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Volumn 10, Issue 10, 2018, Pages

Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity

Author keywords

Bitter; Diet; Dysbiosis; Microbiome; Microbiota; Obesity; T2R; TAS2R

Indexed keywords

CALCIUM ION; CHOLECYSTOKININ; GLUCAGON LIKE PEPTIDE 1; SHORT CHAIN FATTY ACID; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

EID: 85053874831     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu10101336     Document Type: Review
Times cited : (30)

References (69)
  • 1
    • 85021392905 scopus 로고    scopus 로고
    • Sugars, Sweet Taste Receptors, and Brain Responses
    • [CrossRef] [PubMed]
    • Lee, A.A.; Owyang, C. Sugars, Sweet Taste Receptors, and Brain Responses. Nutrients 2017, 9, 653. [CrossRef] [PubMed]
    • (2017) Nutrients , vol.9 , pp. 653
    • Lee, A.A.1    Owyang, C.2
  • 2
    • 85029754062 scopus 로고    scopus 로고
    • Type 1 Taste Receptors in Taste and Metabolism
    • [CrossRef] [PubMed]
    • Kochem, M. Type 1 Taste Receptors in Taste and Metabolism. Ann. Nutr. Metab. 2017, 70 (Suppl 3), 27–36. [CrossRef] [PubMed]
    • (2017) Ann. Nutr. Metab , vol.70 , pp. 27-36
    • Kochem, M.1
  • 3
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • [CrossRef]
    • Zhang, Y.; Hoon, M.A.; Chandrashekar, J.; Mueller, K.L.; Cook, B.; Wu, D.; Zuker, C.S.; Ryba, N.J. Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways. Cell 2003, 112, 293–301. [CrossRef]
    • (2003) Cell , vol.112 , pp. 293-301
    • Zhang, Y.1    Hoon, M.A.2    Chandrashekar, J.3    Mueller, K.L.4    Cook, B.5    Wu, D.6    Zuker, C.S.7    Ryba, N.J.8
  • 5
    • 3242730464 scopus 로고    scopus 로고
    • Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD)
    • [CrossRef] [PubMed]
    • Duffy, V.B. Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite 2004, 43, 5–9. [CrossRef] [PubMed]
    • (2004) Appetite , vol.43 , pp. 5-9
    • Duffy, V.B.1
  • 7
    • 48249123411 scopus 로고    scopus 로고
    • Measures of Individual Differences in Taste and Creaminess Perception
    • [CrossRef] [PubMed]
    • Lim, J.; Urban, L.; Green, B.G. Measures of Individual Differences in Taste and Creaminess Perception. Chem. Senses 2008, 33, 493–501. [CrossRef] [PubMed]
    • (2008) Chem. Senses , vol.33 , pp. 493-501
    • Lim, J.1    Urban, L.2    Green, B.G.3
  • 8
    • 79951772037 scopus 로고    scopus 로고
    • Genetic variation in taste perception: Does it have a role in healthy eating?
    • [CrossRef] [PubMed]
    • Feeney, E.; O’Brien, S.; Scannell, A.; Markey, A.; Gibney, E.R. Genetic variation in taste perception: Does it have a role in healthy eating? Proc. Nutr. Soc. 2011, 70, 135–143. [CrossRef] [PubMed]
    • (2011) Proc. Nutr. Soc , vol.70 , pp. 135-143
    • Feeney, E.1    O’Brien, S.2    Scannell, A.3    Markey, A.4    Gibney, E.R.5
  • 10
    • 84959518053 scopus 로고    scopus 로고
    • The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity
    • [CrossRef] [PubMed]
    • Avau, B.; Depoortere, I. The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity. Acta Physiol. 2016, 216, 407–420. [CrossRef] [PubMed]
    • (2016) Acta Physiol , vol.216 , pp. 407-420
    • Avau, B.1    Depoortere, I.2
  • 11
    • 85012918828 scopus 로고    scopus 로고
    • Extraoral bitter taste receptors in health and disease
    • [CrossRef] [PubMed]
    • Lu, P.; Zhang, C.-H.; Lifshitz, L.M.; ZhuGe, R. Extraoral bitter taste receptors in health and disease. J. Gen. Physiol. 2017, 149, 181–197. [CrossRef] [PubMed]
    • (2017) J. Gen. Physiol. , vol.149 , pp. 181-197
    • Lu, P.1    Zhang, C.-H.2    Lifshitz, L.M.3    Zhuge, R.4
  • 12
    • 79952138344 scopus 로고    scopus 로고
    • Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    • [CrossRef] [PubMed]
    • Janssen, S.; Laermans, J.; Verhulst, P.J.; Thijs, T.; Tack, J.; Depoortere, I. Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc. Natl. Acad. Sci. USA 2011, 108, 2094–2099. [CrossRef] [PubMed]
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 2094-2099
