-
1
-
-
34247109045
-
Natural Products as Sources of New Drugs over the Last 25 Years
-
Newman, D. J.; Cragg, G. M. Natural Products as Sources of New Drugs over the Last 25 Years J. Nat. Prod. 2007, 70, 461-477
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
2
-
-
67650436176
-
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
-
Li, J. W.-H.; Vederas, J. C. Drug Discovery and Natural Products: End of an Era or an Endless Frontier? Science 2009, 325, 161-165
-
(2009)
Science
, vol.325
, pp. 161-165
-
-
Li, J.W.-H.1
Vederas, J.C.2
-
3
-
-
38949138457
-
Function-Oriented Synthesis, Step Economy, and Drug Design
-
Wender, P. A.; Verma, V. A.; Paxton, T. J.; Pillow, T. H. Function-Oriented Synthesis, Step Economy, and Drug Design Acc. Chem. Res. 2008, 41, 40-49
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 40-49
-
-
Wender, P.A.1
Verma, V.A.2
Paxton, T.J.3
Pillow, T.H.4
-
4
-
-
78650111987
-
Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis
-
Szpilman, A. M.; Carreira, E. M. Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis Angew. Chem., Int. Ed. 2010, 49, 2-39
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 2-39
-
-
Szpilman, A.M.1
Carreira, E.M.2
-
5
-
-
77956034361
-
On the Reach of Chemical Science: Creation of a Mini-Pipline from an Academic Laboratory
-
Wilson, R. M.; Danishefsky, S. J. On the Reach of Chemical Science: Creation of a Mini-Pipline from an Academic Laboratory Angew. Chem., Int. Ed. 2010, 49, 6031-3056
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 6031-3056
-
-
Wilson, R.M.1
Danishefsky, S.J.2
-
6
-
-
14844362054
-
Molecular Mechanism Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
-
Sieber, S. A.; Marahiel, M. A. Molecular Mechanism Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics Chem. Rev. 2005, 105, 715-738
-
(2005)
Chem. Rev.
, vol.105
, pp. 715-738
-
-
Sieber, S.A.1
Marahiel, M.A.2
-
7
-
-
67649604461
-
Ribosomal Peptide Natural Products: Bridging the Ribosomal and Nonribosomal Worlds
-
McIntosh, J. A.; Donia, M. S.; Schmidt, E. W. Ribosomal Peptide Natural Products: Bridging the Ribosomal and Nonribosomal Worlds Nat. Prod. Rep. 2009, 26, 537-559
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 537-559
-
-
McIntosh, J.A.1
Donia, M.S.2
Schmidt, E.W.3
-
8
-
-
0028118767
-
Polytheonamides, Unprecedented Highly Cytotoxic Polypeptides, from the Marine Sponge Theonella swinhoei: 1. Isolation and Component Amino Acids
-
Hamada, T.; Sugawara, T.; Matsunaga, S.; Fusetani, N. Polytheonamides, Unprecedented Highly Cytotoxic Polypeptides, from the Marine Sponge Theonella swinhoei: 1. Isolation and Component Amino Acids Tetrahedron Lett. 1994, 35, 719-720
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 719-720
-
-
Hamada, T.1
Sugawara, T.2
Matsunaga, S.3
Fusetani, N.4
-
9
-
-
11844280935
-
Polytheonamides A and B, Highly Cytotoxic, Linear Polypeptides with Unprecedented Structural Features, from the Marine Sponge Theonella swinhoei
-
Hamada, T.; Matsunaga, S.; Yano, G.; Fusetani, N. Polytheonamides A and B, Highly Cytotoxic, Linear Polypeptides with Unprecedented Structural Features, from the Marine Sponge Theonella swinhoei J. Am. Chem. Soc. 2005, 127, 110-118
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 110-118
