메뉴 건너뛰기




Volumn 65, Issue 8, 2016, Pages 2448-2460

Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension, and heart disease

(25)  Yaghootkar, Hanieh a   Lotta, Luca A b   Tyrrell, Jessica a   Smit, Roelof A J c   Jones, Sam E a   Donnelly, Louise d   Beaumont, Robin a   Campbell, Archie e   Tuke, Marcus A a   Hayward, Caroline f   Ruth, Katherine S a   Padmanabhan, Sandosh g   Jukema, J Wouter c,h   Palmer, Colin C d   Hattersley, Andrew a   Freathy, Rachel M a   Langenberg, Claudia b   Wareham, Nicholas J b   Wood, Andrew R a   Murray, Anna a   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY FAT DISTRIBUTION; BODY MASS; DIASTOLIC BLOOD PRESSURE; DISEASE PREDISPOSITION; FAT FREE MASS; FAT MASS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART DISEASE; HEART INFARCTION; HIP CIRCUMFERENCE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ADULT; AGED; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION; GENETICS; HEART DISEASES; MIDDLE AGED; ODDS RATIO; PHYSIOLOGY; RISK FACTOR;

EID: 84974559213     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1671     Document Type: Article
Times cited : (121)

References (23)
  • 1
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese, normal-weight individual revisited
    • Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes 1998;47:699-713
    • (1998) Diabetes , vol.47 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3    Schneider, S.4
  • 3
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective
    • Virtue S, Vidal-Puig A: Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochim Biophys Acta 2010;1801: 338-349
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 5
    • 84881025265 scopus 로고    scopus 로고
    • An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy
    • Weedon MN, Ellard S, Prindle MJ, et al. An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet 2013;45:947-950
    • (2013) Nat Genet , vol.45 , pp. 947-950
    • Weedon, M.N.1    Ellard, S.2    Prindle, M.J.3
  • 6
    • 84879326263 scopus 로고    scopus 로고
    • The role of adiposity in cardiometabolic traits: A Mendelian randomization analysis
    • Fall T, Hägg S, Mägi R, et al.; European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med 2013;10:e1001474
    • (2013) PLoS Med , vol.10 , pp. e1001474
    • Fall, T.1    Hägg, S.2    Mägi, R.3
  • 7
    • 84861537866 scopus 로고    scopus 로고
    • The effect of elevated body mass index on ischemic heart disease risk: Causal estimates from a Mendelian randomisation approach
    • Nordestgaard BG, Palmer TM, Benn M, et al. The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoS Med 2012;9:e1001212
    • (2012) PLoS Med , vol.9 , pp. e1001212
    • Nordestgaard, B.G.1    Palmer, T.M.2    Benn, M.3
  • 8
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • Scott RA, Lagou V, Welch RP, et al.; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012;44:991-1005
    • (2012) Nat Genet , vol.44 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3
  • 9
    • 79960895140 scopus 로고    scopus 로고
    • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    • Kilpeläinen TO, Zillikens MC, Stančákova A, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 2011;43:753-760
    • (2011) Nat Genet , vol.43 , pp. 753-760
    • Kilpeläinen, T.O.1    Zillikens, M.C.2    Stančákova, A.3
  • 10
    • 84906824359 scopus 로고    scopus 로고
    • Genetic evidence for a normalweight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes
    • Yaghootkar H, Scott RA, White CC, et al. Genetic evidence for a normalweight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes 2014;63:4369-4377
    • (2014) Diabetes , vol.63 , pp. 4369-4377
    • Yaghootkar, H.1    Scott, R.A.2    White, C.C.3
  • 11
    • 84911949202 scopus 로고    scopus 로고
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity
    • Scott RA, Fall T, Pasko D, et al.; RISC Study Group; EPIC-InterAct Consortium. Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes 2014;63: 4378-4387
    • (2014) Diabetes , vol.63 , pp. 4378-4387
    • Scott, R.A.1    Fall, T.2    Pasko, D.3
  • 12
