Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat

Behavioural Brain Research

Volumn 148, Issue 1-2, 2004, Pages 1-10

  Orosco, Martine ^a   Rouch, Claude ^a   Beslot, Françoise ^b   Feurte, Sébastien ^c   Regnault, Alain ^c   Dauge, Valérie ^b  

^a CNRS   (France)

^b INSERM   (France)

^c ZAE Les Haies   (France)

Author keywords

Alpha lactalbumin ingestion; Anxiety like behaviour; Hypothalamus; Serotonin; Sucrose consumption

Indexed keywords

ALPHA LACTALBUMIN; CASEIN; SEROTONIN; SUCROSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; DIET; FEEDING; FOOD COMPOSITION; FOOD INTAKE; HYPOTHALAMUS; INGESTION; MALE; MAZE TEST; MEAL; MICRODIALYSIS; MOOD; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; REWARD; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; TIME; TRANQUILIZING ACTIVITY;

EID: 0347626245     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(03)00153-0     Document Type: Article

References (49)

1. Arevalo C., de Miguel R., Hernandez-Tristan R. Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. Pharmacol. Biochem. Behav. 70:2001;123-131.
2. Berk M. Selective serotonin reuptake inhibitors in mixed anxiety-depression. Int. Clin. Psychopharmacol. 15(Suppl. 2):2000;S41-S45.
3. Carboni E., Cadoni C., Tanda G.L., Di Chiara G. Calcium-dependent, tetrodotoxin-sensitive stimulation of cortical serotonin release after a tryptophan load. J. Neurochem. 53:1989;976-978.
4. Cowen P.J. Psychotrophic drugs and human 5-HT neuroendocrinology. Trends Pharmacol. Sci. 8:1987;105-108.
5. Daugé V., Rossignol P., Roques B.P. Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes. Psychopharmacology. 96:1988;343-352.
6. Daugé V., Steimes P., Derrien M., Beau N., Roques B.P., Féger J. CCK8 effects on motivational and emotional states of rats involve CCKA receptors of the postero-median part of the nucleus accumbens. Pharmacol. Biochem. Behav. 34:1989;157-163.
7. Dourish C.T., Hutson P.H., Curzon G. Putative anxiolytics 8-OH-DPAT, busiprone and TVXQ7821 are agonists at 5-HT1A autoreceptors in the raphe nuclei. Trends Pharmacol. Sci. 7:1986;212-214.
8. Fernstrom J.D. Dietary effects on brain serotonin synthesis: relationship to appetite regulation. Am. J. Clin. Nutr. 42:1985;1072-1082.
9. Fernstrom J.D. Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. J. Nutr. Biochem. 1:1990;508-517.
10. Fernstrom J.D., Wurtman R.J. Brain serotonin content: increase following ingestion of a carbohydrate diet. Science. 174:1971;197-204.
11. Fernstrom J.D., Wurtman R.J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 178:1972;414-416.
12. Feurté S., Gerozissis K., Regnault A., Paul F.M. Plasma Trp/LNAA ratio increases during chronic ingestion of an alpha-lactalbumin diet in rats. Nutr. Neurosci. 4:2001;413-418.
13. Handley S.N., McBlan J.W. 5-HT drugs in animal models of anxiety. Psychopharmacology. 112:1993;13-20.
14. Harrison A.A., Markou A. Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors. J. Pharmacol. Exp. Ther. 297:2001;316-325.
15. Heine W., Radke M., Wutzke K.D., Peters E., Kundt G. Alpha-lactalbumin- enriched low-protein infant formulas: a comparison to breast milk feeding. Acta Paediatr. 85:1996;1024-1028.
16. Higgins G.A., Jones B.J., Oakley N.R. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection. Psychopharmacology. 106:1992;261-267.
17. Inoue T., Tsuchiya K., Koyama T. Serotonergic activation reduces defensive freezing in the conditioned fear paradigm. Pharmacol. Biochem. Behav. 53:1994;825-831.
18. Kahn R.S., Van Praag H.M., Wetzler S., Asnis G.M., Barr G. Serotonin and anxiety revisited. Biol. Psychiatry. 23:1988;189-208.
19. Kalen P., Strecker R.E., Rosengren E., Björklund A. Endogenous release of neuronal serotonin and 5-hydroxyindoleacetic acid in the caudate-putamen of the rat as revealed by intracerebral dialysis coupled to high-performance liquid chromatography with fluorimetric detection. J. Neurochem. 51:1988;1422-1435.
20. Koks S., Beljajev S., Koovit I., Abramov U., Bourin M., Vasar E. 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. Psychopharmacology. 153:2001;365-372.
21. Kuhn D.M., Arthur R. Jr., States J.C. Phosphorylation and activation of brain tryptophan hydroxylase: identification of serine-58 as a substrate site for protein kinase A. J. Neurochem. 68:1997;2220-2223.
22. Leibowitz SF. Neurochemical systems of the hypothalamus. Control of feeding and drinking behaviour and water-electrolyte excretion. In: Morgane PJ, Panksepp J, editors. Handbook of the hypothalamus. New York: Marcel Dekker; 1980. p. 299-437.
