Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in southern Italy

Obesity

Volumn 16, Issue 10, 2008, Pages 2289-2295

  Tepper, Beverly J ^a   Koelliker, Yvonne ^a   Zhao, Liqiang ^a   Ullrich, Natalia V ^a   Lanzara, Carmela ^b   D'Adamo, Pio ^b   Ferrara, Antonella ^b   Ulivi, Sheila ^b   Esposito, Laura ^b   Gasparini, Paolo ^b  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROPYLTHIOURACIL; TASTE RECEPTORS, TYPE 2;

ADOLESCENT; ADULT; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALORIC RESTRICTION; FEMALE; GENETIC POLYMORPHISM; GENETICS; HAPLOTYPE; HUMAN; ITALY; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; QUESTIONNAIRE; REGRESSION ANALYSIS; SEX DIFFERENCE; TASTE;

ADIPOSITY; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY HEIGHT; BODY MASS INDEX; BODY WEIGHT; CALORIC RESTRICTION; FEMALE; HAPLOTYPES; HUMANS; ITALY; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; PROPYLTHIOURACIL; QUESTIONNAIRES; RECEPTORS, G-PROTEIN-COUPLED; REGRESSION ANALYSIS; SEX FACTORS; TASTE;

EID: 53849098349     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.357     Document Type: Article

References (46)

