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Volumn 76, Issue 6, 2018, Pages 444-460

Applications for a-lactalbumin in human nutrition

Author keywords

Infant formula; Leucine; Serotonin; Sleep; Tryptophan

Indexed keywords

ALPHA LACTALBUMIN; BRANCHED CHAIN AMINO ACID; CYSTEINE; TRYPTOPHAN; AMINO ACID; ESSENTIAL AMINO ACID; LACTALBUMIN;

EID: 85054474361     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nuy004     Document Type: Review
Times cited : (215)

References (178)
  • 1
    • 0025756737 scopus 로고
    • The importance of a-lactalbumin in infant nutrition
    • Heine WE, Klein PD, Reeds PJ. The importance of a-lactalbumin in infant nutrition. J Nutr. 1991;121:277-283.
    • (1991) J Nutr , vol.121 , pp. 277-283
    • Heine, W.E.1    Klein, P.D.2    Reeds, P.J.3
  • 2
    • 0026537258 scopus 로고
    • Re-evaluation of the whey protein/casein ratio of human milk
    • Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112.
    • (1992) Acta Paediatr , vol.81 , pp. 107-112
    • Kunz, C.1    Lönnerdal, B.2
  • 3
    • 40749088092 scopus 로고    scopus 로고
    • Emerging health properties of whey proteins and their clinical implications
    • Krissansen GW. Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr. 2007;26:713S-723S.
    • (2007) J Am Coll Nutr , vol.26 , pp. 713S-723S
    • Krissansen, G.W.1
  • 4
    • 84989917727 scopus 로고    scopus 로고
    • US Department of Agriculture, Agriculture Research Service. Beltsville, MD: Nutrient Data Laboratory; Slightly revised May 2016. Accessed February 28, 2018
    • US Department of Agriculture, Agriculture Research Service. USDA Food Composition Database. Beltsville, MD: Nutrient Data Laboratory; 2015. https://ndb.nal.usda.gov/ndb/. Slightly revised May 2016. Accessed February 28, 2018.
    • (2015) USDA Food Composition Database
  • 5
    • 0000433381 scopus 로고
    • Nitrogenous components of milk
    • Jensen RG, ed. San Diego, CA: Academic Press
    • Atkinson SA, Lönnerdal B. Nitrogenous components of milk. In: Handbook of Milk Composition. In: Jensen RG, ed. San Diego, CA: Academic Press; 1995:351-387.
    • (1995) Handbook of Milk Composition , pp. 351-387
    • Atkinson, S.A.1    Lönnerdal, B.2
  • 6
    • 0002692649 scopus 로고
    • Protein and amino acid composition of bovine milk
    • Jensen RG, ed. San Diego, CA: Academic Press
    • Swaisgood HE. Protein and amino acid composition of bovine milk. In: Jensen RG, ed. Handbook of Milk Composition. San Diego, CA: Academic Press; 1995:464-467.
    • (1995) Handbook of Milk Composition , pp. 464-467
    • Swaisgood, H.E.1
  • 7
    • 78649380209 scopus 로고    scopus 로고
    • Alpha-lactalbumin: Its production technologies and bioactive peptides
    • Kamau SM, Cheison SC, Chen W, et al. Alpha-lactalbumin: its production technologies and bioactive peptides. Comp Rev Food Sci. 2010;9:197-212.
    • (2010) Comp Rev Food Sci , vol.9 , pp. 197-212
    • Kamau, S.M.1    Cheison, S.C.2    Chen, W.3
  • 8
    • 0027347215 scopus 로고
    • Whey protein concentrates and isolates: Processing and functional properties
    • Morr CV, Ha EY. Whey protein concentrates and isolates: processing and functional properties. Crit Rev Food Sci Nutr. 1993;33:431-476.
    • (1993) Crit Rev Food Sci Nutr , vol.33 , pp. 431-476
    • Morr, C.V.1    Ha, E.Y.2
  • 9
    • 0034685838 scopus 로고    scopus 로고
    • A-Lactalbumin: Structure and function
    • Permyakov EA, Berliner LJ. a-Lactalbumin: structure and function. FEBS Lett. 2000;473:269-274.
    • (2000) FEBS Lett , vol.473 , pp. 269-274
    • Permyakov, E.A.1    Berliner, L.J.2
  • 10
    • 0037563682 scopus 로고    scopus 로고
    • Infant formulas with increased concentrations of alpha-lactalbumin
    • Lien EL. Infant formulas with increased concentrations of alpha-lactalbumin. Am J Clin Nutr. 2003;77:1555S-1558S.
    • (2003) Am J Clin Nutr , vol.77 , pp. 1555S-1558S
    • Lien, E.L.1
  • 11
    • 84896887668 scopus 로고    scopus 로고
    • Infant formula and infant nutrition: Bioactive proteins of human milk and implications for composition of infant formulas
    • Lönnerdal B. Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas. Am J Clin Nutr. 2014;99:712S-717S.
    • (2014) Am J Clin Nutr , vol.99 , pp. 712S-717S
    • Lönnerdal, B.1
  • 12
    • 85054513314 scopus 로고    scopus 로고
    • Accessed February 28, 2018
    • US Food and Drug Administration. Infant formula. 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr¼107.100. Accessed February 28, 2018.
    • (2017) Infant Formula
  • 13
    • 77951443011 scopus 로고    scopus 로고
    • Revised standard for infant formula and formulas for special medical purposes intended for infants. Codex STAN 72-1981
    • Food and Agriculture Organization of the United Nations. Rome, Italy: Food and Agriculture Organization of the United Nations; Revision
    • Food and Agriculture Organization of the United Nations. Revised standard for infant formula and formulas for special medical purposes intended for infants. Codex Stan 72-1981. In: Codex Alimentarius. Rome, Italy: Food and Agriculture Organization of the United Nations; Revision 2007.
    • (2007) Codex Alimentarius
  • 14
    • 0031006642 scopus 로고    scopus 로고
    • Protein and nonprotein nitrogen components in human milk, bovine milk, and infant formula: Quantitative and qualitative aspects in infant nutrition
    • Rudloff S, Kunz C. Protein and nonprotein nitrogen components in human milk, bovine milk, and infant formula: quantitative and qualitative aspects in infant nutrition. J Pediatr Gastroenterol Nutr. 1997;24:328-344.
    • (1997) J Pediatr Gastroenterol Nutr , vol.24 , pp. 328-344
    • Rudloff, S.1    Kunz, C.2
  • 15
  • 16
    • 66849138606 scopus 로고    scopus 로고
    • Lower protein in infant formula is associated with lower weight up to age 2 y: A randomized clinical trial
    • Koletzko B, von Kries R, Closa R, et al. Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009;89:1836-1845.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1836-1845
    • Koletzko, B.1    Von Kries, R.2    Closa, R.3
  • 17
    • 79651468832 scopus 로고    scopus 로고
    • Effect of an a-lactalbumin-enriched infant formula with lower protein on growth
    • Trabulsi J, Capeding R, Lebumfacil J, et al. Effect of an a-lactalbumin-enriched infant formula with lower protein on growth. Eur J Clin Nutr. 2011;65:167-174.
    • (2011) Eur J Clin Nutr , vol.65 , pp. 167-174
    • Trabulsi, J.1    Capeding, R.2    Lebumfacil, J.3
  • 18
    • 0141992791 scopus 로고    scopus 로고
    • Nutritional and physiologic significance of alpha-lactalbumin in infants
    • Lönnerdal B, Lien EL. Nutritional and physiologic significance of alpha-lactalbumin in infants. Nutr Rev. 2003;61:295-305.
    • (2003) Nutr Rev , vol.61 , pp. 295-305
    • Lönnerdal, B.1    Lien, E.L.2
  • 20
    • 6044271725 scopus 로고    scopus 로고
    • Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin
    • Lien EL, Davis AM, Euler AR, et al. Growth and safety in term infants fed reduced-protein formula with added bovine alpha-lactalbumin. J Pediatr Gastroenterol Nutr. 2004;38:170-176.
    • (2004) J Pediatr Gastroenterol Nutr , vol.38 , pp. 170-176
    • Lien, E.L.1    Davis, A.M.2    Euler, A.R.3
  • 21
    • 42249100527 scopus 로고    scopus 로고
    • Effects of a-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition
    • Sandström O, Lönnerdal B, Graverholt G, et al. Effects of a-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition. Am J Clin Nutr. 2008;87:921-928.
    • (2008) Am J Clin Nutr , vol.87 , pp. 921-928
    • Sandström, O.1    Lönnerdal, B.2    Graverholt, G.3
  • 22
    • 0027144747 scopus 로고
    • Symposium: Normal and abnormal REM sleep regulation: The importance of REM sleep for brain maturation
    • Mirmiran M, Van Someren E. Symposium: normal and abnormal REM sleep regulation: the importance of REM sleep for brain maturation. J Sleep Res. 1993;2:188-192.
