Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits

Molecular Nutrition and Food Research

Volumn 60, Issue 7, 2016, Pages 1673-1683

  Ortega, Francisco J ^a,b   Agüera, Zaida ^a,c   Sabater, Mònica ^a,b   Moreno Navarrete, José M ^a,b   Alonso Ledesma, Isabel ^a,b   Xifra, Gemma ^b   Botas, Patricia ^d   Delgado, Elías ^d   Jimenez Murcia, Susana ^a,c   Fernández García, José C ^a,e   Tinahones, Francisco J ^a,e   Baños, Rosa M ^a,f   Botella, Cristina ^a,g   de la Torre, Rafael ^a,h,i   Frühbeck, Gema ^a,j   Rodrigüez, Amaia ^a,j   Estivill, Xavier ^k   Casanueva, Felipe ^a,l   Ricart, Wifredo ^a,b   Fernández Aranda, Fernando ^a,c   Fernández Real, José M ^a,b   more..

^a Instituto de Salud Carlos III   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^d HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^f UNIVERSITY OF VALENCIA   (Spain)

^g UNIVERSITAT JAUME I   (Spain)

^h UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

ⁱ HOSPITAL DEL MAR   (Spain)

^j UNIVERSITY CLINIC OF NAVARRA   (Spain)

^k CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^l UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

more..

Author keywords

Haplotypes; Immune system; Mannose binding lectin; Metabolism; Obesity; Surfactant protein D; Taste receptor type 2 member 38

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MANNOSE BINDING LECTIN; SURFACTANT PROTEIN D; TASTE RECEPTORS, TYPE 2;

ADOLESCENT; ADULT; AGED; BODY MASS; BODY WEIGHT; CASE CONTROL STUDY; COHORT ANALYSIS; FEMALE; GENETICS; HAPLOTYPE; HUMAN; INNATE IMMUNITY; MALE; MIDDLE AGED; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TASTE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BODY MASS INDEX; BODY WEIGHT; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; HAPLOTYPES; HUMANS; IMMUNITY, INNATE; MALE; MANNOSE-BINDING LECTIN; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; RECEPTORS, G-PROTEIN-COUPLED; SMOKING; TASTE; YOUNG ADULT;

EID: 84977603753     PISSN: None     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500804     Document Type: Article

References (54)