-
-
Hamada, T.1
Matsunaga, S.2
Yano, G.3
Fusetani, N.4
-
10
-
-
85027943237
-
Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides
-
Freeman, M. F.; Gurgui, C.; Helf, M. J.; Morinaka, B. I.; Uria, A. R.; Oldham, N. J.; Sahl, H.-G.; Matsunaga, S.; Piel, J. Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides Science 2012, 338, 387-390
-
(2012)
Science
, vol.338
, pp. 387-390
-
-
Freeman, M.F.1
Gurgui, C.2
Helf, M.J.3
Morinaka, B.I.4
Uria, A.R.5
Oldham, N.J.6
Sahl, H.-G.7
Matsunaga, S.8
Piel, J.9
-
11
-
-
77956621008
-
Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge
-
Hamada, T.; Matsunaga, S.; Fujiwara, M.; Fujita, K.; Hirota, H.; Schmucki, R.; Güntert, P.; Fusetani, N. Solution Structure of Polytheonamide B, a Highly Cytotoxic Nonribosomal Polypeptide from Marine Sponge J. Am. Chem. Soc. 2010, 132, 12941-12945
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 12941-12945
-
-
Hamada, T.1
Matsunaga, S.2
Fujiwara, M.3
Fujita, K.4
Hirota, H.5
Schmucki, R.6
Güntert, P.7
Fusetani, N.8
-
12
-
-
81255152587
-
Dynamic Structure of the Polytheonamide B Channel Studied by Normal Mode Analysis
-
Mori, T.; Kokubo, H.; Oiki, S.; Okamoto, Y. Dynamic Structure of the Polytheonamide B Channel Studied by Normal Mode Analysis Mol. Simul. 2011, 37, 975-985
-
(2011)
Mol. Simul.
, vol.37
, pp. 975-985
-
-
Mori, T.1
Kokubo, H.2
Oiki, S.3
Okamoto, Y.4
-
13
-
-
0027360175
-
High-Resolution Conformation of Gramicidin A in a Lipid-Bilayer by Solid-State NMR
-
Ketcham, R. R.; Hu, W.; Cross, T. A. High-Resolution Conformation of Gramicidin A in a Lipid-Bilayer by Solid-State NMR Science 1993, 261, 1457-1460
-
(1993)
Science
, vol.261
, pp. 1457-1460
-
-
Ketcham, R.R.1
Hu, W.2
Cross, T.A.3
-
14
-
-
0031830332
-
Recent Advances in the High Resolution Structures of Bacterial Channels: Gramicidin A
-
Wallace, B. A. Recent Advances in the High Resolution Structures of Bacterial Channels: Gramicidin A J. Struct. Biol. 1998, 121, 123-141
-
(1998)
J. Struct. Biol.
, vol.121
, pp. 123-141
-
-
Wallace, B.A.1
-
16
-
-
0030667666
-
A Channel-Forming Peptide Toxin: Polytheonamide from Marine Sponge (Theonella swinhoei)
-
Oiki, S.; Muramatsu, I.; Matsunaga, S.; Fusetani, N. A Channel-Forming Peptide Toxin: Polytheonamide from Marine Sponge (Theonella swinhoei) Folia Pharmacol. Jpn. 1997, 110 (Suppl. 1) 195-198
-
(1997)
Folia Pharmacol. Jpn.
, vol.110
, Issue.SUPPL. 1
, pp. 195-198
-
-
Oiki, S.1
Muramatsu, I.2
Matsunaga, S.3
Fusetani, N.4
-
17
-
-
77956921248
-
A Cytotoxic Peptide from a Marine Sponge Exhibits Ion Channel Activity through Vectorial-Insertion into the Membrane
-
Iwamoto, M.; Shimizu, H.; Muramatsu, I.; Oiki, S. A Cytotoxic Peptide from a Marine Sponge Exhibits Ion Channel Activity through Vectorial-Insertion into the Membrane FEBS Lett. 2010, 584, 3995-3999
-
(2010)
FEBS Lett.
, vol.584
, pp. 3995-3999
-
-
Iwamoto, M.1
Shimizu, H.2
Muramatsu, I.3
Oiki, S.4
-
18
-
-
77950283409
-
Total Synthesis of the Large Non-Ribosomal Peptide Polytheonamide B
-
Inoue, M.; Shinohara, N.; Tanabe, S.; Takahashi, T.; Okura, K.; Itoh, H.; Mizoguchi, Y.; Iida, M.; Lee, N.; Matsuoka, S. Total Synthesis of the Large Non-Ribosomal Peptide Polytheonamide B Nat. Chem. 2010, 2, 280-285
-
(2010)
Nat. Chem.