23. Manjarrez G.G., Chagoya G.G., Hernandez J. Early nutritional changes modify the kinetics and phosphorylation capacity of tryptophan-5-hydroxylase. Int. J. Dev. Neurosci. 12:1994;695-702.
24. Markus C.R., Panhuysen G., Tuiten A., Koppeschaar H., Fekkes D., Peters M.L. Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task? Appetite. 31:1998;49-65.
25. Markus C.R., Klopping-Ketelaars W.I., Pasman W., Klarenbeek B., Van den Berg H. Dose-dependent effect of alpha-lactalbumin in combination with two different doses of glucose on the plasma Trp/LNAA ratio. Nutr. Neurosci. 3:2000;345-355.
26. Markus C.R., Olivier B., Panhuysen G.E.M., Van der Gugten J., Alles M.S., Tuiten A.et al. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am. J. Clin. Nutr. 71:2000;1536-1544.
27. Meyers S. Use of neurotransmitter precursors for treatment of depression. Altern. Med. Rev. 5:2000;64-71.
28. Moret C., Briley M. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Eur. J. Pharmacol. 295:1996;189-197.
29. Orosco M., Rouch C., Daugé V. Behavioral responses to ingestion of different sources of fat. Involvement of serotonin? Behav. Brain Res. 132:2002;103-109.
30. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press; 1986.
31. Pellow S., Chopin P., File S.E., Briley M. Validation of open/closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
32. Pigott T.A., Hill J.L., Grady T.A., L'Heureux F., Berstein S., Rubinstein C.S.et al. A comparison of the behavioural effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biol. Psychiatry. 33:1993;3-14.
33. Raap D.K., Van de Kar L.D. Selective serotonin reuptake inhibitors and neuroendocrine function. Life Sci. 65:1999;1217-1235.
34. Robert J.J., Orosco M., Rouch C., Cohen Y., Jacquot C. Effects of dexfenfluramine and opioid peptides, alone or in combination on food intake and brain serotonin turnover. Pharmacol. Biochem. Behav. 38:1991;775-780.
35. Rouch C., Nicolaïdis S., Orosco M. Determination, using microdialysis, of hypothalamic serotonin variations in response to different macronutrients. Physiol. Behav. 65:1999;653-657.
36. Rouch C., Nicolaïdis S., Orosco M. Effects of pure macronutrient ingestion on plasma tryptophan and large neutral amino acids. Nutr. Neurosci. 4:2001;63-73.
37. Schaechter J.D., Wurtman R.J. Tryptophan availability modulates serotonin release from rat hypothalamic slices. J. Neurochem. 53:1989;1925-1933.
38. Schwartz D.H., Hernandez L., Hoebel B.G. Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats. Brain Res. Bull. 25:1990;803-807.
39. Sharp T., Bramwell S.R., Grahame-Smith D.G. Effect of acute administration of L-tryptophan on the release of 5-HT in rat hippocampus in relation to serotoninergic neuronal activity: an in vivo microdialysis study. Life Sci. 5:1992;1215-1223.
40. Sprouse J.S., Aghajanian G.K. Electrophysiological responses of serotonergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse. 1:1987;3-9.
41. Stone T.W. Kynurenines in the CNS: from endogenous obscurity to therapeutic importance. Prog. Neurobiol. 64:2001;185-218.
42. Stone T.W., Connick J.H. Quinolinic acid and other kynurenines in the central nervous system. Neuroscience. 15:1985;597-617.
43. Thomson J., Rankin H., Ashcroft G.W., Yates C.M., McQueen J.K., Cummings S.W. The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo. Psychol. Med. 12:1982;741-751.
44. Trulson M.E., Jacobs B.L. Dose-response relationship between systemically administered L-tryptophan or L-5-hydroxytryptophan and raphe unit activity in the rat. Neuropharmacology. 15:1976;339-344.
45. Westerink B.H.C., De Vries J.B. Effect of precursor loading on the synthesis rate and release of dopamine and serotonin in the striatum: a microdialysis study in conscious rats. J. Neurochem. 56:1991;228-233.
46. Willner P., Towell A., Sampson D., Muscat R., Sophokleous S. Reduction of sucrose preference by chronic mild stress and its restoration by a tricyclic antidepressant. Psychopharmacology. 93:1987;358-364.
47. Yokogoshi H., Wurtman R.J. Meal composition and plasma amino acid ratios: effect of various proteins or carbohydrates, and of various protein concentrations. Metabolism. 35:1986;837-842.
48. Young SN. The clinical psychopharmacology of tryptophan. In: Wurtman RJ, Wurtman JJ, editors. Food constituents affecting normal and abnormal behaviors. Nutrition and the brain, vol. 7. New York: Raven Press; 1986. p. 49-88.
49. Young S.N. Behavioral effects of dietary neurotransmitter precursors: basic and clinical aspects. Neurosci. Biobehav. Rev. 20:1996;313-323.