Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Nature Communications

Volumn 7, Issue , 2016, Pages

  Kilpeläinen, Tuomas O ^a,b,c   Carli, Jayne F Martin ^d   Skowronski, Alicja A ^d   Sun, Qi ^e,f   Kriebel, Jennifer ^g,h   Feitosa, Mary F ⁱ   Hedman, Åsa K ^j,k   Drong, Alexander W ^k   Hayes, James E ^c,l   Zhao, Jinghua ^b   Pers, Tune H ^a,m,n,o,p   Schick, Ursula ^c   Grarup, Niels ^a   Kutalik, Zoltán ^q,r   Trompet, Stella ^s   Mangino, Massimo ^t,u   Kristiansson, Kati ^v,w   Beekman, Marian ^s   Lyytikäinen, Leo Pekka ^x,y   Eriksson, Joel ^z   Henneman, Peter ^s,aa   Lahti, Jari ^w,ab   Tanaka, Toshiko ^ac   Luan, Jian'an ^b   Fabiola Del, Greco M ^ad   Pasko, Dorota ^ae   Renström, Frida ^af,ag   Willems, Sara M ^ah   Mahajan, Anubha ^k   Rose, Lynda M ^e   Guo, Xiuqing ^ai   Liu, Yongmei ^aj   Kleber, Marcus E ^ak   Pérusse, Louis ^al   Gaunt, Tom ^am   Ahluwalia, Tarunveer S ^a,an,ao   Ju Sung, Yun ⁱ   Ramos, Yolande F ^s   Amin, Najaf ^ah   Amuzu, Antoinette ^ap   Barroso, Inês ^b,aq,ar   Bellis, Claire ^as,at,au   Blangero, John ^au   Buckley, Brendan M ^av   Böhringer, Stefan ^s   I Chen, Yii Der ^ai   De Craen, Anton J N ^s   Crosslin, David R ^aw,ax   Dale, Caroline E ^ap   Dastani, Zari ^ay   Day, Felix R ^b   Deelen, Joris ^s   Delgado, Graciela E ^ak   Demirkan, Ayse ^s,ah   Finucane, Francis M ^b   Ford, Ian ^az   Garcia, Melissa E ^ba   Gieger, Christian ^g   Gustafsson, Stefan ^j   Hallmans, Göran ^ag   Hankinson, Susan E ^e,f,bb   Havulinna, Aki S ^v   Herder, Christian ^h,bc   Hernandez, Dena ^ac   Hicks, Andrew A ^ad   Hunter, David J ^f   Illig, Thomas ^g,bd   Ingelsson, Erik ^j,be   Ioan Facsinay, Andreea ^s   Jansson, John Olov ^z   Jenny, Nancy S ^bf   Jørgensen, Marit E ^ao   Jørgensen, Torben ^bg,bh,bi   Karlsson, Magnus ^af   Koenig, Wolfgang ^bj,bk,bl   Kraft, Peter ^f   Kwekkeboom, Joanneke ^s   Laatikainen, Tiina ^v,bm,bn   Ladwig, Karl Heinz ^g,bo   Leduc, Charles A ^d   Lowe, Gordon ^az   Lu, Yingchang ^c   Marques Vidal, Pedro ^bp   Meisinger, Christa ^g,h   Menni, Cristina ^t   Morris, Andrew P ^k,bq   Myers, Richard H ^br   