    • (1993) J Sleep Res , vol.2 , pp. 188-192
    • Mirmiran, M.1    Van Someren, E.2
  • 23
    • 0026658312 scopus 로고
    • Tryptophan intake influences infants' sleep latency
    • Steinberg LA, O'Connell NC, Hatch TF, et al. Tryptophan intake influences infants' sleep latency. J Nutr. 1992;122:1781-1791.
    • (1992) J Nutr , vol.122 , pp. 1781-1791
    • Steinberg, L.A.1    O'Connell, N.C.2    Hatch, T.F.3
  • 24
    • 0020614686 scopus 로고
    • Role of precursor availability in control of monoamine biosynthesis in brain
    • Fernstrom JD. Role of precursor availability in control of monoamine biosynthesis in brain. Physiol Rev. 1983;63:484-546.
    • (1983) Physiol Rev , vol.63 , pp. 484-546
    • Fernstrom, J.D.1
  • 25
    • 0026668767 scopus 로고
    • Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
    • Huether G, Poeggeler B, Reimer A, et al. Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci. 1992;51:945-953.
    • (1992) Life Sci , vol.51 , pp. 945-953
    • Huether, G.1    Poeggeler, B.2    Reimer, A.3
  • 26
    • 0031821519 scopus 로고    scopus 로고
    • Cellular mechanisms of melatonin action
    • Vanecek J. Cellular mechanisms of melatonin action. Physiol Rev. 1998;78:687-721.
    • (1998) Physiol Rev , vol.78 , pp. 687-721
    • Vanecek, J.1
  • 27
    • 0034468894 scopus 로고    scopus 로고
    • The significance of tryptophan in infant nutrition
    • Heine WE. The significance of tryptophan in infant nutrition. Adv Exp Med Biol. 1999;467:705-710.
    • (1999) Adv Exp Med Biol , vol.467 , pp. 705-710
    • Heine, W.E.1
  • 28
    • 33645012019 scopus 로고    scopus 로고
    • The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn
    • Cubero J, Valero V, Sanchez J, et al. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett. 2005;26:657-661.
    • (2005) Neuro Endocrinol Lett , vol.26 , pp. 657-661
    • Cubero, J.1    Valero, V.2    Sanchez, J.3
  • 29
    • 0018368204 scopus 로고
    • The role of blood-brain barrier transport of tryptophan and other neutral amino acids in the regulation of substrate-limited pathways of brain amino acid metabolism
    • Pardridge WM. The role of blood-brain barrier transport of tryptophan and other neutral amino acids in the regulation of substrate-limited pathways of brain amino acid metabolism. J Neural Transm Suppl. 1979;15:43-54.
    • (1979) J Neural Transm Suppl , vol.15 , pp. 43-54
    • Pardridge, W.M.1
  • 30
    • 84887625021 scopus 로고    scopus 로고
    • The ingestion of different dietary proteins by humans induces large changes in the plasma tryptophan ratio, a predictor of brain tryptophan uptake and serotonin synthesis
    • Fernstrom JD, Langham KA, Marcelino LM, et al. The ingestion of different dietary proteins by humans induces large changes in the plasma tryptophan ratio, a predictor of brain tryptophan uptake and serotonin synthesis. Clin Nutr. 2013;32:1073-1076.
    • (2013) Clin Nutr , vol.32 , pp. 1073-1076
    • Fernstrom, J.D.1    Langham, K.A.2    Marcelino, L.M.3
  • 31
    • 0021029685 scopus 로고
    • Diet and sleep patterns in newborn infants
    • Yogman MW, Zeisel SH. Diet and sleep patterns in newborn infants. N Engl J Med. 1983;309:1147-1149.
    • (1983) N Engl J Med , vol.309 , pp. 1147-1149
    • Yogman, M.W.1    Zeisel, S.H.2
  • 32
    • 34848865396 scopus 로고    scopus 로고
    • Chrononutrition: Use of dissociated day/ night infant milk formulas to improve the development of the wake-sleep rhythms. Effects of tryptophan
    • Aparicio S, Garau C, Esteban S, et al. Chrononutrition: use of dissociated day/ night infant milk formulas to improve the development of the wake-sleep rhythms. Effects of tryptophan. Nutr Neurosci. 2007;10:137-143.
    • (2007) Nutr Neurosci , vol.10 , pp. 137-143
    • Aparicio, S.1    Garau, C.2    Esteban, S.3
  • 33
    • 9444298458 scopus 로고    scopus 로고
    • Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat
    • Esteban S, Nicolaus C, Garmundi A, et al. Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat. Mol Cell Biochem. 2004;267:39-46.
    • (2004) Mol Cell Biochem , vol.267 , pp. 39-46
    • Esteban, S.1    Nicolaus, C.2    Garmundi, A.3
  • 34
    • 0020390108 scopus 로고
    • Assessing effects of serotonin precursors on newborn behavior
    • Yogman MW, Zeisel SH, Roberts C. Assessing effects of serotonin precursors on newborn behavior. J Psychiatr Res. 1982;17:123-133.
    • (1982) J Psychiatr Res , vol.17 , pp. 123-133
    • Yogman, M.W.1    Zeisel, S.H.2    Roberts, C.3
  • 35
    • 84945481976 scopus 로고    scopus 로고
    • Human breast milk: A review on its composition and bioactivity
    • Andreas NJ, Kampmann B, Mehring Le-Doare K. Human breast milk: a review on its composition and bioactivity. Early Human Dev. 2015;91:629-635.
    • (2015) Early Human Dev , vol.91 , pp. 629-635
    • Andreas, N.J.1    Kampmann, B.2    Mehring Le-Doare, K.3
  • 36
    • 33846953590 scopus 로고    scopus 로고
    • Protection of the neonate by the innate immune system of developing gut and of human milk
    • Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res. 2007;61:2-8.
    • (2007) Pediatr Res , vol.61 , pp. 2-8
    • Newburg, D.S.1    Walker, W.A.2
  • 37
    • 0037901694 scopus 로고    scopus 로고
    • Nutritional and physiologic significance of human milk proteins
    • Lönnerdal B. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr. 2003;77:1537S-1543S.
    • (2003) Am J Clin Nutr , vol.77 , pp. 1537S-1543S
    • Lönnerdal, B.1
  • 38
    • 0033022708 scopus 로고    scopus 로고
    • Isolation and identification of three bactericidal domains in the bovine a-lactalbumin molecule
    • Pellegrini A, Thomas U, Bramaz N, et al. Isolation and identification of three bactericidal domains in the bovine a-lactalbumin molecule. Biochim Biophys Acta. 1999;1426:439-448.
    • (1999) Biochim Biophys Acta , vol.1426 , pp. 439-448
    • Pellegrini, A.1    Thomas, U.2    Bramaz, N.3
  • 39
    • 0030806667 scopus 로고    scopus 로고
    • The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human a-lactalbumin
    • Giuffrida MG, Cavaletto M, Ciunta C, et al. The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human a-lactalbumin. J Protein Chem. 1997;16:747-753.
    • (1997) J Protein Chem , vol.16 , pp. 747-753
    • Giuffrida, M.G.1    Cavaletto, M.2    Ciunta, C.3
  • 40
    • 64549158645 scopus 로고    scopus 로고
    • The expanded biology of serotonin
    • Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009;60:355-366.
    • (2009) Annu Rev Med , vol.60 , pp. 355-366
    • Berger, M.1    Gray, J.A.2    Roth, B.L.3
  • 41
    • 85018516179 scopus 로고    scopus 로고
    • Synthesis of amino acids
    • Boca Raton, FL: CRC Press, Taylor & Francis Group
    • Wu G. Synthesis of amino acids. In: Amino Acids: Biochemistry and Nutrition. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2013:63-96.
    • (2013) Amino Acids: Biochemistry and Nutrition , pp. 63-96
    • Wu, G.1
  • 42
    • 72449121934 scopus 로고    scopus 로고
    • Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function
    • Keszthelyi D, Troost FJ, Masclee AAM. Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function. Neurogastroenterol Motil. 2009;21:1239-1249.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 1239-1249
    • Keszthelyi, D.1    Troost, F.J.2    Masclee, A.A.M.3
  • 43
    • 77949290825 scopus 로고    scopus 로고
    • Invited review: Physiological properties of bioactive peptides obtained from whey proteins
    • Madureira AR, Tavares T, Gomes AM, et al. Invited review: physiological properties of bioactive peptides obtained from whey proteins. J Dairy Sci. 2010;93:437-455.
