2008).
62. Winkler, T. W. Quality control and conduct of genome-wide association meta-analyses. Nat. Protoc. 9, 1192-1212 (2014).
63. Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291-295 (2015).
64. Dastani, Z. et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 8, e1002607 (2012).
65. Chambers, J. C. et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat. Genet. 43, 1131-1138 (2011).
66. Ohlsson, C. et al. Genetic determinants of serum testosterone concentrations in men. PLoS Genet. 7, e1002313 (2011).
67. Fehrmann, R. S. N. et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. PLoS Genet. 7, e1002197 (2011).
68. Zhong, H., Yang, X., Kaplan, L. M., Molony, C., Schadt, E. E. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am. J. Hum. Genet. 86, 581-591 (2010).
69. Min, J. L. et al. Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. PLoS Genet. 8, e1002505 (2012).
70. Myers, A. J. et al. A survey of genetic human cortical gene expression. Nat. Genet. 39, 1494-1499 (2007).