Männistö, Satu ^v   Nalls, Mike A ^ac   Paternoster, Lavinia ^am   Peters, Annette ^g,h,bl   Pradhan, Aruna D ^e,o   Rankinen, Tuomo ^bs   Rasmussen Torvik, Laura J ^bt   Rathmann, Wolfgang ^bc   Rice, Treva K ⁱ   Brent Richards, J ^t,ay   Ridker, Paul M ^e,o   Sattar, Naveed ^bu   Savage, David B ^b   Söderberg, Stefan ^ag   Timpson, Nicholas J ^am   Vandenput, Liesbeth ^z   Van Heemst, Diana ^s   Uh, Hae Won ^s   Vohl, Marie Claude ^al   Walker, Mark ^bv   Wichmann, Heinz Erich ^g,bw,bx   Widén, Elisabeth ^w   Wood, Andrew R ^ae   Yao, Jie ^ai   Zeller, Tanja ^bl,by   Zhang, Yiying ^d   Meulenbelt, Ingrid ^s   Kloppenburg, Margreet ^s   Astrup, Arne ^an   Sørensen, Thorkild I A ^a,o,bz   Sarzynski, Mark A ^bs   Rao, D C ⁱ   Jousilahti, Pekka ^v   Vartiainen, Erkki ^v   Hofman, Albert ^ah   Rivadeneira, Fernando ^ah   Uitterlinden, André G ^ah   Kajantie, Eero ^v,ca,cb   Osmond, Clive ^cc   Palotie, Aarno ^w,aq,cd   Eriksson, Johan G ^v,w,ab   Heliövaara, Markku ^v   Knekt, Paul B ^v   Koskinen, Seppo ^v   Jula, Antti ^v   Perola, Markus ^v,w,ce   Huupponen, Risto K ^cf,cg   Viikari, Jorma S ^cf,cg   Kähönen, Mika ^y,ch   Lehtimäki, Terho ^x,y   Raitakari, Olli T ^cg,ci   Mellström, Dan ^z   Lorentzon, Mattias ^z   Casas, Juan P ^cj   Bandinelli, Stefanie ^ck   März, Winfried ^ak,cl,cm   Isaacs, Aaron ^ah   Van Dijk, Ko W ^s   Van Duijn, Cornelia M ^ah,cn   Harris, Tamara B ^ac   Bouchard, Claude ^bs   Allison, Matthew A ^co   Chasman, Daniel I ^e,o   Ohlsson, Claes ^z   Lind, Lars ^j   Scott, Robert A ^b   Langenberg, Claudia ^b   Wareham, Nicholas J ^b   Ferrucci, Luigi ^ac   Frayling, Timothy M ^ae   Pramstaller, Peter P ^ad,cp,cq   Borecki, Ingrid B ⁱ   Waterworth, Dawn M ^cr   Bergmann, Sven ^r,cs   Waeber, Gérard ^bp   Vollenweider, Peter ^bp   Vestergaard, Henrik ^a,ao   Hansen, Torben ^a,ct   Pedersen, Oluf ^a   Hu, Frank B ^a   Eline Slagboom, P ^f   Grallert, Harald ^s   Spector, Tim D ^g,h   Jukema, J W ^t   Klein, Robert J ^s,cu,cv   Schadt, Erik E ^c   Franks, Paul W ^c   Lindgren, Cecilia M ^f,af,ag   Leibel, Rudolph L ^k,cw,cx   Loos, Ruth J F ^b,c   more..

