-
1
-
-
0038299654
-
HIV-1 pathogenesis
-
Stevenson M (2003) HIV-1 pathogenesis. Nat Med 9: 853-860.
-
(2003)
Nat Med
, vol.9
, pp. 853-860
-
-
Stevenson, M.1
-
2
-
-
22744453432
-
Human immumodeficiency virus (HIV)-1 proteins and cytoskeleton: Partners in viral life and host cell death
-
Matarrese P, Malorni W (2005) Human immumodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death. Cell Death Diller 12 Suppl 1: 932-941.
-
(2005)
Cell Death Diller
, vol.12
, Issue.SUPPL. 1
, pp. 932-941
-
-
Matarrese, P.1
Malorni, W.2
-
4
-
-
0028804160
-
Gcnomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
-
Deacon NJ, Tsykin A, Solomon A, Smith K, Ludford-Menting M, et al. (1995) Gcnomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270: 988-991.
-
(1995)
Science
, vol.270
, pp. 988-991
-
-
Deacon, N.J.1
Tsykin, A.2
Solomon, A.3
Smith, K.4
Ludford-Menting, M.5
-
5
-
-
0025743306
-
Importance of the nef gene for maintenance of high virus loads and for development of AIDS
-
Kestler HW 3rd, Ringler DJ, Mori K, Panicali DL, Sehgal PK, et al. (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651-662.
-
(1991)
Cell
, vol.65
, pp. 651-662
-
-
Kestler 3rd, H.W.1
Ringler, D.J.2
Mori, K.3
Panicali, D.L.4
Sehgal, P.K.5
-
6
-
-
0028835788
-
Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
-
Kirchhoff F, Greenough TC, Brctdcr DB, Sullivan JL, Desrosiers RC (1995) Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1332: 228-232.
-
(1995)
N Engl J Med
, vol.1332
, pp. 228-232
-
-
Kirchhoff, F.1
Greenough, T.C.2
Brctdcr, D.B.3
Sullivan, J.L.4
Desrosiers, R.C.5
-
7
-
-
0030887932
-
The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
-
Baur AS, Sass G, Laffert B, Willbold D, Cheng-Mayer C, et al. (1997) The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6: 283-291.
-
(1997)
Immunity
, vol.6
, pp. 283-291
-
-
Baur, A.S.1
Sass, G.2
Laffert, B.3
Willbold, D.4
Cheng-Mayer, C.5
-
8
-
-
0028485232
-
HIV-1 Nef leads to inhibition or activation of T celb depending on its intracellular localization
-
Baur AS, Sawai ET, Dazin P, Fand VJ, Cheng-Mayer C, et al. (1994) HIV-1 Nef leads to inhibition or activation of T celb depending on its intracellular localization. Immunity 1: 373-384.
-
(1994)
Immunity
, vol.1
, pp. 373-384
-
-
Baur, A.S.1
Sawai, E.T.2
Dazin, P.3
Fand, V.J.4
Cheng-Mayer, C.5
-
9
-
-
0033529258
-
HIV-1 Nef increases T cell activation in a stimulus-dependent manner
-
Schrager JA, Marsh JW (1999) HIV-1 Nef increases T cell activation in a stimulus-dependent manner. Proc Natl Acad Sci U S A 96: 8167-8172.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 8167-8172
-
-
Schrager, J.A.1
Marsh, J.W.2
-
10
-
-
0034602776
-
The Nef protein of HIV-1 associates with rafts and prunes T cells for activation
-
Wang JK, Kiyokawa E, Verdin E, Trono D (2000) The Nef protein of HIV-1 associates with rafts and prunes T cells for activation. Proc Natl Acad Sci U S A 97: 394-399.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 394-399
-
-
Wang, J.K.1
Kiyokawa, E.2
Verdin, E.3
Trono, D.4
-
11
-
-
33646082756
-
Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1
-
Keppler OT, Tibroni N, Venzke S, Rauch S, Fackler OT (2006) Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1. J Leukoc Biol 79: 616-627.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 616-627
-
-
Keppler, O.T.1
Tibroni, N.2
Venzke, S.3
Rauch, S.4
Fackler, O.T.5
-
12
-
-
0034595806
-
Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
-
Manninen A, Renkema GH, Saksela K (2000) Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway. J Biol Chem 275: 16513-16517.
-
(2000)
J Biol Chem
, vol.275
, pp. 16513-16517
-
-
Manninen, A.1
Renkema, G.H.2
Saksela, K.3
-
13
-
-
33745835407
-
The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity
-
Haller C, Rauch S, Michel N, Hanneman S, Lehmann MJ, et al. (2006) The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity. J. Biol Chem 281: 19618-19630.
