Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 16, 2017, Pages 4147-4152

  Nile, Aaron H ^a   Mukund, Susmith ^a   Stanger, Karen ^a   Wang, Weiru ^a   Hannoush, Rami N ^a  

^a GENENTECH INC   (United States)

Author keywords

Cysteine rich domain; Dimerization; Fatty acid; Frizzled; Wnt

Indexed keywords

CARBOXYLIC ACID; CIS FATTY ACID; FRIZZLED PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MONOMER; SECRETED FRIZZLED RELATED PROTEIN 5; UNSATURATED FATTY ACID; WNT PROTEIN; BETA CATENIN; CYSTEINE; LIGAND; PROTEIN BINDING;

ALPHA HELIX; ARTICLE; CELL SURFACE; CRYSTAL STRUCTURE; CYSTEINE RICH DOMAIN; DIMERIZATION; INSECT CELL; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; WNT SIGNALING PATHWAY; CHEMISTRY; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BETA CATENIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; FATTY ACIDS, UNSATURATED; FRIZZLED RECEPTORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; WNT PROTEINS;

EID: 85017659327     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1618293114     Document Type: Article

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