SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

PLoS Pathogens

Volumn 14, Issue 8, 2018, Pages

  Kmiec, Dorota ^a   Akbil, Bengisu ^a   Ananth, Swetha ^b,c   Hotter, Dominik ^a   Sparrer, Konstantin M J ^a   Stürzel, Christina M ^a   Trautz, Birthe ^b,c   Ayouba, Ahidjo ^d   Peeters, Martine ^d   Yao, Zhong ^e   Stagljar, Igor ^e,f   Passos, Vânia ^g   Zillinger, Thomas ^h   Goffinet, Christine ^g   Sauter, Daniel ^a   Fackler, Oliver T ^b,c   Kirchhoff, Frank ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c Partner Site Heidelberg   (Germany)

^d UNIVERSITÉ DE MONTPELLIER   (France)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g HANNOVER MEDICAL SCHOOL   (Germany)

^h UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BONE MARROW STROMAL ANTIGEN 2; CHEMOKINE RECEPTOR CXCR4; LEUCINE; PROTEIN; SERINC5 PROTEIN; SIVCOL NEF PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; NEF PROTEIN; PROTEASOME; SERINC5 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL MIGRATION; CELL SURFACE; COLOBUS; COLOBUS GUEREZA; CONTROLLED STUDY; EMBRYO; EX VIVO STUDY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LYMPHOID TISSUE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION; VIRION; VIRUS INFECTIVITY; VIRUS REPLICATION; XENOPUS; ZEBRA FISH; ANIMAL; CELL CULTURE; GENETICS; HEK293 CELL LINE; JURKAT CELL LINE; METABOLISM; PHYSIOLOGY; SIMIAN IMMUNODEFICIENCY VIRUS; VIROLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COLOBUS; GENE PRODUCTS, NEF; HEK293 CELLS; HIV-1; HUMANS; JURKAT CELLS; LYMPHOID TISSUE; MEMBRANE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 85053081796     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1007269     Document Type: Article

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