    • (2010) J Dairy Sci , vol.93 , pp. 437-455
    • Madureira, A.R.1    Tavares, T.2    Gomes, A.M.3
  • 44
    • 0019444208 scopus 로고
    • Short-term and repetitive administration of oral tryptophan in normal men: Effects on blood tryptophan, serotonin, and kynurenine concentrations
    • Yuwiler A, Brammer GL, Morley JE, et al. Short-term and repetitive administration of oral tryptophan in normal men: effects on blood tryptophan, serotonin, and kynurenine concentrations. Arch Gen Psychiatry. 1981;38:619-626.
    • (1981) Arch Gen Psychiatry , vol.38 , pp. 619-626
    • Yuwiler, A.1    Brammer, G.L.2    Morley, J.E.3
  • 45
    • 0026705686 scopus 로고
    • Effects of tripeptides derived from milk proteins on polymorphonuclear oxidative and phosphoinositide metabolisms
    • Migliore-Samour D, Roch-Arveiller M, Tissot M, et al. Effects of tripeptides derived from milk proteins on polymorphonuclear oxidative and phosphoinositide metabolisms. Biochem Pharmacol. 1992;44:673-680.
    • (1992) Biochem Pharmacol , vol.44 , pp. 673-680
    • Migliore-Samour, D.1    Roch-Arveiller, M.2    Tissot, M.3
  • 46
    • 77955013911 scopus 로고    scopus 로고
    • A-Lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: Growth and gastrointestinal tolerance
    • Dupont C, Rivero M, Grillon C, et al. a-Lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal tolerance. Eur J Clin Nutr. 2010;64:765-767.
    • (2010) Eur J Clin Nutr , vol.64 , pp. 765-767
    • Dupont, C.1    Rivero, M.2    Grillon, C.3
  • 47
    • 0041421092 scopus 로고    scopus 로고
    • Effects of bovine a-lactalbumin on gastric defense mechanisms in naïve rats
    • Ushida Y, Shimokawa Y, Matsumoto H, et al. Effects of bovine a-lactalbumin on gastric defense mechanisms in naïve rats. Biosci Biotechnol Biochem. 2003;67:577-583.
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 577-583
    • Ushida, Y.1    Shimokawa, Y.2    Matsumoto, H.3
  • 48
    • 78649380209 scopus 로고    scopus 로고
    • Alpha-lactalbumin: Its production technologies and bioactive peptides
    • Kamau SM, Cheison SC, Chen W, et al. Alpha-lactalbumin: its production technologies and bioactive peptides. Comp Rev Food Sci Food Safey. 2010;9:197-212.
    • (2010) Comp Rev Food Sci Food Safey , vol.9 , pp. 197-212
    • Kamau, S.M.1    Cheison, S.C.2    Chen, W.3
  • 49
    • 0023176333 scopus 로고
    • Immunostimulating properties and three-dimensional structure of two tripeptides from human and cow caseins
    • Berthou J, Migliore-Samour D, Lifchitz A, et al. Immunostimulating properties and three-dimensional structure of two tripeptides from human and cow caseins. FEBS Lett. 1987;218:55-58.
    • (1987) FEBS Lett , vol.218 , pp. 55-58
    • Berthou, J.1    Migliore-Samour, D.2    Lifchitz, A.3
  • 50
    • 0027054727 scopus 로고
    • Specific binding sites on human phagocytic blood cells for Gly-Leu-Phe and Val-Glu-Pro-Ile-Pro-Tyr, immunostimulating peptides from human milk proteins
    • Jaziri M, Migliore-Samour D, Casabianca-Pignede MR, et al. Specific binding sites on human phagocytic blood cells for Gly-Leu-Phe and Val-Glu-Pro-Ile-Pro-Tyr, immunostimulating peptides from human milk proteins. Biochim Biophys Acta. 1992;1160:251-261.
    • (1992) Biochim Biophys Acta , vol.1160 , pp. 251-261
    • Jaziri, M.1    Migliore-Samour, D.2    Casabianca-Pignede, M.R.3
  • 51
    • 0141950889 scopus 로고    scopus 로고
    • Effect of enzymatically hydrolyzed alpha-LA fractions with pepsin on growth-promoting of Bifidobacgterium longum ATCC 15707
    • Kee HJ, Hong YH, Kim ER, et al. Effect of enzymatically hydrolyzed alpha-LA fractions with pepsin on growth-promoting of Bifidobacgterium longum ATCC 15707. Korean J Dairy Sci. 1998;20:61-68.
    • (1998) Korean J Dairy Sci , vol.20 , pp. 61-68
    • Kee, H.J.1    Hong, Y.H.2    Kim, E.R.3
  • 52
    • 78049504118 scopus 로고    scopus 로고
    • Examination of faecal Bifidobacterium populations in breast- And formula-fed infants during the first 18 months of life
    • Roger LC, Costabile A, Holland DT, et al. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology. 2010;156(pt 11):3329-3341.
    • (2010) Microbiology , vol.156 , pp. 3329-3341
    • Roger, L.C.1    Costabile, A.2    Holland, D.T.3
  • 53
    • 0034076597 scopus 로고    scopus 로고
    • Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods
    • Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr. 2000;30:61-67.
    • (2000) J Pediatr Gastroenterol Nutr , vol.30 , pp. 61-67
    • Harmsen, H.J.1    Wildeboer-Veloo, A.C.2    Raangs, G.C.3
  • 54
    • 77957275373 scopus 로고    scopus 로고
    • Breast- V. Formula-feeding: Impacts on the digestive tract and immediate and long-term health effects
    • Le Huerou-Luron I, Blat S, Boudry G. Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects. Nutr Res Rev. 2010;23:23-36.
    • (2010) Nutr Res Rev , vol.23 , pp. 23-36
    • Le Huerou-Luron, I.1    Blat, S.2    Boudry, G.3
  • 55
    • 1542681459 scopus 로고    scopus 로고
    • RRNA probes used to quantify the effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli
    • Bruck WM, Kelleher SL, Gibson GR, et al. rRNA probes used to quantify the effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr. 2003;37:273-280.
    • (2003) J Pediatr Gastroenterol Nutr , vol.37 , pp. 273-280
    • Bruck, W.M.1    Kelleher, S.L.2    Gibson, G.R.3
  • 56
    • 0020529945 scopus 로고
    • Iron, zinc, copper, and manganese in infant formulas
    • Lönnerdal B, Keen CL, Ohtake M, et al. Iron, zinc, copper, and manganese in infant formulas. Am J Dis Child. 1983;137:433-437.
    • (1983) Am J Dis Child , vol.137 , pp. 433-437
    • Lönnerdal, B.1    Keen, C.L.2    Ohtake, M.3
  • 57
    • 0038474028 scopus 로고    scopus 로고
    • Glycomacropeptide and a-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys
    • Kelleher SL, Chatterton D, Nielsen K, et al. Glycomacropeptide and a-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr. 2003;77:1261-1268.
    • (2003) Am J Clin Nutr , vol.77 , pp. 1261-1268
    • Kelleher, S.L.1    Chatterton, D.2    Nielsen, K.3
  • 58
    • 84863545540 scopus 로고    scopus 로고
    • A-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants
    • Szymlek-Gay EA, Lönnerdal B, Abrams SA, et al. a-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants. J Nutr. 2012;142:1226-1231.
    • (2012) J Nutr , vol.142 , pp. 1226-1231
    • Szymlek-Gay, E.A.1    Lönnerdal, B.2    Abrams, S.A.3
  • 59
    • 0000881423 scopus 로고
    • Effect of pH and iconic strength on the binding of bivalent cations to b-casein
    • Baumy JJ., Brule G. Effect of pH and iconic strength on the binding of bivalent cations to b-casein. Le Lait Dairy Sci Technol. 1988;68:409-417.
    • (1988) Le Lait Dairy Sci Technol , vol.68 , pp. 409-417
    • Baumy, J.J.1    Brule, G.2
  • 60
    • 84899125382 scopus 로고    scopus 로고
    • In vitro iron absorption of a-lactalbumin hydrolysate-iron and b-lactoglobulin hydrolysate-iron complexes
    • Wang X, Ai T, Meng XL, et al. In vitro iron absorption of a-lactalbumin hydrolysate-iron and b-lactoglobulin hydrolysate-iron complexes. J Dairy Sci. 2014;97:2559-2566.
    • (2014) J Dairy Sci , vol.97 , pp. 2559-2566
    • Wang, X.1    Ai, T.2    Meng, X.L.3
  • 61
    • 84983070182 scopus 로고    scopus 로고
    • Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: A randomised trial
    • Szymlek-Gay EA, Domellof M, Hernell O, et al. Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial. Br J Nutr. 2016;116:1046-1060.
