메뉴 건너뛰기




Volumn 63, Issue 1, 2014, Pages 131-142

Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; HUMAN ALPHA LACTALBUMIN MADE LETHAL TO TUMOR CELL; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84889631663     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303715     Document Type: Article
Times cited : (62)

References (30)
  • 1
    • 77953587132 scopus 로고    scopus 로고
    • Molecular markers to individualize adjuvant therapy for colon cancer
    • Gangadhar T, Schilsky RL. Molecular markers to individualize adjuvant therapy for colon cancer. Nat Rev Clin Oncol 2010;7:318-25.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 318-325
    • Gangadhar, T.1    Schilsky, R.L.2
  • 2
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-36.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3
  • 3
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009;361:2449-60.
    • (2009) N Engl J Med , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 4
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 5
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990;247:322-4.
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 6
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 7
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through β-catenin
    • DOI 10.1126/science.1071549
    • Moon RT, Bowerman B, Boutros M, et al. The promise and perils of Wnt signaling through beta-catenin. Science 2002;296:1644-6. (Pubitemid 34579151)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 8
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000;103:311-20.
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 9
    • 67650379261 scopus 로고    scopus 로고
    • Can misfolded proteins be beneficial? the HAMLET case
    • Pettersson-Kastberg J, Aits S, Gustafsson L, et al. Can misfolded proteins be beneficial? The HAMLET case. Ann Med 2009;41:162-76.
    • (2009) Ann Med , vol.41 , pp. 162-176
    • Pettersson-Kastberg, J.1    Aits, S.2    Gustafsson, L.3
  • 11
    • 1542405871 scopus 로고    scopus 로고
    • Human α-Lactalbumin Made Lethal to Tumor Cells (HAMLET) Kills Human Glioblastoma Cells in Brain Xenografts by an Apoptosis-Like Mechanism and Prolongs Survival
    • DOI 10.1158/0008-5472.CAN-03-2661
    • Fischer W, Gustafsson L, Mossberg AK, et al. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. Cancer Res 2004;64:2105-12. (Pubitemid 38339460)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 2105-2112
    • Fischer, W.1    Gustafsson, L.2    Mossberg, A.-K.3    Gronli, J.4    Mork, S.5    Bjerkvig, R.6    Svanborg, C.7
  • 13
    • 2942746332 scopus 로고    scopus 로고
    • Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid
    • Gustafsson L, Leijonhufvud I, Aronsson A, et al. Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. N Engl J Med 2004;350:2663-72.
    • (2004) N Engl J Med , vol.350 , pp. 2663-2672
    • Gustafsson, L.1    Leijonhufvud, I.2    Aronsson, A.3
  • 14
    • 82455188049 scopus 로고    scopus 로고
    • Conserved features of cancer cells define their sensitivity to HAMLET-induced death; C-Myc and glycolysis
    • Storm P, Aits S, Puthia MK, et al. Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis. Oncogene 2011;30:4765-79.
    • (2011) Oncogene , vol.30 , pp. 4765-4779
    • Storm, P.1    Aits, S.2    Puthia, M.K.3
  • 15
    • 65349095292 scopus 로고    scopus 로고
    • Changes in proteasome structure and function caused by HAMLET in tumor cells
    • Gustafsson L, Aits S, Onnerfjord P, et al. Changes in proteasome structure and function caused by HAMLET in tumor cells. PloS One 2009;4:e5229.
    • (2009) PloS One , vol.4
    • Gustafsson, L.1    Aits, S.2    Onnerfjord, P.3
  • 17
    • 77949425311 scopus 로고    scopus 로고
    • Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in ApcMin/+ mice
    • Koehl GE, Spitzner M, Ousingsawat J, et al. Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in ApcMin/+ mice. Oncogene 2010;29:1553-60.
    • (2010) Oncogene , vol.29 , pp. 1553-1560
    • Koehl, G.E.1    Spitzner, M.2    Ousingsawat, J.3
  • 19
    • 0028578064 scopus 로고
    • Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    • Aberle H, Butz S, Stappert J, et al. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 1994;107:3655-63.
    • (1994) J Cell Sci , vol.107 , pp. 3655-3663
    • Aberle, H.1    Butz, S.2    Stappert, J.3
  • 21
    • 0034719170 scopus 로고    scopus 로고
    • GSK-3β-dependent phosphorylation of adenomatous polyposis cop gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin
    • Ikeda S, Kishida M, Matsuura Y, et al. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Oncogene 2000;19:537-45. (Pubitemid 30099367)
    • (2000) Oncogene , vol.19 , Issue.4 , pp. 537-545
    • Ikeda, S.1    Kishida, M.2    Matsuura, Y.3    Usui, H.4    Kikuchi, A.5
  • 22
    • 77951881189 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at ser 552
    • Zhao J, Yue W, Zhu MJ, et al. AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Biochem Biophys Res Commun 2010;395:146-51.
    • (2010) Biochem Biophys Res Commun , vol.395 , pp. 146-151
    • Zhao, J.1    Yue, W.2    Zhu, M.J.3
  • 23
    • 29144506662 scopus 로고    scopus 로고
    • Ion channels and cancer
    • DOI 10.1007/s00232-005-0781-4
    • Kunzelmann K. Ion channels and cancer. J Membr Biol 2005;205:159-73. (Pubitemid 41803693)
    • (2005) Journal of Membrane Biology , vol.205 , Issue.3 , pp. 159-173
    • Kunzelmann, K.1
  • 24
    • 33845373278 scopus 로고    scopus 로고
    • Colorectal cancer and genetic alterations in the Wnt pathway
    • DOI 10.1038/sj.onc.1210059, PII 1210059
    • Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 2006;25:7531-7. (Pubitemid 44885752)
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7531-7537
    • Segditsas, S.1    Tomlinson, I.2
  • 25
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • DOI 10.1242/jcs.00623
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003;116:2627-34. (Pubitemid 36857216)
    • (2003) Journal of Cell Science , vol.116 , Issue.13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 27
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991;325:1593-6.
    • (1991) N Engl J Med , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath Jr., C.W.3
  • 28
    • 78650840096 scopus 로고    scopus 로고
    • Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}
    • Greenspan EJ, Madigan JP, Boardman LA, et al. Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. Cancer Prev Res (Phila) 2011;4:161-71.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 161-171
    • Greenspan, E.J.1    Madigan, J.P.2    Boardman, L.A.3
  • 29
    • 0033065458 scopus 로고    scopus 로고
    • Apoptosis-associated cleavage of β-catenin in human colon cancer and rat hepatoma cells
    • DOI 10.1016/S1357-2725(98)00119-8, PII S1357272598001198
    • Fukuda K. Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. Int J Biochem Cell Biol 1999;31:519-29. (Pubitemid 29112912)
    • (1999) International Journal of Biochemistry and Cell Biology , vol.31 , Issue.3-4 , pp. 519-529
    • Fukuda, K.1
  • 30
    • 84934444496 scopus 로고    scopus 로고
    • Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells)
    • Hallgren O, Aits S, Brest P, et al. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol 2008;606:217-40.
    • (2008) Adv Exp Med Biol , vol.606 , pp. 217-240
    • Hallgren, O.1    Aits, S.2    Brest, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.