-
(2006)
J. Biol Chem
, vol.281
, pp. 19618-19630
-
-
Haller, C.1
Rauch, S.2
Michel, N.3
Hanneman, S.4
Lehmann, M.J.5
-
14
-
-
33745070227
-
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
-
Schindler M, Munch J, Kutsch O, Li H, Santiago MI, et al. (2006) Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 125: 1055-1067.
-
(2006)
Cell
, vol.125
, pp. 1055-1067
-
-
Schindler, M.1
Munch, J.2
Kutsch, O.3
Li, H.4
Santiago, M.I.5
-
15
-
-
33646552033
-
Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
-
Thoulouze MI, Sol-Foulon N, Blanchet F, Dautry-Varsat A, Schwartz O, et al. (2006) Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 24: 547-561.
-
(2006)
Immunity
, vol.24
, pp. 547-561
-
-
Thoulouze, M.I.1
Sol-Foulon, N.2
Blanchet, F.3
Dautry-Varsat, A.4
Schwartz, O.5
-
16
-
-
33646137152
-
Immunological synapse and microclusters: The site for recognition and activation of T cells
-
Saito T, Yokosuka T (2006) Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr Opin Immunol 18: 305-313.
-
(2006)
Curr Opin Immunol
, vol.18
, pp. 305-313
-
-
Saito, T.1
Yokosuka, T.2
-
17
-
-
34548012864
-
Plasma membrane segregation during T cell activation: Probing the order of domains
-
Harder T, Rentero C, Zech T, Gaus K (2007) Plasma membrane segregation during T cell activation: probing the order of domains. Curr Opin Immunol 19: 470-475.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 470-475
-
-
Harder, T.1
Rentero, C.2
Zech, T.3
Gaus, K.4
-
18
-
-
33846626054
-
Rejulation of T-cell activation by the cytoskeletion
-
Billadeau DD, Nolz JC, Gomez TS (2007) Rejulation of T-cell activation by the cytoskeletion. Nat Rev Immunol 7: 131-143.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 131-143
-
-
Billadeau, D.D.1
Nolz, J.C.2
Gomez, T.S.3
-
19
-
-
34047117842
-
T-cell-remptor-dependent actin regulatory mechanisms
-
Huang Y, Burkhardt JK (2007) T-cell-remptor-dependent actin regulatory mechanisms. J Cell Sci 120: 723-730.
-
(2007)
J Cell Sci
, vol.120
, pp. 723-730
-
-
Huang, Y.1
Burkhardt, J.K.2
-
20
-
-
17644395663
-
The T cell receptor: Critical role of the membrane environment in receptor assembly and function
-
Call ME, Wucherpfennig KW (2005) The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol 23: 101-125.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 101-125
-
-
Call, M.E.1
Wucherpfennig, K.W.2
-
21
-
-
0029874657
-
T cell antigen receptor signal transduction pathways
-
Cantrell D (1996) T cell antigen receptor signal transduction pathways. Annu Rev Immunol 14: 259-274.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 259-274
-
-
Cantrell, D.1
-
22
-
-
12144291075
-
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts
-
Krautramer E, Giese SI, Gasteier JE, Muranyi W, Fackler OT (2004) Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts. J Virol 78: 4085-4097.
-
(2004)
J Virol
, vol.78
, pp. 4085-4097
-
-
Krautramer, E.1
Giese, S.I.2
Gasteier, J.E.3
Muranyi, W.4
Fackler, O.T.5
-
23
-
-
12344272845
-
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
-
Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, et al. (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol 6: 80-89.
-
(2005)
Nat Immunol
, vol.6
, pp. 80-89
-
-
Barda-Saad, M.1
Braiman, A.2
Titerence, R.3
Bunnell, S.C.4
Barr, V.A.5
-
24
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, et al. (2002) T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol 158: 1263-1275.
-
(2002)
J Cell Biol
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.C.1
Hong, D.I.2
Kardon, J.R.3
Yamazaki, T.4
McGlade, C.J.5
-
25
-
-
27544441784
-
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
-
Campi G, Varma R, Dustin ML (2005) Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 202: 1031-1036.