, vol.2
, pp. 280-285
-
-
Inoue, M.1
Shinohara, N.2
Tanabe, S.3
Takahashi, T.4
Okura, K.5
Itoh, H.6
Mizoguchi, Y.7
Iida, M.8
Lee, N.9
Matsuoka, S.10
-
19
-
-
79955785158
-
Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide
-
Matsuoka, S.; Shinohara, N.; Takahashi, T.; Iida, M.; Inoue, M. Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide Angew. Chem., Int. Ed. 2011, 50, 4879-4883
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 4879-4883
-
-
Matsuoka, S.1
Shinohara, N.2
Takahashi, T.3
Iida, M.4
Inoue, M.5
-
20
-
-
80053571473
-
Total Synthesis and Functional Analysis of Non-Ribosomal Peptides
-
Inoue, M. Total Synthesis and Functional Analysis of Non-Ribosomal Peptides Chem. Rec. 2011, 11, 284-294
-
(2011)
Chem. Rec.
, vol.11
, pp. 284-294
-
-
Inoue, M.1
-
21
-
-
79953862276
-
Convergent Total Synthesis of the Complex Non-Ribosomal Peptide Polytheonamide B
-
Inoue, M.; Matsuoka, S. Convergent Total Synthesis of the Complex Non-Ribosomal Peptide Polytheonamide B Isr. J. Chem. 2011, 51, 346-358
-
(2011)
Isr. J. Chem.
, vol.51
, pp. 346-358
-
-
Inoue, M.1
Matsuoka, S.2
-
22
-
-
84866763630
-
Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel
-
Shinohara, N.; Itoh, H.; Matsuoka, S.; Inoue, M. Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel ChemMedChem 2012, 7, 1770-1773
-
(2012)
ChemMedChem
, vol.7
, pp. 1770-1773
-
-
Shinohara, N.1
Itoh, H.2
Matsuoka, S.3
Inoue, M.4
-
23
-
-
84865646614
-
Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel
-
Itoh, H.; Matsuoka, S.; Kreir, M.; Inoue, M. Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel J. Am. Chem. Soc. 2012, 134, 14011-14018
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 14011-14018
-
-
Itoh, H.1
Matsuoka, S.2
Kreir, M.3
Inoue, M.4
-
24
-
-
84872304749
-
Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity
-
Itoh, H.; Inoue, M. Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity ACS Med. Chem. Lett. 2013, 4, 52-56
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 52-56
-
-
Itoh, H.1
Inoue, M.2
-
25
-
-
0007193238
-
Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides
-
Humphrey, J. M.; Chamberlin, A. R. Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides Chem. Rev. 1997, 97, 2243-2266
-
(1997)
Chem. Rev.
, vol.97
, pp. 2243-2266
-
-
Humphrey, J.M.1
Chamberlin, A.R.2
-
27
-
-
0023889559
-
Chemical Synthesis of Peptides and Proteins
-
Kent, S. B. H. Chemical Synthesis of Peptides and Proteins Annu. Rev. Biochem. 1988, 57, 957-989
-
(1988)
Annu. Rev. Biochem.
, vol.57
, pp. 957-989
-
-
Kent, S.B.H.1
-
28
-
-
0025767755
-
2-Chlorotrityl Chloride Resin
-
Barlos, K.; Chatzi, O.; Gatos, D.; Stavropoulos, G. 2-Chlorotrityl Chloride Resin Int. J. Pept. Protein Res. 1991, 37, 513-520
-
(1991)
Int. J. Pept. Protein Res.