    • (2016) Br J Nutr , vol.116 , pp. 1046-1060
    • Szymlek-Gay, E.A.1    Domellof, M.2    Hernell, O.3
  • 62
    • 84930443085 scopus 로고    scopus 로고
    • Defining meal requirements for protein to optimize metabolic roles of amino acids
    • Layman DK, Anthony TG, Rasmussen BB, et al. Defining meal requirements for protein to optimize metabolic roles of amino acids. Am J Clin Nutr. 2015;101:1330S-1338S.
    • (2015) Am J Clin Nutr , vol.101 , pp. 1330S-1338S
    • Layman, D.K.1    Anthony, T.G.2    Rasmussen, B.B.3
  • 63
    • 84956881119 scopus 로고    scopus 로고
    • Leucine partially protects muscle mass and function during bed rest in middle-aged adults
    • English KL, Mettler JA, Ellison JB, et al. Leucine partially protects muscle mass and function during bed rest in middle-aged adults. Am J Clin Nutr. 2016;103:465-473.
    • (2016) Am J Clin Nutr , vol.103 , pp. 465-473
    • English, K.L.1    Mettler, J.A.2    Ellison, J.B.3
  • 64
    • 85002441974 scopus 로고    scopus 로고
    • Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- And higher-protein diets: A parallel-group crossover study
    • Murphy CH, Saddler NI, Devries MC, et al. Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- and higher-protein diets: a parallel-group crossover study. Am J Clin Nutr. 2016;104:1594-1606.
    • (2016) Am J Clin Nutr , vol.104 , pp. 1594-1606
    • Murphy, C.H.1    Saddler, N.I.2    Devries, M.C.3
  • 65
    • 0015209704 scopus 로고
    • Brain serotonin content: Increase following ingestion of carbohydrate diet
    • Fernstrom JD, Wurtman RJ. Brain serotonin content: increase following ingestion of carbohydrate diet. Science. 1971;174:1023-1025.
    • (1971) Science , vol.174 , pp. 1023-1025
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 66
    • 0015526241 scopus 로고
    • Brain serotonin content: Physiological regulation by plasma neutral amino acids
    • Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 1972;178:414-416.
    • (1972) Science , vol.178 , pp. 414-416
    • Fernstrom, J.D.1    Wurtman, R.J.2
  • 67
    • 0018184546 scopus 로고
    • Neutral amino acids in the brain: Changes in response to food ingestion
    • Fernstrom JD, Faller DV. Neutral amino acids in the brain: changes in response to food ingestion. J Neurochem. 1978;30:1531-1538.
    • (1978) J Neurochem , vol.30 , pp. 1531-1538
    • Fernstrom, J.D.1    Faller, D.V.2
  • 68
    • 0034085615 scopus 로고    scopus 로고
    • The bovine protein a-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress
    • Markus CR, Olivier B, Panhuysen GE, et al. The bovine protein a-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr. 2000;71:1536-1544.
    • (2000) Am J Clin Nutr , vol.71 , pp. 1536-1544
    • Markus, C.R.1    Olivier, B.2    Panhuysen, G.E.3
  • 69
    • 0035198669 scopus 로고    scopus 로고
    • Plasma Trp/LNAA ratio increases during chronic ingestion of an alpha-lactalbumin diet in rats
    • Feurte S, Gerozissis K, Regnault A, et al. Plasma Trp/LNAA ratio increases during chronic ingestion of an alpha-lactalbumin diet in rats. Nutr Neurosci. 2001;4:413-418.
    • (2001) Nutr Neurosci , vol.4 , pp. 413-418
    • Feurte, S.1    Gerozissis, K.2    Regnault, A.3
  • 70
    • 0347626245 scopus 로고    scopus 로고
    • Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat
    • Orosco M, Rouch C, Beslot F, et al. Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat. Behav Brain Res. 2004;148:1-10.
    • (2004) Behav Brain Res , vol.148 , pp. 1-10
    • Orosco, M.1    Rouch, C.2    Beslot, F.3
  • 71
    • 67649464232 scopus 로고    scopus 로고
    • Meal ingestion, amino acids and brain neurotransmitters: Effects of dietary protein source on serotonin and catecholamine synthesis rates
    • Choi S, Disilvio B, Fernstrom MH, et al. Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates. Physiol Behav. 2009;98:156-162.
    • (2009) Physiol Behav , vol.98 , pp. 156-162
    • Choi, S.1    Disilvio, B.2    Fernstrom, M.H.3
  • 72
    • 0028852487 scopus 로고
    • Brain tryptophan concentrations and serotonin synthesis remain responsive to food consumption after the ingestion of sequential meals
    • Fernstrom MH, Fernstrom JD. Brain tryptophan concentrations and serotonin synthesis remain responsive to food consumption after the ingestion of sequential meals. Am J Clin Nutr. 1995;61:312-319.
    • (1995) Am J Clin Nutr , vol.61 , pp. 312-319
    • Fernstrom, M.H.1    Fernstrom, J.D.2
  • 73
    • 0033036573 scopus 로고    scopus 로고
    • Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers
    • Williams WA, Shoaf SE, Hommer D, et al. Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers. J Neurochem. 1999;72:1641-1647.
    • (1999) J Neurochem , vol.72 , pp. 1641-1647
    • Williams, W.A.1    Shoaf, S.E.2    Hommer, D.3
  • 74
    • 84872143082 scopus 로고    scopus 로고
    • Effects and side effects associated with the non-nutritional use of tryptophan by humans
    • Fernstrom JD. Effects and side effects associated with the non-nutritional use of tryptophan by humans. J Nutr. 2012;142:2236S-2244S.
    • (2012) J Nutr , vol.142 , pp. 2236S-2244S
    • Fernstrom, J.D.1
  • 75
    • 85007005410 scopus 로고    scopus 로고
    • Tryptophan intake in the US adult population is not related to liver or kidney function but is associated with depression and sleep outcomes
    • Lieberman HR, Agarwal S, Fulgoni VL III. Tryptophan intake in the US adult population is not related to liver or kidney function but is associated with depression and sleep outcomes. J Nutr. 2016;146:2609S-2615S.
    • (2016) J Nutr , vol.146 , pp. 2609S-2615S
    • Lieberman, H.R.1    Agarwal, S.2    Fulgoni, V.L.3
  • 77
    • 0000395490 scopus 로고
    • Central-nervous-system effects of ingestion of L-tryptophan by normal subjects
    • Smith B, Prockop DJ. Central-nervous-system effects of ingestion of L-tryptophan by normal subjects. N Engl J Med. 1962;267:1338-1341.
    • (1962) N Engl J Med , vol.267 , pp. 1338-1341
    • Smith, B.1    Prockop, D.J.2
  • 78
    • 0014379185 scopus 로고
    • Drugs and sleep
    • Oswald I. Drugs and sleep. Pharmacol Rev. 1968;20:273-303.
    • (1968) Pharmacol Rev , vol.20 , pp. 273-303
    • Oswald, I.1
  • 79
    • 0014661864 scopus 로고
    • Biogenic amines and the states of sleep
    • Jouvet M. Biogenic amines and the states of sleep. Science. 1969;163:32-41.
    • (1969) Science , vol.163 , pp. 32-41
    • Jouvet, M.1
  • 82
  • 83
    • 0013902688 scopus 로고
    • Some experiments in the chemistry of normal sleep
    • Oswald I, Ashcroft GW, Berger RJ, et al. Some experiments in the chemistry of normal sleep. Br J Psychiatry. 1966;112:391-399.
    • (1966) Br J Psychiatry , vol.112 , pp. 391-399
    • Oswald, I.1    Ashcroft, G.W.2    Berger, R.J.3
  • 85
    • 0019789652 scopus 로고
    • Interval therapy with L-tryptophan in severe chronic insomniacs. A predictive laboratory study
    • Schneider-Helmert D. Interval therapy with L-tryptophan in severe chronic insomniacs. A predictive laboratory study. Int Pharmacopsychiatry. 1981;16:162-173.
    • (1981) Int Pharmacopsychiatry , vol.16 , pp. 162-173
    • Schneider-Helmert, D.1
  • 86
    • 0014960951 scopus 로고
    • Effects of L-tryptophan (a natural sedative) on human sleep
    • Wyatt RJ, Engelman K, Kupfer DJ, et al. Effects of L-tryptophan (a natural sedative) on human sleep. Lancet. 1970;296:842-846.
    • (1970) Lancet , vol.296 , pp. 842-846
    • Wyatt, R.J.1    Engelman, K.2    Kupfer, D.J.3
  • 87
    • 0031975666 scopus 로고    scopus 로고
    • Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and mood
    • Bhatti T, Gillin JC, Seifritz E, et al. Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and mood. Biol Psychiatry. 1998;43:52-59.