    • Janssen, S.1    Laermans, J.2    Verhulst, P.J.3    Thijs, T.4    Tack, J.5    Depoortere, I.6
  • 13
    • 84946718364 scopus 로고    scopus 로고
    • Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation
    • [CrossRef] [PubMed]
    • Avau, B.; Rotondo, A.; Thijs, T.; Andrews, C.N.; Janssen, P.; Tack, J.; Depoortere, I. Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation. Sci. Rep. 2015, 5, 15985. [CrossRef] [PubMed]
    • (2015) Sci. Rep , vol.5 , pp. 15985
    • Avau, B.1    Rotondo, A.2    Thijs, T.3    Andrews, C.N.4    Janssen, P.5    Tack, J.6    Depoortere, I.7
  • 15
    • 84889637546 scopus 로고    scopus 로고
    • Taste receptors of the gut: Emerging roles in health and disease
    • [CrossRef] [PubMed]
    • Depoortere, I. Taste receptors of the gut: Emerging roles in health and disease. Gut 2014, 63, 179–190. [CrossRef] [PubMed]
    • (2014) Gut , vol.63 , pp. 179-190
    • Depoortere, I.1
  • 16
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • [CrossRef] [PubMed]
    • Turnbaugh, P.J.; Backhed, F.; Fulton, L.; Gordon, J.I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008, 3, 213–223. [CrossRef] [PubMed]
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Backhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 18
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • [CrossRef] [PubMed]
    • Ley, R.E.; Turnbaugh, P.J.; Klein, S.; Gordon, J.I. Microbial ecology: Human gut microbes associated with obesity. Nature 2006, 444, 1022–1023. [CrossRef] [PubMed]
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 19
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • [CrossRef] [PubMed]
    • Turnbaugh, P.J.; Ley, R.E.; Mahowald, M.A.; Magrini, V.; Mardis, E.R.; Gordon, J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444, 1027–1031. [CrossRef] [PubMed]
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 20
    • 33846542071 scopus 로고    scopus 로고
    • Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    • [CrossRef] [PubMed]
    • Bäckhed, F.; Manchester, J.K.; Semenkovich, C.F.; Gordon, J.I. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. USA 2007, 104, 979–984. [CrossRef] [PubMed]
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 979-984
    • Bäckhed, F.1    Manchester, J.K.2    Semenkovich, C.F.3    Gordon, J.I.4
  • 21
    • 85050577004 scopus 로고    scopus 로고
    • Gut Microbiome and Obesity: A Plausible Explanation for Obesity
    • [CrossRef] [PubMed]
    • Sanmiguel, C.; Gupta, A.; Mayer, E.A. Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Curr. Obes. Rep. 2015, 4, 250–261. [CrossRef] [PubMed]
    • (2015) Curr. Obes. Rep , vol.4 , pp. 250-261
    • Sanmiguel, C.1    Gupta, A.2    Mayer, E.A.3
  • 22
    • 84856736806 scopus 로고    scopus 로고
    • Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota
    • [CrossRef] [PubMed]
    • Swartz, T.D.; Duca, F.A.; deWouters, T.; Sakar, Y.; Covasa, M. Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota. Br. J. Nutr. 2012, 107, 621–630. [CrossRef] [PubMed]
    • (2012) Br. J. Nutr , vol.107 , pp. 621-630
    • Swartz, T.D.1    Duca, F.A.2    Dewouters, T.3    Sakar, Y.4    Covasa, M.5
  • 23
    • 84912120764 scopus 로고    scopus 로고
    • Bitter taste genetics—The relationship to tasting, liking, consumption and health
    • [CrossRef] [PubMed]
    • Beckett, E.L.; Martin, C.; Yates, Z.; Veysey, M.; Duesing, K.; Lucock, M. Bitter taste genetics—The relationship to tasting, liking, consumption and health. Food Funct. 2014, 5, 3040–3054. [CrossRef] [PubMed]
    • (2014) Food Funct , vol.5 , pp. 3040-3054
    • Beckett, E.L.1    Martin, C.2    Yates, Z.3    Veysey, M.4    Duesing, K.5    Lucock, M.6
  • 25
    • 68649098537 scopus 로고    scopus 로고
    • Genetic Variation in Taste Sensitivity to 6-n-Propylthiouracil and Its Relationship to Taste Perception and Food Selection
    • Beverly, J.T.; Elizabeth, A.W.; Yvonne, K.; Carmela, L.; Pio, D.A.; Paolo, G. Genetic Variation in Taste Sensitivity to 6-n-Propylthiouracil and Its Relationship to Taste Perception and Food Selection. Ann. N. Y. Acad. Sci. 2009, 1170, 126–139.
