Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14408-14416

  Nakamura, Takashi ^a,e   Aizawa, Tomoyasu ^b   Kariya, Ryusho ^c   Okada, Seiji ^c   Demura, Makoto ^b   Kawano, Keiichi ^b,f   Makabe, Koki ^a,d,g   Kuwajima, Kunihiro ^a,d  

^a OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^e Fuji Pharma Co Ltd   (Japan)

^f CHITOSE INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^g YAMAGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; APOPTOTIC ACTIVITY; CANINE MILK LYSOZYME; MOLECULAR MECHANISM; MOLECULAR PROPERTIES; MOLTEN GLOBULE STATE; PULSE FIELD GRADIENTS; TWO-DIMENSIONAL NMR;

CELL MEMBRANES; CYTOTOXICITY; DAIRY PRODUCTS; OLEIC ACID; OLIGOMERS; PROTEINS; TUMORS; TWO DIMENSIONAL;

CYTOLOGY;

ALPHA LACTALBUMIN; APOMYOGLOBIN OLEIC ACID; BETA 2 MICROGLOBULIN OLEIC ACID; CANINE MILK LYSOZYME OLEIC ACID; CYTOTOXIC AGENT; GOAT ALPHA LACTALBUMIUN MADE LETHAL TO TUMOR CELL; HUMAN ALPHA LACTALBUMIUN MADE LETHAL TO TUMOR CELL; MONOMER; OLEIC ACID; OLIGOMER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CELL MEMBRANE TRANSPORT; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; HYDRODYNAMICS; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALPHA-LACTALBUMIN; APOPTOSIS; BIOPHYSICS; FATTY ACID; HAMLET; MOLTEN GLOBULE; NUCLEAR MAGNETIC RESONANCE; PROTEIN FOLDING; PROTEIN-DRUG INTERACTIONS; TUMOR THERAPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG SCREENING ASSAYS, ANTITUMOR; GOATS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTALBUMIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NEOPLASMS; OLEIC ACIDS; PROTEIN BINDING;

EID: 84877882472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.437889     Document Type: Article

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