Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 Is associated with high CD4+ T cell counts in viremic HIV-2 infection

Journal of Virology

Volumn 86, Issue 9, 2012, Pages 4906-4920

  Khalid, Mohammad ^a   Yu, Hangxing ^a   Sauter, Daniel ^a   Usmani, Shariq M ^a   Schmokel, Jan ^a   Feldman, Jerome ^b   Gruters, Rob A ^c   van der Ende, Marchina E ^c   Geyer, Matthias ^d   Rowland Jones, Sarah ^e,f   Osterhaus, Albert D ^c   Kirchhoff, Frank ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b INSTITUT PASTEUR   (France)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^e MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; ISOLEUCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; THREONINE;

ADULT; ALLELE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 2 INFECTION; NEF GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRION; VIRUS GENE; VIRUS INFECTIVITY; VIRUS LOAD;

AMINO ACID SUBSTITUTION; ANTIGENS, CD28; APOPTOSIS; CD4 LYMPHOCYTE COUNT; CELL LINE; DOWN-REGULATION; GENE EXPRESSION; GENE ORDER; HIV INFECTIONS; HIV-2; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PHYLOGENY; PROTEIN BINDING; PROTEIN CONFORMATION; PROVIRUSES; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, CELL SURFACE; RECEPTORS, DEATH DOMAIN; T-LYMPHOCYTES; VIREMIA;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 84861325356     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06856-11     Document Type: Article

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