    • (2009) Ann. N. Y. Acad. Sci , vol.1170 , pp. 126-139
    • Beverly, J.T.1    Elizabeth, A.W.2    Yvonne, K.3    Carmela, L.4    Pio, D.A.5    Paolo, G.6
  • 26
    • 84878846904 scopus 로고    scopus 로고
    • Influence of the PROP Bitter Taste Phenotype and Eating Attitudes on Energy Intake and Weight Status in Pre-adolescents: A 6-year Follow-up Study
    • [CrossRef] [PubMed]
    • Oftedal, K.N.; Tepper, B.J. Influence of the PROP Bitter Taste Phenotype and Eating Attitudes on Energy Intake and Weight Status in Pre-adolescents: A 6-year Follow-up Study. Physiol. Behav. 2013, 118. [CrossRef] [PubMed]
    • (2013) Physiol. Behav , pp. 118
    • Oftedal, K.N.1    Tepper, B.J.2
  • 27
    • 0025279095 scopus 로고
    • Variations in human taste bud density and taste intensity perception
    • [CrossRef]
    • Miller, I.J., Jr.; Reedy, F.E. Jr. Variations in human taste bud density and taste intensity perception. Physiol. Behav. 1990, 47, 1213–1219. [CrossRef]
    • (1990) Physiol. Behav , vol.47 , pp. 1213-1219
    • Miller, I.J.1    Reedy, F.E.2
  • 28
    • 32044451572 scopus 로고    scopus 로고
    • Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake
    • [CrossRef] [PubMed]
    • Dinehart, M.E.; Hayes, J.E.; Bartoshuk, L.M.; Lanier, S.L.; Duffy, V.B. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol. Behav. 2006, 87, 304–313. [CrossRef] [PubMed]
    • (2006) Physiol. Behav , vol.87 , pp. 304-313
    • Dinehart, M.E.1    Hayes, J.E.2    Bartoshuk, L.M.3    Lanier, S.L.4    Duffy, V.B.5
  • 29
    • 85026737395 scopus 로고    scopus 로고
    • Genetic variation in bitter taste receptor gene TAS2R38, PROP taster status and their association with body mass index and food preferences in Indian population
    • [CrossRef] [PubMed]
    • Deshaware, S.; Singhal, R. Genetic variation in bitter taste receptor gene TAS2R38, PROP taster status and their association with body mass index and food preferences in Indian population. Gene 2017, 627, 363–368. [CrossRef] [PubMed]
    • (2017) Gene , vol.627 , pp. 363-368
    • Deshaware, S.1    Singhal, R.2
  • 30
    • 34547112813 scopus 로고    scopus 로고
    • Genetic Sensitivity to 6-n-Propylthiouracil Has No Influence on Dietary Patterns, Body Mass Indexes, or Plasma Lipid Profiles of Women
    • [CrossRef] [PubMed]
    • Drewnowski, A.; Henderson, S.A.; Cockroft, J.E. Genetic Sensitivity to 6-n-Propylthiouracil Has No Influence on Dietary Patterns, Body Mass Indexes, or Plasma Lipid Profiles of Women. J. Am. Diet. Assoc. 2007, 107, 1340–1348. [CrossRef] [PubMed]
    • (2007) J. Am. Diet. Assoc , vol.107 , pp. 1340-1348
    • Drewnowski, A.1    Henderson, S.A.2    Cockroft, J.E.3
  • 31
    • 26944452877 scopus 로고    scopus 로고
    • Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil
    • [CrossRef] [PubMed]
    • Goldstein, G.L.; Daun, H.; Tepper, B.J. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes. Res. 2005, 13, 1017–1023. [CrossRef] [PubMed]