, vol.37
, pp. 513-520
-
-
Barlos, K.1
Chatzi, O.2
Gatos, D.3
Stavropoulos, G.4
-
29
-
-
12044258245
-
1-Hydroxy-7-Azabenzotriazole. An Efficient Peptide Coupling Additive
-
Carpino, L. A. 1-Hydroxy-7-Azabenzotriazole. An Efficient Peptide Coupling Additive J. Am. Chem. Soc. 1993, 115, 4397-4398
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 4397-4398
-
-
Carpino, L.A.1
-
30
-
-
0033397158
-
Polypeptide Synthesis by the Thioester Method
-
Aimoto, S. Polypeptide Synthesis by the Thioester Method Biopolymers 1999, 51, 247-265
-
(1999)
Biopolymers
, vol.51
, pp. 247-265
-
-
Aimoto, S.1
-
31
-
-
77955656511
-
The Effect of Sulfur stereochemistry of l -β,β- Dimethylmethionine S -Oxide on the Physicochemical Properties of Truncated Polytheonamides
-
Matsuoka, S.; Mizoguchi, Y.; Itoh, H.; Okura, K.; Shinohara, N.; Inoue, M. The Effect of Sulfur stereochemistry of l -β,β-Dimethylmethionine S -Oxide on the Physicochemical Properties of Truncated Polytheonamides Tetrahadron Lett. 2010, 51, 4644-4647
-
(2010)
Tetrahadron Lett.
, vol.51
, pp. 4644-4647
-
-
Matsuoka, S.1
Mizoguchi, Y.2
Itoh, H.3
Okura, K.4
Shinohara, N.5
Inoue, M.6
-
32
-
-
0001427872
-
Removal of the N-Terminal Residue of a Protein after Transamination
-
Dixon, H. B. F.; Moret, V. Removal of the N-Terminal Residue of a Protein after Transamination Biochem. J. 1965, 94, 463-469
-
(1965)
Biochem. J.
, vol.94
, pp. 463-469
-
-
Dixon, H.B.F.1
Moret, V.2
-
33
-
-
0030481087
-
Redox-Triggered Secondary Structure Changes in the Aggregated States of a Designed Methionine-Rich Peptide
-
Schenck, H. L.; Dado, G. P.; Gellman, S. H. Redox-Triggered Secondary Structure Changes in the Aggregated States of a Designed Methionine-Rich Peptide J. Am. Chem. Soc. 1996, 118, 12487-12494
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 12487-12494
-
-
Schenck, H.L.1
Dado, G.P.2
Gellman, S.H.3
-
34
-
-
0037449319
-
Activity of Single Ion Channel Proteins Detected with a Planar Microstructure
-
Fertig, N.; Klau, M.; George, M.; Blick, R. H.; Behrends, J. C. Activity of Single Ion Channel Proteins Detected with a Planar Microstructure Appl. Phys. Lett. 2002, 81, 4865-4867
-
(2002)
Appl. Phys. Lett.
, vol.81
, pp. 4865-4867
-
-
Fertig, N.1
Klau, M.2
George, M.3
Blick, R.H.4
Behrends, J.C.5
-
36
-
-
77249178764
-
Nanoscale Ionic Diodes with Tunable and Switchable Rectifying Behavior
-
Macrae, M. X.; Blake, S.; Mayer, M.; Yang, J. Nanoscale Ionic Diodes with Tunable and Switchable Rectifying Behavior J. Am. Chem. Soc. 2010, 132, 1766-1767
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 1766-1767
-
-
Macrae, M.X.1
Blake, S.2
Mayer, M.3
Yang, J.4
-
37
-
-
48849104292
-
A Voltage-Responding Ion Channel Derived by C-Terminal Modification of Gramicidin A
-
Reiß, P.; Al-Momani, L.; Koert, U. A Voltage-Responding Ion Channel Derived by C-Terminal Modification of Gramicidin A ChemBioChem 2008, 9, 377-379
-
(2008)
ChemBioChem
, vol.9
, pp. 377-379
-
-
Reiß, P.1
Al-Momani, L.2
Koert, U.3
-
38
-
-
0030731890
-
Voltage-Dependent Behavior of a "ball-and-Chain" Gramicidin Channel
-
Woolley, G. A.; Zunic, V.; Karanicolas, J.; Jaikaran, A. S. I.; Starostin, A. V. Voltage-Dependent Behavior of a "Ball-and-Chain" Gramicidin Channel Biophys. J. 1997, 73, 2465-2475
-
(1997)
Biophys. J.