    • (1998) Biol Psychiatry , vol.43 , pp. 52-59
    • Bhatti, T.1    Gillin, J.C.2    Seifritz, E.3
  • 88
    • 20544471693 scopus 로고    scopus 로고
    • Evening intake of alpha-lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention
    • Markus CR, Jonkman LM, Lammers JH, et al. Evening intake of alpha-lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. Am J Clin Nutr. 2005;81:1026-1033.
    • (2005) Am J Clin Nutr , vol.81 , pp. 1026-1033
    • Markus, C.R.1    Jonkman, L.M.2    Lammers, J.H.3
  • 89
    • 0036798932 scopus 로고    scopus 로고
    • Gastrointestinal melatonin: Localization, function, and clinical relevance
    • Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci. 202;47:2336-2348.
    • Dig Dis Sci , vol.202 , Issue.47 , pp. 2336-2348
    • Bubenik, G.A.1
  • 90
    • 65649123794 scopus 로고    scopus 로고
    • Melatonin and melatonergic drugs on sleep: Possible mechanisms of action
    • Srinivasan V, Pandi-Perumal SR, Trahkt I, et al. Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. 2009;119:821-846.
    • (2009) Int J Neurosci , vol.119 , pp. 821-846
    • Srinivasan, V.1    Pandi-Perumal, S.R.2    Trahkt, I.3
  • 91
    • 72449202629 scopus 로고    scopus 로고
    • Effects of tryptophan loading on human cognition, mood, and sleep
    • Silber BY, Schmitt JA. Effects of tryptophan loading on human cognition, mood, and sleep. Neurosci Biobehav Rev. 2010;34:387-407.
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 387-407
    • Silber, B.Y.1    Schmitt, J.A.2
  • 92
    • 0003041736 scopus 로고
    • Behavioral effects and brain amine content in rats
    • Hess SM, Doepfner W. Behavioral effects and brain amine content in rats. Arch Int Pharmacodyn Ther. 1961;134:89-99.
    • (1961) Arch Int Pharmacodyn Ther , vol.134 , pp. 89-99
    • Hess, S.M.1    Doepfner, W.2
  • 93
    • 0000264756 scopus 로고
    • The catecholamine hypothesis of affective disorders
    • Schildkraut JJ. The catecholamine hypothesis of affective disorders. Am J Psychiat. 1965;122:509-522.
    • (1965) Am J Psychiat , vol.122 , pp. 509-522
    • Schildkraut, J.J.1
  • 94
    • 0016792256 scopus 로고
    • Letter: Tryptophan/imipramine in depression
    • Jensen K, Fruensgaard K, Ahlfors UG, et al. Letter: tryptophan/imipramine in depression. Lancet. 1975;306:920.
    • (1975) Lancet , vol.306 , pp. 920
    • Jensen, K.1    Fruensgaard, K.2    Ahlfors, U.G.3
  • 95
    • 50549205358 scopus 로고
    • Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan
    • Coppen A, Shaw DM, Farrell JP. Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan. Lancet. 1963;281:79-81.
    • (1963) Lancet , vol.281 , pp. 79-81
    • Coppen, A.1    Shaw, D.M.2    Farrell, J.P.3
  • 96
    • 0017085994 scopus 로고
    • Potentiation of the antidepressant action of clomipramine by tryptophan
    • Walinder J, Skott A, Carlsson A, et al. Potentiation of the antidepressant action of clomipramine by tryptophan. Arch Gen Psychiatry. 1976;33:1384-1389.
    • (1976) Arch Gen Psychiatry , vol.33 , pp. 1384-1389
    • Walinder, J.1    Skott, A.2    Carlsson, A.3
  • 97
    • 49749202298 scopus 로고
    • Potentiation of monoamine-oxidase inhibitors by tryptophan
    • Pare CM. Potentiation of monoamine-oxidase inhibitors by tryptophan. Lancet. 1963;282:527-528.
    • (1963) Lancet , vol.282 , pp. 527-528
    • Pare, C.M.1
  • 98
    • 50549084169 scopus 로고    scopus 로고
    • Serotonin and depression: Pathophysiological mechanism or marketing myth?
    • Cowen PJ. Serotonin and depression: pathophysiological mechanism or marketing myth? Trends Pharmacol Sci. 2008;29:433-436.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 433-436
    • Cowen, P.J.1
  • 99
    • 0014650241 scopus 로고
    • Potentiation of a monoamine oxidase inhibitor by tryptophan
    • Glassman AH, Platman SR. Potentiation of a monoamine oxidase inhibitor by tryptophan. J Psychiatr Res. 1969;7:83-88.
    • (1969) J Psychiatr Res , vol.7 , pp. 83-88
    • Glassman, A.H.1    Platman, S.R.2
  • 100
    • 0017312463 scopus 로고
    • Letter: Tryptophan and depression
    • Rao B, Broadhurst AD. Letter: tryptophan and depression. Br Med J. 1976;1:460.
    • (1976) Br Med J , vol.1 , pp. 460
    • Rao, B.1    Broadhurst, A.D.2
  • 101
    • 54049145467 scopus 로고    scopus 로고
    • Effect of different tryptophan sources on amino acids availability to the brain and mood in healthy volunteers
    • Markus CR, Firk C, Gerhardt C, et al. Effect of different tryptophan sources on amino acids availability to the brain and mood in healthy volunteers. Psychopharmacology (Berl). 2008;201:107-114.
    • (2008) Psychopharmacology (Berl , vol.201 , pp. 107-114
    • Markus, C.R.1    Firk, C.2    Gerhardt, C.3
  • 102
    • 84885829081 scopus 로고    scopus 로고
    • Food can lift mood by affecting mood-regulating neurocircuits via a serotonergic mechanism
    • Kroes MC, van Wingen GA, Wittwer J, et al. Food can lift mood by affecting mood-regulating neurocircuits via a serotonergic mechanism. Neuroimage. 2014;84:825-832.
    • (2014) Neuroimage , vol.84 , pp. 825-832
    • Kroes, M.C.1    Van Wingen, G.A.2    Wittwer, J.3
  • 103
    • 34547136705 scopus 로고    scopus 로고
    • Effects of alpha-lactalbumin on emotional processing in healthy women
    • Scrutton H, Carbonnier A, Cowen PJ, et al. Effects of alpha-lactalbumin on emotional processing in healthy women. J Psychopharmacol. 2007;21:519-524.
    • (2007) J Psychopharmacol , vol.21 , pp. 519-524
    • Scrutton, H.1    Carbonnier, A.2    Cowen, P.J.3
  • 104
    • 26044472785 scopus 로고    scopus 로고
    • The effects of a diet enriched with a-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls
    • Merens W, Booij L, Markus R, et al. The effects of a diet enriched with a-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls. Br J Nutr. 2005;94:415-422.
    • (2005) Br J Nutr , vol.94 , pp. 415-422
    • Merens, W.1    Booij, L.2    Markus, R.3
  • 105
    • 84927581733 scopus 로고    scopus 로고
    • Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women
    • Mohajeri MH, Wittwer J, Vargas K, et al. Chronic treatment with a tryptophan-rich protein hydrolysate improves emotional processing, mental energy levels and reaction time in middle-aged women. Br J Nutr. 2015;113:350-365.
    • (2015) Br J Nutr , vol.113 , pp. 350-365
    • Mohajeri, M.H.1    Wittwer, J.2    Vargas, K.3
  • 106
    • 0036038492 scopus 로고    scopus 로고
    • Epilepsy in the world today: Medical point of view
    • Engel J. Epilepsy in the world today: medical point of view. Epilepsia. 2002;43(suppl 6):12-13.
    • (2002) Epilepsia , vol.43 , pp. 12-13
    • Engel, J.1
  • 108
    • 39849110735 scopus 로고    scopus 로고
    • Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy
    • Mainardi P, Leonardi A, Albano C. Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy. Med Hypotheses. 2008;70:876-879.
    • (2008) Med Hypotheses , vol.70 , pp. 876-879
    • Mainardi, P.1    Leonardi, A.2    Albano, C.3
  • 109
    • 0015415059 scopus 로고
    • Effects of L-tryptophan, L-3, 4, dihydroxy-phenylalanine and tranylcypromine on the electroencephalogram and on photically induced epilepsy in the baboon, Papio papio
    • Meldrum BS, Balzamo E, Wada JA, et al. Effects of L-tryptophan, L-3, 4, dihydroxy-phenylalanine and tranylcypromine on the electroencephalogram and on photically induced epilepsy in the baboon, Papio papio. Physiol Behav. 1972;9:615-621.
