Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy

Medical Hypotheses

Volumn 70, Issue 4, 2008, Pages 876-879

  Mainardi, P ^a   Leonardi, A ^a   Albano, C ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYTRYPTOPHAN; ALPHA LACTALBUMIN; FLUOXETINE; LACTOFERRIN; TRYPTOPHAN;

ARTICLE; BLOOD BRAIN BARRIER; CLINICAL TRIAL; DEPRESSION; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG EXCRETION; DRUG MECHANISM; EPILEPSY; HUMAN; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; TRYPTOPHAN BRAIN LEVEL;

BLOOD-BRAIN BARRIER; BRAIN; DRUG RESISTANCE; EPILEPSY; HUMANS; LACTALBUMIN; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PILOT PROJECTS; SEIZURES; SEROTONIN; TIME FACTORS; TRYPTOPHAN;

EID: 39849110735     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.06.039     Document Type: Article

References (28)

1. Löscher W., and Leppik I.E. Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs. Epilepsy Res 50 (2002) 17-20
2. Perucca E. What can we learn from clinical trials of anticonvulsant drugs in epilepsy?. Eur J Pain 6 Suppl. A (2002) 35-44
3. Perucca E. Patient-tailored antiepileptic drug therapy: predicting response to antiepileptic drugs. Int Congr Ser 1244 (2002) 93-103
4. Truscott T.C. Effects of phenylalanine and 5-hydroxytryptophan on seizure severity in mice. Pharmacol Biochem Behav 3 (1975) 939-941
5. Boggan W.O., and Seiden L.S. 5-Hydroxytryptophan reversal of reserpine enhancement of audiogenic seizure susceptibility in mice. Physiol Behav 10 (1973) 9
6. Wenger G.R., Stitzel R.E., and Craig C.R. The role of biogenic amines in the reserpine-induced alteration of minimal electroshock seizure thresholds in the mouse. Neuropharmacology 12 (1973) 693-703
7. Lazarova M., Bendotti C., and Samanin R. Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate. Arch Pharmacol 322 (1983) 147-152
8. Maynert E., Marczynski T., and Browning R. The role of neurotransmitters in the epilepsies. Adv Neurol 13 (1975) 79-147
9. Pallister P.D. Aggravation of epilepsy by reserpine, associated with possible bleeding and clotting disturbances. Rocky Mt Med J 56 (1982) 45-50
10. Favale E., Rubino V., Mainardi P., Lunardi G., and Albano C. Anticonvulsant effect of fluoxetine in humans. Neurology 45 (1995) 1926
11. Favale E., Audenino D., Cocito L., and Albano C. The anticonvulsant effect of citalopram as an indirect evidence of serotonergic impairment in human epileptogenesis. Seizures 12 (2003) 316
12. Albano C., Cupello A., Mainardi P., Scarrone S., and Favale E. Successful treatment of epilepsy with serotonin reuptake inhibitors: proposed mechanism. Neurochem Res 31 4 (2006) 509-514 Epub 2006 May 13
13. Jobe P.C., and Browning R.A. The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Epilepsy Behav 7 (2005) 602-619
14. Ko F.J., Chiang C.H., Liu W.J., and Chiang W. Alteration of amino acid in plasma and cerebrospinal fluid of children with seizure disorders. Ko Hsiung I Hsueh Ko Hsueh Tsa Chih 9 3 (1993) 131-142
15. Marion J.L., Bigot J.C., and Goas J.Y. Alcoholic epilepsy: decrease of tryptophan levels in the blood and cerebrospinal fluid. Presse Med 14 12 (1985) 681-683
16. Lunardi G., Mainardi P., Rubino V., et al. Tryptophan and epilepsy. In: Allegri Filippini G., and Costa V.L. (Eds). Recent advances in tryptophan research (1995), Plenum Press, New York and London 101-102
17. Mauri M.C., et al. Predictive value of amino acids in the treatment of major depression with fluvoxamine. Neuropsychobiology 44 3 (2001) 134-138
18. Song C., Lin A., Bonaccorso S., et al. The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. J Affect Disorders 49 3 (1998) 211-219
19. Diksic M., Okazawa S., Nishizawa S., Leyton M., and Young S.N. A decrease in blood tryptophan concentration produces regionally specific changes in brain serotonin synthesis in men and women: a PET study with alpha-[11C]methyl-l-tryptophan. Eur Neuropsychopharmacol 12 Suppl. 3 (2002) 403-404
20. Scudder C.L., Karczmar A.G., Everett G.M., Gibson J.E., and Rifkin M. Brain catecholamines and serotonin levels in various strains and genera of mice and a possible interpretation for the correlation of amine levels with electroshock latency and behaviour. Int J Neuropharmacol 5 (1966) 343-351
21. Heine W., et al. The significance of trypthophan in human nutrition. Amino Acid 9 (1995) 191
22. Yokogoshi H., and Wurtman R.J. Meal composition and plasma amino acid ratios: effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism 35 9 (1986) 837-842
23. Markus C.R., et al. Evening intake of alpha-lactoalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. Am J Clin Nutr 71 (2000) 1536
24. Troost F.J., Steijns J., Saris W.H., and Brummer R.J. Gastric digestion of bovine lactoferrin in vivo in adults. J Nutr 131 (2001) 2101-2104
25. Boirie Y., Dangin M., Gachon P., et al. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 94 (1997) 14930-14935
26. Hall W.L., Millward D.J., Long S.J., and Morgan L.M. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Brit J Nutr 89 (2003) 239-248
27. Troost F.J., Saris W.H., and Brummer R.J. Orally ingested human lactoferrin is digested and secreted in the upper astrointestinal tract in vivo in women with ileostomies. J Nutr 132 (2002) 2597-2600
28. Albano C, Mainardi P, Leonardi A. An increasing in brain serotonin improves the clinical outcome in drug resistant epileptic patients. In: 7th European congress on epileptology, Helsinki, 2-8 July; 2006.