    • (2005) Obes. Res , vol.13 , pp. 1017-1023
    • Goldstein, G.L.1    Daun, H.2    Tepper, B.J.3
  • 32
    • 53849098349 scopus 로고    scopus 로고
    • Variation in the Bitter-taste Receptor Gene TAS2R38, and Adiposity in a Genetically Isolated Population in Southern Italy
    • [CrossRef] [PubMed]
    • Tepper, B.J.; Koelliker, Y.; Zhao, L.; Ullrich, N.V.; Lanzara, C.; D’Adamo, P.; Ferrara, A.; Ulivi, S.; Esposito, L.; Gasparini, P. Variation in the Bitter-taste Receptor Gene TAS2R38, and Adiposity in a Genetically Isolated Population in Southern Italy. Obesity 2008, 16, 2289–2295. [CrossRef] [PubMed]
    • (2008) Obesity , vol.16 , pp. 2289-2295
    • Tepper, B.J.1    Koelliker, Y.2    Zhao, L.3    Ullrich, N.V.4    Lanzara, C.5    D’Adamo, P.6    Ferrara, A.7    Ulivi, S.8    Esposito, L.9    Gasparini, P.10
  • 33
  • 34
    • 74449087964 scopus 로고    scopus 로고
    • Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    • [CrossRef] [PubMed]
    • Dotson, C.D.; Shaw, H.L.; Mitchell, B.D.; Munger, S.D.; Steinle, N.I. Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women. Appetite 2010, 54, 93–99. [CrossRef] [PubMed]
    • (2010) Appetite , vol.54 , pp. 93-99
    • Dotson, C.D.1    Shaw, H.L.2    Mitchell, B.D.3    Munger, S.D.4    Steinle, N.I.5
  • 39
    • 84959449511 scopus 로고    scopus 로고
    • Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects
    • [CrossRef] [PubMed]
    • Latorre, R.; Huynh, J.; Mazzoni, M.; Gupta, A.; Bonora, E.; Clavenzani, P.; Chang, L.; Mayer, E.A.; De Giorgio, R.; Sternini, C. Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects. PLoS ONE 2016, 11, e0147468. [CrossRef] [PubMed]
    • (2016) Plos ONE , vol.11
    • Latorre, R.1    Huynh, J.2    Mazzoni, M.3    Gupta, A.4    Bonora, E.5    Clavenzani, P.6    Chang, L.7    Mayer, E.A.8    De Giorgio, R.9    Sternini, C.10
  • 40
    • 84907197891 scopus 로고    scopus 로고
    • Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract
    • [CrossRef] [PubMed]
    • Vegezzi, G.; Anselmi, L.; Huynh, J.; Barocelli, E.; Rozengurt, E.; Raybould, H.; Sternini, C. Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PLoS ONE 2014, 9, e107732. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Vegezzi, G.1    Anselmi, L.2    Huynh, J.3    Barocelli, E.4    Rozengurt, E.5    Raybould, H.6    Sternini, C.7
  • 42
    • 84907222727 scopus 로고    scopus 로고
    • The state of global health in 2014
    • [CrossRef] [PubMed]
    • Sepúlveda, J.; Murray, C. The state of global health in 2014. Science 2014, 345, 1275–1278. [CrossRef] [PubMed]
    • (2014) Science , vol.345 , pp. 1275-1278
    • Sepúlveda, J.1    Murray, C.2
  • 43
    • 84875504222 scopus 로고
    • The influence of dietary alternations on the types of intestinal flora
    • Herter, C.A.; Kendall, A.I. The influence of dietary alternations on the types of intestinal flora. J. Biol. Chem. 1910, 7, 203–236.
