Genetic regulatory signatures underlying islet gene expression and type 2 diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 9, 2017, Pages 2301-2306

  Varshney, Arushi ^a   Scott, Laura J ^b   Welch, Ryan P ^b   Erdos, Michael R ^c   Chines, Peter S ^c   Narisu, Narisu ^c   Albanus, Ricardo D'O ^a   Orchard, Peter ^a   Wolford, Brooke N ^a   Kursawe, Romy ^d   Vadlamudi, Swarooparani ^e   Cannon, Maren E ^e   Didion, John P ^c   Hensley, John ^a   Kirilusha, Anthony ^c   Bonnycastle, Lori L ^c   Taylor, D Leland ^c,f   Watanabe, Richard ^g   Mohlke, Karen L ^e   Boehnke, Michael ^b   Collins, Francis S ^c   Parker, Stephen C J ^a   Stitzel, Michael L ^d   more..

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d JACKSON LABORATORY   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Chromatin; Diabetes; Epigenome; eQTL; Footprint

Indexed keywords

MESSENGER RNA; REGULATORY FACTOR X TRANSCRIPTION FACTOR; ISOPROTEIN; PROTEIN BINDING; TRANSCRIPTOME;

ARTICLE; BINDING AFFINITY; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; ENHANCER REGION; EPIGENETICS; GENE; GENE EXPRESSION; GENETIC REGULATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HISTONE MODIFICATION; HUMAN; HUMAN TISSUE; KCNK16 GENE; KCNK17 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN FOOTPRINTING; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; TRANSCRIPTOMICS; ALLELE; BINDING SITE; CHEMISTRY; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; GENOME IMPRINTING; HUMAN GENOME; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; BASE SEQUENCE; BINDING SITES; CHROMATIN; DIABETES MELLITUS, TYPE 2; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOMIC IMPRINTING; HUMANS; ISLETS OF LANGERHANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN ISOFORMS; QUANTITATIVE TRAIT LOCI; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 85014164610     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1621192114     Document Type: Article

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