Crystal structure of the Frizzled 4 receptor in a ligand-free state

Nature

Volumn 560, Issue 7720, 2018, Pages 666-670

  Yang, Shifan ^a   Wu, Yiran ^a   Xu, Ting Hai ^b   de Waal, Parker W ^b   He, Yuanzheng ^c   Pu, Mengchen ^a   Chen, Yuxiang ^a,d,e   DeBruine, Zachary J ^b   Zhang, Bingjie ^a   Zaidi, Saheem A ^f   Popov, Petr ^f,g   Guo, Yu ^a,d,e   Han, Gye Won ^f   Lu, Yang ^c   Suino Powell, Kelly ^b   Dong, Shaowei ^a,d,e   Harikumar, Kaleeckal G ^h   Miller, Laurence J ^h   Katritch, Vsevolod ^f,g   Xu, H Eric ^b,i   Shui, Wenqing ^a   Stevens, Raymond C ^a   Melcher, Karsten ^b   Zhao, Suwen ^a   Xu, Fei ^a   more..

^a SHANGHAITECH UNIVERSITY   (China)

^b VAN ANDEL RESEARCH INSTITUTE   (United States)

^c HARBIN INSTITUTE OF TECHNOLOGY   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

^h MAYO GRADUATE SCHOOL   (United States)

ⁱ SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FRIZZLED 4 RECEPTOR; FRIZZLED PROTEIN; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG; CYSTEINE; DISHEVELLED PROTEIN; FZD4 PROTEIN, HUMAN; LIGAND;

CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; HUMAN; HYDROPHILICITY; LETTER; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; WNT SIGNALING; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISHEVELLED PROTEINS; FRIZZLED RECEPTORS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN DOMAINS; WNT SIGNALING PATHWAY;

EID: 85052670328     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0447-x     Document Type: Article

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