    • (1910) J. Biol. Chem , vol.7 , pp. 203-236
    • Herter, C.A.1    Kendall, A.I.2
  • 44
    • 0347461937 scopus 로고
    • The Regulation of the Intestinal Flora of Dogs through Diet
    • [PubMed]
    • Torrey, J.C. The Regulation of the Intestinal Flora of Dogs through Diet. J. Med. Res. 1919, 39, 415–447. [PubMed]
    • (1919) J. Med. Res , vol.39 , pp. 415-447
    • Torrey, J.C.1
  • 45
    • 84977622019 scopus 로고    scopus 로고
    • Diet–microbiota interactions as moderators of human metabolism
    • [CrossRef] [PubMed]
    • Sonnenburg, J.L.; Bäckhed, F. Diet–microbiota interactions as moderators of human metabolism. Nature 2016, 535, 56–64. [CrossRef] [PubMed]
    • (2016) Nature , vol.535 , pp. 56-64
    • Sonnenburg, J.L.1    Bäckhed, F.2
  • 46
    • 84987607161 scopus 로고    scopus 로고
    • Role of the gut microbiota in host appetite control: Bacterial growth to animal feeding behaviour
    • [CrossRef] [PubMed]
    • Fetissov, S.O. Role of the gut microbiota in host appetite control: Bacterial growth to animal feeding behaviour. Nat. Rev. Endocrinol. 2016, 13, 11–25. [CrossRef] [PubMed]
    • (2016) Nat. Rev. Endocrinol , vol.13 , pp. 11-25
    • Fetissov, S.O.1
  • 48
    • 84905586295 scopus 로고    scopus 로고
    • Microbiota and diabetes: An evolving relationship
    • [CrossRef] [PubMed]
    • Tilg, H.; Moschen, A.R. Microbiota and diabetes: An evolving relationship. Gut 2014, 63, 1513–1521. [CrossRef] [PubMed]
    • (2014) Gut , vol.63 , pp. 1513-1521
    • Tilg, H.1    Moschen, A.R.2
  • 50
    • 69549084858 scopus 로고    scopus 로고
    • Motile cilia of human airway epithelia are chemosensory
    • [CrossRef] [PubMed]
    • Shah, A.S.; Ben-Shahar, Y.; Moninger, T.O.; Kline, J.N.; Welsh, M.J. Motile cilia of human airway epithelia are chemosensory. Science 2009, 325, 1131–1134. [CrossRef] [PubMed]
    • (2009) Science , vol.325 , pp. 1131-1134
    • Shah, A.S.1    Ben-Shahar, Y.2    Moninger, T.O.3    Kline, J.N.4    Welsh, M.J.5
  • 54
    • 84908151057 scopus 로고    scopus 로고
    • Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms
    • [CrossRef] [PubMed]
    • Alcock, J.; Maley, C.C.; Aktipis, C.A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays 2014, 36, 940–949. [CrossRef] [PubMed]
    • (2014) Bioessays , vol.36 , pp. 940-949
    • Alcock, J.1    Maley, C.C.2    Aktipis, C.A.3
  • 55
    • 84885298843 scopus 로고    scopus 로고
    • Mechanisms underlying weight loss after bariatric surgery
    • [CrossRef] [PubMed]
    • Miras, A.D.; le Roux, C.W. Mechanisms underlying weight loss after bariatric surgery. Nat. Rev. Gastroenterol. Hepatol. 2013, 10, 575–584. [CrossRef] [PubMed]
    • (2013) Nat. Rev. Gastroenterol. Hepatol , vol.10 , pp. 575-584
    • Miras, A.D.1    Le Roux, C.W.2
  • 56
    • 85040461680 scopus 로고    scopus 로고
    • Gut microbial metabolite short-chain fatty acids and obesity
    • [CrossRef] [PubMed]
    • Li, X.; Shimizu, Y.; Kimura, I. Gut microbial metabolite short-chain fatty acids and obesity. Biosci. Microbiota Food Health 2017, 36, 135–140. [CrossRef] [PubMed]
    • (2017) Biosci. Microbiota Food Health , vol.36 , pp. 135-140
    • Li, X.1    Shimizu, Y.2    Kimura, I.3
  • 58
    • 84971373023 scopus 로고    scopus 로고
    • Age-related changes in gut microbiota composition from newborn to centenarian: A cross-sectional study
    • [CrossRef] [PubMed]
    • Odamaki, T.; Kato, K.; Sugahara, H.; Hashikura, N.; Takahashi, S.; Xiao, J.Z.; Abe, F.; Osawa, R. Age-related changes in gut microbiota composition from newborn to centenarian: A cross-sectional study. BMC Microbiol. 2016, 16, 90. [CrossRef] [PubMed]
    • (2016) BMC Microbiol , vol.16 , pp. 90
    • Odamaki, T.1    Kato, K.2    Sugahara, H.3    Hashikura, N.4    Takahashi, S.5    Xiao, J.Z.6    Abe, F.7    Osawa, R.8
  • 59
    • 84861653143 scopus 로고    scopus 로고
    • Changes in the intestinal microbiota from adulthood through to old age. Clinical microbiology and infection: The official publication of the European Society of Clinical Microbiology and Infectious Diseases
    • O’Toole, P.W. Changes in the intestinal microbiota from adulthood through to old age. Clinical microbiology and infection: The official publication of the European Society of Clinical Microbiology and Infectious Diseases. Clin. Microbiol. Infect. 2012, 18, 44–46.