^a Capital Region   (Denmark)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g INSTITUTE OF EPIDEMIOLOGY   (Germany)

^h GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

ⁱ WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UPPSALA UNIVERSITY   (Sweden)

^k UNIVERSITY OF OXFORD   (United Kingdom)

^l Weill Cornell Medical Center   (United States)

^m BOSTON CHILDREN S HOSPITAL   (United States)

ⁿ HARVARD UNIVERSITY   (United States)

^o HARVARD MEDICAL SCHOOL   (United States)

^p STATENS SERUM INSTITUT   (Denmark)

^q UNIVERSITY OF LAUSANNE   (Switzerland)

^r SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^s LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^t KING'S COLLEGE LONDON   (United Kingdom)

^u GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^v NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^w UNIVERSITY OF HELSINKI   (Finland)

^x FIMLAB LABORATORIES   (Finland)

^y TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^z UNIVERSITY OF GOTHENBURG   (Sweden)

^aa VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^ab Folkha'lsan Research Center   (Finland)

^ac NATIONAL INSTITUTE ON AGING   (United States)

^ad University of Lubeck   (Italy)

^ae UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^af LUND UNIVERSITY   (Sweden)

^ag UMEÅ UNIVERSITY   (Sweden)

^ah ERASMUS MEDICAL CENTER   (Netherlands)

^ai LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^aj WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ak UNIVERSITY OF HEIDELBERG   (Germany)

^al UNIVERSITÉ LAVAL   (Canada)

^am UNIVERSITY OF BRISTOL   (United Kingdom)

^an UNIVERSITY OF COPENHAGEN   (Denmark)

^ao STENO DIABETES CENTER   (Denmark)

^ap LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^aq WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ar ADDENBROOKE S HOSPITAL   (United Kingdom)

^as GENOME INSTITUTE OF SINGAPORE   (Singapore)

^at QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^au SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^av UNIVERSITY COLLEGE CORK   (Ireland)

^aw UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^ax UNIVERSITY OF WASHINGTON   (United States)

^ay MCGILL UNIVERSITY   (Canada)

^az UNIVERSITY OF GLASGOW   (United Kingdom)

^ba NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^bb UNIVERSITY OF MASSACHUSETTS   (United States)

^bc LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^bd HANNOVER MEDICAL SCHOOL   (Germany)

^be STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bf UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^bg GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^bh AALBORG UNIVERSITY   (Denmark)

^bi UNIVERSITY OF COPENHAGEN   (Denmark)

^bj UNIVERSITY OF ULM   (Germany)

^bk TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^bl DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^bm UNIVERSITY OF EASTERN FINLAND   (Finland)

^bn Hospital District of North Karelia   (Finland)

^bo TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^bp LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^bq UNIVERSITY OF LIVERPOOL   (United Kingdom)

^br BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bs PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^bt NORTHWESTERN UNIVERSITY   (United States)

^bu UNIVERSITY OF GLASGOW   (United Kingdom)

^bv NEWCASTLE UNIVERSITY   (United Kingdom)

^bw UNIVERSITY OF MUNICH   (Germany)

^bx TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^by UNIVERSITY HEART CENTER HAMBURG   (Germany)

^bz The Capital Region   (Denmark)

^ca UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^cb UNIVERSITY OF OULU   (Finland)

^cc UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^cd MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ce UNIVERSITY OF TARTU   (Estonia)

^cf UNIVERSITY OF TURKU   (Finland)

^cg TURKU UNIVERSITY HOSPITAL   (Finland)

^ch TAMPERE UNIVERSITY HOSPITAL   (Finland)

^ci UNIVERSITY OF TURKU   (Finland)

^cj UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ck SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^cl SYNLAB ACADEMY   (Germany)

^cm MEDICAL UNIVERSITY OF GRAZ   (Austria)

^cn Center of Medical Systems Biology   (Netherlands)

^co UNIVERSITY OF CALIFORNIA   (United States)

^cp General Central Hospital   (Italy)

^cq University of Lu'beck   (Germany)

^cr GLAXOSMITHKLINE   (United States)

^cs UNIVERSITY OF LAUSANNE   (Switzerland)

^ct UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^cu INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^cv Durrer Center for Cardiogenetic Research   (Netherlands)

^cw BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^cx UNIVERSITY OF OXFORD   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MESSENGER RNA;

CELLS AND CELL COMPONENTS; FAT; GENE EXPRESSION; GENETIC ENGINEERING; GENOME; HORMONE; META-ANALYSIS; METABOLISM;

ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; BODY MASS; CONTROLLED STUDY; EXPLANT; FEMALE; FOLLOW UP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC TRAIT; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MOUSE; NONHUMAN; OBESITY; ANIMAL; BLOOD; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; PHYSIOLOGY; TISSUE CULTURE TECHNIQUE;

ADIPOSE TISSUE; ANIMALS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; LEPTIN; MALE; MICE; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES;

EID: 84970934641     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10494     Document Type: Article

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