Bladder cancers respond to intravesical instillation of HAMLET (human α-lactalbumin made lethal to tumor cells)

International Journal of Cancer

Volumn 121, Issue 6, 2007, Pages 1352-1359

  Mossberg, Ann Kristin ^a   Wullt, Björn ^a   Gustafsson, Lotta ^a   Månsson, Wiking ^a   Ljunggren, Eva ^a   Svanborg, Catharina ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

lactalbumin; Apoptosis; Bladder cancer; Protein folding; Therapeutics

Indexed keywords

ALPHA LACTALBUMIN; CIPROFLOXACIN; PHOSPHATE BUFFERED SALINE; SODIUM CHLORIDE; TRIMETHOPRIM;

ADULT; AGED; APOPTOSIS; ARTICLE; BLADDER CARCINOMA; CLINICAL ARTICLE; CYSTOSCOPY; HUMAN; MALE; NICK END LABELING; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA; TRANSURETHRAL RESECTION; TREATMENT DURATION; TREATMENT INDICATION; TUMOR VOLUME;

ADMINISTRATION, INTRAVESICAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, TRANSITIONAL CELL; HUMANS; IN SITU NICK-END LABELING; LACTALBUMIN; MALE; OLEIC ACIDS; URINARY BLADDER NEOPLASMS;

EID: 34548073069     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22810     Document Type: Article

References (16)

1. Sengupta N, Siddiqui E, Mumtaz FH. Cancers of the bladder. J R Soc Health 2004;124:228-9.
2. Soloway MS, Sofer M, Vaidya A. Contemporary management of stage T1 transitional cell carcinoma of the bladder. J Urol 2002;167:1573-83.
3. Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D, Skinner DG. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 2001;19:666-75.
4. Malmstrom PU. Advances in intravesical therapy of urinary bladder cancer. Expert Rev Anticancer Ther 2004;4:1057-67.
5. Schenkman E, Lamm DL. Superficial bladder cancer therapy. Sci World J 2004;4(Suppl 1):387-99.
6. Hudson MA, Herr HW. Carcinoma in situ of the bladder. J Urol 1995;153:564-72.
7. Lamm DL. Efficacy and safety of bacille Calmette-Guerin immunotherapy in superficial bladder cancer. Clin Infect Dis 2000;31(Suppl 3):S86-90.
8. Svensson M, Mossberg AK, Pettersson J, Linse S, Svanborg C. Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human α-lactalbumin made lethal to tumor cells). Protein Sci 2003;12:2805-14.
9. Hakansson A, Zhivotovsky B, Orrenius S, Sabharwal H, Svanborg C. Apoptosis induced by a human milk protein. Proc Natl Acad Sci USA 1995;92:8064-8.
10. Svensson M, Håkansson A, Mossberg AK, Linse S, Svanborg C. Conversion of α-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci USA 2000;97:4221-26.
11. Svensson M, Fast J, Mossberg AK, Duringer C, Gustafsson L, Hallgren O, Brooks CL, Berliner L, Linse S, Svanborg C. α-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human α-lactalbumin made lethal to tumor cells). Protein Sci 2003;12:2794-804.
12. Svensson M, Hakansson A, Mossberg AK, Linse S, Svanborg C. Conversion of α-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci USA 2000;97:4221-6.
13. Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig R, Svanborg C. Human α-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res 2004;64:2105-12.
14. Gustafsson L, Leijonhufvud I, Aronsson A, Mossberg AK, Svanborg C. Treatment of skin papillomas with topical α-lactalbumin-oleic acid. N Engl J Med 2004;350:2663-72.
15. Svanborg C, Agerstam H, Aronson A, Bjerkvig R, Duringer C, Fischer W, Gustafsson L, Hallgren O, Leijonhuvud I, Linse S, Mossberg AK, Nilsson H et al. HAMLET kills tumor cells by an apoptosis-like mechanism - cellular, molecular, and therapeutic aspects. Adv Cancer Res 2003;88:1-29.
16. Schamhart DH, de Boer EC, de Reijke TM, Kurth K. Urinary cytokines reflecting the immunological response in the urinary bladder to biological response modifiers: their practical use. Eur Urol 2000;37(Suppl 3):16-23.