1. Wooding S, Kim UK, Bamshad MJ et al. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet 2004;74:637-646.
2. Shi P, Zhang J, Yang H, Zhang YP. Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 2003;20:805-814.
3. Bufe B, Breslin PA, Kuhn C et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005;15:322-327.
4. Fox AL. The relationship between chemical constitution and taste. Proc Natl Acad Sci 1932;18:115-120.
5. Blakeslee A. Genetics of sensory thresholds: taste for phenyl thiocarbamide. Proc Natl Acad Sci 1932;18:120-130.
6. Guo SW, Reed DR. The genetics of phenylthiocarbamide perception. Ann Hum Biol 2001;28:111-142.
7. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003;299:1221-1225.
8. Bartoshuk LM, Duffy VB, Miller IJ. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav 1994;56:1165-1171.
9. Tepper BJ, Ullrich NV. Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women. Physiol Behav 2002;75:305-312.
10. Zhao L, Kirkmeyer SV, Tepper BJ. A paper screening test to assess genetic taste sensitivity to 6-n-propylthiouracil. Physiol Behav 2003;78:625-633.
11. Prutkin J, Fisher EM, Etter L et al. Genetic variation and inferences about perceived taste intensity in mice and men. Physiol Behav 2000;69:161-173.
12. Dinehart ME, Hayes JE, Bartoshuk LM et al. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav 2006;87:304-313.
13. Tepper BJ, Nurse RJ. Fat perception is related to PROP taster status. Physiol Behav 1997;61:949-954.
14. Keller KL, Steinmann L, Nurse RJ, Tepper BJ. Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children. Appetite 2002;38:3-12.
15. Duffy VB, Davidson AC, Kidd JR et al. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 2004;28:1629-1637.
16. Ullrich NV, Touger-Decker R, O'Sullivan-Maillet J, Tepper BJ. PROP taster status and self-perceived food adventurousness influence food preferences. J Am Diet Assoc 2004;104:543-549.
17. Bell KI, Tepper BJ. Short-term vegetable intake by young children classified by 6-n-propylthoiuracil bitter-taste phenotype. Am J Clin Nutr 2006;84:245-251.
18. Yeomans M, Tepper B, Rietzschel J, Prescott J. Human hedonic responses to sweetness: role of taste genetics and anatomy. Physiol Behav 2007;91:264-273.
19. Tepper BJ. 6-n-Propylthiouracil as a genetic taste marker for fat intake, obesity and chronic disease risk: current evidence and future promise. In: Prescott J, Tepper BJ (eds). Genetic Variation in Taste Sensitivity. Marcel Dekker: New York, 2004, pp. 155-178.
20. Goldstein G, Daun H, Tepper B. Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents. Physiol Behav 2007;90:809-817.
21. Goldstein GL, Daun H, Tepper BJ. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes Res 2005;13:1017-1023.
22. Drewnowski A, Kristal A, Cohen J. Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies. Chem Senses 2001;26:483-489.
23. Drewnowski A, Henderson SA, Cockroft JE. Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J Am Diet Assoc 2007;107:1340-1348.
24. Lawson OJ, Williamson DA, Champagne CM et al. The association of body weight, dietary intake, and energy expenditure with dietary restraint and disinhibition. Obes Res 1995;3:153-161.
25. Lindroos AK, Lissner L, Mathiassen ME et al. Dietary intake in relation to restrained eating, disinhibition, and hunger in obese and nonobese Swedish women. Obes Res 1997;5:175-182.
26. Hays NP, Bathalon GP, McCrory MA et al. Eating behavior correlates of adult weight gain and obesity in healthy women aged 55-65 y. Am J Clin Nutr 2002;75:476-483.
27. Lanzara C, d'Adamo AP, Montico M et al. Use of an Italian isolated population for studying complex diseases. The Carlantino project: study design and preliminary results. Slovenian J Pub Health, in press.
28. Green BG, Dalton P, Cowart B, Shaffer G, Rankin K, Higgins J. Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell. Chem Senses 1996;21:323-334.
29. Tepper BJ, Christensen CM, Cao J. Development of brief methods to classify individuals by PROP taster status. Physiol Behav 2001;73:571-577.
30. Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 1985;29:71-83.
31. Tepper BJ, Choi Y-S, Nayga RM Jr. Understanding food choice in adult men: influence of nutrition knowledge, food beliefs and dietary restraint. Food Qual Pref 1997;8:307-317.
32. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000;66:279-292.
33. Timpson NJ, Heron J, Day IN et al. Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. BMC Genet 2007;8:51.
34. Timpson NJ, Christensen M, Lawlor DA et al. TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Am J Clin Nutr 2005;81:1005-1011.
35. Prodi DA, Drayna D, Forabosco P et al. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem Senses 2004;29:697-702.
36. Essick GK, Chopra A, Guest S, McGlone F. Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects. Physiol Behav 2003;80:289-302.
37. Duffy VB, Lucchina LA, Bartoshuk LM. Genetic variation in taste: potential biomarker for cardiovascular risk? In: Prescott J, Tepper BJ (eds). Genetic Variation in Taste Sensitivity. Marcel Dekker: New York, 2004, pp. 195-228.
38. Tepper BJ, Nurse RJ. PROP taster status is related to the perception and preference for fat. Ann NY Acad Sci 1998;855:802-804.
39. Keller KL, Tepper BJ. Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. Obes Res 2004;12:904-912.
40. Drewnowski A, Henderson SA, Hann CS, Berg WA, Ruffin MT. Genetic taste markers and preferences for vegetables and fruit of female breast care patients. J Am Diet Assoc 2000;100:191-197.
41. Bartoshuk LM. Comparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception. Chem Senses 2000;25:447-460.
42. American Heart Association. Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement: Executive Summary. Circulation 2005;112:e285-e290.
43. Okura T, Koda M, Ando F et al. Association of polymorphisms in the estrogen receptor α gene with body fat distribution. Int J Obes Relat Metab Disord 2003;27:1020-1027.
44. Gonzalez Sanchez JL, Proenza AM, Martinez Larrad MT et al. The glutamine 27 glutamic acid polymorphism of the β2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain. Clin Endocrinol (Oxf) 2003;59:476-481.
45. Martinez JA, Corbalan MS, Sanchez-Villegas A et al. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu β2-adrenoceptor polymorphism. J Nutr 2003;133:2549-2554.
46. Heutink P, Oostra BA. Gene finding in genetically isolated populations. Hum Mol Genet 2002;11:2507-2515.