α-Lactalbumin and casein-glycomacropeptide do not affect iron absorption from formula in healthy term infants

Journal of Nutrition

Volumn 142, Issue 7, 2012, Pages 1226-1231

  Szymlek Gay, Ewa A ^a,b   Lönnerdal, Bo ^c   Abrams, Steven A ^d   Kvistgaard, Anne S ^e   Domellöf, Magnus ^b   Hernell, Olle ^b  

^a DEAKIN UNIVERSITY   (Australia)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e Arla Foods   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LACTALBUMIN; CASEIN; FERRITIN; GLYCOPROTEIN; MILK PROTEIN;

ARTICLE; ARTIFICIAL MILK; BREAST FEEDING; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; ERYTHROPOIESIS; FERRITIN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INFANT; INFANT FEEDING; INFANT NUTRITION; IRON ABSORPTION; IRON DEFICIENCY ANEMIA; IRON STORAGE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

ANEMIA, IRON-DEFICIENCY; CASEINS; DIET; ERYTHROPOIESIS; FEMALE; FERRITINS; HUMANS; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INTESTINAL ABSORPTION; IRON; IRON, DIETARY; LACTALBUMIN; MALE; NUTRITIONAL STATUS; PEPTIDE FRAGMENTS; REFERENCE VALUES;

EID: 84863545540     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.153890     Document Type: Article

References (42)