    • (1972) Physiol Behav , vol.9 , pp. 615-621
    • Meldrum, B.S.1    Balzamo, E.2    Wada, J.A.3
  • 110
    • 0015434599 scopus 로고
    • Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio)
    • Wada JA, Balzamo E, Meldrum BS, et al. Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio). Electroencephalogr Clin Neurophysiol. 1972;33:520-526.
    • (1972) Electroencephalogr Clin Neurophysiol , vol.33 , pp. 520-526
    • Wada, J.A.1    Balzamo, E.2    Meldrum, B.S.3
  • 111
    • 0027957693 scopus 로고
    • Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats
    • Yan QS, Jobe PC, Dailey JW. Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. Eur J Pharmacol. 1994;252:105-112.
    • (1994) Eur J Pharmacol , vol.252 , pp. 105-112
    • Yan, Q.S.1    Jobe, P.C.2    Dailey, J.W.3
  • 112
    • 0017936879 scopus 로고
    • Manipulation of cerebral monoamines in the treatment of human epilepsy: A pilot study
    • Chadwick D, Trimble M, Jenner P, et al. Manipulation of cerebral monoamines in the treatment of human epilepsy: a pilot study. Epilepsia. 1978;19:3-10.
    • (1978) Epilepsia , vol.19 , pp. 3-10
    • Chadwick, D.1    Trimble, M.2    Jenner, P.3
  • 113
    • 0021014969 scopus 로고
    • Tryptophan in hyperactive child syndrome associated with epilepsy: A controlled study
    • Ghose KL. Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. Neuropsychobiology. 1983;10:111-114.
    • (1983) Neuropsychobiology , vol.10 , pp. 111-114
    • Ghose, K.L.1
  • 114
    • 0017837886 scopus 로고
    • Has tryptophan any anticonvulsive effect?
    • Raotma H. Has tryptophan any anticonvulsive effect? Acta Psychiatr Scand. 1978;57:253-258.
    • (1978) Acta Psychiatr Scand , vol.57 , pp. 253-258
    • Raotma, H.1
  • 115
    • 79957951224 scopus 로고    scopus 로고
    • Preclinical activity profile of a-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy
    • Citraro R, Scicchitano F, De Fazio S, et al. Preclinical activity profile of a-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. Epilepsy Res. 2011;95:60-69.
    • (2011) Epilepsy Res , vol.95 , pp. 60-69
    • Citraro, R.1    Scicchitano, F.2    De Fazio, S.3
  • 116
    • 84867283591 scopus 로고    scopus 로고
    • Protective activity of a-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis
    • Russo E, Scicchitano F, Citraro R, et al. Protective activity of a-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience. 2012;226:282-288.
    • (2012) Neuroscience , vol.226 , pp. 282-288
    • Russo, E.1    Scicchitano, F.2    Citraro, R.3
  • 117
    • 85007004321 scopus 로고    scopus 로고
    • A perspective on the safety of supplemental tryptophan based on its metabolic fates
    • Fernstrom JD. A perspective on the safety of supplemental tryptophan based on its metabolic fates. J Nutr. 2016;146:2601S-2608S.
    • (2016) J Nutr , vol.146 , pp. 2601S-2608S
    • Fernstrom, J.D.1
  • 118
    • 84873412061 scopus 로고    scopus 로고
    • An expanding range of targets for kynurenine metabolites of tryptophan
    • Stone TW, Stoy N, Darlington LG. An expanding range of targets for kynurenine metabolites of tryptophan. Trends Pharmacol Sci. 2013;34:136-143.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 136-143
    • Stone, T.W.1    Stoy, N.2    Darlington, L.G.3
  • 119
    • 56549106178 scopus 로고    scopus 로고
    • NMDA-induced seizure intensity is enhanced in COX-2 deficient mice
    • Toscano CD, Kingsley PJ, Marnett LJ, et al. NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008;29:1114-1120.
    • (2008) Neurotoxicology , vol.29 , pp. 1114-1120
    • Toscano, C.D.1    Kingsley, P.J.2    Marnett, L.J.3
  • 120
    • 0020677595 scopus 로고
    • Biochemistry of tryptophan in health and disease
    • Bender DA. Biochemistry of tryptophan in health and disease. Mol Aspects Med. 1983;6:101-197.
    • (1983) Mol Aspects Med , vol.6 , pp. 101-197
    • Bender, D.A.1
  • 121
    • 0024551587 scopus 로고
    • Neuroactive metabolites of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid. Effect of tryptophan loading
    • During MJ, Freese A, Heyes MP, et al. Neuroactive metabolites of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid. Effect of tryptophan loading. FEBS Lett. 1989;247:438-444.
    • (1989) FEBS Lett , vol.247 , pp. 438-444
    • During, M.J.1    Freese, A.2    Heyes, M.P.3
  • 122
    • 84859582577 scopus 로고    scopus 로고
    • Quinolinic acid, the inescapable neurotoxin
    • Guillemin GJ. Quinolinic acid, the inescapable neurotoxin. FEBS J. 2012;279:1356-1365.
    • (2012) FEBS J , vol.279 , pp. 1356-1365
    • Guillemin, G.J.1
  • 123
    • 0034490318 scopus 로고    scopus 로고
    • Immunomodulatory properties of milk
    • Cross ML, Gill HS. Immunomodulatory properties of milk. Br J Nutr. 2000;84:S81-S89.
    • (2000) Br J Nutr , vol.84 , pp. S81-S89
    • Cross, M.L.1    Gill, H.S.2
  • 124
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G, Fang YZ, Yang S, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489-492.
    • (2004) J Nutr , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3
  • 126
    • 84922693699 scopus 로고    scopus 로고
    • Dairy intake is associated with brain glutathione concentration in older adults
    • Choi IY, Lee P, Denney DR, et al. Dairy intake is associated with brain glutathione concentration in older adults. Am J Clin Nutr. 2015;101:287-293.
    • (2015) Am J Clin Nutr , vol.101 , pp. 287-293
    • Choi, I.Y.1    Lee, P.2    Denney, D.R.3
  • 127
    • 0024817818 scopus 로고
    • The influence of dietary whey protein on tissue glutathione and the diseases of aging
    • Bounous G, Gervais F, Amer V, et al. The influence of dietary whey protein on tissue glutathione and the diseases of aging. Clin Invest Med. 1989;12:343-349.
    • (1989) Clin Invest Med , vol.12 , pp. 343-349
    • Bounous, G.1    Gervais, F.2    Amer, V.3
  • 128
    • 0242488033 scopus 로고    scopus 로고
    • Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein
    • Grey V, Mohammed SR, Smountas AA, et al. Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibros. 2003;2:195-198.
    • (2003) J Cyst Fibros , vol.2 , pp. 195-198
    • Grey, V.1    Mohammed, S.R.2    Smountas, A.A.3
  • 130
    • 29144501452 scopus 로고    scopus 로고
    • Comparative nutrition and metabolism: Explication of open questions with emphasis on protein and amino acids
    • Baker DH. Comparative nutrition and metabolism: explication of open questions with emphasis on protein and amino acids. Proc Nat Acad Sci U S A. 2005;102:17897-17902.
    • (2005) Proc Nat Acad Sci U S A , vol.102 , pp. 17897-17902
    • Baker, D.H.1
  • 131
    • 84942052973 scopus 로고    scopus 로고
    • An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly
    • McCarty MF, DiNicolantonio JJ. An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly. Age (Dordr). 2015;37:96. doi:10.1007/ s11357-015-9823-8
    • (2015) Age (Dordr) , vol.37 , pp. 96
    • McCarty, M.F.1    DiNicolantonio, J.J.2
  • 132
    • 0020459343 scopus 로고
    • Influence of dietary proteins on the immune system of mice
    • Bounous G, Kongshavn PAL. Influence of dietary proteins on the immune system of mice. J Nutr. 1982;112:1747-1755.
    • (1982) J Nutr , vol.112 , pp. 1747-1755
    • Bounous, G.1    Kongshavn, P.A.L.2
  • 133
    • 0020789262 scopus 로고
    • Influence of dietary protein type on the immune system of mice
    • Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr. 1983;113:1415-1421.
    • (1983) J Nutr , vol.113 , pp. 1415-1421
    • Bounous, G.1    Letourneau, L.2    Kongshavn, P.A.L.3
  • 134
    • 0346095559 scopus 로고    scopus 로고
    • Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content
    • Mariotti F, Simbelie KL, Makarios-Lahham K, et al. Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr. 2004;134:128-131.
    • (2004) J Nutr , vol.134 , pp. 128-131
    • Mariotti, F.1    Simbelie, K.L.2    Makarios-Lahham, K.3
  • 135
    • 0035131418 scopus 로고    scopus 로고
    • Effects of dietary protein types on immune respnses and levels of infecion with Eimeria vermiformis in mice
    • Ford JT, Wong CW, Colditz IG. Effects of dietary protein types on immune respnses and levels of infecion with Eimeria vermiformis in mice. Immunol Cell Biol. 2001;79:23-28.