1. Wooding, S., Gunn, H., Ramos, P, Thalmann, S. et al., Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables. Chem. Senses 2010, 35, 685-692.
2. Tepper, B. J., Banni, S., Melis, M., Crnjar, R. et al., Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with physiological mechanisms controlling body mass index (BMI). Nutrients 2014, 6, 3363-3381.
3. Lipchock, S. V., Mennella, J. A., Spielman, A. I., Reed, D. R., Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. Am. J. Clin. Nutr. 2013, 98, 1136-1143.
4. Tepper, B. J., Koelliker, Y., Zhao, L., Ullrich, N. V. et al., Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring) 2008, 76, 2289-2295.
5. Reed, D. R., Zhu, G., Breslin, P. A., Duke, F. F. et al., The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum. Mol. Genet. 2010, 79, 4278-4285.
6. Sandell, M. A., Breslin, P. A., Variability in a taste-receptor gene determines whether we taste toxins in food. Curr. Biol. 2006, 76, R792-R794.
7. Bartoshuk, L. M., Duffy, V. B., Miller, I. J., PTC/PROP tasting: Anatomy, psychophysics, and sex effects. Physiol. Behav. 1994, 56, 1165-1171.
8. Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B. et al., T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J. Clin. Invest. 2012, 722, 4145-4159.
9. Lee, R. J., Cohen, N. A., Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J. Mol. Med. (Berl). 2014, 92, 1235-1244.
10. Fernandez-Real, J. M., Pickup, J. C., Innate immunity, insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 2008, 79, 10-16.
11. Sano, H., Kuroki, Y., The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity. Mol. Immunol. 2005, 42, 279-287.
12. Crouch, E. C., Surfactant protein-D and pulmonary host defense. Respir. Res. 2000, 7, 93-108.
13. Petersen, S. V., Thiel, S., Jensenius, J. C., The mannan-binding lectin pathway of complement activation: Biology and disease association. Mol. Immunol. 2001, 38, 133-149.
14. Keller, M., Liu, X., Wohland, T., Rohde, K. et al., TAS2R38 and its influence on smoking behavior and glucose homeostasis in the German Sorbs. PLoS One 2013, 8, e80512.
15. Dotson, C. D., Zhang, L., Xu, H., Shin, Y. K. et al., Bitter taste receptors influence glucose homeostasis. PLoS One 2008, 3, e3974.
16. Hoppu, U., Laitinen, K., Jaakkola, J., Sandell, M., The hTAS2R38 genotype is associated with sugar and candy consumption in preschool boys. J. Hum. Nutr. Diet. 2015, 28 Suppl 7, 45-51.
17. Sandell, M., Hoppu, U., Mikkila, V., Mononen, N. et al., Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults. Genes Nutr. 2014, 9, 433.
18. Prutkin, J., Fisher, E. M., Etter, L., Fast, K. et al., Genetic variation and inferences about perceived taste intensity in mice and men. Physiol. Behav. 2000, 69, 161-173.
19. Feeney, E., O'Brien, S., Scannell, A., Markey, A. et al., Genetic variation in taste perception: Does it have a role in healthy eating? Proc. Nutr. Soc. 2011, 70, 135-143.
20. Gorovic, N., Afzal, S., Tjonneland, A., Overvad, K. et al., Genetic variation in the hTAS2R38 taste receptor and brassica vegetable intake. Scand. J. Clin. Lab. Invest. 2011, 77, 274-279.
21. Mennella, J. A., Pepino, M. Y., Duke, F. F., Reed, D. R., Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet. 2010, 77, 60.
22. Winkler, S., Garg, A. K., Mekayarajjananonth, T., Bakaeen, L. G. et al., Depressed taste and smell in geriatric patients. J. Am. Dent. Assoc. 1999, 730, 1759-1765.
23. Jounio, U., Rantala, A., Bloigu, A., Juvonen, R. et al., Smoking status interacts with the association between mannose-binding lectin serum levels and gene polymorphism and the carriage of oropharyngeal bacteria. Hum. Immunol. 2010, 77, 298-303.
24. Fernandez-Aranda, F., Aguera, Z., Fernandez-Garcia, J. C., Garrido-Sanchez, L. et al., Smell-taste dysfunctions in extreme weight/eating conditions: Analysis of hormonal and psychological interactions. Endocrine 2016, 57, 256-267.
25. Banos, R. M., Cebolla, A., Moragrega, I., Van Strien, T. et al., Relationship between eating styles and temperament in an anorexia nervosa, healthy control, and morbid obesity female sample. Appetite 2014, 76, 76-83.
26. Valdes, S., Botas, P., Delgado, E., Alvarez, F. et al., Population-based incidence of type 2 diabetes in northern Spain: The Asturias Study. Diabetes Care 2007, 30, 2258-2263.
27. Moreno-Navarrete, J. M., Ortega, F. J., Bassols, J., Castro, A. et al., Association of circulating lactoferrin concentration and 2 nonsynonymous LTF gene polymorphisms with dyslipidemia in men depends on glucose-tolerance status. Clin. Chem. 2008, 54, 301-309.