1. de Benoist B, McLean E, Egli I, Cogswell ME. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. Geneva: WHO; 2008.
2. Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Longlasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64:S34-43.
3. McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr. 2007;85:931-45.
4. Baker RD, Greer FR. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010;126:1040-50.
5. Koletzko B, Baker S, Cleghorn G, Neto UF, Gopalan S, Hernell O, Hock QS, Jirapinyo P, Lönnerdal B, Pencharz P, et al. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastroenterol Nutr. 2005;41:584-99.
6. Commission Directive 2006/141/EC of 22 December 2006 on infant formulae and follow-on formulae and amending Directive 1999/21/EC. Official Journal of the European Union; 2006;49:1-33 [cited 2011 Jan 27]. Available from: http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L:06:401:SOM:EN:HTML.
7. Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr. 2006; 84:1261-76.
8. Aggett PJ, Agostoni C, Axelsson I, Bresson J-L, Goulet O, Hernell O, Koletzko B, Lafeber HL, Michaelsen KF, Micheli J-L, et al. Iron metabolism and requirements in early childhood: do we know enough? A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2002;34:337-45.
9. Stekel A, Olivares M, Pizarro F, Chadud P, Lopez I, Amar M. Absorption of fortification iron from milk formulas in infants. Am J Clin Nutr. 1986;43:917-22.
10. Kastenmayer P, Davidsson L, Galan P, Cherouvrier F, Hercberg S, Hurrell RF. A double stable isotope technique for measuring iron absorption in infants. Br J Nutr. 1994;71:411-24.
11. Fomon SJ, Ziegler EE, Serfass RE, Nelson SE, Frantz JA. Erythrocyte incorporation of iron is similar in infants fed formulas fortified with 12mg/L or 8mg/L of iron. J Nutr. 1997;127:83-8.
12. Davidsson L, Ziegler EE, Kastenmayer P, Hurrell RF. Erythrocyte incorporation of iron by infants: iron bioavailability from a low-iron infant formula and an evaluation of the usefulness of correcting erythrocyte incorporation values, using a reference dose or plasma ferritin concentrations. Br J Nutr. 2000;84:847-53.
13. Lönnerdal B, Lien EL. Nutritional and physiologic significance of alphalactalbumin in infants. Nutr Rev. 2003;61:295-305.
14. Etzel MR. Manufacture and use of dairy protein fractions. JNutr. 2004;134: S996-1002.
15. Lönnerdal B, Glazier C. Calcium binding by alpha-lactalbumin in human milk and bovine milk. J Nutr. 1985;115:1209-16.
16. Ren J, Stuart DI, Acharya KR. Alpha-lactalbumin possesses a distinct zinc binding site. J Biol Chem. 1993;268:19292-8.
17. Manso MA, López-Fandiño R. κ-Casein macropeptides from cheese whey: physicochemical, biological, nutritional, and technological features for possible uses. Food Rev Int. 2004;20:329-55.
18. Traving C, Schauer R. Structure, function and metabolism of sialic acids. Cell Mol Life Sci. 1998;54:1330-49.
19. Brück WM, Redgrave M, Tuohy KM, Lönnerdal B, Graverholt G, Hernell O, Gibson GR. Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. J Pediatr Gastroenterol Nutr. 2006;43:673-9.
20. Andersson Y, Hammarström ML, Lönnerdal B, Graverholt G, Fält H, Hernell O. Formula feeding skews immune cell composition toward adaptive immunity compared to breastfeeding. J Immunol. 2009; 183:4322-8.
21. Sandström O, Lönnerdal B, Graverholt G, Hernell O. Effects of alphalactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition. Am J Clin Nutr. 2008;87:921-8.
22. Chatterton D, Holst HH. A process for preparing a kappa-caseino glycomacropeptide or a derivative thereof. Viby (Denmark): MD Foods AMBA; 1999.
23. Holt C, McPhail D, Nevison I, Nylander T, Otte J, Ipsen RH, Bauer R, Ogendal L, Olieman K, de Kruif KG, et al. Apparent chemical composition of nine commercial or semi-commercial whey protein concentrates, isolates and fractions. Int J Food Sci Technol. 1999;34:543-56.
24. WHO. Anthro for personal computers, version 3.1; 2010. Software for assessing growth and development of the world's children. Geneva: WHO [cited 2010 Nov 5]. Available from: http://www.who.int/childgrowth/software/en/
25. Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lönnerdal B. Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. J Nutr. 2006;136:2435-8.
26. Abrams SA. Using stable isotopes to assess mineral absorption and utilization by children. Am J Clin Nutr. 1999;70:955-64.
27. Saarinen UM, Siimes MA. Developmental changes in red blood cell counts and indices of infants after exclusion of iron deficiency by laboratory criteria and continuous iron supplementation. J Pediatr. 1978;92:412-6.
28. Saarinen UM, Siimes MA. Developmental changes in serum iron, total iron-binding capacity, and transferrin saturation in infancy. J Pediatr. 1977;91:875-7.
29. Saarinen UM, Siimes MA. Serum ferritin in assessment of iron nutrition in healthy infants. Acta Paediatr Scand. 1978;67:745-51.
30. Butte NF, Lopez-Alarcon MG, Garza C. Nutrient adequacy of exclusive breastfeeding for the term infant during the first six months of life. Geneva: WHO; 2002.
31. Kelleher SL, Chatterton D, Nielsen K, Lönnerdal B. Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr. 2003;77:1261-8.
32. Murakami K, Berliner LJ. A distinct zinc binding site in the alphalactalbumins regulates calcium binding. Is there a physiological role for this control? Biochemistry. 1983;22:3370-4.
33. Lönnerdal B. Biological effects of novel bovine milk fractions. Nestle Nutr Workshop Ser Pediatr Program. 2011;67:41-54.
34. Berglund S, Lönnerdal B, Westrup B, Domellöf M. Effects of iron supplementation on serum hepcidin and serum erythropoietin in lowbirth-weight infants. Am J Clin Nutr. 2011;94:1553-61.
35. Ganz T. Hepcidin and iron regulation, 10 years later. Blood. 2011; 117:4425-33.
36. Lönnerdal B, Hernell O. Iron, zinc, copper and selenium status of breast-fed infants and infants fed trace element fortified milk-based infant formula. Acta Paediatr. 1994;83:367-73.
37. Hernell O, Lönnerdal B. Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides. Am J Clin Nutr. 2002;76:858-64.
38. Saarinen UM, Siimes MA, Dallman PR. Iron absorption in infants: high bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin. J Pediatr. 1977;91:36-9.
39. Abrams SA, Wen J, Stuff JE. Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants. Pediatr Res. 1997;41: 384-90.
40. Davidsson L, Kastenmayer P, Yuen M, Lönnerdal B, Hurrell RF. Influence of lactoferrin on iron absorption from human milk in infants. Pediatr Res. 1994;35:117-24.
41. Domellöf M, Lönnerdal B, Abrams SA, Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr. 2002;76:198-204.
42. Lönnerdal B, Hernell O. Homeostatic regulation of iron and its role in normal and abnormal iron status in infancy and childhood. Ann Nestlé. 2010;68:96-104.