    • (2001) Immunol Cell Biol , vol.79 , pp. 23-28
    • Ford, J.T.1    Wong, C.W.2    Colditz, I.G.3
  • 136
    • 34447301540 scopus 로고    scopus 로고
    • Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal
    • Blouet C, Mariotti F, Mikogami T, et al. Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal. J Nutr Biochem. 2007;18:519-524.
    • (2007) J Nutr Biochem , vol.18 , pp. 519-524
    • Blouet, C.1    Mariotti, F.2    Mikogami, T.3
  • 137
    • 0036932921 scopus 로고    scopus 로고
    • Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients
    • Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr. 2002;41:12-18.
    • (2002) Eur J Nutr , vol.41 , pp. 12-18
    • Micke, P.1    Beeh, K.M.2    Buhl, R.3
  • 138
    • 0035105157 scopus 로고    scopus 로고
    • Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients
    • Micke P, Beeh KM, Schlaak JF, et al. Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients. Eur J Clin Invest. 2001;31:171-178.
    • (2001) Eur J Clin Invest , vol.31 , pp. 171-178
    • Micke, P.1    Beeh, K.M.2    Schlaak, J.F.3
  • 139
    • 0034131064 scopus 로고    scopus 로고
    • Effects of whey protein and resistance exercise on body composition and muscle strength in women with HIV infection
    • Agin D, Kotler DP, Papandreou D, et al. Effects of whey protein and resistance exercise on body composition and muscle strength in women with HIV infection. Ann N Y Acad Sci. 2000;904:607-609.
    • (2000) Ann N Y Acad Sci , vol.904 , pp. 607-609
    • Agin, D.1    Kotler, D.P.2    Papandreou, D.3
  • 140
    • 84881254292 scopus 로고    scopus 로고
    • Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the PROT-AGE Study Group
    • Bauer J, Biolo G, Cederholm T, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc. 2013;14:542-559.
    • (2013) J Am Med Dir Assoc , vol.14 , pp. 542-559
    • Bauer, J.1    Biolo, G.2    Cederholm, T.3
  • 141
    • 0033489873 scopus 로고    scopus 로고
    • Glutamine and the immune system
    • Calder PC, Yaqoob P. Glutamine and the immune system. Amino Acids. 1999;17:227-241.
    • (1999) Amino Acids , vol.17 , pp. 227-241
    • Calder, P.C.1    Yaqoob, P.2
  • 142
    • 31544455514 scopus 로고    scopus 로고
    • Branched-chain amino acids and immunity
    • Calder PC. Branched-chain amino acids and immunity. J Nutr. 2006;136:288S-293S.
    • (2006) J Nutr , vol.136 , pp. 288S-293S
    • Calder, P.C.1
  • 143
    • 85027991309 scopus 로고    scopus 로고
    • Branched-chain amino acids and muscle protein synthesis in humans: Myth or reality?
    • Wolfe RR. Branched-chain amino acids and muscle protein synthesis in humans: myth or reality? J Inter Soc Sports Nutr. 2017;17:30-37.
    • (2017) J Inter Soc Sports Nutr , vol.17 , pp. 30-37
    • Wolfe, R.R.1
  • 144
    • 58149107240 scopus 로고    scopus 로고
    • Maximizing muscle protein anabolism: The role of protein quality
    • Tang JE, Phillips SM. Maximizing muscle protein anabolism: the role of protein quality. Curr Opin Clin Nutr Metab Care. 2009;12:66-71.
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 66-71
    • Tang, J.E.1    Phillips, S.M.2
  • 145
    • 83455176892 scopus 로고    scopus 로고
    • Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men
    • Groen BB, Res PT, Pennings B, et al. Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men. Am J Physiol Endocrinol Metab. 2012;302:E52-E60.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E52-E60
    • Groen, B.B.1    Res, P.T.2    Pennings, B.3
  • 146
    • 84863981572 scopus 로고    scopus 로고
    • Protein ingestion before sleep improves post-exercise overnight recovery
    • Res PT, Groen B, Pennings B, et al. Protein ingestion before sleep improves post-exercise overnight recovery. Med Sci Sports Exerc. 2012;44:1560-1569.
    • (2012) Med Sci Sports Exerc , vol.44 , pp. 1560-1569
    • Res, P.T.1    Groen, B.2    Pennings, B.3
  • 147
    • 84930798108 scopus 로고    scopus 로고
    • Protein ingestion before sleep increases muscle mass and strength gains during prolonged resistance-type exercise training in healthy young men
    • Snijders T, Res PT, Smeets JS, et al. Protein ingestion before sleep increases muscle mass and strength gains during prolonged resistance-type exercise training in healthy young men. J Nutr. 2015;145:1178-1184.
    • (2015) J Nutr , vol.145 , pp. 1178-1184
    • Snijders, T.1    Res, P.T.2    Smeets, J.S.3
  • 148
    • 0032530784 scopus 로고    scopus 로고
    • Interrelations between sleep and the somato-tropic axis
    • Van Cauter E, Plat L, Copinschi G. Interrelations between sleep and the somato-tropic axis. Sleep. 1998;21:553-566.
    • (1998) Sleep , vol.21 , pp. 553-566
    • Van Cauter, E.1    Plat, L.2    Copinschi, G.3
  • 149
    • 0015043521 scopus 로고
    • Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man
    • Marliss EB, Aoki TT, Pozefsky T, et al. Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man. J Clin Invest. 1971;50:814-817.
    • (1971) J Clin Invest , vol.50 , pp. 814-817
    • Marliss, E.B.1    Aoki, T.T.2    Pozefsky, T.3
  • 150
    • 0036233129 scopus 로고    scopus 로고
    • Branched-chain amino acid supplementation and the immune response of long-distance athletes
    • Bassit RA, Sawada LA, Bacurau RFP, et al. Branched-chain amino acid supplementation and the immune response of long-distance athletes. Nutrition. 2002;18:376-379.
    • (2002) Nutrition , vol.18 , pp. 376-379
    • Bassit, R.A.1    Sawada, L.A.2    Bacurau, R.F.P.3
  • 151
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311-326.
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 152
    • 84951907695 scopus 로고    scopus 로고
    • Branched-chain amino acids as biomarkers in diabetes
    • Giesbertz P, Daniel H. Branched-chain amino acids as biomarkers in diabetes. Curr Opin Clin Nutr Metab Care. 2016;19:48-54.
    • (2016) Curr Opin Clin Nutr Metab Care , vol.19 , pp. 48-54
    • Giesbertz, P.1    Daniel, H.2
  • 153
    • 84969793241 scopus 로고    scopus 로고
    • Specific metabolic profiles and their relationship to insulin resistance in recent-onset type 1 and type 2 diabetes
    • Knebel B, Strassburger K, Szendroedi J, et al. Specific metabolic profiles and their relationship to insulin resistance in recent-onset type 1 and type 2 diabetes. J Clin Endocrinol Metab. 2016;101:2130-2140.
    • (2016) J Clin Endocrinol Metab , vol.101 , pp. 2130-2140
    • Knebel, B.1    Strassburger, K.2    Szendroedi, J.3
  • 154
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
    • e21187.
    • Macotela Y, Emanuelli B, Bang AM, et al. Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011;6:e21187. doi:10.1371/journal.pone.0021187
    • (2011) PLoS One , vol.6
    • Macotela, Y.1    Emanuelli, B.2    Bang, A.M.3
  • 155
    • 84878622190 scopus 로고    scopus 로고
    • Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity
    • Lackey DE, Lynch CJ, Olson KC, et al. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab. 2013;304:E1175-E1187.
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E1175-E1187
    • Lackey, D.E.1    Lynch, C.J.2    Olson, K.C.3
  • 157
    • 31544440119 scopus 로고    scopus 로고
    • Potential importance of leucine in treatment of obesity and the metabolic syndrome
    • Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006;136(1 suppl):319S-323S.
    • (2006) J Nutr , vol.136 , Issue.1 , pp. 319S-323S
    • Layman, D.K.1    Walker, D.A.2
  • 158
    • 84927173996 scopus 로고    scopus 로고
    • Branched-chain amino acids in metabolic signalling and insulin resistance
    • Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014;10:723-736.
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 723-736
    • Lynch, C.J.1    Adams, S.H.2
  • 159
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17:448-453.
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3
  • 160
    • 84930966126 scopus 로고    scopus 로고
    • Reviewing the effects of L-leucine supplementation in the regulation of food intake, energy balance, and glucose homeostasis
    • Pedroso JA, Zampieri TT, Donato J Jr. Reviewing the effects of L-leucine supplementation in the regulation of food intake, energy balance, and glucose homeostasis. Nutrients. 2015;7:3914-3937.