-
(2005)
J Exp Med
, vol.202
, pp. 1031-1036
-
-
Campi, G.1
Varma, R.2
Dustin, M.L.3
-
26
-
-
0033776709
-
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulsde class I major histocompatibility complexes
-
Piguet V, Wan L, Borel C, Mangasarian A, Demaurex N, et al. (2000) HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulsde class I major histocompatibility complexes. Nat Cell Biol 2: 163-167.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 163-167
-
-
Piguet, V.1
Wan, L.2
Borel, C.3
Mangasarian, A.4
Demaurex, N.5
-
27
-
-
0032076086
-
Interactions between HIV1 Nef and vacuolar ATPase facilitate & internalization of CD4
-
Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM (1998) Interactions between HIV1 Nef and vacuolar ATPase facilitate & internalization of CD4. Immunity 8: 647-656.
-
(1998)
Immunity
, vol.8
, pp. 647-656
-
-
Lu, X.1
Yu, H.2
Liu, S.H.3
Brodsky, F.M.4
Peterlin, B.M.5
-
28
-
-
33644778761
-
A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2
-
Agopian K, Wei BL, Garcia JV, Gabuzda D (2006) A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2. J Virol 80: 3050-3061.
-
(2006)
J Virol
, vol.80
, pp. 3050-3061
-
-
Agopian, K.1
Wei, B.L.2
Garcia, J.V.3
Gabuzda, D.4
-
29
-
-
33750614324
-
-
Giese SI, Woerz I, Homann S, Tibroni N, Geyer M, et al. (2006) Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Virology 355: 175-191.
-
Giese SI, Woerz I, Homann S, Tibroni N, Geyer M, et al. (2006) Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Virology 355: 175-191.
-
-
-
-
30
-
-
0034894379
-
Structure-function relationships in HIV-1 Nef
-
Geyer M, Fackler OT, Peterlin BM (2001) Structure-function relationships in HIV-1 Nef. EMBO Rep 2: 580-585.
-
(2001)
EMBO Rep
, vol.2
, pp. 580-585
-
-
Geyer, M.1
Fackler, O.T.2
Peterlin, B.M.3
-
31
-
-
0028878783
-
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of GD4
-
Saksela K, Cheng G, Baltimore D (1995) Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of GD4. Embo J 14: 484-491.
-
(1995)
Embo J
, vol.14
, pp. 484-491
-
-
Saksela, K.1
Cheng, G.2
Baltimore, D.3
-
32
-
-
0032566903
-
SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase
-
Manninen A, Hiipakka M, Vihinen M, Lu W, Mayer BJ, et al. (1998) SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 25G: 273-282.
-
(1998)
Virology
, vol.25 G
, pp. 273-282
-
-
Manninen, A.1
Hiipakka, M.2
Vihinen, M.3
Lu, W.4
Mayer, B.J.5
-
33
-
-
0029064101
-
A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity
-
Sawai ET, Baur AS, Peterlin BM, Levy JA, Cheng-Mayer C (1995) A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J Biol Chem 270: 15307-15314.
-
(1995)
J Biol Chem
, vol.270
, pp. 15307-15314
-
-
Sawai, E.T.1
Baur, A.S.2
Peterlin, B.M.3
Levy, J.A.4
Cheng-Mayer, C.5
-
34
-
-
0037869152
-
T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses
-
Jordan S, Rodgers W (2003) T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses. J Immumol 171: 78-87.
-
(2003)
J Immumol
, vol.171
, pp. 78-87
-
-
Jordan, S.1
Rodgers, W.2
-
35
-
-
6344241298
-
CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes
-
Tavano R, Gri G, Molon B, Marinari B, Rudd CE, et al. (2004) CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes. J Immunol 173: 5392-5397.
-
(2004)
J Immunol
, vol.173
, pp. 5392-5397
-
-
Tavano, R.1
Gri, G.2
Molon, B.3
Marinari, B.4
Rudd, C.E.5
-
36
-
-
0042931251
-
Regulation of sustained actin dynamics by die TCR and costimulation as a mechanism of receptor localization
-
Tskvitaria-Fuller I, Rozelle AL, Yin HL, Wulfing C (2003) Regulation of sustained actin dynamics by die TCR and costimulation as a mechanism of receptor localization. J Immunol 171: 2287-2295.
-
(2003)
J Immunol
, vol.171
, pp. 2287-2295
-
-
Tskvitaria-Fuller, I.1
Rozelle, A.L.2
Yin, H.L.3
Wulfing, C.4
-
37
-
-
4444298148
-
-
Li QJ, Dinner AR, Qi S, Irvine DJ, Huppa JB, et 'al. (2004) CD4 enhances T cell sensitivity to antigen bv coordinating Lck accumulation at the immunological synapse. Nat Immunol 5: 791-799.