28. Villarejo, C., Fernandez-Aranda, F., Jimenez-Murcia, S., Penas-Lledo, E. et al., Lifetime obesity in patients with eating disorders: Increasing prevalence, clinical and personality correlates. Eur. Eat. Disord. Rev. 2012, 20, 250-254.
29. Mueller, C., Kallert, S., Renner, B., Stiassny, K. et al., Quantitative assessment of gustatory function in a clinical context using impregnated "taste strips". Rhinology 2003, 47,2-6.
30. Hummel, T., Sekinger, B., Wolf, S. R., Pauli, E. et al., 'Sniffin' sticks': Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem. Senses 1997, 22, 39-52.
31. He, L., Sillanpaa, M. J., Silventoinen, K., Kaprio, J. et al., Estimating modifying effect of age on genetic and environmental variance components in twinmodels. Genetics 2016, 202, 1313-1328.
32. Schubert, C. R., Cruickshanks, K. J., Fischer, M. E., Huang, G. H. et al., Olfactory impairment in an adult population: The Beaver Dam Offspring Study. Chem. Senses 2012, 37, 325-334.
33. Mullol, J., Alobid, I., Marino-Sanchez, F, Quinto, L. et al., Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: A population-based survey (OLFACAT study). BMJ Open. 2012, 2(6), pii: E001256.
34. Richardson, B. E., Vander Woude, E. A., Sudan, R., Thompson, J. S. et al., Altered olfactory acuity in the morbidly obese. Obes. Surg. 2004, 74, 967-969.
35. Simchen, U., Koebnick, C., Hoyer, S., Issanchou, S. et al., Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight. Eur. J. Clin. Nutr. 2006, 60, 698-705.
36. Sartor, F., Donaldson, L. F., Markland, D. A., Loveday, H. et al., Taste perception and implicit attitude toward sweet related to body mass index and soft drink supplementation. Appetite 2011, 57, 237-246.
37. Richardson, B. E., Vanderwoude, E. A., Sudan, R., Leopold, D. A. et al., Gastric bypass does not influence olfactory function in obese patients. Obes. Surg. 2012, 22, 283-286.
38. Meguid, M. M., Koseki, M., Yang, Z. J., Gleason, J. R. et al., Acute adaptive changes in food intake pattern following olfactory ablation in rats. Neuroreport 1997, 8,1439-1444.
39. O'Brien, S. A., Feeney, E. L., Scannell, A. G., Markey, A. et al., Bitter taste perception and dietary intake patterns in irish children. J. Nutrigenet. Nutrigenomics 2013, 6, 43-58.
40. Epstein, L. H., Carr, K. A., Scheid, J. L., Gebre, E. et al., Taste and food reinforcement in non-overweight youth. Appetite 2015, 97, 226-232.
41. Moreno-Navarrete, J. M., Fernandez-Real, J. M., Antimicrobial-sensing proteins in obesity and type 2 diabetes: The buffering efficiency hypothesis. Diabetes Care 2011, 34, Suppl 2, S335-S341.
42. Fernandez-Real, J. M., Straczkowski, M., Vendrell, J., Soriguer, F. et al., Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin. Diabetologia. 2006, 49, 2402-2411.
43. Fernandez-Real, J. M., Valdes, S., Manco, M., Chico, B. et al., Surfactant protein d, a marker of lung innate immunity, is positively associated with insulin sensitivity. Diabetes Care 2010, 33, 847-853.
44. Yackinous, C., Guinard, J. X., Relation between PROP taster status and fat perception, touch, and olfaction. Physiol. Behav. 2001, 72, 427-137.
45. McCormack, F. X., Whitsett, J. A., The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J. Clin. Invest. 2002, 109, 707-712.
46. Endo, Y., Matsushita, M., Fujita, T., The role of ficolins in the lectin pathway of innate immunity. Int. J. Biochem. Cell Biol. 2011, 43, 705-712.
47. Shah, A. S., Ben-Shahar, Y., Moninger, T. O., Kline, J. N. et al., Motile cilia of human airway epithelia are chemosensory. Science 2009, 325, 1131-1134.
48. Goldstein, G. L., Daun, H., Tepper, B. J., Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes. Res. 2005, 13, 1017-1023.
49. Drewnowski, A., Henderson, S. A., Cockroft, J. E., Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J.Am. Diet Assoc. 2007, 107, 1340-1348.
50. Sausenthaler, S., Rzehak, P., Wichmann, H. E., Heinrich, J., Lack of relation between bitter taste receptor TAS2R38 and BMI in adults. Obesity (Silver Spring). 2009, 17, 937-938; author reply 939.
51. Santos, K. W., Echeveste, S. S., Vidor, D. C., Influence of gustatory and olfactory perception in the oral phase of swallowing in smokers. Codas 2014, 26, 68-75.
52. Sato, K., Endo, S., Tomita, H., Sensitivity of three loci on the tongue and soft palate to four basic tastes in smokers and non-smokers. Acta Otolaryngol. Suppl. 2002, 546, 74-82.
53. Krut, L. H., Perrin, M. J., Bronte-Stewart, B., Taste perception in smokers and non-smokers. Br. Med. J. 1961, 1, 384-387.
54. Mangold, J. E., Payne, T. J., Ma, J. Z., Chen, G. et al., Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J. Med. Genet. 2008, 45, 578-582.