Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors

Trends in Biochemical Sciences

Volumn 43, Issue 12, 2018, Pages 1033-1046

  Zhang, Xianjun ^a,b,c   Dong, Shaowei ^a,b,c   Xu, Fei ^a  

^a SHANGHAITECH UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

class Frizzled receptors; ligand binding site; lipid binding groove; structure

Indexed keywords

CHOLESTEROL; FRIZZLED G PROTEIN COUPLED RECEPTOR; FRIZZLED PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; G PROTEIN COUPLED RECEPTOR; SMOOTHENED PROTEIN;

BINDING SITE; CRYSTAL STRUCTURE; DIMERIZATION; DRUG DESIGN; HUMAN; HYDROPHILICITY; LIGAND BINDING; LIPID MEMBRANE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; UPREGULATION; ANIMAL; CHEMISTRY; METABOLISM;

ANIMALS; FRIZZLED RECEPTORS; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; SMOOTHENED RECEPTOR;

EID: 85054450985     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2018.09.002     Document Type: Review

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