-
Li QJ, Dinner AR, Qi S, Irvine DJ, Huppa JB, et 'al. (2004) CD4 enhances T cell sensitivity to antigen bv coordinating Lck accumulation at the immunological synapse. Nat Immunol 5: 791-799.
-
-
-
-
38
-
-
0032559586
-
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism
-
Lowin-Kropf B, Shapiro VS, Weiss A (1998) Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J Cell Biol. 1440: 861-871.
-
(1998)
J Cell Biol
, vol.1440
, pp. 861-871
-
-
Lowin-Kropf, B.1
Shapiro, V.S.2
Weiss, A.3
-
39
-
-
0033013962
-
Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
-
Mangasarian A, Piguet V, Wang JK, Chen YL, Trono D (1999) Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking. J Virol 73: 1964-1973.
-
(1999)
J Virol
, vol.73
, pp. 1964-1973
-
-
Mangasarian, A.1
Piguet, V.2
Wang, J.K.3
Chen, Y.L.4
Trono, D.5
-
40
-
-
18044378256
-
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
-
Michel N, Allespach I, Venzke S, Fackler OT, Keppler OT (2005) The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr Biol 15: 714-723.
-
(2005)
Curr Biol
, vol.15
, pp. 714-723
-
-
Michel, N.1
Allespach, I.2
Venzke, S.3
Fackler, O.T.4
Keppler, O.T.5
-
41
-
-
33746582688
-
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling
-
Michel N, Granter K, Venzke S, Bitzegeio J, Fackler OT, et al. (2006) The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell 17: 3578-3590.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 3578-3590
-
-
Michel, N.1
Granter, K.2
Venzke, S.3
Bitzegeio, J.4
Fackler, O.T.5
-
42
-
-
10344258588
-
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHc-I cytoplasmic tail
-
Roeth JF, Williams M, Kasper MR, Filzen TM, Collins KL (2004) HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHc-I cytoplasmic tail. J Cell Biol 167: 903-913.
-
(2004)
J Cell Biol
, vol.167
, pp. 903-913
-
-
Roeth, J.F.1
Williams, M.2
Kasper, M.R.3
Filzen, T.M.4
Collins, K.L.5
-
43
-
-
33746838437
-
The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner
-
Casartelli N, Giolo G, Neri F, Haller C, Potesta M, et al. (2006) The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner. J Gen Virol 87: 2291-2296.
-
(2006)
J Gen Virol
, vol.87
, pp. 2291-2296
-
-
Casartelli, N.1
Giolo, G.2
Neri, F.3
Haller, C.4
Potesta, M.5
-
44
-
-
0037074008
-
HIV-1 Nef downregulates MHG-I by a PACS-1 - and P13K-regulated ARF6 endocytic pathway
-
Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, Hung CH, Thomas G (2002) HIV-1 Nef downregulates MHG-I by a PACS-1 - and P13K-regulated ARF6 endocytic pathway. Cell 111: 853-866.
-
(2002)
Cell
, vol.111
, pp. 853-866
-
-
Blagoveshchenskaya, A.D.1
Thomas, L.2
Feliciangeli, S.F.3
Hung, C.H.4
Thomas, G.5
-
45
-
-
11844255388
-
Oligomerization of the diaphanous-related formin FHOD1 requires a coded-coil motif critical for its cytoskeletal and transcriptional activities
-
Madrid R, Casteier JE, Bouchet J, Schroder S, Geyer M, et al. (2005) Oligomerization of the diaphanous-related formin FHOD1 requires a coded-coil motif critical for its cytoskeletal and transcriptional activities. FEBS Lett 579: 441-448.
-
(2005)
FEBS Lett
, vol.579
, pp. 441-448
-
-
Madrid, R.1
Casteier, J.E.2
Bouchet, J.3
Schroder, S.4
Geyer, M.5
-
46
-
-
0036678882
-
Function of dynein and dynactin in herpes simplex virus capsid transport
-
Dohner K, Wolfstein A, Prank U, Echeverri C, Dojardin D, et al. (2002) Function of dynein and dynactin in herpes simplex virus capsid transport. Mol Biol Cell 13: 2795-2809.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 2795-2809
-
-
Dohner, K.1
Wolfstein, A.2
Prank, U.3
Echeverri, C.4
Dojardin, D.5
-
47
-
-
0035075507
-
Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
-
Bunnell SC, Kapoor V, Trible RP, Zhang W, Samelson LE (2001) Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14: 315-329.
-
(2001)
Immunity
, vol.14
, pp. 315-329
-
-
Bunnell, S.C.1
Kapoor, V.2
Trible, R.P.3
Zhang, W.4
Samelson, L.E.5
|