Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F0F1-ATPase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 26, 2000, Pages 14766-14771

  Salomon, Arthur R ^a   Voehringer, David W ^a   Herzenberg, Leonard A ^a   Khosla, Chaitan ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; APOPTOLIDIN; ASPARTATE AMINOTRANSFERASE; CYTOTOXIC AGENT; CYTOVARICIN; LACTIC ACID; OLIGOMYCIN; OSSAMYCIN; POLYKETIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE KINASE; UNCLASSIFIED DRUG;

ANAEROBIC METABOLISM; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER CENTER; CARBON DIOXIDE FIXATION; CENTRAL NERVOUS SYSTEM TUMOR; COLON CANCER; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG SELECTIVITY; EXPERIMENTAL MODEL; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA CELL LINE; MELANOMA CELL; OVARY CANCER; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SENSITIZATION;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; DNA-BINDING PROTEINS; HT29 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MACROLIDES; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; OLIGOMYCINS; PROTON-TRANSLOCATING ATPASES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034687837     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.26.14766     Document Type: Article

References (24)

1. Hayakawa, Y., Kim, J. W., Adachi, H., Shinya, K., Fujita, K. & Seto, H. (1998) J. Am. Chem. Soc. 120, 3524-3525.
2. Kim, J. W., Adachi, H., Shin-ya, K., Hayakawa, Y. & Seto, H. (1997) J. Antibiol. (Tokyo) 50, 628-630.
3. Salomon, A. R., Voehringer, D., Herzenberg, L. A. & Khosla, C. (2000) Chem. Biol., in press.
4. Matsuyama, S., Llopis, J., Deveraux, Q. L., Tsien, R. Y. & Reed, J. C. (2000) Nat. Cell Biol. 2, 318-325.
5. Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A., et al. (1991) J. Natl. Cancer Inst. 83, 757-766.
6. Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A., Scudiero, D. A., Rubinstein, L., Plowman, J. & Boyd, M. R. (1989) J. Natl. Cancer Inst. 81, 1088-1092.
7. Paull, K. D., Hamel, E. & Malspeis, L. (1993) in Cancer Chemotherapeutic Agents, ed. Foye, W. E. (Am. Chem. Soc., Washington, DC), pp. 9-45.
8. Ross, D. T., Scherf, U., Eisen, M. B., Perou, C. M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S. S., Van de Rijn, M., Waltham, M., et al. (2000) Nat. Genet. 24, 227-235.
9. Scherf, U., Ross, D. T., Waltham, M., Smith, L. H., Lee, J. K., Tanahe, L., Kohn, K. W., Reinhold, W. C., Myers, T. G., Andrews, D. T., et al. (2000) Nat. Genet. 24, 236-244.
10. Criddle, R. S., Packer, L. & Shieh, P. (1977) Proc. Natl. Acad. Sci. USA 74, 4306-4310.
11. John, U. P. & Nagley, P. (1986) FEBS Lett. 207, 79-83.
12. Nagley, P., Hall, R. M. & Ooi, B. G. (1986) FEBS Lett. 195, 159-163.
13. Eigenbrodt, E., Reinacher, M., Scheefers-Borchel, U., Scheefers, H. & Friis, R. (1992) Crit. Rev. Oncog. 3, 91-115.
14. Yamada, K. & Noguchi, T. (1999) Biochem. Biophys. Res. Commun. 256, 257-262.
15. Greenhouse, W. V. & Lehninger, A. L. (1976) Cancer Res. 36, 1392-1396.
16. Greenhouse, W. V. & Lehninger, A. L. (1977) Cancer Res. 37, 4173-4181.
17. Lopez-Alarcon, L. & Eboli, M. L. (1986) Cancer Res. 46, 5589-5591.
18. Semenza, G. L. (1999) Annu. Rev. Cell Dev. Biol. 15, 551-578.
19. Hanahan, D. & Folkman, J. (1996) Cell 86, 353-364.
20. Story, M. D., Voehringer, D. W., Malone, C. G., Hobbs, M. L. & Meyn, R. E. (1994) Int. J. Radiat. Biol. 66, 659-668.
21. Warburg, O. (1924) Biochem Z. 152, 319-344.
22. Warburg, O. (1956) Science 123, 309-314.
23. Green, D. R. & Reed, J. C. (1998) Science 281, 1309-1312.
24. Narita, M., Shimizu, S., Ito, T., Chittenden, T., Lutz, R. J., Matsuda, H. & Tsujimoto, Y. (1998) Proc. Natl. Acad. Sci. USA 95, 14681-14686.