    • (2015) Nutrients , vol.7 , pp. 3914-3937
    • Pedroso, J.A.1    Zampieri, T.T.2    Donato, J.3
  • 161
    • 0022409215 scopus 로고
    • Mechanism of altered B-cell response induced by changes in dietary protein type in mice
    • Bounous G, Shenouda N, Kongshavn PAL, et al. Mechanism of altered B-cell response induced by changes in dietary protein type in mice. J Nutr. 1985;115:1409-1417.
    • (1985) J Nutr , vol.115 , pp. 1409-1417
    • Bounous, G.1    Shenouda, N.2    Kongshavn, P.A.L.3
  • 162
    • 0028902218 scopus 로고
    • Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats
    • Mcintoch GH, Regester GO, Le Leu RK, et al. Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats. J Nutr. 1995;125:809-816.
    • (1995) J Nutr , vol.125 , pp. 809-816
    • Mcintoch, G.H.1    Regester, G.O.2    Le Leu, R.K.3
  • 163
    • 0033959892 scopus 로고    scopus 로고
    • Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats
    • Hakkak R, Korourian S, Shelnutt SR, et al. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev. 2000;9:113-117.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 113-117
    • Hakkak, R.1    Korourian, S.2    Shelnutt, S.R.3
  • 164
    • 0037303477 scopus 로고    scopus 로고
    • Effect of whey proein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells
    • Kent KD, Harper WJ, Bomser JA. Effect of whey proein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol in Vitro. 2003;17:27-33.
    • (2003) Toxicol in Vitro , vol.17 , pp. 27-33
    • Kent, K.D.1    Harper, W.J.2    Bomser, J.A.3
  • 165
    • 85012913916 scopus 로고    scopus 로고
    • HAMLET-a protein-lipid complex with broad tumoricidal activity
    • Ho JCS, Nadeem A, Svanborg C. HAMLET-a protein-lipid complex with broad tumoricidal activity. Biochem Biophys Res Comm. 2017;482:454-458.
    • (2017) Biochem Biophys Res Comm , vol.482 , pp. 454-458
    • Ho, J.C.S.1    Nadeem, A.2    Svanborg, C.3
  • 166
    • 84979782485 scopus 로고    scopus 로고
    • Structure and potential cellular targets of HAMLET-like anti-cancer compounds made from milk components
    • Rath EM, Duff AP, Hakansson AP, et al. Structure and potential cellular targets of HAMLET-like anti-cancer compounds made from milk components. J Pharm Pharm Sci. 2015;18:773-824.
    • (2015) J Pharm Pharm Sci , vol.18 , pp. 773-824
    • Rath, E.M.1    Duff, A.P.2    Hakansson, A.P.3
  • 167
    • 73949096838 scopus 로고    scopus 로고
    • BAMLET activates a lysosomal cell death program in cancer cells
    • Rammer P, Groth-Pedersen L, Kirkegaard T, et al. BAMLET activates a lysosomal cell death program in cancer cells. Mol Cancer Ther. 2010;9:24-32.
    • (2010) Mol Cancer Ther , vol.9 , pp. 24-32
    • Rammer, P.1    Groth-Pedersen, L.2    Kirkegaard, T.3
  • 168
    • 84878114780 scopus 로고    scopus 로고
    • The biological activities of protein/oleic acid complexes reside in the fatty acid
    • Fontana A, Spolaore B, Polverino de Laureto P. The biological activities of protein/oleic acid complexes reside in the fatty acid. Biochim Biophys Acta. 2013;1834:1125-1143.
    • (2013) Biochim Biophys Acta , vol.1834 , pp. 1125-1143
    • Fontana, A.1    Spolaore, B.2    Polverino De Laureto, P.3
  • 169
    • 33646386189 scopus 로고    scopus 로고
    • A-Lactalbumin species variation, HAMLET formation, and tumor cell death
    • Pettersson J, Mossberg AK, Svanborg C. a-Lactalbumin species variation, HAMLET formation, and tumor cell death. Biochem Biophys Res Comm. 2006;345:260-270.
    • (2006) Biochem Biophys Res Comm , vol.345 , pp. 260-270
    • Pettersson, J.1    Mossberg, A.K.2    Svanborg, C.3
  • 170
    • 84930947026 scopus 로고    scopus 로고
    • The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the a-lactalbumin component
    • Delgado Y, Morales-Cruz M, Figueroa CM, et al. The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the a-lactalbumin component. FEBS Open Bio. 2015;5:397-404.
    • (2015) FEBS Open Bio , vol.5 , pp. 397-404
    • Delgado, Y.1    Morales-Cruz, M.2    Figueroa, C.M.3
  • 171
    • 84877882472 scopus 로고    scopus 로고
    • Molecular mechanisms of the cytotoxicity of human a-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes
    • Nakamura T, Aizawa T, Kariya R, et al. Molecular mechanisms of the cytotoxicity of human a-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes. J Biol Chem. 2013;288:14408-14416.
    • (2013) J Biol Chem , vol.288 , pp. 14408-14416
    • Nakamura, T.1    Aizawa, T.2    Kariya, R.3
  • 172
    • 84891869306 scopus 로고    scopus 로고
    • The effect of proteolysis on the induction of cell death by monomeric alpha-lactalbumin
    • Bruck WM, Gibson GR, Bruck TB. The effect of proteolysis on the induction of cell death by monomeric alpha-lactalbumin. Biochimie. 2014;97:138-143.
    • (2014) Biochimie , vol.97 , pp. 138-143
    • Bruck, W.M.1    Gibson, G.R.2    Bruck, T.B.3
  • 173
    • 84905565494 scopus 로고    scopus 로고
    • Gastric digestion of a-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling
    • Sullivan LM, Kehoe JJ, Barry L, et al. Gastric digestion of a-lactalbumin in adult human subjects using capsule endoscopy and nasogastric tube sampling. Br J Nutr. 2014;112:638-646.
    • (2014) Br J Nutr , vol.112 , pp. 638-646
    • Sullivan, L.M.1    Kehoe, J.J.2    Barry, L.3
  • 174
    • 2942746332 scopus 로고    scopus 로고
    • Treatment of skin papillomas with topical a-lacalbumin-oleic acid
    • Gustafsson L, Leijonhufvud I, Aronsson A, et al. Treatment of skin papillomas with topical a-lacalbumin-oleic acid. N Engl J Med. 2004;350:2663-2672.
    • (2004) N Engl J Med , vol.350 , pp. 2663-2672
    • Gustafsson, L.1    Leijonhufvud, I.2    Aronsson, A.3
  • 175
    • 34548073069 scopus 로고    scopus 로고
    • Bladder cancers respond to intravesical instillation of HAMLET (human a-lactalbumin made lethal to tumor cells)
    • Mossberg AK, Wullt B, Gustafsson L, et al. Bladder cancers respond to intravesical instillation of HAMLET (human a-lactalbumin made lethal to tumor cells). Int J Cancer. 2007;121:1352-1359.
    • (2007) Int J Cancer , vol.121 , pp. 1352-1359
    • Mossberg, A.K.1    Wullt, B.2    Gustafsson, L.3
  • 176
    • 77949288877 scopus 로고    scopus 로고
    • HAMLET treatment delays bladder cancer development
    • Mossberg AK, Hou Y, Svensson M, et al. HAMLET treatment delays bladder cancer development. J Urol. 2010;183:1590-1597.
    • (2010) J Urol , vol.183 , pp. 1590-1597
    • Mossberg, A.K.1    Hou, Y.2    Svensson, M.3
  • 177
    • 1542405871 scopus 로고    scopus 로고
    • Human a-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brian xenografts by an apoptosis-like mechanism and prolongs survival
    • Fischer W, Gustafsson L, Mossberg AK, et al. Human a-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brian xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res. 2004;64:2105-2112.
    • (2004) Cancer Res , vol.64 , pp. 2105-2112
    • Fischer, W.1    Gustafsson, L.2    Mossberg, A.K.3
  • 178
    • 84889631663 scopus 로고    scopus 로고
    • Prevention and treatment of colon cancer by peroral administratioin of HAMLET (human a-lactalbumin made lethal to tu-mour cells)
    • Puthia M, Storm P, Nadeem A, et al. Prevention and treatment of colon cancer by peroral administratioin of HAMLET (human a-lactalbumin made lethal to tu-mour cells). Gut. 2013;63:131-142.
    • (2013) Gut , vol.63 , pp. 131-142
    • Puthia, M.1    Storm, P.2    Nadeem, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.