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke AE, Kahali B, Berndt SI, et al.; Life Lines Cohort Study; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015;518:197-206
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3
  • 13
    • 84859215798 scopus 로고    scopus 로고
    • What makes UK Biobank special?
    • Collins R. What makes UK Biobank special? Lancet 2012;379:1173-1174
    • (2012) Lancet , vol.379 , pp. 1173-1174
    • Collins, R.1
  • 14
    • 84899513456 scopus 로고    scopus 로고
    • Fast principal component analysis of large-scale genome-wide data
    • Abraham G, Inouye M. Fast principal component analysis of large-scale genome-wide data. PLoS One 2014;9:e93766
    • (2014) PLoS One , vol.9 , pp. e93766
    • Abraham, G.1    Inouye, M.2
  • 15
    • 0031590552 scopus 로고    scopus 로고
    • Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulindependent diabetes mellitus. The DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland. Medicines Monitoring Unit
    • Morris AD, Boyle DI, McMahon AD, Greene SA, MacDonald TM, Newton RW. Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulindependent diabetes mellitus. The DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland. Medicines Monitoring Unit. Lancet 1997;350: 1505-1510
    • (1997) Lancet , vol.350 , pp. 1505-1510
    • Morris, A.D.1    Boyle, D.I.2    McMahon, A.D.3    Greene, S.A.4    MacDonald, T.M.5    Newton, R.W.6
  • 16
    • 84881595724 scopus 로고    scopus 로고
    • Cohort profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness
    • Smith BH, Campbell A, Linksted P, et al. Cohort profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. Int J Epidemiol 2013;42:689-700
    • (2013) Int J Epidemiol , vol.42 , pp. 689-700
    • Smith, B.H.1    Campbell, A.2    Linksted, P.3
  • 17
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in Elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB, et al.; PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in Elderly Individuals at Risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002;360: 1623-1630
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 18
    • 0032707276 scopus 로고    scopus 로고
    • The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER study group. Prospective study of pravastatin in the elderly at risk
    • Shepherd J, Blauw GJ, Murphy MB, et al. The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Am J Cardiol 1999; 84:1192-1197
    • (1999) Am J Cardiol , vol.84 , pp. 1192-1197
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 19
    • 1542725074 scopus 로고    scopus 로고
    • Diet and cancer-The European prospective investigation into cancer and nutrition
    • Bingham S, Riboli E. Diet and cancer-the European Prospective Investigation into Cancer and Nutrition. Nat Rev Cancer 2004;4:206-215
    • (2004) Nat Rev Cancer , vol.4 , pp. 206-215
    • Bingham, S.1    Riboli, E.2
  • 20
    • 84923169934 scopus 로고    scopus 로고
    • New genetic loci link adipose and insulin biology to body fat distribution
    • Shungin D, Winkler TW, Croteau-Chonka DC, et al.; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; Life Lines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015;518:187-196
    • (2015) Nature , vol.518 , pp. 187-196
    • Shungin, D.1    Winkler, T.W.2    Croteau-Chonka, D.C.3
  • 21
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-595
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3
  • 22
    • 34247636362 scopus 로고    scopus 로고
    • PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    • Medina-Gomez G, Gray SL, Yetukuri L, et al. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 2007;3:e64
    • (2007) PLoS Genet , vol.3 , pp. e64
    • Medina-Gomez, G.1    Gray, S.L.2    Yetukuri, L.3
  • 23
    • 1342282912 scopus 로고    scopus 로고
    • Differential roles of insulin receptor substrates in brown adipocyte differentiation
    • Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol 2004;24: 1918-1929
    • (2004) Mol Cell Biol , vol.24 , pp. 1918-1929
    • Tseng, Y.H.1    Kriauciunas, K.M.2    Kokkotou, E.3    Kahn, C.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.