, vol.73
, pp. 2465-2475
-
-
Woolley, G.A.1
Zunic, V.2
Karanicolas, J.3
Jaikaran, A.S.I.4
Starostin, A.V.5
-
39
-
-
0018694217
-
A Double-Stranded β-Helix with Antiparallel Chains in a Crystalline Oligo- l - D -Peptide
-
Benedetti, E.; Di Blasio, B.; Pedone, C.; Lorenzi, G. P.; Tomasic, L.; Gramlich, V. A Double-Stranded β-Helix with Antiparallel Chains in a Crystalline Oligo- l-d -Peptide Nature 1979, 282, 630
-
(1979)
Nature
, vol.282
, pp. 630
-
-
Benedetti, E.1
Di Blasio, B.2
Pedone, C.3
Lorenzi, G.P.4
Tomasic, L.5
Gramlich, V.6
-
40
-
-
0031567125
-
Crystal Structure of the Gramicidin/Potassium Thiocyanate Complex
-
Doyle, D. A.; Wallace, B. A. Crystal Structure of the Gramicidin/Potassium Thiocyanate Complex J. Mol. Biol. 1997, 266, 963-977
-
(1997)
J. Mol. Biol.
, vol.266
, pp. 963-977
-
-
Doyle, D.A.1
Wallace, B.A.2
-
41
-
-
1242272756
-
Conformational and Structural Analysis of the Equilibrium between Single- and Double-Strand β-Helix of a d, l -Alternating Oligonorleucine
-
Navarro, E.; Fenude, E.; Celda, B. Conformational and Structural Analysis of the Equilibrium between Single- and Double-Strand β-Helix of a d, l -Alternating Oligonorleucine Biopolymers 2004, 73, 229-241
-
(2004)
Biopolymers
, vol.73
, pp. 229-241
-
-
Navarro, E.1
Fenude, E.2
Celda, B.3
-
42
-
-
14844296372
-
The Antiviral Antibiotic Feglymycin: First Direct-Methods Solution of a 1000+ Equal-Atom Structure
-
Bunkóczi, G.; Vértesy, L.; Sheldrick, G. M. The Antiviral Antibiotic Feglymycin: First Direct-Methods Solution of a 1000+ Equal-Atom Structure Angew. Chem., Int. Ed. 2005, 44, 1340-1342
-
(2005)
Angew. Chem., Int. Ed.
, vol.44
, pp. 1340-1342
-
-
Bunkóczi, G.1
Vértesy, L.2
Sheldrick, G.M.3
-
43
-
-
0348109450
-
The Growing Impact of Click Chemistry on Drug Discovery
-
Kolb, H. C.; Sharpless, K. B. The Growing Impact of Click Chemistry on Drug Discovery Drug Discovery Today 2003, 8, 1128-1137
-
(2003)
Drug Discovery Today
, vol.8
, pp. 1128-1137
-
-
Kolb, H.C.1
Sharpless, K.B.2
-
44
-
-
77953297817
-
Molecular Recognition at the Membrane-Water Interface: Controlling Integral Peptide Helices by Off-Membrance Nucleobase Pairing
-
For synthesis of 28-mer d, l -alternating peptide, see
-
For synthesis of 28-mer d, l -alternating peptide, see: Schneggenburger, P. E.; Müllar, S.; Worbs, B.; Steinem, C.; Diederichsen, U. Molecular Recognition at the Membrane-Water Interface: Controlling Integral Peptide Helices by Off-Membrance Nucleobase Pairing J. Am. Chem. Soc. 2010, 132, 8020-8028
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 8020-8028
-
-
Schneggenburger, P.E.1
Müllar, S.2
Worbs, B.3
Steinem, C.4
Diederichsen, U.5
-
45
-
-
0019883199
-
Pyranine (8-Hydroxy-1,3,6-pyrenetrisulfonate) as a Probe of Internal Aqueous Hydrogen Ion Concentration in Phospholipid Vesicles
-
Clement, N. R.; Gould, J. M. Pyranine (8-Hydroxy-1,3,6- pyrenetrisulfonate) as a Probe of Internal Aqueous Hydrogen Ion Concentration in Phospholipid Vesicles Biochemistry 1981, 20, 1534-1538
-
(1981)
Biochemistry
, vol.20
, pp. 1534
-
-
Clement, N.R.1
Gould, J.M.2
|