    • (2012) Clin. Microbiol. Infect , vol.18 , pp. 44-46
    • O’Toole, P.W.1
  • 61
    • 84961190691 scopus 로고    scopus 로고
    • The sweetness and bitterness of childhood: Insights from basic research on taste preferences
    • [CrossRef] [PubMed]
    • Mennella, J.A.; Bobowski, N.K. The sweetness and bitterness of childhood: Insights from basic research on taste preferences. Physiol. Behav. 2015, 152, 502–507. [CrossRef] [PubMed]
    • (2015) Physiol. Behav , vol.152 , pp. 502-507
    • Mennella, J.A.1    Bobowski, N.K.2
  • 62
    • 33645906238 scopus 로고    scopus 로고
    • Effects of ageing on smell and taste
    • [CrossRef] [PubMed]
    • Boyce, J.M.; Shone, G.R. Effects of ageing on smell and taste. Postgrad. Med. J. 2006, 82, 239–241. [CrossRef] [PubMed]
    • (2006) Postgrad. Med. J , vol.82 , pp. 239-241
    • Boyce, J.M.1    Shone, G.R.2
  • 64
    • 85037335100 scopus 로고    scopus 로고
    • The Association Between Artificial Sweeteners and Obesity
    • [CrossRef] [PubMed]
    • Pearlman, M.; Obert, J.; Casey, L. The Association Between Artificial Sweeteners and Obesity. Curr. Gastroenterol. Rep. 2017, 19, 64. [CrossRef] [PubMed]
    • (2017) Curr. Gastroenterol. Rep , vol.19 , pp. 64
    • Pearlman, M.1    Obert, J.2    Casey, L.3
  • 65
    • 84877999280 scopus 로고    scopus 로고
    • Molecular genetic testing and the future of clinical genomics
    • [CrossRef] [PubMed]
    • Katsanis, S.H.; Katsanis, N. Molecular genetic testing and the future of clinical genomics. Nat. Rev. Genet. 2013, 14, 415–426. [CrossRef] [PubMed]
    • (2013) Nat. Rev. Genet , vol.14 , pp. 415-426
    • Katsanis, S.H.1    Katsanis, N.2
  • 67
    • 84978863785 scopus 로고    scopus 로고
    • Emerging Technologies for Gut Microbiome Research
    • [CrossRef] [PubMed]
    • Arnold, J.W.; Roach, J.; Azcarate-Peril, M.A. Emerging Technologies for Gut Microbiome Research. Trends Microbiol. 2016, 24, 887–901. [CrossRef] [PubMed]
    • (2016) Trends Microbiol , vol.24 , pp. 887-901
    • Arnold, J.W.1    Roach, J.2    Azcarate-Peril, M.A.3
  • 68
    • 84904859627 scopus 로고    scopus 로고
    • Microbiome analysis—From technical advances to biological relevance
    • [CrossRef] [PubMed]
    • Smith, M.I.; Turpin, W.; Tyler, A.D.; Silverberg, M.S.; Croitoru, K. Microbiome analysis—From technical advances to biological relevance. F1000Prime Rep. 2014, 6, 51. [CrossRef] [PubMed]
    • (2014) F1000prime Rep , vol.6 , pp. 51
    • Smith, M.I.1    Turpin, W.2    Tyler, A.D.3    Silverberg, M.S.4    Croitoru, K.5
  • 69
    • 85030152000 scopus 로고    scopus 로고
    • GPCRs: Emerging anti-cancer drug targets
    • [CrossRef] [PubMed]
    • Nieto Gutierrez, A.; McDonald, P.H. GPCRs: Emerging anti-cancer drug targets. Cell. Signal. 2018, 41, 65–74. [CrossRef] [PubMed]
    • (2018) Cell. Signal , vol.41 , pp. 65-74
    • Nieto Gutierrez, A.1    McDonald, P.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.